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Nathan Goodyear

Statin use and risk of diabetes mellitus - 0 views

www.ncbi.nlm.nih.gov/...PMC4360430

statin statin therapy diabetes insulin resistance GLUT4 HgbA1c

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • An increase in new onset diabetes, i.e., 3% in statin arm and 2.4% in placebo arm was reported. This was accompanied by increase in median value of glycated haemoglobin and was one of the earlier studies to report the increase in new onset diabetes in patients on statins
  • Even after adjustment for potential confounders, statin therapy was associated with an increased risk of new-onset diabetes mellitus
  • Authors suggest that statin-induced diabetes mellitus is a medication class effect
  • ...10 more annotations...
  • Another study also reported that as compared to placebo, statin group showed a higher risk of physician reported incident diabetes and it was also observed that risk was higher in women as compared to men
  • Meta-analysis of randomized controlled trials by Sattar et al[25] involving 91140 non-diabetic patients showed that statin therapy was associated with 9% increased risk of incident diabetes
  • A number of studies showed dose dependent association between statin administration and incident diabetes
  • intensive dose of statins was associated with high incidence of new - onset diabetes
  • Treatment with atorvastatin and simvastatin may be associated with an increased risk of new onset diabetes as compared to pravastatin
  • Increased incidence of diabetes was seen with atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial
  • Increased insulin resistance secondary to statins was demonstrated in a prospective non randomised study in patients with coronary bypass surgery
  • downregulation of GLUT4
  • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
  • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
  • Nathan Goodyear on 04 Oct 17
     
    Great review article of the increased risk of worsening insulin resistance, glycated hemoglobin, and diabetes risk.  Atorvastatin appears to be the worst culprit.  Mechanism partially through a decrease in GLUT4.
Nathan Goodyear

Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and g... - 0 views

www.ncbi.nlm.nih.gov/...PMC4114109

statin statin therapy statins sperm men male fertility atorvastatin hormones

shared by Nathan Goodyear on 04 Sep 14 - No Cached
  • Nathan Goodyear on 04 Sep 14
     
    I really don't understand the purpose of this study.  Why give "healthy" men with normal lipids atorvastatin???  The study found a reduction in TC and LDL, but also a reduction in sperm number, decreased sperm vitality, increased sperm morphology, decreased prostatic acid pho sphatases, epididymal neutral alpha-glucosidase and L-carnitine levels resulted.  
Nathan Goodyear

The Effect of Atorvastatin and Atorvastatin-Ezetimibe Combination T... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25350347

statin therapy statins PCOS polycystic ovarian syndrome androgens Testosterone women female hormone hormones

shared by Nathan Goodyear on 11 Nov 14 - No Cached
  • Nathan Goodyear on 11 Nov 14
     
    Cholesterol lowering drug, atorvastatin, lowers androgen levels in women with PCOS.  The same has been shown in men.
Nathan Goodyear

The effect of rosuvastatin and atorvastatin on e... [Kardiol Pol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24142756

statins ED men

shared by Nathan Goodyear on 30 Oct 13 - No Cached
  • Nathan Goodyear on 30 Oct 13
     
    Increased ED found with atorvastatin, but not with Rosuvastatin.  Statin therapy has been suggested to be the cause of ED in some men.  This study points to the fact that the effects may vary between statins.
Nathan Goodyear

Prevention of coronary and stroke events with atorvastatin in hypertensive patients who... - 0 views

www.ncbi.nlm.nih.gov/...15765890

statin statin therapy diabetes

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    Only abstract available here, but atorvastatin associated with a reduction in cardiovascular events but also associated with increased risk of diabetes.
Nathan Goodyear

Risk of incident diabetes among patients treated with statins: population based study |... - 0 views

www.bmj.com/bmj.f2610

statin statin therapy diabetes

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    Higher dosed and higher potency statins are associated with greater risk of new onset diabetes.  Atorvastatin was the worst statin in this regard.
Nathan Goodyear

Atorvastatin treatment reduces exercise capac... [J Appl Physiol. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21852406

statin mitochondria energy ATP muscle damage performance exercise

shared by Nathan Goodyear on 16 Mar 12 - No Cached
  • Nathan Goodyear on 16 Mar 12
     
    statin therapy damages mitochondria. Mitochondria are the powerhouses of the cell: they are the energy producers of the cell.  It is no surprise that damage to the cells capacity to make energy will in turn decrease the capacity of muscle to perform.
Nathan Goodyear

Statin Therapy Worsens Insulin Sensitivity in Women With Polycystic Ovary Syndrome (PCO... - 0 views

jcem.endojournals.org/...4798.abstract

statin statins atorvastatin diabetes women insulin sensitivity resistance PCOS polycystic ovarian syndrome polycystic ovary syndrome

shared by Nathan Goodyear on 11 Dec 13 - No Cached
  • Nathan Goodyear on 11 Dec 13
     
    Statin therapy worsens insulin sensitivity and thus glucose regulation in women with PCOS.  Women with PCOS are at increased risk for type II Diabetes.  Statins interfere with glucose metabolism and thus will increase the effective risk for these women.  This study was a randomized, prospective study.
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