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Nathan Goodyear

Epigallocatechin-3-gallate ameliorates experimental autoimmune encephalomyelitis by altering balance among CD4+ T-cell subsets. - ResearchGate - 0 views

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    EGCG found to reduce cytokine production in animal model of MS, experimental autoimmune encephalomyelitis.  Specifically, EGCG reduced interferon gamma, IL017, IL-6, IL-1beta, TNF-alpha and decreased Th1 and Th17 cells with an increase in Treg cells.
Nathan Goodyear

Sex hormones as immunomodulators in heal... [Int Immunopharmacol. 2001] - PubMed - NCBI - 0 views

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    Estradiol in mice predisposed to Lupus have increased inflammation and characteristics of Lupus.  In contrast, Estradiol in those without predisposition, do not.  Clearly this is an inflammatory signaling problem.  Studies have shown an Interferon gamma signaling deficit in those with Lupus.  Testosterone decreases the above inflammation signaling.
Nathan Goodyear

Gamma-linolenic acid induces apoptosis in B-chroni... [Leuk Lymphoma. 2001] - PubMed result - 0 views

  • n the presence of GLA 5 microg/ml and dexamethasone the degree of apoptosis was 86%
  • These results demonstrate that GLA induces apoptosis in B-CLL B- and T-cells cells in vitro and that they are more susceptible to GLA-induced apoptosis than normal peripheral blood B- and T-cells.
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    GLA, omega-6 found in plant based oils,  kills 42% of leukemia cells; with dexamethasone, the kill rate increases to 86%
Nathan Goodyear

Saccharomyces boulardii decreases inflammation and intestinal colonization by Candida albicans in a mouse model of chemically-induced colitis. - PubMed - NCBI - 0 views

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    Saccharomyces boulardii decreased TNF-alpha and INF-gamma as well as decreased candida colonization.
Nathan Goodyear

Oncolytic virotherapy promotes intratumoral T cell infiltration and improves Anti-PD-1... - 0 views

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    Study found that viral oncolytic therapy improved efficacy of PD-1 check point inhibitors by 62%. Increased CD8 expression, interferon-gamma...Interesting, starting CD8 levels played no role in predicting outcome.
Nathan Goodyear

Gamma-glutamyl transpeptidase as an aid in the diagnosis of liver metastases. - PubMed - NCBI - 0 views

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    elevated GGTP helpful in identifying liver metastasis.
Nathan Goodyear

Germane facts about germanium sesquioxide: I. Chemistry and anticancer properties. - PubMed - NCBI - 0 views

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    only abstract available here.  Great review and discussion of the research behind Germanium Sesquioxide and its immune effects in the fight against cancer.  Primary effects are via increase in Interferon gamma and increase in NK cell activity; but it also inhibits tumor growth and metastatic potential. The germanium compound is specific to the sesquioxide compound.
Nathan Goodyear

Thymosin alpha 1: A comprehensive review of the literature - 0 views

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    Awesome review article on TA-1 and its broad immunomodulatory effects, i.e. increase IL-1, IFN-gamma, increase dendritic cell activity, inhibition of tumor growth…
marccure

Buy m-lorax cream for cattle |used antiseptic purposes | Marccure - 0 views

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    M-Lorax is a veterinary cream which generally used to treat various type of wounds eg. cut wound, Lacerated wound, surgical wound & Maggot wound with Fly repellent Properties. M-Lorax cream has Gamma Benzene Hexachloride which is also helpful in treatment of scabies and lice infestations, Proflavin Hemisulphate & cetrimide which is widely used for antiseptic purposes. Uses of M-Lorax cream: Used to treat various types of wounds. Also useful in treatment of scabies and lice infestations. It is widely used as antiseptic. It heals wounds and cuts with excellent efficacy. Benefits: It is an antiseptic for pets. It prevents pets from lice and mites. Improves scalps from insects. Reduces rashes caused by bacterias. Effective in treatment of scabies. Prevent pets from itching & burning sensation.
Nathan Goodyear

Peroxisome proliferator-activated receptors in inflammation control - 0 views

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    PPARs are key regulators in inflammation control. PPARs are nuclear transcription factors that decrease NF-KappaB transcription.
Nathan Goodyear

Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism : Nature Communications - 0 views

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    fascinating read on gut inflammation and glucose metabolism.  The gut bacteria implicated her is Akkermansia muciniphila.
Nathan Goodyear

Lipid-soluble antioxidants and pregnancy: maternal serum levels of coenzyme Q10, alpha-tocopherol and gamma-tocopherol in preeclampsia and normal p... - PubMed - NCBI - 0 views

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    Women with preeclampsia have lower CoQ10 levels compared to normal pregnant women.
Nathan Goodyear

ingentaconnect Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Re... - 0 views

  • “M1” or “classically activated” macrophages
  • PPAR-gamma agonists
  • “M2” or an “alternatively activated” anti-inflammatory phenotype
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    ATMs and obesity induced inflammation initiates insulin resistance and thus type II diabetes. The bodies reaction to a fat cell is no different than a bacterial, viral, or parasitic infection.  The body recognizes something (fat) that shouldn't be there and it attempts to destroy it and remove it.
Nathan Goodyear

Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism. - 0 views

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    Study shows that gastrointestinal epithelial dysfunction is found in autism. This would play a critical role in systemic inflammation and would contribute to ASD symptoms through the gut-brain connection.
Nathan Goodyear

Evening primrose oil (Efamol) in the treatmen... [Thromb Haemost. 1985] - PubMed - NCBI - 0 views

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    patients given 6 grams of Evening primrose oil had improvement in Raynaud's symptoms in 8 weeks.
Nathan Goodyear

The antioxidant effects of vitamin C on liver enzymes: aspartate aminotransferase, alanine aminotranferease, alkaline phosphatase and gamma-glutamyltransferase activities in rats under Paraquat insult | Okolonkwo | Journal of Xenobiotics - 0 views

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    Vitamin C, in oral route, prevents elevations in liver enzymes after liver insult from Paraquat.
Nathan Goodyear

Antidepressants inhibit interferon-gamma-induced ... [Exp Neurol. 2007] - PubMed - NCBI - 0 views

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    anti-depressants inhibit inflammatory IL-6 production from microglial cells in brain, suggesting anti-inflammatory effects of antidepressants as role in improving depression symptoms
Nathan Goodyear

Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids. - 0 views

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    GLA found to inhibit 5 alpha reductase activity in prostate cancer cells.
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