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Nathan Goodyear

ingentaconnect Immunonutrition in Surgical Patients - 0 views

www.ingentaconnect.com/...art00009

immunonutrition surgery surgical patients

shared by Nathan Goodyear on 21 Mar 11 - No Cached
  • Surgery induces an inflammatory response
  • A range of nutrients, including several amino acids, antioxidant vitamins and minerals, ω-3 fatty acids, and nucleotides, are able to modulate inflammation and the associated oxidative stress, and maintain or improve immune function
  • parenteral glutamine is recommended in patients receiving parenteral nutrition
  • ...2 more annotations...
  • Antioxidants, particularly selenium, should be considered for critically ill patients
  • enteral formulas enriched with fish oils are recommended for patients with acute respiratory distress syndrome.
  • Nathan Goodyear on 21 Mar 11
     
    nutrition to improve inflammation in surgical patiens
Nathan Goodyear

The definition and risks of Cytokine Release Syndrome-Like in 11 COVID-19-Infected Pneu... - 0 views

www.medrxiv.org/...2020.02.26.20026989v1

cytokine storm

shared by Nathan Goodyear on 22 Apr 20 - No Cached
  • Nathan Goodyear on 22 Apr 20
     
    To be read
Nathan Goodyear

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis - 1 views

www.ncbi.nlm.nih.gov/...PMC3937164

sepsis IV vitamin C vitamin C CRP

shared by Nathan Goodyear on 11 Oct 17 - No Cached
  • Padayatty and colleagues showed that high-level ascorbic acid plasma concentrations could only be achieved by intravenous administration
  • No patient in the low or high dose ascorbic acid treatment arms of this study suffered any identifiable adverse event
  • a pharmacologic ascorbic acid treatment strategy in critically ill patients with severe sepsis appears to be safe
  • ...7 more annotations...
  • subnormal plasma ascorbic acid levels are a predictable feature in patients with severe sepsis
  • Ascorbic acid depletion in sepsis results from ascorbic acid consumption by the reduction of plasma free iron, ascorbic acid consumption by the scavenging of aqueous free radicals (peroxyl radicals), and by the destruction of the oxidized form of ascorbic acid dehydroascorbic acid
  • Sepsis further inhibits intracellular reduction of dehydroascorbic acid, producing acute intracellular ascorbic acid depletion
  • Ascorbic acid treated patients in this study exhibited rapid and sustained increases in plasma ascorbic acid levels using an intermittent every six hours administration protocol
  • Septic ascorbic acid-deficient neutrophils fail to undergo normal apoptosis. Rather, they undergo necrosis thereby releasing hydrolytic enzymes in tissue beds, thus contributing to organ injury
  • We speculate that intravenous ascorbic acid acts to restore neutrophil ascorbic acid levels
  • Repletion of ascorbic acid in this way allows for normal apoptosis, thus, preventing the release of organ damaging hydrolytic enzymes.
  • Nathan Goodyear on 11 Oct 17
     
    Study finds IV vitamin C in patients with sepsis is very safe and blunts the effects (endothelial damage, end organ damage...) of sepsis.  Of note, the IV vitamin C group reached serum levels of ascorbic acid of 1,592 to 5,722 micromol/L.  The IV groups maintained elevated serum C levels for up to 96 hours post infusion.  
Nathan Goodyear

Global Vitamin C Status and Prevalence of Deficiency: A Cause for Concern? - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC7400810

hypovitaminosis vitamin C global vitamin C deficiency worldwide ascorbic acid

shared by Nathan Goodyear on 29 Jun 22 - No Cached
  • rsf123 on 01 Jul 22
     
    Vitamin levels decreased in the critically ill. https://t.me/amsterdamdarkmarket
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