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Startling study on the knowledge of Testosterone and cardiovascular disease in general practitioners and cardiologists in Canada.  Eight-eight percent did not screen patients with cardiovascular disease for low Testosterone.  A whopping 67% of physicians did not know that low T was a risk factor for cardiovascular disease, yet 62% believed Testosterone would increase exercise tolerance. The lack of knowledge displayed by physicians today is staggering and is an indictment of the governing bodies.  This was a survey conducted in Canada so there are obvious limitations to the strength/conclusion of this study.

In this study, estradiol is associate with increased IL-6 in elderly men. No correlation was seen with TNFalpha, and CRP.

This study shows that older men are associated with low TSH, reduced response to TRH, lowered T3, and normal T4 levels.  The main find in this study was the decrease in pituitary responsiveness to TRH and the reduced TSH as we age.  TSH is unreliable as a test.

Mediterranean diet shown to reduce all cause mortality in elderly adults by > 50%.

Awesome review on the current understanding of Testosterone and Diabetes, metabolic syndrome, and CVD.  This article even goes into the literature on androgen receptors.

This study found that lower TT and E1 associated with more "poor health" as defined by questionnaire.  The conclusion might lead one to think that Estrogen therapy is need in men.  Eightly percent of estrogen production in men occurs from Testosterone.  If Testosterone declines, then estrogen production will likewise decline.  A simple fact that the authors did not comment on.  Also, E1 binds with high affinity to ER alpha, which is pro-inflammatory and pro-proliferative: neither of which is a positive health benefit.   This appears to point more to a broad HPA suppression as an association to the "poor health".

Low Serum Testosterone inversely associated metabolic syndrome in men.  This study was conducted in the Ikaria islands.  No association was found with women and Testosterone.  In men, Testosterone was inversely associated with waist circumference, hs-CRP, insulin, and HDL.

Study of men and women finds that low free Testosterone, physical activity, and IGF1 is associated with muscle mass in men; no such relationship between sex hormone and muscle mass in women was found.

low serum total Testosterone associated with Metabolic Syndrome in elderly men.  The authors of this study went so far as to state low Testosterone is "predicting" of MetS.

This article points to the impact of T:E2 on ED in men.  A declining T:E2 increases ED in older men.  

low testosterone and Estrogen in men

this study showed that oral testosterone did not increase CRP.  This is a different finding than other studies.  I question the use of the oral testosterone due to first pass metabolism.  This would result in less testosterone reaching the peripheral sites of aromatase activity.  

Testosterone therapy shown to increase cardiovascular events in elderly men. No comment in study if they evaluated the aromatization of the replacement therapy to estrogen.  I anticipate that this would explain the increase events.

omega-3 supplementation shown to slow cognitive decline in study of elderly Chinese women and men

Diabetes associated with an increased risk of Parkinson's disease in young men, middle aged women, and the elderly.

discussion of the declining levels of androgens in the aging male.  But the focus of this entire article is wrong.  They are focusing on the blood levels of these androgens.  The biological effects of hormones occur in tissue not blood.  Though this article provides a good discussion of how transport of androgens are effected, it falls far short of providing any useful clinical application, because it fails to discuss peripheral levels of androgens.  

no correlation between Testosterone, estradiol, and DHEAS levels and homocysteine in men >40.

Review of the sources of estrogens in men and the impact it has on a man's physiology.

Meta-analysis finds DHEA beneficial in men.  The main outcome this study looked at was weight loss and/or body composition (i.e. muscle, fat...).

Study looked at aromatase activity in androgen production in older men.  The study found that aromatase inhibition with arimidex increased Testosterone production.  PSA was also monitored and PSA increased in the smaller dose group versus the high dose group.