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Nathan Goodyear

The Beneficial Effects of Antioxidant Supplementation in Enteral Feeding in Critically ... - 0 views

www.anesthesia-analgesia.org/...857.long

IV intravenous vitamin C E critically ill sepsis antioxidant therapy treatment

shared by Nathan Goodyear on 29 Feb 12 - No Cached
  • Nathan Goodyear on 29 Feb 12
     
    IV vitamin C and vitamin E was found to lower the mortality rate in those with critical illness at the 28 day mark.  This study showed the safety and efficacy of IV vitamin C and vitamin E in those critically ill.
Nathan Goodyear

Total vitamin C, ascorbic acid, and dehydroascorbic acid concentrations in plasma of cr... - 0 views

europepmc.org/...8615361

ascorbic acid vitamin C critical care critically ill

shared by Nathan Goodyear on 29 Jun 22 - No Cached
  • Nathan Goodyear on 29 Jun 22
     
    Vitamin levels decreased in critically ill.
Nathan Goodyear

The Association of Vitamin D Status With Pediatric Critical Illness - 0 views

pediatrics.aappublications.org/...429.abstract

vitamin D deficiency low children pediatrics vitamin d

shared by Nathan Goodyear on 18 Sep 12 - No Cached
  • Nathan Goodyear on 18 Sep 12
     
    Vitamin D deficiency found more prevalent in those children with critical illnesses; and with greater severity of illness.
Nathan Goodyear

Reduced Activation and Increased Inactivation of Thyroid Hormone in Tissues of Critical... - 0 views

jcem.endojournals.org/...3202.full

TSH hypothyroid hypothyroidism T3 rT3 T4 thyroid hormone inflammation

shared by Nathan Goodyear on 07 Feb 12 - No Cached
  • Nathan Goodyear on 07 Feb 12
     
    critical illness is associated with low TSH, reduced T3, and increased rT3 production.  Inflammation is critically involved in this process.  This study from JCEM shows how unreliable TSH and T4 are.
Nathan Goodyear

Reduced Activation and Increased Inactivation of Thyroid Hormone in Tissues of Critical... - 0 views

jcem.endojournals.org/...3202

low T3 hypothyroid illness

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • T3 syndrome of severe illness.
  • Nathan Goodyear on 01 Feb 11
     
    low T3 (thyroid) seen in those with severe illness
Nathan Goodyear

Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommend... - 0 views

www.ncbi.nlm.nih.gov/...PMC5725835

vitamin C deficiency hypovitaminosis C IV vitamin C septic shock critically ill hypovitaminosis ICU critical illness vitamin C critical care sepsis

shared by Nathan Goodyear on 14 Jul 22 - No Cached
  • Nathan Goodyear on 14 Jul 22
     
    Septic patients have lower vitamin C levels and respond less to typical dosing due to inflammaiton
Nathan Goodyear

Reduced activation and increased ina... [J Clin Endocrinol Metab. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12843166

inflammation illness thyroid hypothyroid hypothyroidism TSH free T3 rT3 T3:rT3 ratio

shared by Nathan Goodyear on 02 Feb 12 - No Cached
  • These observed changes, in correlation with a low T(3)/rT(3) ratio, may represent tissue-specific ways to reduce thyroid hormone bioactivity during cellular hypoxia and contribute to the low T(3) syndrome of severe illness.
  • Nathan Goodyear on 02 Feb 12
     
    inflammation and critical illness associated with low TSH, low T3, elevated rT3 and low T3:rT3 ratio.
Nathan Goodyear

Vitamin D Deficiency in Critically Ill Children - 0 views

pediatrics.aappublications.org/...421.abstract

vitamin D deficiency low children vitamins pediatrics vitamin d

shared by Nathan Goodyear on 18 Sep 12 - No Cached
  • Nathan Goodyear on 18 Sep 12
     
    vitamin D deficiency found highly prevalent in children with critical illness
Nathan Goodyear

Vitamin C may reduce the duration of mechanical ventilation in critically ill patients:... - 0 views

jintensivecare.biomedcentral.com/...s40560-020-0432-y

ventilation IV vitamin C vitamin C

shared by Nathan Goodyear on 11 Aug 20 - No Cached
  • Nathan Goodyear on 11 Aug 20
     
    Meta-analysis finds that vitamin C shortened ventilation time by 25% in critical ill.
Nathan Goodyear

Free T4, Free T3, and Reverse T3 in Critically III, Thermall... : The Journal of Trauma - 0 views

journals.lww.com/...everse_T3_in_Critically.1.aspx

free reverse T3 thyroid hypothyroid hypothyroidism

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Significant suppression of serum concentrations of 3,5,3'-triiodothyronine (T3) and elevation of serum concentrations of 3,3',5'-triiodothyronine (rT3) were seen
  • Nathan Goodyear on 08 Mar 11
     
    low free T3: elevated reverse T3 in critically ill patients
Nathan Goodyear

Vitamin C revisited | Critical Care | Full Text - 0 views

ccforum.biomedcentral.com/...s13054-014-0460-x

IV vitamin C vitamin C sepsis stroke oxidative stress LPS

shared by Nathan Goodyear on 22 Aug 17 - No Cached
  • Nathan Goodyear on 22 Aug 17
     
    Great read on IV vitamin C in the critically ill.
Nathan Goodyear

Luteinizing hormone secretion and hypoandrogenaemia in critically ill men: effect of do... - 0 views

onlinelibrary.wiley.com/...abstract

low T Testosterone men dopamine LH

shared by Nathan Goodyear on 18 Mar 14 - No Cached
  • Nathan Goodyear on 18 Mar 14
     
    Decreased pulse amplitude and Testosterone in ill men.  The addition of dopamine for vascular effects worsened these findings.
Nathan Goodyear

Depletion of plasma antioxidants in surgical intensive care unit patients requiring par... - 0 views

www.nutritionjrnl.com/...abstract

antioxidant antioxidants vitamin C glutathione E Zinc nutrition

shared by Nathan Goodyear on 29 Feb 12 - No Cached
  • Nathan Goodyear on 29 Feb 12
     
    Critically ill patients found to be depleted in glutathione, vitamin C, Zinc, and too a lesser extent: vitamin E.  The obvious treatment would be to replace those identified deficiencies
Nathan Goodyear

Thyroid Replacement Therapy and Heart Failure - 0 views

circ.ahajournals.org/...385.full

thyroid T3 hormone hormones cardiovascular disease heart health failure CHF MI myocardial infarction heart attack heart disease

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • A good biomarker of intracardiac TH signaling would be helpful but has not been identified. In the absence of such a marker, a rational, cautious therapeutic approach might be to restore and maintain over time biochemical euthyroidism as documented by normal circulating levels of TSH, FT4, and FT3.
  • a low-T3 state resulting from altered peripheral TH metabolism secondary to caloric restriction is associated with impaired cardiac contractility
  • Low-T3 syndrome is the central finding and defines the illness in a variety of acute and chronic severe nonthyroidal illnesses with cardiac origin, including MI, HF, and surgically treated cardiac disease.1 Low circulating levels of T3 in the absence of primary thyroid hypofunction have been found in 20% to 30% of patients with dilated cardiomyopathy.
  • ...1 more annotation...
  • FT3 levels were inversely correlated to coronary artery disease
  • Nathan Goodyear on 24 Sep 14
     
    Great review of the current understanding of thyroid hormone metabolism in cardiac tissue.  Low T3 and increased rT3 (via increased D3 activity) is CLEARLY associated with poor cardiac performance and post MI and CHF is associated with poor outcomes.  T3 is critical in cardiac remodeling and recovery post MI.  T3 is actually a vasodilatory in the coronary arteries.   Why a endocrinologist would call rT3 useless only points to their ignorance of the literature.
Nathan Goodyear

A critical view on transgenerational epigenetic inheritance in humans | Nature Communic... - 0 views

www.nature.com/...s41467-018-05445-5

intergenerational inheritance epigenetics fetal programming

shared by Nathan Goodyear on 29 Jul 23 - No Cached
  • Nathan Goodyear on 29 Jul 23
     
    Is there something here missed on the authors. If one had ill intentions, could one not recommend a pregnant mother as the ideal candidate to program, or reprogram the offspring. Changes induced to F2 are called inter generational inheritance.
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