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Nathan Goodyear

Imbalance in Sex Hormone Levels Exacerbates Diabetic Renal Disease - 0 views

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    Diabetes associated with low serum testosterone.  This study points to a 4.7 fold decrease.  This is accompanied by a 2.9 fold increase in estradiol.  Castration worsened this imbalance by decreasing the testosterone level further.  Likely the low T and increased aromatase activity aid in the development of diabetic renal disease. Numerous studies have shown that testosterone therapy improves glucose homeostasis.
Nathan Goodyear

ScienceDirect.com - Journal of the American College of Cardiology - High Serum Testosterone Is Associated With Reduced Risk of Cardiovascular Events in Elderly Men: The MrOS (Osteoporotic Fractures in Men) Study in Sweden - 0 views

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    This study found that high serum testosterone associated with a reduction of cardiovascular events in elderly men.  Studies have shown that low T is associated with increased cardiovascular mortality and in cardiovascular events, but this study takes it one step further: testosterone reduces those risks. 
Nathan Goodyear

Divergent trends in obesity and fat intake patterns... [Am J Med. 1997] - PubMed - NCBI - 0 views

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    Fat intake is inversely associated with the obesity trend.  During, the 80's, a low fat diet was all the craze.  However, the obesity trend increased with the incorporation of the the low fat diet in America.
Nathan Goodyear

Effect of a low-carbohydrate diet on appetite... [Ann Intern Med. 2005] - PubMed - NCBI - 0 views

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    low carbohydrate diet found to improve glucose and insulin function in those obese with type II diabetes
Nathan Goodyear

Effect of 6-month adherence to a very low carbohydrate diet program - 0 views

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    low carb diet resulted in 6 month weight loss.
Nathan Goodyear

http://onlinelibrary.wiley.com/store/10.1002/art.11105/asset/11105_ftp.pdf;jsessionid=4C65AF80E4193903EA1042174A607429.f03t01?v=1&t=iomr25hd&s=21ef8244f39f50c74a498f0b304f97b75c90268c - 0 views

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    good review of sex hormones and LUPUS; whether it is causative or not, sex hormones trends exist in LUPUS i.e. low DHEA in both sexes, low progesterone in women, and low Testosterone in women>men.
Nathan Goodyear

Role of certain trace minerals in oxidative stress, inflammation, CD4/CD8 lymphocyte ratios and lung function in asthmatic patients - 0 views

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    Asthma associated with low selenium, low zinc, high copper, low glutathione peroxidase, glutathione reductase, and catalase activity; in contrast, increased hs-CRP, and TBARS was  noted.  Interesting that FEV1 and FVC positively correlated with Se levels.
Nathan Goodyear

Reduced Number of Circulating Endothelial Progenitor Cells in Hypogonadal Men - 0 views

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    low Testosterone in young men (small trial) associated with low endothelial progenitor cells.  This has been associated with increased atherosclerosis.  High Testosterone replacement in these 10 young men increased EPCs.  
Nathan Goodyear

Prevalence of Neuroendocrine Dysfunction in Patients Recovering from Traumatic Brain Injury - 0 views

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    TBI results in pituitary dysfunction.  The result in low cortisol, low thyroid, and low HGH.  Other hormones appeared to be unaffected
Nathan Goodyear

JAMA Network | JAMA: The Journal of the American Medical Association | Low-Fat Dietary Pattern and Risk of Colorectal CancerThe Women's Health Initiative Randomized Controlled Dietary Modification Trial - 0 views

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    The women's health initiative dietary modification trial of almost 50,000 women found no association between a low fat diet and a reduction of colorectal cancer.  Translation: a low fat diet does not lower the risk of colorectal cancer.
Nathan Goodyear

Estrogens in Men: Clinical Implications for Sexual Function and the Treatment of Testosterone Deficiency - Kacker - 2012 - The Journal of Sexual Medicine - Wiley Online Library - 0 views

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    Several flaws with this study. First, the majority of testing done in the meta-analysis was serum--unreliable.  Second, this study flies in the face of many other studies that have shown elevated estrogens contribute to low testosterone in men.  Third, this flies in the face of observation.  I see over and over again, by lowering a male's estrogen level, he in turn will start producing more Testosterone.  And finally, the environmental xenoestrogens have helped to contribute to a all time low of testosterone/infertility rate in men today.
Nathan Goodyear

http://onlinelibrary.wiley.com/store/10.1002/hep.21080/asset/21080_ftp.pdf;jsessionid=C45939E71FD1E43279D6DC7447C7FC1A.f04t01?v=1&t=hrgzlf7k&s=06a20991c511bb972b76d7ad9ed62c56370452a3 - 0 views

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    small study looked at patients with liver cirrhosis.  The authors used a low dose of IV vitamin C (5 grams) and found that this improved endothelial dysfunction.  Patients with cirrhosis were found to be low in vitamin C.  The IV vitamin C was well tolerated, despite a low dose.
Nathan Goodyear

Predictive parameters of accelerated muscle loss in... [Am J Med. 2014] - PubMed - NCBI - 0 views

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    Study looked at muscle loss in older men and found that low activity, type II diabetes, low Total Testosterone and low free Testosterone, and increased PTH are associated with an increased muscle loss 
Nathan Goodyear

Metabolic syndrome in men with low testosterone le... [J Sex Med. 2013] - PubMed - NCBI - 0 views

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    Metabolic syndrome and Low T definitely run together.  Whether one causes the other or merely associations, they reflect the risk of the other.  It is known that increasing MetS parameters drives the Testosterone Lower.  In this study, they found ED, obesity, PVD, and Etoh intake associated with increased incidence of MetS.  ED and obesity are both associated with Low T.
Nathan Goodyear

Endogenous Sex Hormones and Metabolic Syndrome in Aging Men - 0 views

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    Hormones and metabolic syndrome in men.  Low Testosterone, Low free Testosterone and Increased SHBG associated with MetS in men.
Nathan Goodyear

Low plasma testosterone and elevated carotid... [Atherosclerosis. 2012] - PubMed - NCBI - 0 views

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    Study finds that low Total T and "bioavailable", also known as free, Testosterone  is associated with an increase in carotid intima-media thickness, which is a marker of CVD.  Higher CRP increased the IMT in those with low T.
Nathan Goodyear

Obesity and age as dominant correlates of low test... [Andrology. 2013] - PubMed - NCBI - 0 views

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    Nice study.  This study tries to get to the source of problem.  The authors of this study found that low T in men is more associated with increasing BMI and age versus the presence of diabetes.
Nathan Goodyear

Prevalence of low testosterone and its relationsh... [Aging Male. 2013] - PubMed - NCBI - 0 views

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    This study found an association between increasing BMI and low T in men with BPH.
Nathan Goodyear

Low testosterone elevates interleukin family cyto... [J Surg Res. 2014] - PubMed - NCBI - 0 views

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    low Testosterone associated with increased inflammatory cytokines in animal model.  The cytokines IL-2, IL-6, IL-10, Il-12, and IL-13 were specifically found to be elevated.  Translated, in animal model, low T equals increased inflammation.
Nathan Goodyear

Low Testosterone at Time of Transplant Is Independent... [J Urol. 2014] - PubMed - NCBI - 0 views

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    More and more, low Testosterone is clearly a marker of poor health in men.  This study finds that low T at the time of renal transplant is associated with increase graft rejection/loss and patient death.  It appears to me that Testosterone levels should be a part of assessment for any man in poor health and/or headed for surgery.
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