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Nathan Goodyear

Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF-κB-independent mechanism - 0 views

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    resveratrol inhibits inflammation in in-vivo airway model, independent of NF-KB
Nathan Goodyear

Anti-Inflammatory Effects of Progesterone in Lipopolysaccharide-Stimulated BV-2 Microglia - 0 views

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    Progesterone and its anti-inflammatory effects.
Nathan Goodyear

Transcriptional profiling of the LPS induced NF-κB response in macrophages - 0 views

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    LPS increases NF-kappaB expression and inhibits apoptosis.
Nathan Goodyear

High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer - 0 views

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    High TLR4 and MyD88 expression on the surface of colorectal cancer cells associated with increase liver mets potential and worsened prognosis.  LPS works through TLR4 and MyD88.
Nathan Goodyear

Frontiers | Impact of the gut microbiota on the development of obesity and type 2 diabetes mellitus | Microbiology - 0 views

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    great review on how LPS from the gut causes systemic insulin resistance
Nathan Goodyear

Antiinflammatory and Antiatherogenic Effects of the NF-κB Inhibitor Acetyl-11-Keto-β-Boswellic Acid in LPS-Challenged ApoE−/− Mice | Arteriosclerosis, Thrombosis, and Vascular Biology - 0 views

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    animal study finds LPS, via injection in this mouse study, increases atherosclerosis via increased .  What is very interesting is that Boswellia inhibited LPS stimulate NF-kappa B
Nathan Goodyear

Metabolic endotoxaemia - a potential novel link between ovarian inflammation and impaired progesterone production: Gynecological Endocrinology: Vol 31, No 4 - 0 views

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    Systemic LPS, metabolic endotoxemia, that is the result of inflammation originating out of the gut found to cause luteal phase dysfunction--low progesterone.  Now, we have the gut-hormone connection.
Nathan Goodyear

Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers - 0 views

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    Study finds spore probiotic for 30 days reduced LPS endotoxin by 42%, while the placebo group found a 36% increase.  As a result, and to no surprise, there was a significant drop in IL-beta.  Also, in the spore probiotic group, there was a 24% reduction in triglycerides.
Nathan Goodyear

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages: Cell - 0 views

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    Fascinating study: inflammation via LPS induces pro-inflammatory move by macrophages that induces a change in mitochondria to increase inflammation and decrease ATP production.
Nathan Goodyear

Lipopolysaccharide induces inflammation and facilitates lung metastasis in a breast cancer model via the prostaglandin E2-EP2 pathway. - PubMed - NCBI - 0 views

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    LPS found to increase breast cancer metastasis via increase in VEGF. It also increases NF-kappaB.
Nathan Goodyear

Lipopolysaccharide‐induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion - Harmey - 2002 - International Journal of Cancer - Wiley Online Library - 0 views

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    LPS increases angiogenesis and metastasis in cancer tumor model.
Nathan Goodyear

Diabetes - 0 views

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    Elevated LPS and metabolic endotoxemia associated with weight gain and type II diabetes
Nathan Goodyear

Nutrients | Free Full-Text | Effect of Probiotics on Metabolic Outcomes in Pregnant Women with Gestational Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | HTML - 0 views

  • The gut microbial composition is altered during pregnancy
  • probiotic supplements may contribute to the maintenance of bacterial diversity and glucose homeostasis in individuals with metabolic disturbances
  • Assessment of four randomized controlled trials in this review involving 288 pregnant women with GDM found that a 6–8 week probiotic intervention did not improve FBG or LDL-cholesterol levels
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  • probiotic supplementation in women with GDM was associated with significant reductions in insulin resistance
  • One proposed method is by the production of short chain fatty acids (SCFAs), generated as a by-product of bacterial fermentation of dietary fibers. SCFAs act as an energy source for intestinal cells and have been found to regulate the production of hormones effecting energy intake and expenditure such as leptin and grehlin
  • Another hypothesized mechanism of SCFA action includes reducing gastrointestinal permeability by upregulating transcription of tight junction proteins, enhancing production of Glucagon-like peptide-2 (GLP-2) which promotes crypt cell proliferation, and reducing inflammation in colonic epithelial cells by increasing PPAR-gamma activation
  • Maintenance of the integrity of the gut barrier minimizes the concentration of lipopolysaccharide (LPS) in circulation
  • LPS is a structural component of gram negative bacterial cell walls, which induces an immune-cell response upon absorption into the human bloodstream, stimulating proinflammatory cytokine production and the onset of insulin resistance and hyperglycemia
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    Review (4 studies) found that 6-8 weeks of probiotic therapy of pregnant women with gestational diabetes improved insulin resistance.
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Nathan Goodyear

Dysbiosis of Gut Microbiota (DOGMA)--a novel theory for the development of Polycystic Ovarian Syndrome. - PubMed - NCBI - 0 views

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    LPS and PCOS--the DOGMA theory.
Nathan Goodyear

Connections between the human gut microbiome and gestational diabetes mellitus | GigaScience | Oxford Academic - 0 views

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    Gestational Diabetes risk may just begin in the gut flora.
Nathan Goodyear

Eczema in early life: Genetics, the skin barrier, and lessons learned from birth cohort studies - 0 views

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    LPS implicated, through CD14, in eczema.  This was linked to those with high genetic prediposition.  This review article also discusses the heterogeneous disease eczema is.
Nathan Goodyear

LPS-Induced TLR4 Signaling in Human Colorectal Cancer Cells Increases β1 Integrin-Mediated Cell Adhesion and Liver Metastasis | Cancer Research - 0 views

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    cull culture study finds inhibition of LPS activated TLR4 in colorectal cancer cells decreased metastasis.
Nathan Goodyear

Quercetin Reduces Inflammatory Responses in LPS-Stimulated Cardiomyoblasts - 0 views

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    Quercetin lowers LPS levels
Nathan Goodyear

EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: Evidence for a PPAR-γ-dependent mechanism - ScienceDirect - 0 views

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    Omega 3 essential fatty acids, specifically EPA and DHA, decrease LPS activation of NF-kappaB via PPAR-gamma activation.
Nathan Goodyear

Purple Carrot Anthocyanins Decrease LPS Stimulated Nitric Oxide Production - 0 views

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    Anthocyanins decrease LPS stimulated NO production in a dose dependent manner.
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