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Nathan Goodyear

Incidence of low-triiodothyronine syndrome in patients with septic shock - 0 views

www.ncbi.nlm.nih.gov/...PMC7853677

T4 TSH non-thyroidal illness syndrome septic shock sepsis T3

shared by Nathan Goodyear on 13 Apr 21 - No Cached
  • In the course of different disease states, the levels of T3, T4, and TSH decrease
  • euthyroid sick syndrome
  • low T3 can contribute to associated organ dysfunction
  • ...5 more annotations...
  • proportionally associated with disease severity and survival
  • nonthyroidal illness syndrome
  • Patients with persistent deterioration of hormone levels (T3, T4) during the study period had higher mortality than those who normalized the function of the thyroid axis
  • LT3S in patients with septic shock is part of the pathophysiology of this disease and/or an associated organ (endocrine-metabolic) failure and not just an adaptive phenomenon
  • substitution treatment with synthetic thyroid hormones could modify the hemodynamic symptoms of septic patients, contributing in part to the decrease in their morbidity and mortality
    • Nathan Goodyear
      Nathan Goodyear on 13 Apr 21
       
      Important statement
  • Nathan Goodyear on 13 Apr 21
     
    Septic shock and low T3
Nathan Goodyear

Salivary Cortisol Can Replace Free Serum Cortisol Measurements in Patients With Septic ... - 0 views

chestjournal.chestpubs.org/...1216.long

saliva salivary cortisol hormone hormones septic shock testing

shared by Nathan Goodyear on 10 Jul 12 - No Cached
  • Nathan Goodyear on 10 Jul 12
     
    Salivary cortisol shown to correlate, significantly, with serum free cortisol.  This can be used as an alternative means to evaluate cortisol in those with septic shock, as this study did.  "Salivary cortisol testing is noninvasive, easy to perform, and can be conducted daily".
Nathan Goodyear

The Effect of Glutathione and N-Acetylcysteine on Lipoperoxidative Damage in Patients w... - 0 views

171.66.122.149/...1907

IV glutathione NAC therapy treatment septic shock oxidative stress

shared by Nathan Goodyear on 10 Nov 11 - No Cached
  • Nathan Goodyear on 10 Nov 11
     
    IV glutathione and NAC shown to reduce oxidative stress markers associated with septic shock
Nathan Goodyear

New clinical criteria for septic shock: serum lactate level as new emerging vital sign - 0 views

www.ncbi.nlm.nih.gov/...PMC4958885

lactate septic shock

shared by Nathan Goodyear on 18 Sep 18 - No Cached
  • Nathan Goodyear on 18 Sep 18
     
    serum lactate to evaluate septic shock.
Nathan Goodyear

Vitamin C for Sepsis and Septic Shock - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/34264892

vitamin C septic shock sepsis

shared by Nathan Goodyear on 07 Jun 22 - No Cached
  • Nathan Goodyear on 07 Jun 22
     
    Review article on vitamin C in the treatment of sepsis and septic shock. The most common dose is 1.5 gram Q6 is inadequate secondary to all the constraints on vitamin C, i.e., 1/2 life, metabolic demands, deficiency, weight, inflammation…A one size fits all approach never WORKS!
Nathan Goodyear

The Role of Vitamin C in Human Immunity and Its Treatment Potential Against COVID-19: A... - 0 views

www.ncbi.nlm.nih.gov/...PMC9925039

COVID-19 SARS-CoV-2 COVID WBC ascorbic acid vitamin C

shared by Nathan Goodyear on 01 Sep 23 - No Cached
  • vitamins A, B, C, E, B6, B12, folate, zinc, iron, copper, and selenium
  • White blood cells, including neutrophils and monocytes, accumulate concentrations of vitamin C up to 100 times greater than that of plasma
  • Vitamin C is a crucial component of both the innate (nonspecific) and adaptive (specific) portions of the immune system
  • ...52 more annotations...
  • play a role during the initial chemotactic response of neutrophils shortly after infection
  • following vitamin C supplementation, a 20% increase in neutrophil chemotactic activity was observed
  • also contributes to the phagocytosis and killing of microbes by neutrophils
  • low levels of vitamin C occurring in high-stress situations
  • maturation, proliferation, and viability of T cells have all been shown to be upregulated by the presence of normal physiologic concentrations of vitamin C
  • Vitamin C has been shown to directly affect the number of Igs released from B cells
  • vitamin C among healthy young adult males showed a significant increase in serum levels of IgA, IgG, and IgM
  • effects of high-dose vitamin C on cytokine levels in cancer patients, finding decreased amounts of the cytokines Interleukin-1 alpha (IL-1 alpha), IL-2, IL-8, and tumor necrosis factor-alpha (TNF-alpha) after high-dose vitamin C infusion
  • when vitamin C was supplemented with vitamin E in healthy adults, it increased the production of cytokines IL-1 beta and TNF-alpha
  • vitamin C acts to modulate the levels of cytokines to prevent them from fluctuating in either direction
  • vitamin C also acts as an important antioxidant to the cells of the immune system.
  • human leukocytes, neutrophils, in particular, possess the ability to transport the oxidized form of vitamin C across its membrane to use as a defense mechanism against ROS produced during an immune response
  • Vitamin C also can recover other endogenous antioxidants in the body such as vitamin E and glutathione, returning them to their active state
  • vitamin C can decrease the activation of NF-kB
  • can reduce harmful nitrogen-based compounds such as N-nitrosamines and nitrosamides, both of which are carcinogenic 
  • subjects taking oral vitamin C supplementation saw a 60% to 90% reduction in oxidative stress compared to a placebo control
  • subjects infused with vitamin C alone had a 516% increase in glutathione levels compared to subjects not provided the 500 mg daily supplementation
  • hydroxylating proline and lysine
  • mature and stabilize the tissue of a healing wound
  • healing
  • oral surgery
  • improved soft tissue regeneration
  • vitamin C increases the mRNA levels of type I and type III collagen in the human dermis
  • Studies have demonstrated that those with low levels of vitamin C are at a significantly higher risk of respiratory infection compared to those with normal levels
  • viral cold duration was reduced by about 8% in adults and 13.5% in children using prophylactic daily doses of 200 mg of oral vitamin C
  • prophylactically supplementing vitamin C decreases the risk of infection with respiratory viruses such as the common cold
  • combined with probiotics, oral vitamin C supplementation showed a 33% decrease in the incidence of respiratory tract infections in preschool-age children [
  • high-dose oral supplementation of vitamin C managed to prevent or reduce symptoms if taken before or just after the onset of cold- or flu-like symptoms
  • improvements in oxygen saturation and decreased IL-6 levels (a marker of inflammation) in the treatment group compared to the control group
  • 8 g doses of oral vitamin C
  • there is a negative correlation between age and serum levels of vitamin C
  • Patients with COVID-19 will likely also experience depletion in serum levels of vitamin C as a direct result of the upregulation of the immune system to combat the infection
  • Colunga et al. suggested that oral vitamin C can be combined with oral Quercetin, an antiviral flavonoid, to improve Quercetin’s ability to block viral membrane fusion of SARS-CoV-2
  • high doses of 1-2 g/day of oral vitamin C could prevent other upper respiratory infections
  • It appears vitamin C supplementation by itself does not provide a striking benefit in preventing COVID-19 infection for those without a deficiency
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Flawed statement. What is normal? Vitamin D. Many variables effect levels and dose, including the two compartment kinetics and absorption.
  • Hiedra et al. were able to show decreases in inflammatory biomarkers, such as D-dimer and ferritin
  • some evidence to support that prophylactic use of vitamin C helps reduce the severity of respiratory infection symptoms once a subject has already been infected
  • oral vitamin C in combination with zinc provided the largest amount of antibody titers 42 days
  • linear relationship between days of vitamin C therapy and survival duration
  • other studies were unable to find any definitive improvement concerning therapy with vitamin C
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Either these studies are designed to fail or the authors are lacking some basic understanding of pharmacokinetics and pharmacodynamics with vitamin C.
  • Fowler et al. aimed to see if a high-dose vitamin C infusion would benefit patients affected by ARDS, but they were unable to conclude that vitamin C infusion, compared to a placebo, could decrease vascular inflammation and damage in ARDS
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      At what dose, duration, frequency???
  • in a sample of 67 COVID-19-positive ICU patients, 82% of them displayed plasma vitamin C levels below 0.4 mg/dL
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      They are kind of make the point from my earlier note.
  • continuous vitamin C infusion at a rate of 60 mg/kg/day for four days decreased the need for mechanical ventilation and vasopressor use but had no significant effect on overall mortality
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Again, designed to fail or ignorance designed the study which failed
  • Carr et al. suggested that high-dose IV vitamin C is most effective when treating sepsis as septic patients receiving the normal daily recommendations through diet still showed decreased vitamin C levels
  • High-dose IV vitamin C treatment has also been shown by Kakodkar et al. to decrease syndecan-1, an endothelial glycocalyx that contributes to mortality in septic patients
  • combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA scores and none of the patients treated developed organ failure
  • combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA scores and none of the patients treated developed organ failure
  • reduced overall mortality
  • reduced overall mortality
  • propose the use for high-dose vitamin C to aid in the treatment of septic shock-induced hypotension
  • treatment of severe sepsis using a high dose (up to 200 mg/kg/day) of IV vitamin C was explored in phase I, a double-blind, randomized, placebo-controlled trial by Fowler et al. [75]. Their findings included a reduction in SOFA scores and decreased vascular injury compared to a placebo control group, all while showing minimal adverse side effects
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      High dose here is laughable. Again, duration and frequency also.
  • Maintaining a daily intake of 75 and 100 mg for men and women, respectively, as recommended by the U.S. Institute of Medicine
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      This recommendation is FRANK IGNORANCE
Nathan Goodyear

Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommend... - 0 views

www.ncbi.nlm.nih.gov/...PMC5725835

vitamin C deficiency hypovitaminosis C IV vitamin C septic shock critically ill hypovitaminosis ICU critical illness vitamin C critical care sepsis

shared by Nathan Goodyear on 14 Jul 22 - No Cached
  • Nathan Goodyear on 14 Jul 22
     
    Septic patients have lower vitamin C levels and respond less to typical dosing due to inflammaiton
Nathan Goodyear

Salivary Cortisol Can Replace Free Serum Cortisol Measurements in Patients With Septic ... - 0 views

chestjournal.chestpubs.org/...1216.abstract

salivary saliva cortisol hormone testing BHRT measurements

shared by Nathan Goodyear on 26 Nov 11 - No Cached
  • Nathan Goodyear on 26 Nov 11
     
    salivary cortisol testing is shown to be good alternative to serum cortisol testing.  "very good correlation", "noninvasive", "easy to perform" are just some of the descriptions of salivary cortisol testing in this study
Nathan Goodyear

Cytokine storm and sepsis and disease - 0 views

www.ncbi.nlm.nih.gov/...28555385

cytokine storm sepsis inflammation septic shock

shared by Nathan Goodyear on 03 Apr 20 - No Cached
  • Nathan Goodyear on 03 Apr 20
     
    To be read
Nathan Goodyear

Short-term beneficial effects of methylene blue on kidney damage in septic shock patien... - 0 views

www.ncbi.nlm.nih.gov/...PMC2228379

methylene blue MB sepsis renal failure renal injury

shared by Nathan Goodyear on 19 Jun 22 - No Cached
  • Nathan Goodyear on 19 Jun 22
     
    1 mg/kg improved renal function in sepsis patients
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