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Nathan Goodyear

PLOS Medicine: Erectile Dysfunction Severity as a Risk Marker for Cardiovascular Disease Hospitalisation and All-Cause Mortality: A Prospective Cohort Study - 0 views

www.plosmedicine.org/...journal.pmed.1001372

erectile dysfunction ED CVD cardiovascular disease

shared by Nathan Goodyear on 02 Feb 13 - No Cached
  • Nathan Goodyear on 02 Feb 13
     
    As ED is a cardiovascular problem, it is no surprise that those with ED have an increase in CVD.
Nathan Goodyear

JAMA Network | JAMA Internal Medicine | Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults - 0 views

archinte.jamanetwork.com/article.aspx

resveratrol CVD CAD heart disease polyphenols red wine chocolate inflammation

shared by Nathan Goodyear on 13 May 14 - No Cached
  • Nathan Goodyear on 13 May 14
     
    New study finds no cardiovascular benefits from resveratrol.  It has long been claimed that reserveratrol is the polyphenol from red wine and chocolate that is the source of cardiovascular benefits such as found in the "french paradox".  However, this new study finds that resveratrol provides no benefit.  Studies still point to dark chocolate and red wine as means to reduce inflammation and reduce CVD risk, this study just points away from resveratrol as the source of the benefit.
Nathan Goodyear

Kidney International - Abstract of article: Inflammation enhances cardiovascular risk and mortality in hemodialysis patients - 0 views

www.nature.com/...4490624a.html

inflammation CRP cardiovascular disease risk

shared by Nathan Goodyear on 04 Feb 11 - No Cached
  • Nathan Goodyear on 04 Feb 11
     
    Inflammation (point 5 of 5 points of wellness) increases CRP, which increases cardiovascular risk
Nathan Goodyear

Apolipoprotein A1 Is a Stronger Prognostic Marker Than Are HDL and LDL Cholesterol for Cardiovascular Disease and Mortality in Elderly Men - 0 views

biomedgerontology.oxfordjournals.org/...1262.abstract

apolipoprotein a a1 cardiovascular disease cholesterol LDL HDL

shared by Nathan Goodyear on 10 May 11 - No Cached
  • Nathan Goodyear on 10 May 11
     
    Apolipoprotein A1 is a better indicator of cardiovascular disease risk than HDL or LDL in men
Nathan Goodyear

Leukocyte Telomere Length and Mortality in the Cardiovascular Health Study - 0 views

biomedgerontology.oxfordjournals.org/...421.abstract

Telomere aging

shared by Nathan Goodyear on 18 May 11 - No Cached
  • Nathan Goodyear on 18 May 11
     
    Telomere length weakly correlated with mortality rate
Nathan Goodyear

Blood Lead Levels and Death from All Causes, Cardiovascular Disease, and Cancer: Results from the NHANES III Mortality Study - 0 views

www.ncbi.nlm.nih.gov/...PMC1626441

lead exposure Pb heavy metals mortality blood levels death cardiovascular disease cancer NHANES III

shared by Nathan Goodyear on 16 Apr 12 - No Cached
  • Nathan Goodyear on 16 Apr 12
     
    NHANES III reveals increased risk of death from all causes, but particularly CVD and cancer in very small exposures to lead.  No lead exposure is safe.
Nathan Goodyear

Nature Clinical Practice Endocrinology & Metabolism | Testosterone and ill-health in aging men | Article - 0 views

www.nature.com/...ncpendmet1050.html

low T Testosterone health men male hormone hormones metabolic syndrome metabolic syndrome MetS insulin resistance diabetes aging

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Levels of total and bioavailable testosterone and SHBG were reported to be inversely correlated with the prevalence of the metabolic syndrome in men aged 40–80 years
  • as were total testosterone and SHBG in men aged 65–96 years
  • and in a cross-sectional analysis of a large cohort of non-diabetic men aged 70–89 years
  • ...18 more annotations...
  • In longitudinal studies, decreased levels of total testosterone and SHBG predicted an increased incidence of metabolic syndrome in nonobese men
  • Free testosterone level is not associated with the prevalence of metabolic syndrome in middle-aged and older men
  • Levels of free, bioavailable and total testosterone are lower in men with T2DM than in age-matched controls,34, 35 and decreased total testosterone level predicts incident T2DM in middle-aged men.
  • men with T2DM commonly have low total or free testosterone levels
  • Total, bioavailable and free testosterone levels are inversely correlated with fasting insulin level and insulin resistance in middle-aged men without T2DM
  • total testosterone is positively correlated with insulin sensitivity in men with normal or impaired glucose tolerance or T2DM
  • low SHBG level is more strongly associated with metabolic syndrome than low total testosterone in aging men
  • the recognized association between low SHBG level and insulin resistance
  • Low levels of SHBG are also associated with smaller, denser LDL-cholesterol molecules in nondiabetic men,58 and were found to predict increased cardiovascular disease mortality in one study of older men
  • Low levels of SHBG might reflect obesity, insulin resistance and overall poor health
  • Compared with those who have normal testosterone levels, men aged 40 years or more with total testosterone levels <9.8 nmol/l or elevated LH level have greater CIMT
  • In men aged 73–94 years, total testosterone was inversely correlated with CIMT
  • a prospective analysis of men aged 73–91 years, progression of CIMT was not related to total testosterone level, but it was inversely related to free testosterone level
  • A study of men aged 55 years or more found that those with total and bioavailable testosterone levels in the highest tertile had a lower risk of severe aortic atherosclerosis (detected by radiography as abdominal aortic calcification) than those with the lowest testosterone levels.
  • a large study of men aged 69–80 years, those with total or free testosterone in the lowest quartile had increased odds of lower-extremity peripheral arterial disease
  • the possibility of reverse causation has to be considered, as systemic illness can result in decreased testosterone levels
  • previous case–control studies and longitudinal studies have failed to identify low testosterone levels as strong predictors of clinically significant coronary disease
  • Reviews of trials on testosterone therapy in men with either low or low-to-normal testosterone levels have not shown consistent beneficial effects either on lipid profiles or on actual cardiovascular events.24, 54, 55 These trials, however, have not been designed or powered to detect treatment-related differences in cardiovascular outcome
  • Nathan Goodyear on 03 Mar 14
     
    Declining Testosterone or low Testosterone is clearly associated with poor health in men.   Very nice review of the association between low Testosterone and metabolic dysfunction.  Low T is associated with increased metabolic syndrome, Diabetes, weight gain, insulin resistance...
Nathan Goodyear

Low Serum Testosterone Increases Mortality Risk among Male Dialysis Patients - 0 views

jasn.asnjournals.org/...613.full

low serum testosterone mortality male patients hemodialysis CVD cardiovascular disease

shared by Nathan Goodyear on 26 Apr 12 - No Cached
  • Nathan Goodyear on 26 Apr 12
     
    low Testosterone associated with increased CVD in male hemodialysis patients
Nathan Goodyear

Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease - NEJM - 0 views

www.nejm.org/...NEJMoa060900

HOPE-2 trial vitamin B12 Vitamins B6 folic acid folate homocysteine CVD cardiovascular disease events stroke MI

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    Vitamin B12, B6, and folic acid shown to lower homocysteine levels and decreased the incidence of stroke.  However, overall mortality and CVD deaths were not.
Nathan Goodyear

PLOS ONE: Association of Blood Lead (Pb) and Plasma Homocysteine: A Cross Sectional Survey in Karachi, Pakistan - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0011706

cardiovascular disease Pb lead homocysteine

shared by Nathan Goodyear on 18 Sep 14 - No Cached
  • Nathan Goodyear on 18 Sep 14
     
    No amount of Pb level exposure is considered safe as levels as low as 3 mcg/dl has been shown to be associated with increased cardiac mortality.  This study found higher Pb levels in men versus women in Pakistan. This correlated with elevated homocysteine levels.  
Nathan Goodyear

Low-T3 Syndrome - 0 views

circ.ahajournals.org/...708.long

T3 low T3 cardiac heart disease CVD cardiovascular thyroid hormone hormones hypothyroid hypothyroidism

shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • More than 80% of the biologically active hormone triiodothyronine (T3) derives from peripheral conversion of prohormone thyroxine (T4) secreted by the thyroid gland
  • Low thyroid hormone concentrations, in particular low serum T3 concentrations, are a common finding in patients with nonthyroidal illnesses, including cardiac disorders
  • a direct relationship between low circulating levels of T3 and adverse prognosis of cardiac patients
  • ...4 more annotations...
  • The present study clearly shows the existence of a strong association between the reduction of biologically active T3 and mortality in a large population of cardiac hospitalized patients
  • highly significant increase in the incidence of cardiac and cumulative deaths in patients with low T3 compared with patients with normal T3 levels
  • the relevance of the low T3 state as a strong, independent predictor of mortality in cardiac patients
  • low T3 concentrations are a strong independent predictive marker of poor prognosis in cardiac patients
  • Nathan Goodyear on 03 Jul 12
     
    low T3 associated with poor prognosis in cardiac patients.   Poor prognosis = death.  T3 is important in cardiac remodeling, which is inherently important with cardiac disease.
Nathan Goodyear

Thyroid Hormone and Cardiac Disease: From Basic Concepts to Clinical Application - 0 views

www.ncbi.nlm.nih.gov/...PMC3134399

T3 cardiovascular death disease heart health MI myocardial infarction CHF heart failure thyroid hormone hormones hypothyroid hypothyroidism CVD

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Low T3 post MI is associated with increased CHF, morbidity and mortality.  Article discusses thyroid hormones and cardiac function/remodeling post infarct.  The article also lays the ground work for a new study of T3 in patients post MI to be followed for 6 months.
Nathan Goodyear

Hormone Replacement Therapy Associated with Lower Mortality - American College of Cardiology - 0 views

www.acc.org/...ssociated-with-lower-mortality

HRT hormone replacement therapy hormones menopause atherosclerosis cardiovascular disease hormone therapy

shared by Nathan Goodyear on 22 Mar 17 - No Cached
  • Nathan Goodyear on 22 Mar 17
     
    Just a press release of yet to be published study that finds women on HRT have lower atherosclerosis, calcium score, and death than younger women not on HRT.
Nathan Goodyear

Androgen Deprivation Therapy, Insulin Resistance, and Cardiovascular Mortality: An Inconvenient Truth -- Basaria 29 (5): 534 -- Journal of Andrology - 0 views

www.andrologyjournal.org/...534

leptin resistance low T testosterone low T hormone hormones insulin cardiovascular disease men male

shared by Nathan Goodyear on 28 Aug 12 - No Cached
  • Nathan Goodyear on 28 Aug 12
     
    leptin resistance, increased leptin, reduces testosterone production in men.
Nathan Goodyear

Elderly men over 65 years of age with late-onset hypogonadism benefit as much from testosterone treatment as do younger men - 0 views

www.ncbi.nlm.nih.gov/...PMC4392031

low T low Testosterone Testosterone men male hormone hormones late onset hypogonadism hypogonadism

shared by Nathan Goodyear on 21 May 15 - No Cached
  • The benefits of restoring serum testosterone in men with LOH were not significantly different between men older than 65 years of age and younger men. There were no indications that side effects were more severe in elderly men. The effects on prostate and urinary function and hematocrit were within safe margins.
  • obesity, but also impaired general health, are the more common causes of low testosterone in aging men
  • Severe LOH is associated with substantially higher risks of all-cause and cardiovascular mortality,
  • ...30 more annotations...
  • advanced age, obesity, a diagnosis of metabolic syndrome, and poor general health status were predictors of LOH
  • Diabetes mellitus was correlated with hypogonadism in most studies
  • coronary heart disease, hypertension, stroke, and peripheral arterial disease did not predict hypogonadism, they did correlate with the incidence of low testosterone
  • LOH can be defined by the presence of at least three sexual symptoms associated with a total testosterone level of less than 11 nmol/L (3.2 ng/mL) and a free testosterone level of less than 220 pmol/L (64 pg/mL)
    • Nathan Goodyear
      Nathan Goodyear on 27 May 15
       
      the European Male Aging study defined low T as total < 320 ng/dl and free < 64 pg/ml.  
  • Mean weight decreased
  • Waist circumference decreased
  • Total cholesterol decreased
  • Low-density lipoprotein decreased
  • Triglycerides decreased
  • High-density lipoprotein (HDL) increased
  • ratio of total cholesterol to HDL improved
  • Prostate volume increased
  • PSA increased
  • The benefits for men older than 65 years of age were compared with those of younger men, and the improvements in body weight, metabolic factors, psychological functioning, and sexual functioning were of the same magnitude in both age groups
  • weight loss was progressive over the 6-year period, effects of testosterone on lipids and on psychological and sexual functioning reached a plateau after approximately 3 years and these effects were sustained
  • Effects of testosterone on hematopoiesis, on the prostate, and on bladder function were not more severe in older men than in younger men
  • observe a mild increase in prostate volume and serum PSA over time, which is a normal finding in aging men. Maybe somewhat surprising, postvoiding residue and the IPSS did not deteriorate with aging but showed a degree of improvement
  • the severity of the metabolic syndrome is associated with the severity of lower urinary tract symptoms
  • The symptoms of the metabolic syndrome improve upon testosterone treatment and testosterone may thus have a favorable effect on lower urinary tract symptoms
  • it seems reasonable to conclude that the risks of testosterone administration to elderly men are not disproportionately higher in elderly men than in younger men.
  • Despite evidence to the contrary, physicians still harbor a wrongful association between testosterone and the development of prostate pathology (prostate cancer and benign prostate hyperplasia)
  • Not surprisingly, the incidence of prostate cancer was higher in older men; however, it was lower than expected in both groups
  • These observations suggest that the incidence of prostate cancer in patients receiving testosterone therapy, both in the younger and in the older group, was not greater than in the general population not receiving testosterone treatment
  • The historical fear that raising testosterone levels will result in more prostate cancer has been dispelled, particularly by the work of Abraham Morgentaler
  • Higher serum testosterone levels fail to show an increased risk of prostate cancer, and supraphysiological testosterone does not increase prostate volume or PSA in healthy men
  • This apparent paradox is explained by the "saturation model,"
  • Recent studies indicate no increased risk of prostate cancer among men with serum testosterone in the therapeutic range
  • In the present observational study, no cases of major adverse cardiovascular events occurred.
  • the benefits of testosterone therapy are fully achieved only by long-term treatment
  • To achieve maximal benefits, good patient adherence is a prerequisite
  • Nathan Goodyear on 21 May 15
     
    Study finds new difference in Testosterone benefits and/or side effects between men < 65 with low T and men > 65 with low T.
Nathan Goodyear

Testosterone Making an Entry Into the Cardiometabolic World - 0 views

circ.ahajournals.org/...2658.full

low Testosterone T CVD cardiovascular disease mortality men

shared by Nathan Goodyear on 26 Apr 12 - No Cached
  • Nathan Goodyear on 26 Apr 12
     
    low Testosterone associated with increased CVD and death.
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