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Nathan Goodyear

Low-T3 Syndrome - 0 views

circ.ahajournals.org/...708.long

T3 low T3 cardiac heart disease CVD cardiovascular thyroid hormone hormones hypothyroid hypothyroidism

shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • More than 80% of the biologically active hormone triiodothyronine (T3) derives from peripheral conversion of prohormone thyroxine (T4) secreted by the thyroid gland
  • Low thyroid hormone concentrations, in particular low serum T3 concentrations, are a common finding in patients with nonthyroidal illnesses, including cardiac disorders
  • a direct relationship between low circulating levels of T3 and adverse prognosis of cardiac patients
  • ...4 more annotations...
  • The present study clearly shows the existence of a strong association between the reduction of biologically active T3 and mortality in a large population of cardiac hospitalized patients
  • highly significant increase in the incidence of cardiac and cumulative deaths in patients with low T3 compared with patients with normal T3 levels
  • the relevance of the low T3 state as a strong, independent predictor of mortality in cardiac patients
  • low T3 concentrations are a strong independent predictive marker of poor prognosis in cardiac patients
  • Nathan Goodyear on 03 Jul 12
     
    low T3 associated with poor prognosis in cardiac patients.   Poor prognosis = death.  T3 is important in cardiac remodeling, which is inherently important with cardiac disease.
Nathan Goodyear

Thyroid Replacement Therapy and Heart Failure - 0 views

circ.ahajournals.org/...385.full

thyroid T3 hormone hormones cardiovascular disease heart health failure CHF MI myocardial infarction heart attack heart disease

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • A good biomarker of intracardiac TH signaling would be helpful but has not been identified. In the absence of such a marker, a rational, cautious therapeutic approach might be to restore and maintain over time biochemical euthyroidism as documented by normal circulating levels of TSH, FT4, and FT3.
  • a low-T3 state resulting from altered peripheral TH metabolism secondary to caloric restriction is associated with impaired cardiac contractility
  • Low-T3 syndrome is the central finding and defines the illness in a variety of acute and chronic severe nonthyroidal illnesses with cardiac origin, including MI, HF, and surgically treated cardiac disease.1 Low circulating levels of T3 in the absence of primary thyroid hypofunction have been found in 20% to 30% of patients with dilated cardiomyopathy.
  • ...1 more annotation...
  • FT3 levels were inversely correlated to coronary artery disease
  • Nathan Goodyear on 24 Sep 14
     
    Great review of the current understanding of thyroid hormone metabolism in cardiac tissue.  Low T3 and increased rT3 (via increased D3 activity) is CLEARLY associated with poor cardiac performance and post MI and CHF is associated with poor outcomes.  T3 is critical in cardiac remodeling and recovery post MI.  T3 is actually a vasodilatory in the coronary arteries.   Why a endocrinologist would call rT3 useless only points to their ignorance of the literature.
Nathan Goodyear

Acute Effects of Triiodothyronine (T3) Replacement Therapy in Patients with Chronic Hea... - 0 views

jcem.endojournals.org/...1351.long

T3 fT3 thyroid disease low T3 syndrome T3 syndrome cardiomyopathy CHF congestive heart failure

shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • Nathan Goodyear on 03 Jul 12
     
    IV T3 was given to patients with chronic heart failure.  What the study found may surprise you: improved heart function (ventricular), improved BNP, decrease heart rate, no side effects.  T3 has been shown to be more predictive of cardiac death in those with cardiac disease, than elevated lipids or decreased ejection fraction.
Nathan Goodyear

Elsevier: Article Locator - 0 views

linkinghub.elsevier.com/...S0140673674920704

low T3 hypothyroid hypothyroidism

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • The most striking abnormality detected in 75 sick euthyroid patients was a highly significant reduction in the mean total serum-triiodothyronine (T3) levels, with most patients having total T3 levels in the hypothyroid range. The severity of the illness correlated well with the reduction in total serum-T3 levels.
  • Nathan Goodyear on 08 Mar 11
     
    low T3 in sick euthyroid clients; severity correlated with decreasing T3
Nathan Goodyear

Free T4, Free T3, and Reverse T3 in Critically III, Thermall... : The Journal of Trauma - 0 views

journals.lww.com/...everse_T3_in_Critically.1.aspx

free reverse T3 thyroid hypothyroid hypothyroidism

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Significant suppression of serum concentrations of 3,5,3'-triiodothyronine (T3) and elevation of serum concentrations of 3,3',5'-triiodothyronine (rT3) were seen
  • Nathan Goodyear on 08 Mar 11
     
    low free T3: elevated reverse T3 in critically ill patients
Nathan Goodyear

Reverse T3 levels in affective disorders. [Psychiatry Res. 1983] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...6417704

reverse t3 free depression TSH T4

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • In the group of patients with acute major depressive disorder, however, a significant increase in reverse T3 levels and a significant decrease in T3 levels, but no significant difference in T4 or TSH levels
  • Nathan Goodyear on 08 Mar 11
     
    low free T3:elevated reverse T3 correlates with major depression and TSH and free T4 do not.
Nathan Goodyear

Reduced activation and increased ina... [J Clin Endocrinol Metab. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12843166

inflammation illness thyroid hypothyroid hypothyroidism TSH free T3 rT3 T3:rT3 ratio

shared by Nathan Goodyear on 02 Feb 12 - No Cached
  • These observed changes, in correlation with a low T(3)/rT(3) ratio, may represent tissue-specific ways to reduce thyroid hormone bioactivity during cellular hypoxia and contribute to the low T(3) syndrome of severe illness.
  • Nathan Goodyear on 02 Feb 12
     
    inflammation and critical illness associated with low TSH, low T3, elevated rT3 and low T3:rT3 ratio.
Nathan Goodyear

Acute Effects of Triiodothyronine (T3) Replacement Therapy in Patients with Chronic Hea... - 0 views

jcem.endojournals.org/...1351.short

T3 low cardiac dysfunction heart replacement

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    T3 replacement in people with low T3 and cardiac dysfunction found to improve cardiac performance.
Nathan Goodyear

Reciprocal Changes in Serum Concentrations of 3,3',5'-Triiodothyronine (Reverse T3) and... - 0 views

jcem.endojournals.org/...1043

reverse T3 free hypothyroid hypothyroidism thyroid

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • The mechanism or the biological significance of such a diversion of T4, from the normally occurring conversion to highly potent T3, to the generation of poorly calorigenic rT3 in systemic illness
  • such a change in the metabolism of T4 can be reversible.
  • Nathan Goodyear on 08 Mar 11
     
    effects of systemic illness on thyroid function: elevated Reverse T3 and low free T3
Nathan Goodyear

TSH and free triiodothyronine concentrations are associated with weight loss in a lifes... - 0 views

www.eje-online.org/...323.abstract

free T3 T3 overweight obesity weight loss children

shared by Nathan Goodyear on 05 Mar 13 - No Cached
  • Nathan Goodyear on 05 Mar 13
     
    weight loss in obese children with low TSH and free T3 indicates high risk or regain of weight.  The important value here is the free T3.
Nathan Goodyear

T3 increases mitochondrial ATP production in oxidative muscle despite increased express... - 0 views

ajpendo.physiology.org/...E761.full.pdf

T3 hypothyroid hypothyroidism Cancer

shared by Nathan Goodyear on 28 Jun 13 - No Cached
  • Nathan Goodyear on 28 Jun 13
     
    T3 increases mitochondrial oxidative phosphorylation. This has huge impacts on which hypothyroidism is currently managed (only evaluate TSH and T4) and disease implication. We know that decoupling of oxidative phosporylation and a shift to glycolysis and glutaminolysis (substrate-level phosphorylation) results in genomic mutability and cancer, then a low T3 has implications in cancer prevention
Nathan Goodyear

Combination L-T3 and L-T4... [Curr Opin Endocrinol Diabetes Obes. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23974776

hypothyroid hypothyroidism T4 T3 thyroid therapy

shared by Nathan Goodyear on 09 Sep 13 - No Cached
  • Nathan Goodyear on 09 Sep 13
     
    This article reviews the genetic polymorphisms that play role in low T4 to T3 conversion and thus combination T4/T3 therapy is indicated.  This study fails to recognize the environmental impacts on the deiodinase enzymes.
Nathan Goodyear

Low-T3 Syndrome: A Strong Prognostic Predictor of Death in Patients With Heart Disease ... - 0 views

circ.ahajournals.org/...708

low t3 syndrome heart disease cardiac

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • Conclusions— Low-T3 syndrome is a strong predictor of death in cardiac patients and might be directly implicated in the poor prognosis of cardiac patients.
  • Nathan Goodyear on 01 Feb 11
     
    low T3 proves to be a strong predictor of death in patients with heart disease
Nathan Goodyear

Safety and Hemodynamic Effects of Intravenous Triiodothyronine in Advanced Congestive H... - 0 views

www.ajconline.org/...abstract

CHF T3 hypothyroid hypothyroidism heart failure

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    Patients with CHF often have low T3 levels.  In this study, IV T3 was shown to be safe and well tolerated
Nathan Goodyear

Thyroid Hormone and Cardiac Disease: From Basic Concepts to Clinical Application - 0 views

www.ncbi.nlm.nih.gov/...PMC3134399

T3 cardiovascular death disease heart health MI myocardial infarction CHF heart failure thyroid hormone hormones hypothyroid hypothyroidism CVD

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Low T3 post MI is associated with increased CHF, morbidity and mortality.  Article discusses thyroid hormones and cardiac function/remodeling post infarct.  The article also lays the ground work for a new study of T3 in patients post MI to be followed for 6 months.
Nathan Goodyear

Serum concentrations of total T4, T3, reverse T3 a... [Hum Nutr Clin Nutr. 1985] - PubM... - 0 views

www.ncbi.nlm.nih.gov/...4055428

free T3 hypothyroidism hypothyroid obesity

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Nathan Goodyear on 08 Mar 11
     
    poor nutrition leads to low free T3 in tissue which lowers cellular metabolism which leads to obesity
Nathan Goodyear

Acute Effects of Triiodothyronine (T3) Replacement Therapy in Patients with Chronic Hea... - 0 views

jcem.endojournals.org/...1351

T3 hypothyroid hypothyroidism cardiac disease

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • In DC patients, short-term synthetic L-T3 replacement therapy significantly improved neuroendocrine profile and ventricular performance
  • Nathan Goodyear on 01 Feb 11
     
    T3 provides significant improvement in cardiac function in those with dilated cardiomyopathy
Nathan Goodyear

Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling - 0 views

www.ncbi.nlm.nih.gov/...PMC2647704

thyroid hormone T3 T4 rT3 deiodinase selenium hormones

shared by Nathan Goodyear on 10 Nov 14 - No Cached
  • Nathan Goodyear on 10 Nov 14
     
    Anything and everything one would want to know regarding thyroid hormone signaling.  Doctors, especially endocrinologists, need to read this.  T4 is not or is ever inside target cells.  The enzymes, deiodinase types 1, 2, and 3, are what control the thyroid hormone at the cellular levels.  Deiodinase-2 is what generates T3 in the cytosol of the cell.  In contrast, deiodinase-3 is what generates rT3 which is inactive.  High Fat diet increases deiodinase-3.
Nathan Goodyear

Low-T3 Syndrome - 0 views

circ.ahajournals.org/...708.full

low T3 syndrome T4 TSH CVD cardiac hypothyroid hypothyroidism thyroid

shared by Nathan Goodyear on 07 Feb 12 - No Cached
  • Nathan Goodyear on 07 Feb 12
     
    low T3, not T4 or TSH, found to be associated with a strong predictor of death in cardiac patients.  This also has implications in predicting outcome in cardiac patients.
Nathan Goodyear

Low-T3 Syndrome - 0 views

circ.ahajournals.org/...708.short

T3 low hypothyroid hypothyroidism cardiac CHF

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    low T3 is found to be a poor prognostic finding in cardiac patients.
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