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Nathan Goodyear

Testosterone level and mortality in elderly men with systolic chronic heart failure - 0 views

www.ncbi.nlm.nih.gov/...PMC3739581

low T testosterone heart failure mortality congestive CHF men male hormone hormones hypogonadism

shared by Nathan Goodyear on 06 Apr 14 - No Cached
  • Nathan Goodyear on 06 Apr 14
     
    Good article.  Heart failure in men associated with lower Total Testosterone and estimated Free Testosterone. The severity of disease was associated with lower Testosterone levels.   I wish they would have measured free levels not estimated them.   Increased SHBG concentrations was associated increased CHF as well. This study found no association with mortality.
Nathan Goodyear

Long-Term Testosterone Treatment in Elderly Men wi... [J Sex Med. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24712761

low T Testosterone undecanoate metabolic syndrome cholesterol triglycerides glucose weight BMI men male hormone hormones hypogonadism

shared by Nathan Goodyear on 22 Apr 14 - No Cached
  • Nathan Goodyear on 22 Apr 14
     
    Testosterone therapy, undecanoate in this study, found to improve body weight, decrease waist circumference, BMI, lower Total Cholesterol, lower triglycerides, decrease fasting glucose, decrease HgbA1c, decrease blood pressure and increase HDL in men >59.  
Nathan Goodyear

Association of endogenous sex hormone with C-reactive protein levels in middle-aged and... - 0 views

www.ncbi.nlm.nih.gov/...17302874

inflammation men hormones CRP hsCRP estradiol estrogen Testosterone total Testosterone bioavailable Testosterone

shared by Nathan Goodyear on 14 Sep 15 - No Cached
  • Nathan Goodyear on 14 Sep 15
     
    total and bioavailable Estradiol associated with increased hsCRP in men age 40-80.  Bioavailable is calculated with serum calculated free Testosterone and albumin bound Testosterone.
Nathan Goodyear

Effects of testosterone on lean mass gain in elderly men: systemati... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25637335

Testosterone men male hormone muscle mass fat mass

shared by Nathan Goodyear on 02 Feb 15 - No Cached
  • Nathan Goodyear on 02 Feb 15
     
    Meta-analysis finds that Testosterone therapy in men over 60 increased lean mass and decreased fat mass.
Nathan Goodyear

Fat-free mass index and fat mass index percentiles in Caucasians aged 1898 y - 0 views

www.nature.com/...0802037a.html

FMI FFMI body composition BMI fat mass index

shared by Nathan Goodyear on 27 Jul 16 - No Cached
  • BMI is the sum of FFMI+FMI
  • FMI were significantly higher in elderly subjects as compared to younger ones
  • During menopause and aging39,40 changes in FFM and FM are not adequately picked up by changes in BMI
  • ...8 more annotations...
  • One advantage of FMI, as compared to the BMI concept, is that it amplifies the relative effect of aging on body fat
  • We believe that the definition of obesity based on relative body fat (ie percentage) remains of great value for the definition of obesity. However, in a situation in which a patient is losing weight without substantially changing his/her relative body fat (as is the case with crash diets), the calculation of FMI will quantitatively reveal the amount of body fat store lost.
  • high sensitivity of FMI (respectively FFMI) to a slight change of body fat stores
  • Sarcopenic obesity has been defined as a low FFM associated with a high body fat
  • relative FFM lower than 73% (ie a relative body fat greater than 27%) in men and a FFM lower than 62% (ie a body fat greater than 38%) in women.
  • FMIs greater than 8.2 kg/m2 in men and 11.8 kg/m2 in women would define the 'overfat' status (rather than the overweight range) in terms of fat mass
  • In young women, FMI averaged 5.5 kg/m2 (range 5th-95th percentile: 3.5-8.7 kg/m2) ie 38% higher than in males
  • the average FMI for young men was 4.0 kg/m2
  • Nathan Goodyear on 27 Jul 16
     
    good review of FMI, FFMI, and BMI.
Nathan Goodyear

Transdermal testosterone replacement therapy in men - 0 views

www.ncbi.nlm.nih.gov/...PMC3891651

Testosterone replacement transdermal low T male hormone hormones

shared by Nathan Goodyear on 05 Feb 14 - No Cached
  • a recent study has suggested that it may sometimes be inaccurate because of abnormal fluctuation of other circulating androgens
    • Nathan Goodyear
      Nathan Goodyear on 05 Feb 14
       
      The authors are referencing the increase in the suggestions to use other testing techniques i.e. saliva.
  • Testosterone therapy can inhibit hepcidin transcription and is associated with increased iron incorporation into red blood cells and increased erythropoietin concentrations
  • Transdermal TRT has a more favorable adverse effect profile when compared to buccal testosterone formulations
  • ...13 more annotations...
  • Approximately 0.3% of testosterone is converted into estradiol by aromatase (CYP19A1)
  • the recommendation for injectable testosterone esters is to check the serum concentration midway between injections
  • it is recommended for serum testosterone to be evaluated 3 to 12 hours after application of the transdermal patch
  • testosterone concentrations should be checked 2–3 months after initiation of therapy and after adjusting the dose
  • a study from 1989 utilizing testosterone transdermally containing 5, 10, or 15 mg of testosterone showed that peak concentrations of testosterone were achieved 3 to 8 hours after scrotal application in hypogonadal men
  • It is used for many medications and has the advantage of high bioavailability, absence of hepatic first pass metabolism, increased therapeutic efficacy, and steadiness of plasma concentrations of the drug
  • evaluate serum testosterone at the end of the dosing interval for testosterone pellets
  • increased amount of fat leads to increased extragonadal aromatase activity, resulting in increased concentrations of estradiol. High circulating concentrations of estradiol down regulate the HPG axis and decrease the amount of circulating testosterone
  • Up to 80% of plasma estradiol originates from aromatization of testosterone and less than 20% of estradiol in the circulation is secreted by the testes
  • A PSA concentration, digital rectal examination, and hematocrit should be performed at baseline and at 3 months, 6 months, then yearly after TRT is initiated.
  • measure serum testosterone any time after the patient has been on treatment with gel for at least 1 week
  • If the hematocrit rises above 54%, treatment should be discontinued
  • elderly men having higher estradiol serum concentrations than postmenopausal women
Nathan Goodyear

Low serum testosterone level was associated with extensive coronary artery calcificatio... - 0 views

www.ncbi.nlm.nih.gov/...25968306

low T low Testosterone CAD coronary artery disease men male hormone s

shared by Nathan Goodyear on 22 May 15 - No Cached
  • Nathan Goodyear on 22 May 15
     
    In men > 65, low Testosterone is associated with CAD.
Nathan Goodyear

Short-Term Aromatase-Enzyme Blockade Unmasks Impaired Feedback Adaptations in Luteinizi... - 0 views

jcem.endojournals.org/...211

low Testosterone estrogen LH

shared by Nathan Goodyear on 14 Jan 11 - No Cached
  • administration of a potent and selective aromatase antagonist reduces estradiol and elevates mean LH concentrations equivalently in young and older men. The low estrogen-feedback state in elderly men unmasks diminished incremental LH pulse amplitude and area; absence of further acceleration of LH pulse frequency; impaired regulation of the orderliness of LH release; and reduced testosterone to SHBG ratios
  • Nathan Goodyear on 14 Jan 11
     
    estrogen decreases testosterone production
Nathan Goodyear

Apolipoprotein A1 Is a Stronger Prognostic Marker Than Are HDL and LDL Cholesterol for ... - 0 views

biomedgerontology.oxfordjournals.org/...1262.abstract

apolipoprotein a a1 cardiovascular disease cholesterol LDL HDL

shared by Nathan Goodyear on 10 May 11 - No Cached
  • Nathan Goodyear on 10 May 11
     
    Apolipoprotein A1 is a better indicator of cardiovascular disease risk than HDL or LDL in men
Nathan Goodyear

Effects of Aromatase Inhibition in Elderly Men with Low or Borderline-Low Serum Testost... - 0 views

jcem.endojournals.org/...1174

aromatase testosterone low high estrogen

shared by Nathan Goodyear on 01 Mar 11 - No Cached
  • These data demonstrate that aromatase inhibition increases serum bioavailable and total testosterone levels to the youthful normal range in older men with mild hypogonadism
  • Nathan Goodyear on 01 Mar 11
     
    Low T actually the result of higher E through aromatase activity
Nathan Goodyear

Sex Hormone-Binding Globulin and Insulin-Like Growth Factor-Binding Protein-1 as Indica... - 0 views

jcem.endojournals.org/...1550.abstract

SHBG insulin metabolic syndrome metabolic syndrome

shared by Nathan Goodyear on 11 Dec 12 - No Cached
  • Nathan Goodyear on 11 Dec 12
     
    SHBG decreased in hyperinsulinemic states, such as in metabolic syndrome.  Low Testosterone has proven to be the same, though not looked at in this study.   Also, in this study, low SHBG is associated with increased cardiovascular mortality.
Nathan Goodyear

Low-level lead exposure, metabolic syndrome, and h... [Environ Health Perspect. 2006] -... - 0 views

www.ncbi.nlm.nih.gov/...17107858

lead toxicity oxidative stress metabolic syndrome

shared by Nathan Goodyear on 18 Feb 11 - No Cached
  • The results suggest that elderly men with MetS were more susceptible to autonomic dysfunction in association with chronic lead exposure as measured in patella. The modification by MetS is consistent with a role for oxidative stress in lead toxicity on the cardiovascular system.
  • Nathan Goodyear on 18 Feb 11
     
    low lead levels through oxidative stress contribute to metabolic syndrome
Nathan Goodyear

Thyroid Hormone Concentrations, Disease, Physical Function, and Mortality in Elderly Me... - 0 views

jcem.endojournals.org/...6403

hormone thyroid concentrations rT3 reverse T3 hypothyroid hypothyroidism

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • High serum rT3 may result from a decreased peripheral metabolism of thyroid hormones due to the aging process itself and/or disease and may reflect a catabolic state.
  • Nathan Goodyear on 08 Mar 11
     
    elevated serum rT3 indicates tissue hypothyroidism; very different than rT3 in the pituitary, where high concentrations accumulate
Nathan Goodyear

Association between Serum Uric Acid Level and Metabolic Syndrome and Its Sex Difference... - 0 views

www.ncbi.nlm.nih.gov/...PMC4129973

uric acid metabolic syndrome inflammation

shared by Nathan Goodyear on 27 Aug 14 - No Cached
  • We found that higher SUA level, even within normal range, was associated with an increased prevalence of MetS even after adjusting for confounding factors. This association of MetS risk by SUA levels was more robust in women than in men.
  • Just in the past decade, prevalence of MetS in China has increased about 8%
  • Nathan Goodyear on 27 Aug 14
     
    Increasing uric acid levels, even in the normal range, are associated with increased incidence of metabolic syndrome. This was found more prevalent in women, but positive correlations were seen in both sexes.
Nathan Goodyear

Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skelet... - 0 views

link.springer.com/...10.1007%2Fs00125-012-2717-8

epigenetics methylation nutrition high fat diet

shared by Nathan Goodyear on 03 Oct 17 - No Cached
  • short-term HFO introduces DNA methylation changes on a genome-wide scale in human skeletal muscle
  • These changes were only partly reversed after 6–8 weeks
  • The induction of DNA methylation changes after 5 days of HFO supports the growing awareness of DNA methylation as a dynamic signal that is possibly relevant to short-term day-to-day metabolic adaptations, including acute exercise
  • ...4 more annotations...
  • Diverging DNA methylation levels between elderly, but not young, genetically identical twins indicate that environmental exposures throughout life may permanently influence DNA methylation, suggesting some preservation of de novo DNA methylation in adults
  • our finding of a slow reversibility rate indicates the demethylation process may be somewhat impeded compared with the induction of methylation changes by diet, which could have implications for the preservation or build-up of CpG methylation over time
  • A slow reversibility of DNA methylation induced by carcinogenic agents has likewise been observed due to ingestion of high-fat diets in rodents
  • the relationship between DNA methylation and gene expression is not always straightforward
  • Nathan Goodyear on 03 Oct 17
     
    Study finds variability of methylation and some genetic expression alteration with high fat diet.  Restated, what you eat interacts with your DNA to alter genetic expression.  This has implications on initiation of therapy as well as response to therapy.
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