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Nathan Goodyear

Decreased Basal and Stimulated Thyrotropin Secretion in Healthy Elderly Men - 0 views

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    This study shows that older men are associated with low TSH, reduced response to TRH, lowered T3, and normal T4 levels.  The main find in this study was the decrease in pituitary responsiveness to TRH and the reduced TSH as we age.  TSH is unreliable as a test.
Nathan Goodyear

Suppression of thyrotropin-releasing horm... [Neuroendocrinology. 1994] - PubMed - NCBI - 0 views

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    IL-1beta inhibits TRH gene activity.  Previous study has shown that IL-1 suppresses TSH production also.
Nathan Goodyear

Suppression of Rat Thyrotroph and Thyroid Cell Function by Tumor Necrosis Factor-&#x3b1... - 0 views

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    TNF-alpha inhibits TSH secretion in response to TRH stimulus.
Nathan Goodyear

Regulation of mitochondrial biogenesis by thyroid hormone - 0 views

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    Study describes the T3 effect on mitochondrial biogenesis.  T3 interacts with receptors involved with mitochondrial biogenesis in 3 ways: thyroid hormone receptors (TR), thyroid hormone receptor elements (TRE), and a combination of the two.
Nathan Goodyear

A Radioimmunoassay for 3,3',5'-L-Triiodothyronine (Reverse T3): Assessment of Thyroid G... - 0 views

  • Both pregnancy and estrogen administration were associated with increases in serum reverse T3 concentrations presumably because of their ability to augment thyroxine binding globulin synthesis.
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    oral estrogen supplementation increase reverse T3 and lowers metabolism and leads to weight gain
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