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Nathan Goodyear

Review of health risks of low testosterone and testosterone administration - 0 views

www.ncbi.nlm.nih.gov/...PMC4391003

low Testosterone low T Testosterone men male hormone hormones health

shared by Nathan Goodyear on 28 Apr 15 - No Cached
  • Hypogonadism may be defined either as serum concentration of T (either total T, bioavailable T or free T) or as low T plus symptoms of hypogonadism
  • The Baltimore Longitudinal Study on Aging reported the incidence of total serum T < 325 ng/dL to be 20% for men in their 60s, 30% for men in their 70s and 50% for men over 80
  • The Massachusetts Aging Male Study reported that 12.3% of men aged 40 to 70 had a total serum T of < 200 ng/dL with 3 or more symptoms of hypogonadism
  • ...19 more annotations...
  • The Boston Area Community Health Study reported that 5.6% of men aged 30 to 70 were hypogonadal, as defined by total serum T < 300 ng/dL; or, free serum T < 5 ng/dL plus 3 or more symptoms of hypogonadism
  • In a health screening project among 819 men in Taiwan, the prevalence of hypogonadism (total serum T < 300 ng/dL) ranged from 16.5% for men in their 40s, 23.0% for men in their 50s, 28.9% for men in their 60s, and 37.2% for men older than 70 years of age
  • The prevalence of hypogonadism among men in Taiwan is higher than the prevalence reported in the Massachusetts Male Aging Study
  • CAG repeat sequence, within the androgen receptor (AR). Rajender et al[12] reviewed over 30 studies on the AR trinucleotide repeat and infertility
  • suggestion that CAG repeat length may determine androgen responsiveness, this issue is not clearly settled
  • reported prevalence of low T in older men range from 5.6% to 50%
  • Those in the hypogonadal group (n = 4269) had direct health care costs, that exceeded the eugonadal group (n = 4269) by an average of $7100 over the course of the observation window
  • higher economic burden and presence of co-morbidities for hypogonadism
  • minor to moderate improvements in lean mass and muscle strength
  • increased bone mineral density
  • modest enhancement in sexual function
  • reduced adiposity
  • lessening of depressive symptoms
  • Meta-analyses of clinical TRT trials as of 2010 have identified three major adverse events resulting from TRT: (1) polycythemia; (2) an increase in prostate-related events; and (3) and a slight reduction in serum high-density lipoprotein (HDL) cholesterol
  • polycythemia (> 3.5-fold increase in risk
  • TRT produced a 40% prostate enlargement in older hypogonadal male Veterans over 12 mo
  • no published analysis has reported measurable increases in prostate cancer risk or Gleason score in men undergoing TRT, or in hypogonadal men with a history of prostate cancer undergoing TRT
  • the prostate which highly expresses the type II 5α-reductase enzyme. Inhibition of this enzyme via finasteride (a type II 5α-reductase inhibitor) or dutasteride (a dual type I and II 5α-reductase inhibitor) reduces circulating DHT 50%-75% and > 90%, respectively[47], and reduces prostate mass[48] and prostate cancer risk
  • Normally estradiol partially regulates testosterone levels, at the hypothalamus, blunting LH and FSH release from the pituitary. As a selective estrogen receptor modulator, CC interrupts this pathway, and consequently there is a greater stimulation for the production of testosterone in Leydig cells
    • Nathan Goodyear
      Nathan Goodyear on 28 Apr 15
       
      this would only apply if E1 and/or E2 levels were elevated, which the authors make no mention of.
  • Nathan Goodyear on 28 Apr 15
     
    to be read
Nathan Goodyear

Prevalence of cardiovascular disease risk factors ... [JAMA. 2009] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...19470988

cardiovascular prevalence disease NFL players

shared by Nathan Goodyear on 14 May 11 - No Cached
  • NFL players had a lower prevalence of impaired fasting glucose, less reported smoking, a similar prevalence of dyslipidemia, and a higher prevalence of hypertension. Increased size measured by BMI was associated with increased CVD risk factors in this combined population.
  • Nathan Goodyear on 14 May 11
     
    higher disease risk in NFL players
Nathan Goodyear

Hypogonadal Symptoms Are Associated With Different S... [Urology. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25288577

Testosterone total testosterone low T low T low Testosterone hypogonadism men male hormone hormones

shared by Nathan Goodyear on 08 Oct 14 - No Cached
  • Nathan Goodyear on 08 Oct 14
     
    This study looked at Total Testosterone and prevalence of low T symptoms.  As the authors stated, increased prevalence was found between 320 and 375 ng/dl.  Whereas, < 300 ng/dl was consistent with predictable low T symptoms.  It would have be more thorough if they had looked at salivary Testosterone levels and bioavailable as well.
Nathan Goodyear

Association between Serum Uric Acid Level and Metabolic Syndrome and Its Sex Difference... - 0 views

www.ncbi.nlm.nih.gov/...PMC4129973

uric acid metabolic syndrome inflammation

shared by Nathan Goodyear on 27 Aug 14 - No Cached
  • We found that higher SUA level, even within normal range, was associated with an increased prevalence of MetS even after adjusting for confounding factors. This association of MetS risk by SUA levels was more robust in women than in men.
  • Just in the past decade, prevalence of MetS in China has increased about 8%
  • Nathan Goodyear on 27 Aug 14
     
    Increasing uric acid levels, even in the normal range, are associated with increased incidence of metabolic syndrome. This was found more prevalent in women, but positive correlations were seen in both sexes.
Nathan Goodyear

Genetic Determinants of Serum Testosterone Concentrations in Men - 0 views

www.ncbi.nlm.nih.gov/...PMC3188559

epigenetics low Testosterone SNPs Testosterone

shared by Nathan Goodyear on 19 Sep 17 - No Cached
  • mean serum testosterone concentrations were found to be lower in men with GG than in those with TT genotype for rs12150660
  • men with the CT genotype for rs6258 had lower serum testosterone concentrations than those with CC genotype.
  • The two autosomal SNPs identified by GWAS had a significant influence on the risk of having low serum testosterone (serum testosterone &lt;300 ng/dl) in both the discovery and the replication cohorts with a combined odds ratio (OR) per minor allele of 0.72 (95% CI, 0.65 – 0.79) and 2.7 (95% CI, 2.1 – 3.5) for rs12150660 and rs6258, respectively
  • ...3 more annotations...
  • The risk of having low serum testosterone concentrations increased by the number of risk alleles with an OR of 1.62 (95% CI, 1.41 – 1.86) for each risk allele (Figure S4). Low serum testosterone concentrations were 6.5-times more prevalent in men with ≥3 risk alleles (30.1% prevalence of low serum testosterone) compared to men without any risk allele (4.6% prevalence of low serum testosterone;
  • SNP rs5934505 was associated with serum testosterone without SHBG-adjustment (combined p-value of 1.7×10−9) and with free testosterone (combined p-value of 6.7×10−15), but not with SHBG
  • The mean serum testosterone and calculated free testosterone but not SHBG concentrations were lower in men with T genotype than in those with C genotype for rs5934505
  • Nathan Goodyear on 19 Sep 17
     
    Genetic SNP rs5934505 associated with lower total Testosterone and lower calculated free Testosterone.  No effects on SHBG.
Nathan Goodyear

Statins use and coronary artery plaque composition: Results from the International Mult... - 0 views

www.ncbi.nlm.nih.gov/...PMC4277888

statin statins plaque CAD coronary artery disease coronary artery calcium cardiovascular disease

shared by Nathan Goodyear on 17 Oct 17 - No Cached
  • Statin use is associated with an increased prevalence and extent of coronary plaques possessing calcium
  • As compared with individuals not taking statins, those taking statins possessed a significantly higher prevalence of obstructive CAD, as well as higher numbers of vessels with obstructive CAD
  • non-calcified plaques (NCP)
  • ...11 more annotations...
  • non-calcified (NCP), mixed (MP), or calcified (CP) plaque
  • statin use was each associated with a significantly higher prevalence of NCP, MP and CP
  • statin use was associated with increased presence of MP [odds ratio (OR) 1.46, 95% confidence interval (CI) 1.27–1.68, p &lt; 0.001] and CP (OR 1.54, 95% CI 1.36–1.74, p &lt; 0.001], but not NCP
  • statin use was associated with increasing numbers of coronary segments possessing MP and CP but not associated with increasing numbers of coronary segments possessing NCP
  • North America, Europe and Asia
  • A total of 6673 individuals (2413 on statin therapy and 4260 not on statin therapy) comprised the study population
  • we identified a strong association of statin use to coronary artery plaque features
  • statin use was associated with a differentially increased prevalence and extent of MP and CP
  • one potential unifying hypothesis is that rather than regression of coronary plaque, statins may contribute to the conversion of coronary plaque constituents, perhaps by conversion of NCP to plaque possessing calcium
  • Coronary computed tomographic angiography (CCTA)
  • Statin use was associated with a higher frequency of severe coronary artery stenoses as well as numbers of coronary vessels with obstructive CAD
  • Nathan Goodyear on 17 Oct 17
     
    Study finds statin therapy associated with increased coronary plaque with calcium.
pharmacybiz

Conditions Causing Type 2 Diabetes And High BP : Study - 0 views

www.pharmacy.biz/abetes-and-high-blood-pressure

pharmacy-business Prevalence-of-hypertension-in-type-2-diabetes Type-2-diabetes-and-hypertension-treatment Type-1-diabetes-and-hypertension Hypertension-and-diabetes

shared by pharmacybiz on 17 Jan 22 - No Cached
  • pharmacybiz on 17 Jan 22
     
    A study by scientists in a UK university has shown the scale of the prevalence of a condition that can lead to various cardiometabolic diseases. The study published in the Annals of Internal Medicine journal on Tuesday (January 4) has prompted calls for changes to healthcare policy after researchers revealed, for the first time, the scale of the impact of the condition associated with benign tumours that can lead to type 2 diabetes and high blood pressure. Up to 10 per cent of adults have a benign tumour, or lump, known as an 'adrenal incidentaloma' in their adrenal glands which can be associated with the overproduction of hormones including the stress steroid hormone cortisol that can lead to type 2 diabetes and high blood pressure. Previous small studies suggested that one in three adrenal incidentalomas produce excess cortisol, a condition called mild autonomous cortisol secretion (MACS). An international research team led by the University of Birmingham carried out the largest ever prospective study of over 1,305 patients with adrenal incidentalomas to assess their risk of high blood pressure and type 2 diabetes and their cortisol production by comparing patients with and without MACS.
Nathan Goodyear

Mounting Evidence for Vitamin D as an Environmental Factor Affecting Autoimmune Disease... - 0 views

ebm.rsmjournals.com/...1136.full

low vitamin D vitamin D deficiency vitamin D autoimmune disease autoimmune disease environmental factor

shared by Nathan Goodyear on 15 May 13 - No Cached
  • Nathan Goodyear on 15 May 13
     
    low vitamin D associated with increase prevalence of autoimmune disease.
Nathan Goodyear

Reduction in Human Papillomavirus (HPV) Prevalence Among Young Women Following HPV Vacc... - 0 views

jid.oxfordjournals.org/...385.long

HPV gardasil vaccine vaccinations vaccines

shared by Nathan Goodyear on 11 May 16 - No Cached
  • Nathan Goodyear on 11 May 16
     
    study points to the lower HPV rats with the advent of the HPV vaccine; yet the greatest reduction in  HPV prevalence was in unvaccinated girls.
Nathan Goodyear

Biomedical Papers: The prevalence of non organ specific and thyroid autoimmunity in pat... - 0 views

biomed.papers.upol.cz/..._polycystic_ovary_syndrome.php

PTO autoimmune disease autoimmune thyroid PCOS polycystic ovarian syndrome hormones

shared by Nathan Goodyear on 14 Jun 16 - No Cached
  • Nathan Goodyear on 14 Jun 16
     
    high prevalence of thyroid antibodies, TPO, in women with PCOS.  This does not prove cause and effect, merely an association.  Both are inflammation driven.
Nathan Goodyear

BMC Public Health | Abstract | High prevalence of vitamin D insufficiency and its assoc... - 0 views

www.biomedcentral.com/...abstract

vitamin-D D D3 obesity weight-loss metabolic syndrome vitamin overweight

shared by Nathan Goodyear on 08 Dec 11 - No Cached
  • Nathan Goodyear on 08 Dec 11
     
    Malaysians with metabolic syndrome and obesity found to have high prevalence of vitamin D insufficiency.  Role for vitamin D therapy for those with metabolic syndrome and obesity.
Nathan Goodyear

Testosterone deficiency syndrome and cardiovascular health: An assessment of beliefs, k... - 0 views

www.ncbi.nlm.nih.gov/...PMC3929476

low T Testosterone cardiovascular disease physicians men male hormone hormones

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • The vast majority (88%) did not screen cardiac patients for TDS.
  • Testosterone deficiency has a prevalence of 7% in the general population, rising to 20% in elderly males
  • Males with CAD have lower testosterone levels than those with normal coronary angiograms of the same age,5 suggesting that the prevalence of testosterone deficiency is much higher in the CAD population
  • ...14 more annotations...
  • Men with hypertension, another established risk factor for CAD, have lower testosterone compared to normotensive men
  • Recent meta-analyses showed that testosterone levels are generally lower among patients with metabolic syndrome, regardless of the various definitions of metabolic syndrome that are used
  • Testosterone (total and bioavailable) and sex-hormone binding globulin (SHBG) are inversely associated with the prevalence of metabolic syndrome in men between the ages of 40 and 80, and this association persists across racial and ethnic backgrounds
  • ower levels of testosterone and SHBG predict a higher incidence of metabolic syndrome.
  • Low testosterone levels have been related to increased insulin resistance and cardiovascular mortality,12 even in the absence of overt type 2 diabetes mellitus.
  • testosterone levels (total and bioavailable) in middle-aged men are inversely correlated with insulin resistance
  • The Massachusetts Male Aging Study (MMAS) demonstrated that low levels of testosterone and SHBG are independent risk factors for the development of type 2 diabetes,
  • Andropausal men (age 58 ± 7 years) have a higher maximal carotid artery intima-media thickness
  • There is an inverse linear correlation between body mass index (BMI) and wait-to-hip ratio with testosterone and insulin-like growth factor-1 levels.
  • Testosterone supplementation for 1 year in hypogonadal men has been shown to cause a significant improvement in body weight, BMI, waist size, lipid profile, and C-reactive protein levels
  • TRT for 3 months in hypogonadal men with type 2 diabetes significantly improved fasting insulin sensitivity, fasting blood glucose and glycated hemoglobin.
  • Testosterone replacement can improve angina symptoms and delay the onset of cardiac ischemia, likely through a coronary vasodilator mechanism
  • ADT is associated with an increased risk of cardiovascular events, including myocardial infarction and cardiovascular mortality.
  • ADT significantly increases fat mass, decreases lean body mass,29,30 increases fasting plasma insulin and decreases insulin sensitivity31 and increases serum cholesterol and triglyceride levels
  • Nathan Goodyear on 03 Mar 14
     
    Startling study on the knowledge of Testosterone and cardiovascular disease in general practitioners and cardiologists in Canada.  Eight-eight percent did not screen patients with cardiovascular disease for low Testosterone.  A whopping 67% of physicians did not know that low T was a risk factor for cardiovascular disease, yet 62% believed Testosterone would increase exercise tolerance. The lack of knowledge displayed by physicians today is staggering and is an indictment of the governing bodies.  This was a survey conducted in Canada so there are obvious limitations to the strength/conclusion of this study.
Nathan Goodyear

Prevalence and Incidence of Androgen Deficiency in Middle-Aged and Older Men: Estimates... - 0 views

press.endocrine.org/...jc.2003-031719

low T Testosterone hypogonadism age men male hormone hormones aging

shared by Nathan Goodyear on 24 Apr 14 - No Cached
  • Nathan Goodyear on 24 Apr 14
     
    Total prevalence of low Testosterone in this study was 12.3% per 1,000 person years.  With increasing age, comes decreasing Tesosteorne levels in men.
Nathan Goodyear

Prevalence of Symptomatic Androgen Deficiency in Men: The Journal of Clinical Endocrino... - 0 views

press.endocrine.org/...jc.2007-1245

low T Testosterone male men hormone hormones hypogonadism

shared by Nathan Goodyear on 24 Apr 14 - No Cached
  • Nathan Goodyear on 24 Apr 14
     
    Prevalence of low T is 5-10% based on this study from 2007.
Nathan Goodyear

Arsenic Exposure and Prevalence of Type 2 Diabetes in US Adults, August 20, 2008, Navas... - 0 views

jama.ama-assn.org/...814

arsenic exposure diabetes

shared by Nathan Goodyear on 14 Feb 11 - No Cached
  • After adjustment for biomarkers of seafood intake, total urine arsenic was associated with increased prevalence of type 2 diabetes. This finding supports the hypothesis that low levels of exposure to inorganic arsenic in drinking water, a widespread exposure worldwide, may play a role in diabetes prevalence
  • Nathan Goodyear on 14 Feb 11
     
    Arsenic and type 2 Diabetes link
Nathan Goodyear

The prevalence of prediabetes in population of Polish men with late-onset hypogonadism,... - 0 views

informahealthcare.com/...13685538.2014.936000

low T Testosterone low T low Testosterone men male hormone hormones hypogonadism diabetes pre diabetes pre-diabetes

shared by Nathan Goodyear on 07 Jul 14 - No Cached
  • Nathan Goodyear on 07 Jul 14
     
    Study of late onset of low T in polish men found a significantly increased prevalence of glucose metabolism dysregulation when compared to normal T control group.  In the low T group, Total Testosterone and Free Testosterone levels were decreased. 
Nathan Goodyear

Low Testosterone Has a Similar Prevalence among Men with Sexual Dys... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25580982

low Testosterone low T ED Peyronie's disease Testosterone men male hormone hormones

shared by Nathan Goodyear on 27 Jan 15 - No Cached
  • Nathan Goodyear on 27 Jan 15
     
    low Testosterone prevalence found to be no different between men with ED or Peyronie's disease.
Nathan Goodyear

Levels of serum testosterone predict prevalent but not incident non... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25708291

Testosterone NAFLD non-alcoholic fatty liver liver disease men male hormone hormones

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • Nathan Goodyear on 02 Mar 15
     
    Lower Testosterone associated with increased prevalence of NAFLD in men.   Higher Testosterone levels did not reduce or reverse progression of NAFLD in men. This points to Testosterone as just one piece of the metabolic puzzle in metabolic syndrome, NAFLD... in men.  
Nathan Goodyear

The prevalence of metabolic syndrom... [Metab Syndr Relat Disord. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23249214

metabolic syndrome MetS metabolic syndrome children kids heath obesity obese overweight

shared by Nathan Goodyear on 02 Aug 14 - No Cached
  • Nathan Goodyear on 02 Aug 14
     
    prevalence of MetS in children in US is high.
Nathan Goodyear

High Prevalence of Chronic Pituitary and Target-Organ Hormone Abnormalities after Blast... - 0 views

www.ncbi.nlm.nih.gov/...PMC3273706

brain injury TBI traumatic brain injury PTHP post traumatic hypopituitarism low Testosterone T Testosterone hormones

shared by Nathan Goodyear on 20 Jan 16 - No Cached
  • Nathan Goodyear on 20 Jan 16
     
    The prevalence of post traumatic hypopituitarism post TBI sits at around 35%.  
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