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Nathan Goodyear

Toll-like receptors in innate immunity - 0 views

intimm.oxfordjournals.org/...1.full

Toll-like receptors Toll-like receptors TLRs innate immune system immunity

shared by Nathan Goodyear on 15 Jun 14 - No Cached
  • Nathan Goodyear on 15 Jun 14
     
    Great review of Toll-like receptors.
Nathan Goodyear

Toll-like Receptor Status in Obesity and Metabolic Syndrome: A Translational Perspectiv... - 0 views

press.endocrine.org/...jc.2013-3092

toll like receptors toll-like receptors TLRs TLR-4 TLR4 inflammation metabolic syndrome MetS insulin resistance IR Diabetes obesity

shared by Nathan Goodyear on 06 Jan 14 - No Cached
  • Nathan Goodyear on 06 Jan 14
     
    Only the abstract is available publicly.   Toll-like receptors, particularly TLR-4 has been shown to be associated with insulin resistance.  These TLRs have specific pathogen recognition sites.  TLRs are stimulated by fatty acids (FA) and endotoxemia from bacteria.  Thus, dietary intake of high trans fats, inflammation originating from the gut can be the source of insulin receptor dysfunction through TLRs.
Nathan Goodyear

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC3099529

TLR toll-like receptors toll-like receptors fatty acids fat metabolic syndrome obesity overweight inflammation dietary

shared by Nathan Goodyear on 08 Oct 12 - No Cached
  • Activation of the innate immune system controls macronutrient metabolism
  • the innate immune response is the first line of defense against invading pathogens, wherein highly conserved pathogen-associated molecular patterns (PAMPs) are recognized by cognate pattern recognition receptors (PRRs
  • many studies have supported the idea that cytokine signaling directly promotes insulin resistance
  • ...10 more annotations...
  • innate immune system may be causally linked to obesity
  • adipose tissue contains a substantial population of macrophages, and macrophage-driven adipose inflammation contributes significantly to the pathogenesis of obesity
  • Collectively, activation of the innate immune system is strongly associated with ASCVD, insulin resistance, and obesity, and recent evidence suggests that much of this association can be traced to a unique family of PRRs known as TLRs
  • TLRs are a family of type I transmembrane receptors, currently thought to comprise at least 13 members in mammals, that specifically recognize a variety of microbial PAMPs and trigger host cellular responses
  • Free SFAs have indeed been demonstrated to elicit TLR4-dependent and TLR2-dependent responses in several cell types.
  • Endogenous SFAs released from adipocytes activate cocultured macrophages via TLR4 [18], indicating the potential for cellular crosstalk in adipose tissue. Collectively, there is a growing body of evidence that SFAs promote, whereas long chain PUFA antagonize, TLR4-dependent and TLR2-dependent signaling in multiple cell models
  • In an elegant study, Shi et al. [16] demonstrated that SFAs activate TLR4-dependent signaling in both macrophages and adipocytes, and mice lacking TLR4 are protected against insulin resistance driven by intravenous lipid infusion
  • In addition to effects in macrophages and adipocytes, SFAs can activate TLR4 in the hypothalamus, which triggers a central inflammatory response that results in resistance to anorexigenic signals
  • endogenous SFAs can indeed promote innate immunity and inflammatory disease
  • This finding strongly supports the work of Hwang and coworkers [19–22] demonstrating that ω-3 PUFAs can effectively counteract SFA-induced TLR4 activation in cultured macrophages and dendritic cells.
  • Nathan Goodyear on 08 Oct 12
     
    high dietary fatty acids linked to metabolic syndrome through TLR.
Nathan Goodyear

Toll-like Receptors, Infection | Learn Science at Scitable - 0 views

www.nature.com/...that-detect-infection-14396559

toll-like receptors TLRs inflammation immune system

shared by Nathan Goodyear on 01 Oct 12 - No Cached
  • Nathan Goodyear on 01 Oct 12
     
    basic summary of TLRs
Nathan Goodyear

Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cycloo... - 0 views

www.jbc.org/...16683.long

TLR-4 TLR4 TLR DHA EPA toll like receptors Toll-like receptors omega 3 omega-3 inflammation NF-kappaB lkappaB-alpha lkkb

shared by Nathan Goodyear on 11 Sep 14 - No Cached
  • Nathan Goodyear on 11 Sep 14
     
    OMega-3 inhibits inflammation via decreased phosphorylation of lkappaBalpha and resultant decreased disassociation of NF-kappaB and decreased cytokine production.  This occurs through TLR-4.
Nathan Goodyear

Toll-like receptors in innate immunity | International Immunology | Oxford Academic - 0 views

academic.oup.com/...721976

immunotherapy toll-like receptors toll like receptors TLR immune system

shared by Nathan Goodyear on 22 May 20 - No Cached
  • Nathan Goodyear on 22 May 20
     
    good review of TLRs
Nathan Goodyear

Suppressive effects of sunitinib on a TLR activation-induced cytokine storm - ScienceDi... - 0 views

www.sciencedirect.com/...S0014299919302870

cytokine storm TLR4 cancer toll-like receptors

shared by Nathan Goodyear on 14 May 20 - No Cached
  • Nathan Goodyear on 14 May 20
     
    Toll-like receptors trigger cytokine storm.
Nathan Goodyear

Toll-like receptor 4 as a predictor of clinical outcomes of estrogen receptor-negative ... - 0 views

www.ncbi.nlm.nih.gov/...PMC5338938

NF-kapppB TLR-4 toll-like receptors inflammation NF-κB NF-KappaB toll like receptors metastasis TLRs TLR4 NFKB recurrence cancer

shared by Nathan Goodyear on 21 Jul 22 - No Cached
  • Nathan Goodyear on 21 Jul 22
     
    TLR4 promotes tumor progression, aggression, and resistance in ER-
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Windows customers support number 1-800-261-4071 - 0 views

www.classifiedads.com/...cw83xxp1lcbf

Windows technical customer support services tech

shared by Windows Customer Support Number on 01 Aug 16 - No Cached
  • Windows Customer Support Number on 01 Aug 16
     
    If your Pc hassle from one of these problem just call us our Windows technical support toll free number 1-800-261-4071 we will help you. We are providing for windows like windows installation, windows update, windows upgrade, security setting, data recovery from the disk. Dial our Windows tech support number 1-800-261-4071 for an instant help, for more details you can also visit our websites as http://technicalsupportnumberforwindows.com
Nathan Goodyear

Obesity - Inducible Toll-like Receptor and NF-[kappa]B Regulatory Pathway Expression in... - 0 views

www.nature.com/...oby200825a.html

TLR-4 TLR Toll-like receptors NF-kapppB inflammation obesity

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • TLRs are functionally inducible and associated with downstream NF-B activation and proinflammatory cytokine production.
  • TLRs represent a family of receptors that are critical to the innate immune response against foreign pathogens and microorganisms
  • LPS has been shown to induce proinflammatory chemokine gene expression in differentiated human adipocytes through TLR and NF-B action
  • ...2 more annotations...
  • Stimulation of TLRs initiates intracellular signaling cascades resulting in downstream NF-B and mitogen-activated protein kinase activation and production of proinflammatory chemokines associated with mechanisms of metabolic dysfunction and cardiovascular disease progression.
  • Elevated fatty acids levels associated with obesity activate TLR4 signaling in fat cells and macrophages, and induce insulin resistance in murine models
  • Nathan Goodyear on 19 Jan 12
     
    TLR, especially TLR-4, is directly involved in NF-KappaB activation and release of inflammatory cytokines
Nathan Goodyear

Toll-like receptors, inflammation, metabolism and obesity, Archives of Physiology and B... - 0 views

informahealthcare.com/...13813455.2011.562514

TLR TLR-4 Toll-like Receptors inflammation obesity Diabetes DM

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    TLR, inflammation and obesity.  involved in inflammation.
Nathan Goodyear

Increased Toll-Like Receptor Activity in Patients With Metabolic Syndrome - 0 views

care.diabetesjournals.org/...dc11-2375

TLR4 TLR2 toll-like receptors inflammation metabolic syndrome MetS cytokines IL-1Beta IL-6 IL-8 TNF-alpha obesity overweight

shared by Nathan Goodyear on 29 Feb 12 - No Cached
  • Nathan Goodyear on 29 Feb 12
     
    TLR2 and TLR4 are increased in patients with metabolic syndrome.  No surprise that IL-1Beta, IL-6, IL-8, TNF-alpha were increased as well.
Nathan Goodyear

Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Ins... - 0 views

diabetes.diabetesjournals.org/...1986.long

TLR-4 TLR4 toll like receptors high fat diet LPS endotoxin insulin resistance IR obesity

shared by Nathan Goodyear on 20 Jul 13 - No Cached
  • Nathan Goodyear on 20 Jul 13
     
    HFD and LPS endotoxin induce inflammation through TLR-4 to increase insulin resistance and obesity.
Nathan Goodyear

The Journal of Steroid Biochemistry and Molecular Biology | Vol 141, Pgs 1-170, (May 20... - 0 views

www.sciencedirect.com/...141

toll like receptors Toll-like receptors vitamin D D3 1 25-dihydroxyvitamin

shared by Nathan Goodyear on 24 Jun 14 - No Cached
  • Nathan Goodyear on 24 Jun 14
     
    vitamin D3 associated with down regulation of most TLRs associated with inflammation.  Though, vitamin D3 did increase TLR-10.
Nathan Goodyear

Lipopolysaccharide (LPS) increases the invasive ability of pancreatic cancer cells thro... - 0 views

onlinelibrary.wiley.com/...jso.21392

LPS cancer pancreatic cancer NF-kappaB

shared by Nathan Goodyear on 10 Jan 21 - No Cached
  • Nathan Goodyear on 10 Jan 21
     
    Lipopolysaccharide (LPS) activates Toll-like 4 receptors (TLR-4) to increase cancer invasion, growth, and metastasis.
Nathan Goodyear

Role of toll-like receptor 4 on the immune escape of human oral squamous cell carcinoma... - 0 views

www.ncbi.nlm.nih.gov/...PMC3496658

toll-like receptors TLR-4 chemoresistance TLR4 chemotherapy cancer

shared by Nathan Goodyear on 12 Jun 20 - No Cached
  • Nathan Goodyear on 12 Jun 20
     
    TLR-4 receptor increase increases chemotherapy resistance.
Nathan Goodyear

Pattern recognition receptors (PRRs): toll-like receptors | British Society for Immunology - 0 views

www.immunology.org/...ern-recognition-receptors-prrs

immune system pattern recognition receptors TLR PPR toll-like receptors

shared by Nathan Goodyear on 22 Aug 20 - No Cached
  • Nathan Goodyear on 22 Aug 20
     
    Not an article, but a good review of TLRs and their immunologic role
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