Here is my problems with "statistics". The statement "No significant difference in the report of sexual ideation was found..." If you are the one women that had decreased sexual function after having your ovaries removed: isn't it comforting to know you are not statistically significant. Come on. Some did, and that is enough and should be considered significant. This is a permanent change to these woman's lives and marriage.
In women with PCOS, inflammation DIRECTLY stimulates androgen production from the ovaries. Inflammation is the driving force behind the high androgen levels in women with PCOS.
Chiro-inositol increases the action of insulin in patients with the polycystic ovary syndrome, thereby improving ovulatory function and decreasing serum androgen concentrations, blood pressure, and plasma triglyceride concentrations.
great review of the menopause transition and the effect of weight and hormones. For example, muscle loss is found in menopause vs perimenopause. Increased estrogen production occurs from non-ovary sites i.e. visceral and SQ fat.
For most women, the practice of pre-menopausal, preventative removal of ovaries should be no more. Evidence does not support a reduction in ovarian cancer; but, it does support an increased risk of depression, hyper lipidemia, cardiac arrhythmia, CAD, arthritis, asthma, COPD, and asthma.
insulin, in women with PCOS, promotes increased 5-alpha reductase activity. This results in a dysregulated HPA axis, promoting increased cortisol and androgen levels.
Menopausal rats and rats that had ovaries removed have increased low grade inflammatory signaling. This study treated the rats in question with either Estradiol and Losartan and both decreased inflammatory signaling.
This was the WHI review of data as it pertains to dementia and cognitive decline in women. The take home here is that the data provides little evidence for premarin with or without medroxyprogesterone acetate in > 65 for prevention of dementia. However, this is in women > 65 and studies show that younger women do indeed receive benefit, especially in those with early ovary removal. Another point here, MPA (medroxyprogesterone acetate) increases cognitive decline. Just don't take MPA, it is a bad drug all the way around!
Untold risk of early ovary removal appears to be cognitive decline and increased risk of dementia. The earlier the age of removal, the more the increased risk of cognitive decline.
Statin therapy worsens insulin sensitivity and thus glucose regulation in women with PCOS. Women with PCOS are at increased risk for type II Diabetes. Statins interfere with glucose metabolism and thus will increase the effective risk for these women. This study was a randomized, prospective study.
Study finds higher Pb levels in young girls is associated with delayed puberty onset. This occurs through an inverse relationship with inhibin B and follicular development. This relationship was also found with Cadmium. Both of these heavy metals are toxic to the ovaries.