Skip to main content

Home/ Dr. Goodyear/ Group items tagged elderly men

Rss Feed Group items tagged

Nathan Goodyear

Testosterone deficiency syndrome and cardiovascular health: An assessment of beliefs, k... - 0 views

  • The vast majority (88%) did not screen cardiac patients for TDS.
  • Testosterone deficiency has a prevalence of 7% in the general population, rising to 20% in elderly males
  • Males with CAD have lower testosterone levels than those with normal coronary angiograms of the same age,5 suggesting that the prevalence of testosterone deficiency is much higher in the CAD population
  • ...14 more annotations...
  • Men with hypertension, another established risk factor for CAD, have lower testosterone compared to normotensive men
  • Recent meta-analyses showed that testosterone levels are generally lower among patients with metabolic syndrome, regardless of the various definitions of metabolic syndrome that are used
  • Testosterone (total and bioavailable) and sex-hormone binding globulin (SHBG) are inversely associated with the prevalence of metabolic syndrome in men between the ages of 40 and 80, and this association persists across racial and ethnic backgrounds
  • ower levels of testosterone and SHBG predict a higher incidence of metabolic syndrome.
  • Low testosterone levels have been related to increased insulin resistance and cardiovascular mortality,12 even in the absence of overt type 2 diabetes mellitus.
  • testosterone levels (total and bioavailable) in middle-aged men are inversely correlated with insulin resistance
  • The Massachusetts Male Aging Study (MMAS) demonstrated that low levels of testosterone and SHBG are independent risk factors for the development of type 2 diabetes,
  • Andropausal men (age 58 ± 7 years) have a higher maximal carotid artery intima-media thickness
  • There is an inverse linear correlation between body mass index (BMI) and wait-to-hip ratio with testosterone and insulin-like growth factor-1 levels.
  • Testosterone supplementation for 1 year in hypogonadal men has been shown to cause a significant improvement in body weight, BMI, waist size, lipid profile, and C-reactive protein levels
  • TRT for 3 months in hypogonadal men with type 2 diabetes significantly improved fasting insulin sensitivity, fasting blood glucose and glycated hemoglobin.
  • Testosterone replacement can improve angina symptoms and delay the onset of cardiac ischemia, likely through a coronary vasodilator mechanism
  • ADT is associated with an increased risk of cardiovascular events, including myocardial infarction and cardiovascular mortality.
  • ADT significantly increases fat mass, decreases lean body mass,29,30 increases fasting plasma insulin and decreases insulin sensitivity31 and increases serum cholesterol and triglyceride levels
  •  
    Startling study on the knowledge of Testosterone and cardiovascular disease in general practitioners and cardiologists in Canada.  Eight-eight percent did not screen patients with cardiovascular disease for low Testosterone.  A whopping 67% of physicians did not know that low T was a risk factor for cardiovascular disease, yet 62% believed Testosterone would increase exercise tolerance. The lack of knowledge displayed by physicians today is staggering and is an indictment of the governing bodies.  This was a survey conducted in Canada so there are obvious limitations to the strength/conclusion of this study.
Nathan Goodyear

Estradiol and inflammatory markers in Older Men - 0 views

  •  
    In this study, estradiol is associate with increased IL-6 in elderly men. No correlation was seen with TNFalpha, and CRP.
Nathan Goodyear

Decreased Basal and Stimulated Thyrotropin Secretion in Healthy Elderly Men - 0 views

  •  
    This study shows that older men are associated with low TSH, reduced response to TRH, lowered T3, and normal T4 levels.  The main find in this study was the decrease in pituitary responsiveness to TRH and the reduced TSH as we age.  TSH is unreliable as a test.
Nathan Goodyear

Mediterranean Diet, Lifestyle Factors, and 10-Year Mortality in Elderly European Men an... - 0 views

  •  
    Mediterranean diet shown to reduce all cause mortality in elderly adults by > 50%.
Nathan Goodyear

Beyond the male sex hormone: deciphering the metabolic and vascular actions of testoste... - 0 views

  • androgen deprivation therapy results in unfavorable changes in body composition, insulin resistance, and dyslipidemia and predisposes men to develop atherosclerosis and an increased risk of cardiovascular mortality
  • The hypogonadal–obesity cycle hypothesis was originally proposed by Cohen in 1999 to explain the relationship between low testosterone levels and metabolic disease. It was based on the finding that obesity impairs testosterone levels by increasing the aromatization of testosterone to estradiol, while low testosterone levels promote increased fat deposition
  • adipocytokines contribute to low testosterone levels as well as to the processes underlying metabolic syndromes and type 2 diabetes
  • ...15 more annotations...
  • hypogonadal–obesity–adipocytokine hypothesis
  • The presence of estradiol and the adipocytokines TNF-α, IL6, and leptin (as a result of leptin resistance in obesity) inhibits the hypothalamic–pituitary–testicular axis response to decreasing androgen levels
  • An increasing number of studies have illustrated the potential for applying metabolomics to the field of androgen research
  • As early as the 1940s, the therapeutic use of testosterone was reported to improve angina pectoris in men with coronary artery disease
  • most of the epidemiological studies reported increased cardiovascular risk and mortality in men with low testosterone levels
  • long-term testosterone replacement appears to be a safe and effective means of treating hypogonadal elderly men
  • a recent interventional trial showed that testosterone treatment was associated with decreased mortality when compared with no testosterone treatment in an observational cohort of men with low testosterone levels
  • a number of short-term studies conducted support the notion that testosterone therapy reduces the cardiovascular risk
  • The majority of animal studies support the hypothesis that the actions of testosterone on vascular relaxation are both endothelium-dependent and -independent vasodilatory effects
  • Endothelial-dependent actions of testosterone increase the expression or activity of endothelial nitric oxide synthase and enhance nitric oxide production, which in turn activates cyclic guanosine monophosphate to induce vasorelaxation in smooth muscle cells
  • Endothelial-independent mechanisms of testosterone are believed to occur primarily via inhibition of voltage-operated Ca2+ channels and/or activation of K+ channels in smooth muscle cells
  • Testosterone may also inhibit intracellular Ca2+ influx via store-operated Ca2+ channels by blocking the response to prostaglandin F2α
  • testosterone has demonstrated anti-inflammatory effects to protect against atherogenesis in animal studies
  • both genomic AR activation to modulate gene transcription and non-genomic activation to modulate the rapid intracellular signaling pathways of ion channels may mediate testosterone effects on vascular function and inflammation.
  • Butenandt & Ruzicka first showed how testosterone is synthesized and responsible for masculine characteristics in the early 1930s
  •  
    Awesome review on the current understanding of Testosterone and Diabetes, metabolic syndrome, and CVD.  This article even goes into the literature on androgen receptors.
Nathan Goodyear

Longitudinal and cross-sectional rel... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

  •  
    This study found that lower TT and E1 associated with more "poor health" as defined by questionnaire.  The conclusion might lead one to think that Estrogen therapy is need in men.  Eightly percent of estrogen production in men occurs from Testosterone.  If Testosterone declines, then estrogen production will likewise decline.  A simple fact that the authors did not comment on.  Also, E1 binds with high affinity to ER alpha, which is pro-inflammatory and pro-proliferative: neither of which is a positive health benefit.   This appears to point more to a broad HPA suppression as an association to the "poor health".
Nathan Goodyear

Low testosterone levels are associated with metabolic syndrome, in elderly men: the rol... - 0 views

  •  
    Low Serum Testosterone inversely associated metabolic syndrome in men.  This study was conducted in the Ikaria islands.  No association was found with women and Testosterone.  In men, Testosterone was inversely associated with waist circumference, hs-CRP, insulin, and HDL.
Nathan Goodyear

Predictors of skeletal muscle mass in elderly men and women - 0 views

  •  
    Study of men and women finds that low free Testosterone, physical activity, and IGF1 is associated with muscle mass in men; no such relationship between sex hormone and muscle mass in women was found.
Nathan Goodyear

Low Total Testosterone Levels are Associated... [Rev Diabet Stud. 2013] - PubMed - NCBI - 0 views

  •  
    low serum total Testosterone associated with Metabolic Syndrome in elderly men.  The authors of this study went so far as to state low Testosterone is "predicting" of MetS.
Nathan Goodyear

Endocrine milieu and erectile dysfunction: is oestradiol-testosterone imbalance, a risk... - 0 views

  •  
    This article points to the impact of T:E2 on ED in men.  A declining T:E2 increases ED in older men.  
Nathan Goodyear

Effects of Aromatase Inhibition in Elderly Men with Low or Borderline-Low Serum Testost... - 0 views

  • aromatase inhibition increases serum bioavailable and total testosterone levels to the youthful normal range in older men with mild hypogonadism
  •  
    low testosterone and Estrogen in men
Nathan Goodyear

Oral testosterone supplementation and chronic low-grade inflammation in elderly men: A ... - 0 views

  •  
    this study showed that oral testosterone did not increase CRP.  This is a different finding than other studies.  I question the use of the oral testosterone due to first pass metabolism.  This would result in less testosterone reaching the peripheral sites of aromatase activity.  
Nathan Goodyear

Adverse Events Associated with Testosterone Administration - NEJM - 0 views

  •  
    Testosterone therapy shown to increase cardiovascular events in elderly men. No comment in study if they evaluated the aromatization of the replacement therapy to estrogen.  I anticipate that this would explain the increase events.
Nathan Goodyear

Omega-3 polyunsaturated fatty acid suppl... [J Nutr Health Aging. 2011] - PubMed - NCBI - 0 views

  •  
    omega-3 supplementation shown to slow cognitive decline in study of elderly Chinese women and men
Nathan Goodyear

Risk of Parkinson Disease Onset in Patients With Diabetes - 0 views

  •  
    Diabetes associated with an increased risk of Parkinson's disease in young men, middle aged women, and the elderly.
Nathan Goodyear

The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implicat... - 0 views

  •  
    discussion of the declining levels of androgens in the aging male.  But the focus of this entire article is wrong.  They are focusing on the blood levels of these androgens.  The biological effects of hormones occur in tissue not blood.  Though this article provides a good discussion of how transport of androgens are effected, it falls far short of providing any useful clinical application, because it fails to discuss peripheral levels of androgens.  
Nathan Goodyear

Serum sex hormone and plasma homocysteine levels in middle-aged and elderly men - 0 views

  •  
    no correlation between Testosterone, estradiol, and DHEAS levels and homocysteine in men >40.
Nathan Goodyear

Estradiol in elderly men. [Aging Male. 2002] - PubMed - NCBI - 0 views

  • Plasma levels of estradiol do not necessarily reflect tissue-level activity
  • age-associated increased aromatization of testosterone
  • Estradiol levels are highly significantly positively related to body fat mass and more specifically to subcutaneous abdominal fat
  •  
    Review of the sources of estrogens in men and the impact it has on a man's physiology.
Nathan Goodyear

Dehydroepiandrosterone Supplementation in Elderly Men: A Meta-Analysis Study of Placebo... - 0 views

  •  
    Meta-analysis finds DHEA beneficial in men.  The main outcome this study looked at was weight loss and/or body composition (i.e. muscle, fat...).
Nathan Goodyear

Effects of Aromatase Inhibition in Elderly Men with Low or Borderline-Low Serum Testost... - 0 views

  •  
    Study looked at aromatase activity in androgen production in older men.  The study found that aromatase inhibition with arimidex increased Testosterone production.  PSA was also monitored and PSA increased in the smaller dose group versus the high dose group.
‹ Previous 21 - 40 of 55 Next ›
Showing 20 items per page