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The Diagnostic Applications of Saliva- A Review - 0 views

cro.sagepub.com/...197.long saliva salivary hormone hormones testing cortisol testosterone estradiol estrone estriol DHEA aldosterone insulin androstendione
shared by Nathan Goodyear on 14 Aug 12 - No Cached
  • Nathan Goodyear on 14 Aug 12
     
    Fantastic article on the review of the clinical use of saliva testing.  Of note, is the extensive documentation of the validation studies of hormone saliva testing.  Clearly, if a physician is against saliva testing, it is because of a lack of knowledge on the subject.
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An endocrine pathway in the prostate, ERβ, AR, 5α-androstane-3β,17β-diol, and... - 0 views

www.pnas.org/...13589.full 3-beta androstanediol DHT metabolite prostate cancer ER-beta ER beta CYP7b1 cytochrome male hormone hormones men
shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • Although the prostate is an androgen-dependent tissue, estrogens influence both normal functions and pathological changes in this gland
  • This dual action may be due to the existence of two estrogen receptors, ERα and ERβ
  • ERα and ERβ have similar affinities for estradiol-17β
  • ...6 more annotations...
  • In this study we have shown that regulation of the levels of 3βAdiol by CYP7B1 is a key factor in regulation of prostatic growth
  • We provide evidence that proliferating cells in the prostate epithelium have elevated levels of AR and that AR protein but not mRNA levels are regulated by ERβ and its ligand 3βAdiol in the prostate epithelium.
  • because inhibition of 5α-reductase causes accumulation of testosterone and removal of ERβ action increases the level of AR in the prostate, the overall effect of Finasteride would be to favor proliferation of the prostate epithelium
  • studies show that ERβ tends to be lost in advanced prostate cancer.
  • DHEA is converted in the body to 5-androstene-3β,17β-diol, which is also a ligand for estrogen receptors (25, 39) and a substrate for CYP7B1
  • At the peak of proliferation, the proliferating epithelial cells in the ventral prostate expressed high levels of CYP7B1 but had no detectable ERβ, whereas in nonproliferating cells the level of ERβ was high and that of CYP7B1 was low.
  • Nathan Goodyear on 27 Jan 14
     
    3-beta androstanediola, a product of 3alpha-HSD from DHT binds to ER beta and down regulates AR in prostate cancer.  This study proposes that the mechanism is via CYP7B1.  CYP7B1 inactivates 3-beta androstanediol.  Interesting, because 3-beta androstanediol is considered "inactive" when compared to 3-alpha androstanediol and its interaction with ER alpha.  
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Benign prostatic hyperplasia: a new meta... [J Endocrinol Invest. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24458832 BPH benign prostatic hypertrophy Toll-like receptors TLRs hormone hormones low Testosterone T estrogen estradiol aromatase prostate metabolism
shared by Nathan Goodyear on 20 Feb 14 - No Cached
  • Nathan Goodyear on 20 Feb 14
     
    The authors of this paper describe BPH as a metabolic disease: involving inflammation with increased expression of TLRs, hormone imbalance and altered metabolism
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Estrogen excess associated with novel gain-of-f... [N Engl J Med. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12736278 gynecomastia Man Boobs hypogonadotropic hypogonadism low T Testosterone aromatase estrogen estradiol men male hormone hormones
shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Nathan Goodyear on 03 Mar 14
     
    Presentation of a familial incidence of male gynecomastia and hypogonadotropic hypogonadism via peripheral aromatase activity.
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Local aromatase expression in human pro - PubMed Mobile - 0 views

www.ncbi.nlm.nih.gov/...15126575 aromatase prostate cancer disease Testosterone estrogen estradiol male hormone hormones
shared by Nathan Goodyear on 24 Sep 13 - No Cached
  • Nathan Goodyear on 24 Sep 13
     
    Local prostate aromatase activity described in this article.
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Aromatase and prostate cancer. - PubMed Mobile - 0 views

www.ncbi.nlm.nih.gov/...16498360 aromatase prostate cancer male hormone hormones Testosterone estrogen estradiol ER ER alpha ER beta
shared by Nathan Goodyear on 24 Sep 13 - No Cached
  • Nathan Goodyear on 24 Sep 13
     
    Study finds that aromatase activity is present in the prostate.  Additionally, the balance of estrogen receptors plays a role in the interpretation of the increased estrogen production in the prostate.
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[Changes of sex hormo... [Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24175566 atherosclerosis Low T estradiol testosterone hormone hormones male prostate cancer
shared by Nathan Goodyear on 05 Nov 13 - No Cached
  • Nathan Goodyear on 05 Nov 13
     
    study looked at post hormonal effects on atherosclerosis after castration for prostate cancer.  They found significant decrease in sex hormones, significant increase in the E2:T ratio and an increase in atherosclerosis.
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Sex steroids and the thyroid. [Best Pract Res Clin Endocrinol Metab. 2009] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...19942152 sex hormones Estrogen Progesterone Testosterone Estradiol thyroid function steroids
shared by Nathan Goodyear on 07 Aug 11 - No Cached
  • Nathan Goodyear on 07 Aug 11
     
    sex hormones effect thyroid function
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Hormone Balance in Males - 0 views

www.johnleemd.com/...male_hormone.html hormone therapy hormonal BHRT testosterone estrogen estradiol andropause saliva testing salivary male hormones balance
shared by Nathan Goodyear on 10 Oct 11 - Cached
  • Nathan Goodyear on 10 Oct 11
     
    Fantastic article written by John Lee, MD.  This article is a great review on saliva testing and hormone therapy as it relates to both men and women; even though this article is in reference to men.  Worth your time to read
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Inclusion of Endogenous Hormone Levels in Risk ... [J Clin Oncol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25135988 post-menopause post menopause women female hormones hormone estradiol estrone testosterone DHEA prolactin SHBG dehydroepiandrosterone breast cancer
shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    study finds hormone evaluations in post menopause women aids in breast cancer risk assessment.
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Sex hormones and the immune response in humans | Human Reproduction Update | Oxford Aca... - 0 views

academic.oup.com/...874969 NK cells hormones natural killer cells Testosterone estradiol
shared by Nathan Goodyear on 13 Sep 19 - No Cached
  • Nathan Goodyear on 13 Sep 19
     
    To be read
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Effects of transdermal application of DHEA on the levels of steroids, gonadotropins and... - 0 views

www.ncbi.nlm.nih.gov/...11252535 DHEA LH hormones DHEA-S Testosterone estradiol androstenedione
shared by Nathan Goodyear on 02 Oct 17 - No Cached
  • Nathan Goodyear on 02 Oct 17
     
    topical DHEA found to significantly decrease LH.
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Sex hormone synthesis, regulation, and function | McMaster Pathophysiology Review - 0 views

www.pathophys.org/sexhormones hormones HPA Testosterone DHEA estradiol LH FSH Progesterone androgens estrogen
shared by Nathan Goodyear on 02 Oct 17 - No Cached
  • Nathan Goodyear on 02 Oct 17
     
    Good review of the HPA-sex hormone pathways, called the Hypothalamic-Pituitary-Gondal axis, including HP feedback.  This is not a study but has nice diagrams. This is based on 14 referenced articles and 1 book chapter.
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