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Nathan Goodyear

Testosterone substitution with a new transdermal, hydroalcoholic gel applied to scrotal... - 0 views

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    testosterone gel as effect, and better tolerated, than patch in androgen replacement in men.
Nathan Goodyear

Prevalence of Symptomatic Androgen Deficiency in Men - 0 views

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    5.6% of men today suffer from symptoms of androgen deficiency.  This problem is expected to amount to 6.5 million men by 2025.
Nathan Goodyear

Testosterone supplementation in Heart Failure: A meta-analysis - 0 views

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    study shows that testosterone therapy provides benefits in heart failure patients.
Nathan Goodyear

Testosterone deficiency syndrome and cardiovascular health: An assessment of beliefs, k... - 0 views

  • The vast majority (88%) did not screen cardiac patients for TDS.
  • Testosterone deficiency has a prevalence of 7% in the general population, rising to 20% in elderly males
  • Males with CAD have lower testosterone levels than those with normal coronary angiograms of the same age,5 suggesting that the prevalence of testosterone deficiency is much higher in the CAD population
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  • Men with hypertension, another established risk factor for CAD, have lower testosterone compared to normotensive men
  • Recent meta-analyses showed that testosterone levels are generally lower among patients with metabolic syndrome, regardless of the various definitions of metabolic syndrome that are used
  • Testosterone (total and bioavailable) and sex-hormone binding globulin (SHBG) are inversely associated with the prevalence of metabolic syndrome in men between the ages of 40 and 80, and this association persists across racial and ethnic backgrounds
  • ower levels of testosterone and SHBG predict a higher incidence of metabolic syndrome.
  • Low testosterone levels have been related to increased insulin resistance and cardiovascular mortality,12 even in the absence of overt type 2 diabetes mellitus.
  • testosterone levels (total and bioavailable) in middle-aged men are inversely correlated with insulin resistance
  • The Massachusetts Male Aging Study (MMAS) demonstrated that low levels of testosterone and SHBG are independent risk factors for the development of type 2 diabetes,
  • Andropausal men (age 58 ± 7 years) have a higher maximal carotid artery intima-media thickness
  • There is an inverse linear correlation between body mass index (BMI) and wait-to-hip ratio with testosterone and insulin-like growth factor-1 levels.
  • Testosterone supplementation for 1 year in hypogonadal men has been shown to cause a significant improvement in body weight, BMI, waist size, lipid profile, and C-reactive protein levels
  • TRT for 3 months in hypogonadal men with type 2 diabetes significantly improved fasting insulin sensitivity, fasting blood glucose and glycated hemoglobin.
  • Testosterone replacement can improve angina symptoms and delay the onset of cardiac ischemia, likely through a coronary vasodilator mechanism
  • ADT is associated with an increased risk of cardiovascular events, including myocardial infarction and cardiovascular mortality.
  • ADT significantly increases fat mass, decreases lean body mass,29,30 increases fasting plasma insulin and decreases insulin sensitivity31 and increases serum cholesterol and triglyceride levels
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    Startling study on the knowledge of Testosterone and cardiovascular disease in general practitioners and cardiologists in Canada.  Eight-eight percent did not screen patients with cardiovascular disease for low Testosterone.  A whopping 67% of physicians did not know that low T was a risk factor for cardiovascular disease, yet 62% believed Testosterone would increase exercise tolerance. The lack of knowledge displayed by physicians today is staggering and is an indictment of the governing bodies.  This was a survey conducted in Canada so there are obvious limitations to the strength/conclusion of this study.
Nathan Goodyear

Andropause: Current concepts - 0 views

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    Review of low T, evaluation, and health benefits of physiologic Testosterone replacement.
Nathan Goodyear

Andropause. Testosterone replacement therapy for aging men. - 0 views

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    always think low Testosterone with men with anemia
Nathan Goodyear

Hormone Balance in Males - 0 views

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    Fantastic article written by John Lee, MD.  This article is a great review on saliva testing and hormone therapy as it relates to both men and women; even though this article is in reference to men.  Worth your time to read
Nathan Goodyear

Characteristics of Secondary, Primary, and Compensated Hypogonadism in Aging Men: Evide... - 0 views

  • Circulating testosterone (T) in men declines progressively by 0.4–2% per year from the third decade onward
  • late-onset hypogonadism (LOH) (6, 7), whereas others have used various terms including andropause, male menopause, and androgen deficiency syndrome of the aging male.
    • Nathan Goodyear
       
      all names for Low T--interesting
  • Secondary hypogonadism is associated with obesity (and potentially reversible) independently of age
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  • primary hypogonadism (probably the genuine form of LOH) is strongly associated with age
  • Compensated hypogonadism represents a distinct clinical entity that warrants continued monitoring to prevent or preempt further deterioration
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    Study divides low T into primary (age), secondary (weight), and compensated hypogonadism (elevated LH with normal T)
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