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Nathan Goodyear

Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Re... - 0 views

  • Long-term DPs play a large role in determining the selective environment that the gut microbiota faces, ultimately influencing the composition and diversity of taxa maintained within the gut microbial community
  • Americans consuming unrestricted diets maintained less diverse fecal microbiota than those of individuals adhering to a plant-rich diet with restricted caloric intake
  • Experiments in mice have shown that multigenerational exposure to a Western diet poor in “microbiota-accessible carbohydrates” can lead to extirpation of specific bacterial lineages
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    Diet is the key to gut microbe diversity.  Gut microbes are key to maintaining optimal cellular metabolism.  Nutrition can be a prescription for improving and reprogramming gut bacteria.
Nathan Goodyear

Richness of human gut microbiome correlates with metabolic markers. - 0 views

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    Gut bacteria diversity, the authors of this study called it "richness" associated with decreased inflammation and obesity.  Lower gut diversity associated with increased inflammation and obesity.
Nathan Goodyear

Associations of the Fecal Microbiome With Urinary Estrogens and Estrogen Metabolites in... - 0 views

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    women with increased gut microbiome diversity found to have increased estrogen metabolites compared to parent estrogen i.e. gut microbiome diversity in women effects estrogen metabolism. 
Nathan Goodyear

Population-based metagenomics analysis reveals markers for gut microbiome composition a... - 0 views

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    good review of the effects of the diversity of the gut microbiome.  Only abstracts available here.
Nathan Goodyear

The multitude and diversity of environmental carci... [Environ Res. 2007] - PubMed result - 0 views

  • Of major concerns are: outdoor air pollution by carbon particles associated with polycyclic aromatic hydrocarbons; indoor air pollution by environmental tobacco smoke, formaldehyde and volatile organic compounds such as benzene and 1,3 butadiene, which may particularly affect children, and food pollution by food additives and by carcinogenic contaminants such as nitrates, pesticides, dioxins and other organochlorines. In addition, carcinogenic metals and metalloids, pharmaceutical medicines and cosmetics may be involved
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    diversity of environmental carcinogens
Nathan Goodyear

Posttraumatic Stress Disorder: Does the Gut Microbiome Hold the Key? - 0 views

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    Gut microbiome diversity is different in stressed mice and calm mice in animal study.  Authors propose intricate connection between gut:brain and possible evaluation and therapy in PTSD.
Nathan Goodyear

Access : What are the consequences of the disappearing human microbiota? : Nature Revie... - 0 views

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    Changes in our gut microbiota are contributing to the health decline of Americans.  The mechanisms of this microbiota change is diverse.
Nathan Goodyear

Dietary intervention impact on gut microbial gene ric... [Nature. 2013] - PubMed - NCBI - 0 views

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    Gut bacteria diversity associated with metabolic dysfunction, low-grade inflammation and obesity
Nathan Goodyear

Proton pump inhibitors decrease diversity in gut microbiome, increase risk for complica... - 0 views

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    Remember those PPIs that you have been taking for years (though the black box label is for 12 weeks)?  Those same PPIs decrease gut microbiome biodiversity.
Nathan Goodyear

ftp://www.bf.lu.lv/grozs/MolekularasBiologijas/Imunol%20II/Publik%C4%81cijas%20semin%C4... - 0 views

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    full article to previous abstract:  fecal transplant from male mice to female mice resulted in an increase in Testosterone production in the female mice revealing a link between the gut microbial population, diversity and Testosterone production.
Nathan Goodyear

Associations of the Fecal Microbiome With Urinary Estrogens and Estrogen Metabolites in... - 0 views

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    Post-menopause women with increased gut microbiome diversity found to be associated with increased urinary excretion of estrogen metabolites compared to parent estrogens.  This relationship has been shown to be associated with a reduced breast cancer risk.
Nathan Goodyear

The diagnostic applications of saliva--a review. [Crit Rev Oral Biol Med. 2002] - PubMe... - 0 views

  • These constituents are derived from the local vasculature of the salivary glands and also reach the oral cavity via the flow of gingival fluid. Analysis of saliva may be useful for the diagnosis of hereditary disorders, autoimmune diseases, malignant and infectious diseases, and endocrine disorders, as well as in the assessment of therapeutic levels of drugs and the monitoring of illicit drug use
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    saliva testing can be used for diverse diagnostic purposes 
Nathan Goodyear

From the Cover: Pharmacologic doses of ascorbate act as a prooxidant and decrease growt... - 0 views

  • An extensive panel of 43 tumor and 5 normal cell lines were exposed to ascorbate in vitro for ≤2 h to mimic clinical pharmacokinetics
  • effective concentration that decreased survival 50% (EC50) was determined. EC50 was <10 mM for 75% of tumor cells tested, whereas cytotoxicity was not evident in normal cells with >20 mM ascorbate
  • The addition of catalase to the medium ameliorated death of ovarian carcinoma (Ovcar5), pancreatic carcinoma (Pan02), and glioblastoma (9L) cells exposed to 10 mM ascorbate (1 h), indicating cytotoxicity was mediated by H2O2
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  • A treatment dose of 4 g ascorbate/kg body weight either once or twice daily did not produce any discernible adverse effects
  • Xenograft experiments showed that parenteral ascorbate as the only treatment significantly decreased both tumor growth and weight by 41–53%
  • Peak plasma concentrations of ascorbate approached 30 mM
  • Pharmacologic concentrations of ascorbate decreased tumor volumes 41–53% in diverse cancer types known for both their aggressive growth and limited treatment options.
  • Our findings showed that pharmacologic ascorbic acid concentrations were cytotoxic to many types of cancer cells in vitro (Fig. 1A) and significantly impeded tumor progression in vivo without toxicity to normal tissues
  • The amelioration of ascorbate cytotoxicity in vitro by the addition of catalase was consistent among sensitive cancer cells (Fig. 1B) and points unambiguously to H2O2 generation in the extracellular medium
  • the current in vivo data support that pharmacologic ascorbate concentrations, which can readily be achieved in humans (Fig. 3E), diminished growth of several aggressive cancer types in mice (Fig. 2) without causing apparent adverse effects.
  • These intratumoral H2O2 concentrations of >125 μM persisted for >3 h after ascorbate administration
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    Tumor xenograft model in mice finds reduction in growth rates of ovarian cancer, pancreatic cancer, and glioblastoma with daily IV vitamin C.
Nathan Goodyear

Chemotherapy‐driven dysbiosis in the intestinal microbiome - Montassier - 201... - 0 views

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    high‐dose Carmustine (Bis‐chloroethylnitrosourea), Etoposide, Aracytine and Melphalan found to alter gut bacteria diversity.
Nathan Goodyear

Colonic Microbiota Encroachment Correlates With Dysglycemia in Humans - Cellular and Mo... - 0 views

  • most (86%) were overweight, many (45%) were obese
  • third (14 out of 42) had diabetes
  • in obese persons with diabetes, bacteria could be found in the dense inner mucus and in close proximity to the epithelium
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    Gut bacteria proximity, not just balance and diversity, to mucosa lining linked to systemic inflammation and insulin resistance in type II diabetes.  The role of type II diabetes may simply be the gut.  This has been called metabolic endotoxemia.
Nathan Goodyear

Stool Microbiome Profiling of Patients with Metastatic Renal Cell Carcinoma Receiving A... - 0 views

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    Gut microbiome diversity associated with increase in immunotherapy efficacy; particularly akermansia
krsnaphysio1

Physiotherapist in Gurgaon - 0 views

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    Since its establishment in the year 2011, Krshna Physio Plus is aimed to provide patients with comprehensive, high quality and professional physiotherapy treatments and rehabilitation to people in need. The efficient team of three, Dr. Ravi Sahauta - A very well-known complex trauma surgeon and Orthopaedician, Dr. Dharm Pal Sharma - an ex-Air force Physio trainer and Dr. Parmila Sharma - an experienced and talented physio expert, Krshna Physio Plus is counted among the well-known Physiotherapy clinic in Gurgaon and Delhi/NCR regions.  This clinic is one of the oldest organizations which was started with a vision to help people suffering from diverse dysfunctionalities with proper guidance and treatment which encompasses mainly physical, psychological, emotional, and social well being. With 8 centers in Delhi/NCR and Bihar, we are aimed at setting over 300 centers across Asia by 2020 and become the Physiotherapy clinic in Gurgaon.  Moreover, KRSNA Physio Plus is well equipped with various advanced facilities and equipment used to treat people to assure patient satisfaction and fast recovery. We have with us Top Physiotherapist in Gurgaon and Delhi/NCR regions with us who are specialized in offering treatment in physiotherapy dealing with Orthopedic, Neurological, Pediatric, Cardio-pulmonary, and Sports Injury, etc. All the experts here put their best for providing the best results.  Our experienced team of doctors and physiotherapists in Gurgaon who would be better able to diagnose what might be making it impossible for you to crane your neck, or pick articles off the floor, or simply kneel before your deity. Sports-Related Injuries Could Happen to Anyone It could be just that badminton match on a winter evening, or an office football match. Before you realize what is happening you've pulled a back muscle or your hamstring. Playing tug-of-war in colleges and office parties is fraught with the risk of a rotator cuff injury. Cricketers diving to save
spineneuro

Spine And Neuro Surgery Hospital India: New Hope for Spinal Issues With List of Top Lum... - 0 views

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    India is a specialist destination for spine surgery techniques. Lately, India has emerged as the most favored destination for overseas patients with back pain. A large number of patients from throughout the globe travel to India every year with a view to getting the diverse techniques of the lumbar spine from a list of top lumbar spine surgeons in India.
spineneuro

French to India Medical Travel: Nouvel espoir pour les problèmes de colonne v... - 0 views

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    Un grand nombre de patients du monde entier se rendent chaque année en Inde dans le but d'obtenir les diverses techniques de la colonne lombaire parmi une liste des meilleurs chirurgiens de la colonne lombaire en Inde.
spineneuro

Spine Masters: Spotlight on the Best Lumbar Surgeons Shaping India's Care! - 0 views

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    The high quality of training and specialization exhibited by the best lumbar spine surgeons of India and staff contribute to India's global recognition in nearly all medical procedures. Best lumbar spine surgeons in India have successfully conducted a diverse range of spinal surgery procedures to address issues such as herniated discs, degenerative discs, and other spinal problems.
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