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Nathan Goodyear

Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy--A unif... - 0 views

www.surgicalneurologyint.com/...rolInt21107-2574138_070901.pdf

immunoexcitotoxicity excitoxicity TBI traumatic brain injury chronic NFL players football soldiers combat

shared by Nathan Goodyear on 08 Feb 12 - No Cached
  • Nathan Goodyear on 08 Feb 12
     
    Article discusses the immunoexcitotoxic process involved in chronic TBI. This is likely to be the underlying process involved in NFL and other football players delayed neurological effects. A similar process has been see in combat veterans returning from the theatre.
Nathan Goodyear

The long-term consequences of exposure to lead. [Isr Med Assoc J. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20108558

heavy metals lead chelation exposure

shared by Nathan Goodyear on 18 Mar 14 - No Cached
  • Nathan Goodyear on 18 Mar 14
     
    Study discusses the long term consequences of chronic lead exposure.  Acute lead toxicity is not the only mechanism of lead toxicity.  Lead can be toxic in chronic exposure.  This study also touches on the aspect that serum levels on reveal recent exposure as challenge and chelation are the only way to draw out and eliminate the stored metals.  When individuals lack detoxification enzymes i.e. glutathione these metals promote more symptoms and/or disease.
Nathan Goodyear

A Critical Appraisal of "Chronic Lyme Disease" - NEJM - 0 views

www.nejm.org/...NEJMra072023

chronic lyme disease

shared by Nathan Goodyear on 26 Aug 13 - No Cached
  • Nathan Goodyear on 26 Aug 13
     
    Review of Chronic Lyme Disease.
Nathan Goodyear

Chronic Lyme Disease: An appraisal - 0 views

www.ncbi.nlm.nih.gov/...PMC2430045

chronic lyme disease

shared by Nathan Goodyear on 26 Aug 13 - No Cached
  • Nathan Goodyear on 26 Aug 13
     
    Nice review of the literature on Chronic lyme, also known as Post Treatment Lyme Syndrome.
Nathan Goodyear

Complement Split Products C3a and C4a in Chronic Lyme Disease - Stricker - 2008 - Scand... - 0 views

onlinelibrary.wiley.com/...abstract

C4a chronic lyme disease immunology complement

shared by Nathan Goodyear on 26 Aug 13 - No Cached
  • Nathan Goodyear on 26 Aug 13
     
    C4a a useful marker in those with symptoms of chronic lyme disease.
Nathan Goodyear

Lead-Chelation Therapy -- A Treatment for Chronic Renal Disease? - General Medicine - 1 views

general-medicine.jwatch.org/...1

EDTA chelation renal insufficiency lead

shared by Nathan Goodyear on 15 Dec 10 - No Cached
  • Therapy with EDTA delayed the progression of chronic renal insufficiency in patients with high-normal body lead burdens
  • Nathan Goodyear on 15 Dec 10
     
    Therapy with EDTA delayed the progression of chronic renal insufficiency in patients with high-normal body lead burdens
Nathan Goodyear

Uric acid in chronic heart failure: a marker of chronic inflammation - 0 views

eurheartj.oxfordjournals.org/...1814.full

uric acid heart failure inflammation

shared by Nathan Goodyear on 15 Aug 11 - No Cached
  • Nathan Goodyear on 15 Aug 11
     
    uric acid is inflammatory marker associated with chronic heart failure
Nathan Goodyear

Complement Split Products C3a and C4a in Chronic Lyme Disease - Stricker - 2008 - Scand... - 0 views

onlinelibrary.wiley.com/...full

chronic lyme disease complement C3a C4a inflammation

shared by Nathan Goodyear on 12 Sep 11 - No Cached
  • Nathan Goodyear on 12 Sep 11
     
    complement C3a and C4a in chronic lyme disease
Nathan Goodyear

Chronic fatigue syndrome and mitochondrial dysfunction - 0 views

www.ncbi.nlm.nih.gov/...PMC2680051

mitochondria CFS fatigue chronic fatigues syndrome

shared by Nathan Goodyear on 18 Aug 14 - No Cached
  • Nathan Goodyear on 18 Aug 14
     
    Discussion of the mitochondrial role in chronic fatigue syndrome.  As the authors conclude, there is dysfunction, but whether the cause is primary or secondary or likely varies from individual to individual is yet undetermined.
  • Blu Electronic Cigarettes on 20 Aug 14
     
    very helpful post!
Nathan Goodyear

Toxicity of the spike protein of COVID-19 is a redox shift phenomenon: A novel therapeu... - 0 views

www.sciencedirect.com/...S0891584923005014

COVID19 COVID-19 cancer inflammation SARS-CoV-2 spike proteins COVID spikeopathy

shared by Nathan Goodyear on 01 Sep 23 - No Cached
  • Redox shift is due to Warburg effect and mitochondrial impairment.
  • Redox shift is due to Warburg effect and mitochondrial impairment.
  • Redox shift is due to Warburg effect and mitochondrial impairment.
  • ...88 more annotations...
  • The cytokine storm is a consequence of mitochondrial dysfunction
  • The cytokine storm is a consequence of mitochondrial dysfunction
  • The cytokine storm is a consequence of mitochondrial dysfunction
  • The cytokine storm is a consequence of mitochondrial dysfunction
  • Lipoic acid, Methylene Blue and Chlorine dioxide relieve COVID-19 spike protein toxicity
  • Lipoic acid, Methylene Blue and Chlorine dioxide relieve COVID-19 spike protein toxicity
  • Lipoic acid, Methylene Blue and Chlorine dioxide relieve COVID-19 spike protein toxicity
  • Lipoic acid, Methylene Blue and Chlorine dioxide relieve COVID-19 spike protein toxicity
  • most diseases display a form of anabolism due to mitochondrial impairment
  • most diseases display a form of anabolism due to mitochondrial impairment
  • most diseases display a form of anabolism due to mitochondrial impairment
  • infection by Covid-19 follows a similar pattern
  • chronic inflammation
  • Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
  • Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
  • Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
  • Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
  • infection by Covid-19 follows a similar pattern
  • unrelenting anabolism leads to the cytokine storm,
  • unrelenting anabolism leads to the cytokine storm,
  • unrelenting anabolism leads to the cytokine storm,
  • chronic inflammation
  • chronic inflammation
  • infection by Covid-19 follows a similar pattern
  • Lipoic acid and Methylene Blue have been shown to enhance the mitochondrial activity, relieve the Warburg effect and increase catabolism
  • Lipoic acid and Methylene Blue have been shown to enhance the mitochondrial activity, relieve the Warburg effect and increase catabolism
  • Lipoic acid and Methylene Blue have been shown to enhance the mitochondrial activity, relieve the Warburg effect and increase catabolism
  • Methylene Blue, Chlorine dioxide and Lipoic acid may help reduce long-term Covid-19 effects by stimulating the catabolism
  • Methylene Blue, Chlorine dioxide and Lipoic acid may help reduce long-term Covid-19 effects by stimulating the catabolism
  • Methylene Blue, Chlorine dioxide and Lipoic acid may help reduce long-term Covid-19 effects by stimulating the catabolism
  • direct consequence of redox iMeBalance, itself a consequence of decreased energy yield by the mitochondria
  • direct consequence of redox iMeBalance, itself a consequence of decreased energy yield by the mitochondria
  • mitochondrial dysfunction and increased levels of lactate, which are important characteristics of metabolic shift and Warburg effect in many diseases
  • mitochondrial dysfunction and increased levels of lactate, which are important characteristics of metabolic shift and Warburg effect in many diseases
  • increased lactate dehydrogenase activity (LDH) was observed in COVID-19 patients
  • increased lactate dehydrogenase activity (LDH) was observed in COVID-19 patients
  • almost every disease presents an increased anabolism
  • almost every disease presents an increased anabolism
  • cell division is the most sophisticated way to release entropy
  • cell division is the most sophisticated way to release entropy
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Wow
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Wow
  • transition from catabolism to anabolism is driven by a redox shift
  • transition from catabolism to anabolism is driven by a redox shift
  • viral spike protein binds to ACE2 receptor of the host cell [22,23].
  • redox signaling plays an important role in regulating immune function and inflammation, and disruptions in this signaling can lead to excessive cytokine production and immune system activation
  • Aging is associated with a poor control of the redox balance
  • thiol/disulfide homeostasis
  • reduced extracellular environment in the elderly and the increased susceptibility to Covid-19 infection
  • reduced extracellular environment in the elderly and the increased susceptibility to Covid-19 infection
  • Redox signaling tightly modulates the inflammatory response and oxidative stress has been reported in acute Covid-19
  • People at high risk are the elderly, patients suffering from metabolic syndrome such as obesity, or those suffering from chronic diseases such as cancer or inflammation
  • COVID-19 patients with severe disease have higher levels of oxidative stress markers and lower antioxidant levels
  • oxidative stress can activate the NLRP3 inflammasome, which is a protein complex that plays a key role in the cytokine storm
  • inflammation leads to the formation of ROS and RNS, while redox iMeBalance results in cellular damage, which in turn triggers an inflammatory response
  • persistently elevated mtROS triggers endothelial dysfunction and inflammation, which results in a vicious loop involving ROS, inflammation, and mitochondrial dysfunction
  • Damaged mitochondria releasing ROS induce inflammation via the NLRP3 inflammasome
  • Damaged mitochondria releasing ROS induce inflammation via the NLRP3 inflammasome
  • reduced environment during the cytokine storm
  • IL-2 is highly up-regulated in Covid-19 patients [37], and IL-2 is known to significantly stimulate the generation of NO in patients
  • Nitric acid is also the key mediator of IL-2-induced hypotension and vascular leak syndrome
  • mitochondrial dysfunction has been linked to the pathogenesis of Covid-19
  • mitochondrial dysfunction triggered by SARS-CoV-2 leads to damage to the mitochondria
  • mitochondrial dysfunction triggered by SARS-CoV-2 leads to damage to the mitochondria
  • As catabolism is decreased, entropy is released through anabolism
  • Elevated levels of lactate, a characteristic of the Warburg effect, were also reported in the high-risk Covid-19
  • elevated levels of ventricular lactic acid consistent with oxidative stress
  • A decrease of ΔΨm is implicated in several inflammation-related diseases
  • decrease in ΔΨm in leucocytes from Covid-19 patients
  • vaccinated with RNA or DNA vaccines triggering the synthesis of the viral spike protein in human cells
  • viral reactivation in varicella-zoster virus [55] or hepatitis [56], coagulopathy and resulting stroke and myocarditis following both DNA-based vaccines [57] and RNA-based vaccines
  • Covid-19, mitochondrial impairment
  • characteristic of the Warburg effect is present in almost every disease and appears to be a central feature in most of the hallmarks of cancer
  • inflammation, mitochondrial dysfunction and increased lactate concentrations in the extracellular fluid
  • In Covid-19, like any inflammation, there is a metabolic rewiring where cells rely on glycolysis
  • As the mitochondria are impaired, the infected cell cannot catabolize efficiently. It will release lactic acid in the blood stream
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Mitochondrial impairment
  • Striking similarities are seen between cancer, Alzheimer's disease and Covid-19, all related to the Warburg effect
  • Cancer, inflammation, Alzheimer's, and Parkinson's diseases share a common peculiarity, the inability of the cell to export entropy outside the body in the harmless form of heat
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Entropy: lack of order or predictability; gradual decline into disorder.
  • MEB relieves the Warburg effect [87], improves memory [77], is active in the treatment of depressive episodes [79,80] and reduces the importance of ischemic strokes
  • MEB relieves the Warburg effect [87], improves memory [77], is active in the treatment of depressive episodes [79,80] and reduces the importance of ischemic strokes
  • MEB has been shown to inhibit SARS-Cov-2 replication in vitro
  • MEB has been shown to inhibit SARS-Cov-2 replication in vitro
  • It has been shown that Covid-19-patients treated with MEB, have a significant reduction in hospital stay duration and mortality
  • MeB is an acceptor-donor molecule
  • MeB + can take a pair of electrons (of H atoms) and MeBH can release this pair easily, so that MeB is partially recycled like a catalyst
  • MeB acts as an electron bridge between a donor (FADH2, FMNH, NADH) and an acceptor (complex IV of ETC or oxygen itself)
  • As a coenzyme of pyruvate dehydrogenase (PDH), alpha-lipoic acid (ALA) initiates the formation of acetyl-CoA to feed the TCA cycle
  • ALA enhances the catabolism of carbon. cycle and therefore may reduce the Warburg effect and consequently, lactate production
  • Methylene Blue plays a similar role after the TCA cycle, by carrying electrons to complex IV of the electron transport chain
  • Drugs such as lipoic acid and MeB, which target the metabolism, decrease the redox shift by increasing catabolism
Nathan Goodyear

Low Grade Chronic Inflammation in Women with Polycystic Ovarian Syndrome - 0 views

jcem.endojournals.org/...2453.full

inflammation PCOS polycystic ovarian syndrome women

shared by Nathan Goodyear on 05 Nov 12 - No Cached
  • Nathan Goodyear on 05 Nov 12
     
    low grade, chronic inflammation associated with PCOS and common disease states associated with PCOS.  It is known that high androgen levels in women causes inflammation.
Nathan Goodyear

Erectile dysfunction and depression in patients with chronic lead poisoning - Gonulalan... - 0 views

onlinelibrary.wiley.com/...abstract

erectile dysfunction ED lead Pb

shared by Nathan Goodyear on 10 Jun 13 - No Cached
  • Nathan Goodyear on 10 Jun 13
     
    chronic lead toxicity linked with increased ED in men.
Nathan Goodyear

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging - 0 views

www.sciencedirect.com/...S0092867413005941

aging disease SIRT1 inflammation circadian rhythm chronic disease of aging

shared by Nathan Goodyear on 24 Jun 13 - No Cached
  • Nathan Goodyear on 24 Jun 13
     
    SIRT1, known to reduce inflammatory signaling, found to help maintain circadian rhythm.  Loss of the circadian rhythm is know to contribute to chronic disease.  Likewise, SIRT1 has been shown to reduce inflammation, which will reduce disease.  Is this their link?
Nathan Goodyear

Replacement therapy with DHEA plus corticosteroids in patients with chronic inflammator... - 0 views

www.ncbi.nlm.nih.gov/...11155790

DHEA inflammation disease hormones

shared by Nathan Goodyear on 09 May 16 - No Cached
  • Nathan Goodyear on 09 May 16
     
    DHEA is reduced in chronic inflammatory conditions.
Nathan Goodyear

Deficient Glutathione in the Pathophysiology of Mycotoxin-Related Illness - 0 views

www.ncbi.nlm.nih.gov/...PMC3942754

myctotoxins glutathione GSH mold

shared by Nathan Goodyear on 12 Jan 15 - No Cached
  • Decreased function of the enzymes of glutathione production results in a microenvironment depleted of glutathione on a chronic basis
  • In humans, deficiency of glutathione can lead to chronic conditions [97], including chronic asthma
  • Nathan Goodyear on 12 Jan 15
     
    Mycotoxins deplete glutathione production and this depletion of glutathione is a portion go the toxicity/ill effects related to mycotoxins.  This article also points to evidence that glutathione can actually be employed in the treatment of mycotoxin related conditions/illnesses.
Nathan Goodyear

Hypothalamic-pituitary-adrenal stress axis function and the relationship with chronic w... - 0 views

www.ncbi.nlm.nih.gov/...PMC1257426

stress HPA adrenal adrenals cortisol saliva salivary pain

shared by Nathan Goodyear on 01 May 12 - No Cached
  • Nathan Goodyear on 01 May 12
     
    Those with chronic pain shown to have HPA dysfunction.  Elevated cortisol was found via saliva evaluation.  This with pain had the higher cortisol levels.
Nathan Goodyear

Acute Effects of Triiodothyronine (T3) Replacement Therapy in Patients with Chronic Hea... - 0 views

jcem.endojournals.org/...1351.long

T3 fT3 thyroid disease low T3 syndrome T3 syndrome cardiomyopathy CHF congestive heart failure

shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • Nathan Goodyear on 03 Jul 12
     
    IV T3 was given to patients with chronic heart failure.  What the study found may surprise you: improved heart function (ventricular), improved BNP, decrease heart rate, no side effects.  T3 has been shown to be more predictive of cardiac death in those with cardiac disease, than elevated lipids or decreased ejection fraction.
Nathan Goodyear

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance ... - 0 views

www.sciencedirect.com/...S0092867408010088

chronic overnutrition NF-kappaB IKK-Beta inflammation obesity overweight weight-loss ER endoplasmic reticulum stress

shared by Nathan Goodyear on 17 Jan 12 - No Cached
  • Nathan Goodyear on 17 Jan 12
     
    chronic overnutrition (ie overeating) results in activation of the IKKBeta/NF-kappaB complex, increase NF-kappaB transcription and inflammation.  This leads to ER (endoplasmic reticulum) stress
Nathan Goodyear

Inflammation (Chronic Inflammation) - Elevated C-Reactive Protein, Glycation - Life Ext... - 0 views

www.lef.org/...prtcl-146.shtml

inflammation aging CRP IL-6

shared by Nathan Goodyear on 23 Jan 12 - No Cached
  • Nathan Goodyear on 23 Jan 12
     
    good review of chronic inflammation and the systemic detrimental effects of it: aging.  
Nathan Goodyear

Chronic inflammation in fat plays a crucial role in the development of obesity-related ... - 0 views

www.ncbi.nlm.nih.gov/...PMC296998

obesity inflammation overweight weight-loss WAT white adipose tissue macrophages insulin resistance fat

shared by Nathan Goodyear on 16 Jan 12 - No Cached
  • Nathan Goodyear on 16 Jan 12
     
    chronic low-grade inflammation plays role in development of insulin resistance and eventually obesity.  This occurs in White Adipose Tissue
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