Group items tagged Alzheimer's disease - Dr. Goodyear

Ketone bodies as a therapeutic for Alzheim... [Neurotherapeutics. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18625458

ketone bodies ketosis Alzheimer's disease Alzheimer's neurodegenerative disease

shared by Nathan Goodyear on 25 Jun 12 - No Cached

Nathan Goodyear on 25 Jun 12

Ketone bodies have been shown to benefit the mitochondria in the brains of those with Alzheimer's disease. This ketosis can be achieved through low carb/protein, high fat diet.

<div class="cArrow"> </div><div class="cContentInner">Ketone bodies have been shown to benefit the mitochondria in the brains of those with Alzheimer's disease. This ketosis can be achieved through low carb/protein, high fat diet.</div>

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Alzheimer's disease--synergistic effects of ... [J Neural Transm. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9720973

AD AGE advanced glycation end products Alzheimer's disease neurofibrillary tangles Beta-amyloid protein microglia brain neurology oxidative stress alzheimer

shared by Nathan Goodyear on 11 Jun 12 - No Cached

AGEs are protein modifications that contribute to the formation of the histopathological and biochemical hallmarks of AD: amyloid plaques, neurofibrillary tangles and activated microglia
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Nathan Goodyear on 11 Jun 12

good review of understanding of how poor glucose control, oxidative stress result in AGE and Alzheimer's disease.

<div class="cArrow"> </div><div class="cContentInner">good review of understanding of how poor glucose control, oxidative stress result in AGE and Alzheimer's disease.</div>

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JAMA Network | Archives of Neurology | Reduced Risk of Alzheimer Disease in Users of An... - 0 views

archneur.jamanetwork.com/article.aspx

vitamin C vitamin E C E Alzheimer's disease Alzheimer's oxidative damage oxidative stress neurology antioxidant vitamin

shared by Nathan Goodyear on 13 Jun 12 - No Cached

Nathan Goodyear on 13 Jun 12

Use of Vitamin C and Vitamin E associated with a 78% reduced prevalence of Alzheimer's disease.

<div class="cArrow"> </div><div class="cContentInner">Use of Vitamin C and Vitamin E associated with a 78% reduced prevalence of Alzheimer's disease.</div>

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Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer Disease - 0 views

www.lycoredindia.com/...TI_18.pdf

oxidative damage oxidative stress 8-hydroxy-2-deoxyguanosine free radicals Alzheimer's Alzheimer's disease neurology brain

shared by Nathan Goodyear on 13 Jun 12 - No Cached

Nathan Goodyear on 13 Jun 12

This study found an inverse association between elevated 8-hydroxy-2-deoxyguanosine and low antioxidants in individuals with Alzheimer's disease.

<div class="cArrow"> </div><div class="cContentInner">This study found an inverse association between elevated 8-hydroxy-2-deoxyguanosine and low antioxidants in individuals with Alzheimer's disease.</div>

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http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.po... - 0 views

www.plosone.org/...fetchObject.action

alzheimer's disease Alzheimer's disease Alzheimers dementia huperzine A

shared by Nathan Goodyear on 30 Sep 14 - No Cached

Nathan Goodyear on 30 Sep 14

Another meta-analysis, this time of 20 studies, finds benefit of huperzine A in the treatment of Alzheimer's disease.

<div class="cArrow"> </div><div class="cContentInner">Another meta-analysis, this time of 20 studies, finds benefit of huperzine A in the treatment of Alzheimer's disease.</div>

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Neuroprotective Sirtuin ratio reversed by ApoE4 - 0 views

www.pnas.org/...1314145110.abstract

ApoE4 alzheimer's disease Alzheimer's disease sirtuins SIRT1 resveratrol

shared by Nathan Goodyear on 23 Oct 13 - No Cached

Nathan Goodyear on 23 Oct 13

ApoE4 allele is known to increase Alzheimer's disease by 10 fold. One mechanism is through a lowering of SirT1 and an increase in the SirT1:SirT2 ratio. This SirT1 is the target of resveratrol in red wine.

<div class="cArrow"> </div><div class="cContentInner">ApoE4 allele is known to increase Alzheimer's disease by 10 fold. One mechanism is through a lowering of SirT1 and an increase in the SirT1:SirT2 ratio. This SirT1 is the target of resveratrol in red wine.</div>

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Efficacy of tablet huperzine-A on me... [Zhongguo Yao Li Xue Bao. 1995] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8701750

Huperzine A Huperzine-A alzheimer's disease Alzheimer's disease memory cognition brain

shared by Nathan Goodyear on 06 Nov 13 - No Cached

Nathan Goodyear on 06 Nov 13

8 week study finds Huperzine A improved memory, cognition, and behavior in those with Alzheimer's disease at 400 mcg.

<div class="cArrow"> </div><div class="cContentInner">8 week study finds Huperzine A improved memory, cognition, and behavior in those with Alzheimer's disease at 400 mcg.</div>

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Hypometabolism as a therapeutic target in Alzheimer's disease - 0 views

www.ncbi.nlm.nih.gov/...PMC2604900

cocconut oil brain Alzheimer's disease ketones

shared by Nathan Goodyear on 11 Nov 13 - No Cached

Nathan Goodyear on 11 Nov 13

Medium chain fatty acids, such as cocconut oil, benefit brain with glucose hypometabolism problems such as in Alzheimer's disease.

<div class="cArrow"> </div><div class="cContentInner">Medium chain fatty acids, such as cocconut oil, benefit brain with glucose hypometabolism problems such as in Alzheimer's disease.</div>

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Low Testosterone Level and Risk of Alzheimer's Disease in the Elderly Men: a Systematic... - 0 views

www.ncbi.nlm.nih.gov/...26154489

low T low Testosterone alzheimer's disease Testosterone men hormones hormone

shared by Nathan Goodyear on 21 Jul 15 - No Cached

Nathan Goodyear on 21 Jul 15

Just abstract available here; low Testosterone in meta-analysis found to be associated with increased Alzheimer's disease risk in elderly men.

<div class="cArrow"> </div><div class="cContentInner">Just abstract available here; low Testosterone in meta-analysis found to be associated with increased Alzheimer's disease risk in elderly men.</div>

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Mitochondria: a therapeutic target in neurodegener... [Biochim Biophys Acta. 2010] - Pu... - 0 views

www.ncbi.nlm.nih.gov/...19853657

mitochondria Alzheimer's Parkinson's Huntington's ALS neurodegenerative disease

shared by Nathan Goodyear on 07 Feb 11 - No Cached

mitochondrial dysfunction has a central role in the pathogenesis of Alzheimer's, Parkinson's and Huntington's diseases and amyotrophic lateral sclerosis
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Nathan Goodyear on 07 Feb 11

mitochondrial dysfunction has a central role in the pathogenesis of Alzheimer's, Parkinson's and Huntington's diseases and amyotrophic lateral sclerosis

<div class="cArrow"> </div><div class="cContentInner">mitochondrial dysfunction has a central role in the pathogenesis of Alzheimer's, Parkinson's and Huntington's diseases and amyotrophic lateral sclerosis</div>

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Insulin resistance and Alzheimer's disease. [BMB Rep. 2009] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...19712582

alzheimer's disease insulin resistance neurodegenerative

shared by Nathan Goodyear on 20 Feb 11 - No Cached

there are dual mechanisms of brain insulin resistance leading to AD-type neurodegeneration: one mediated by endogenous, CNS factors; and the other, peripheral insulin resistance with excess cytotoxic ceramide production.
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Nathan Goodyear on 20 Feb 11

Insulin resistance has dual mechanism of contribution to Alzheimer's disease

<div class="cArrow"> </div><div class="cContentInner">Insulin resistance has dual mechanism of contribution to Alzheimer's disease</div>

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Indoleamine 2,3 dioxygenase and quinolinic acid im... [Neuropathol Appl Neurobiol. 2005... - 0 views

www.ncbi.nlm.nih.gov/...16008823

indoleamine 2 3 Alzheimer's disease inflammation

shared by Nathan Goodyear on 20 Apr 11 - No Cached

kynurenine pathway is up-regulated in Alzheimer's disease (AD) brain
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increases in the excitotoxin quinolinic acid (QUIN
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indoleamine 2,3 dioxygenase (IDO) is abundant in AD compared with controls
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...1 more annotation...
QUIN may be involved in the complex and multifactorial cascade leading to neuro-degeneration in AD
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Nathan Goodyear on 20 Apr 11

immune system, inflammation, and brain come together to develop Alzheimer's disease

<div class="cArrow"> </div><div class="cContentInner">immune system, inflammation, and brain come together to develop Alzheimer's disease</div>

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Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Agg... - 0 views

www.nature.com/srep34477

neurodegenerative disease amyloid alzheimer's disease Parkinson's disease gut gut flora gut microbiome gut microbiota gut-brain

shared by Nathan Goodyear on 06 Oct 16 - No Cached

Our work suggests that protein misfolding and immune activation in neurodegenerative disorders are triggered through cross-seeding by exposure to exogenous microbial amyloids in the nose, mouth and gut.
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Streptococcus mutans, Staphlococcus aureus, Salmonella enterica, Mycobacterium tuberculosis and others
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Gene homologs encoding curli were recently determined also in four phyla: Bacteroidetes, Proteobacteria, Firmicutes, and Thermodesulfobacteria
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...8 more annotations...
changes in the gut microbiota induced by antibiotics alter neuroinflammation and amyloid deposition in a mouse model of AD
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Our data suggest that amyloid proteins in the microbiota are involved in the origination and maintenance of neurodegenerative disease.
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exposure to bacteria producing a functional extracellular amyloid protein enhances aggregation of AS in brain neurons in aged rats and in muscle cells in nematodes
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AS aggregates seed aggregation of tau
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involvement of the vagus nerve in PD
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microgliosis, astrogliosis and enhanced expression of IL-6, TLR2 and TNF in the brain following curli exposure suggest the occurrence of an enhanced local sterile inflammatory response to AS in the brain.
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the immune system in both AD and PD have now been extensively established
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TLR2 activation through exposure to bacterial amyloid is pathogenic
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Nathan Goodyear on 06 Oct 16

Gut bacteria may play crucial role in systemic inflammation that leads to Alzheimer's and Parkinson's disease. These amyloid production bacteria trigger systemic inflammation that leads to microglia activation and amyloid in the brain. More establishment of the gut-brain connection.

<div class="cArrow"> </div><div class="cContentInner">Gut bacteria may play crucial role in systemic inflammation that leads to Alzheimer's and Parkinson's disease. These amyloid production bacteria trigger systemic inflammation that leads to microglia activation and amyloid in the brain. More establishment of the gut-brain connection. </div>

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Modifiable Risk Factors and Brain Positron Emission Tomography Measures of Amyloid and ... - 0 views

www.ajgponline.org/...fulltext

nutrition exercise mediterranean diet BMI weight alzheimer's disease brain

shared by Nathan Goodyear on 22 Aug 16 - No Cached

Nathan Goodyear on 22 Aug 16

Can Alzheimer's be prevented? New study suggests that nutrition, exercise, and healthy weight are key to Alzheimer's prevention. A decrease in amyloid plaques and tau tangles were noted in normal BMI individuals, those with greater physical activity and those on a mediterranean diet.

<div class="cArrow"> </div><div class="cContentInner">Can Alzheimer's be prevented? New study suggests that nutrition, exercise, and healthy weight are key to Alzheimer's prevention. A decrease in amyloid plaques and tau tangles were noted in normal BMI individuals, those with greater physical activity and those on a mediterranean diet.</div>

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Huperzine a as potential treatment of Alzheim... [Chem Biodivers. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21766442

Huperzine-A Alzheimer's disease Alzheimer's

shared by Nathan Goodyear on 03 Oct 12 - No Cached

Nathan Goodyear on 03 Oct 12

Huperzine A at doses up to 400 mcg shown to benefit people with Alzheimer's disease, with no significant side effects.

<div class="cArrow"> </div><div class="cContentInner">Huperzine A at doses up to 400 mcg shown to benefit people with Alzheimer's disease, with no significant side effects.</div>

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S-adenosylmethionine reduces the progress of... [Neurobiol Aging. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22221883

SAMe Alzheimer's disease Alzheimer's aging

shared by Nathan Goodyear on 27 Jun 12 - No Cached

Nathan Goodyear on 27 Jun 12

SAMe helps to correct disordered homocysteine metabolism due to B- vitamin deficiency found in Alzheimer's disease. SAMe show to reduce amyloid production, improve memory, decrease Tau, and reduced plaque formation. Now, this was in a mice model, but SAMe as a methyl donor can benefit clients with dementia with minimal side effects.

<div class="cArrow"> </div><div class="cContentInner">SAMe helps to correct disordered homocysteine metabolism due to B- vitamin deficiency found in Alzheimer's disease. SAMe show to reduce amyloid production, improve memory, decrease Tau, and reduced plaque formation. Now, this was in a mice model, but SAMe as a methyl donor can benefit clients with dementia with minimal side effects.</div>

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Glucose tolerance status and risk of dementia in the community - 0 views

neurology.org/...1126.abstract

dementia Alzheimer's Alzheimer's disease OGTT post prandial glucose tolerance test glucose tolerance

shared by Nathan Goodyear on 11 Jun 12 - No Cached

Nathan Goodyear on 11 Jun 12

elevated 2 hour post prandial OGTT associated with all-cause dementia, including Alzheimer's disease. Interestingly, the association was not found with fasting glucose levels.

<div class="cArrow"> </div><div class="cContentInner">elevated 2 hour post prandial OGTT associated with all-cause dementia, including Alzheimer's disease. Interestingly, the association was not found with fasting glucose levels.</div>

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Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms o... - 0 views

www.ncbi.nlm.nih.gov/...PMC3665200

turmeric Alzheimer's disease alzheimer disease dementia curcumin

shared by Nathan Goodyear on 13 Aug 13 - No Cached

Nathan Goodyear on 13 Aug 13

Small case study of 3 finds significant improvement in Alzheimer's with Turmeric.

<div class="cArrow"> </div><div class="cContentInner">Small case study of 3 finds significant improvement in Alzheimer's with Turmeric.</div>

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Antiinflammatory Effects of Estrogen on Microglial Activation - 0 views

endo.endojournals.org/...3646.long

Estradiol E2 neurodegenerative disease Parkinsons's Alzheimer's inflammation microglial glial cells hormones hormone estrogen

shared by Nathan Goodyear on 07 Jun 12 - No Cached

Nathan Goodyear on 07 Jun 12

Estradiol (E2) shown to be neuroprotective in those with microglial excitotoxicity diseases, such as Parkinson's and Alzheimer's disease. this study looked at a rat model. The effect was not through inhibition of NF-kappaB, but through MAP kinase.

<div class="cArrow"> </div><div class="cContentInner">Estradiol (E2) shown to be neuroprotective in those with microglial excitotoxicity diseases, such as Parkinson's and Alzheimer's disease. this study looked at a rat model. The effect was not through inhibition of NF-kappaB, but through MAP kinase.</div>

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New Prevalence Study Suggests Dramatically Rising Numbers of People with Alzheimer's Di... - 0 views

www.nia.nih.gov/...PR20030818prevalence.htm

neurodegenerative disease Alzheimer's prevalence