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Nathan Goodyear

High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fat... - 0 views

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    Study finds strong correlation between Apo B and Apo B:apo A1 in fatal MI risk in men and women.  Apo B was a stronger than LDL in predicting risk in men and women.  Apo A1 was noted to be protective, but the stats were less strong.
Nathan Goodyear

http://www.aacc.org/members/nacb/LMPG/OnlineGuide/PublishedGuidelines/risk/Documents/Ch... - 0 views

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    chapter points to the evidence on Apolipoprotien B and Apolipoprotein A1.  The evidence is strongest for Apo B and the Apo B:Apo A1 ratio.  
Nathan Goodyear

Associations between apolipoprotein B, apolipop... [J Intern Med. 2006] - PubMed - NCBI - 0 views

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    Meta-analysis finds "strong association" between Apo A1, Apo B and the ratio Apo B:A1 and cardiovascular risk.
Nathan Goodyear

Apo B/Apo A-I Ratio is Statistically A Better Predictor of Cardiovascular Disease (CVD)... - 0 views

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    Apo B:apo A1 is a better predictor of cardiovascular risk than a traditional cholesterol panel is.
Nathan Goodyear

Apolipoprotein A1 Is a Stronger Prognostic Marker Than Are HDL and LDL Cholesterol for ... - 0 views

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    Apolipoprotein A1 is a better indicator of cardiovascular disease risk than HDL or LDL in men
Nathan Goodyear

Effect of potentially modifiable risk facto... [Lancet. 2004 Sep 11-17] - PubMed - NCBI - 0 views

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    Stronger association found with apo B:apo A1 and cardiovascular disease risk than compared to cholesterol panel.
Nathan Goodyear

Nonfasting Apolipoprotein B and Triglyceride Levels as a Useful Predictor of Coronary H... - 0 views

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    non fasting apo B plus HDL is predictive of cardiovascular disease risk. Apo a1 was not predictive.  
Nathan Goodyear

Preventing Chronic Disease | Plasma Vitamin D and Biomarkers of Cardiometabolic Disease... - 0 views

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    Higher vitamin D levels associated with lower cardio biomarkers: insulin, insulin resistance, triglycerides, TC, LDL and TC:HDL.  Not found to be associated: glucose, apoliporotein A1 and B, CRP, fibrinogen, and homocysteine.
Nathan Goodyear

Association between plasma total tes... [J Clin Endocrinol Metab. 1997] - PubMed - NCBI - 0 views

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    low Total Testosterone associated with increased BMI, systolic blood pressure, glucose, triglycerides, total cholesterol, LDL apolipoprotien B and A1. Low Testosterone is associated with increased cardiovascular disease.  Men at risk for cardiovascular disease must be evaluated for hormones.
Nathan Goodyear

Plasma lipoproteins: composition, structure and biochemistry - 0 views

  • triacylglycerols
  • The most abundant lipid constituents are triacylglycerols, free cholesterol, cholesterol esters and phospholipids (phosphatidylcholine and sphingomyelin especially ), though fat-soluble vitamins and anti-oxidants are also transported in this way
  • the lipoprotein aggregates should be described in terms of the different protein components or apoproteins (or 'apolipoproteins'
  • ...8 more annotations...
  • these classes can be further refined by improved separation procedures, and intermediate-density lipoproteins (IDL) and subdivisions of the HDL (e.g. HDL1, HDL2, HDL3 and so forth
  • Density is determined largely by the relative concentrations of triacylglycerols and proteins and by the diameters of the broadly spherical particles
  • Lipoproteins are spherical (VLDL, LDL, HDL) to discoidal (nascent HDL) in shape with a core of non-polar lipids, triacylglycerols and cholesterol esters, and a surface monolayer, ~20Å thick, consisting of apoproteins, phospholipids and non-esterified cholesterol, which serves to present a hydrophobic face to the aqueous phase
  • the various lipid components should not be considered as absolute, as they are in a state of constant flux
  • Apo A1 is the main protein component of HDL
  • Apo A2 is the second most important HDL apolipoprotein
  • the main groups are classified as chylomicrons (CM), very-low-density lipoproteins (VLDL), low-density lipoproteins (LDL) and high-density lipoproteins (HDL), based on the relative densities of the aggregates on ultracentrifugation
  • The lipoproteins can be categorised simplistically according to their two main metabolic functions. The principal role of the chylomicrons and VLDL is to transport triacylglycerols ‘forward’ as a source of fatty acids from the intestines or liver to the peripheral tissues. In contrast, the HDL remove excess cholesterol from peripheral tissues and deliver it to the liver for excretion in bile in the form of bile acids (‘reverse cholesterol transport’). While these functions are considered separately here for convenience, it should be recognised that the processes are highly complex and inter-related, and they involve transfer of apoproteins, enzymes and lipid constituents among the heterogeneous mix of all the lipoprotein fractions.
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    Awesome review of apolipoproteins, their function, and their metabolism.
modernsouq

مشد رجالى لإخفاء الكرش - مشد البطن للرجال بالسعودية - مودرن سوق - 0 views

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    أفضل مشد رجالى لإخفاء الكرش - مشد البطن رجالي كامل للجسم لتخسيس البطن والأرداف وتفتيت دهون البطن وإزالة الكرش حيث يجب إرتداء المشد الرجالى الحرارى حول منطقة البطن للرجال لتخفيف الكرش و إزالته و عودة البطن بالشكل الطبيعى إطلب الأن مشد رجالى لإخفاء الكرش - مشد البطن للرجال في السعودية والشحن ومجاناً
Nathan Goodyear

Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi - 0 views

  • Plant miRNA miR168a was found to present in the sera of mammals including human and regulate human gene LDLRAP1
  • plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression emerged. Broccoli sourced miR159 was found in human sera and proved to inhibit breast cancer growth through targeting the gene TCF7
  • This miRNA, with same 6mer and 7mer-A1 target seed sequence as hsa-miR-4259 and hsa-miR-4715-5p, was predicted to target human JAK-STAT signaling pathway gene SPRY4 and transcription regulation genes through miRTar
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  • plant miRNAs present in human circulating system were proven to be able to target human genes
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    Plant microRNA found in human serum.  Previous studies have shown that these plant microRNA's can interact with the human genome.
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