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Study finds new difference in Testosterone benefits and/or side effects between men < 65 with low T and men > 65 with low T.

Low Hormones, post-ovary removal, linked to low libido

low dose pesticide (organophosphates) exposure associated with delayed sexual development in boys and girls.  In addition, there was an inverse correlation with free T4 and a positive correlation with TSH.  

In men older than 65 with low Testosterone, Testosterone therapy improved sexual function and mood.

increased testosterone to estrogen conversion, in part, stimulated by inflammatory cytokines: TNF, and IL-6.  They propose aromatase inhibition to decrease testosterone to estrogen conversion.  This study looked at individuals with HIV.

Several flaws with this study. First, the majority of testing done in the meta-analysis was serum--unreliable.  Second, this study flies in the face of many other studies that have shown elevated estrogens contribute to low testosterone in men.  Third, this flies in the face of observation.  I see over and over again, by lowering a male's estrogen level, he in turn will start producing more Testosterone.  And finally, the environmental xenoestrogens have helped to contribute to a all time low of testosterone/infertility rate in men today.

review of the literature finds that Testosterone therapy in women with low libido improves sexual activity without CVD and breast cancer risk in postmenopausal women.  Post menopause is a time associated with an increased risk of CVD in women.

Sex is one of the most significant and pleasurable activities for men and women. Persons don't have sex only to conceive offspring. Why persons extend to have sex after having children? I have renowned numerous persons who relish sex even after the age of seventies so sex has no expiry time.

Here is where science and particularly conclusions fail the public.  The authors conclusions are that tadalifl improves ED and sexual function irrespective of Testosterone levels.  However, the results say something different.  The group with normal Testosterone responded better versus the low Testosterone group.  This difference didn't reach statistical significance though.  This lack of statistical significance does not exclude the fact that there indeed was a difference.  The authors conlcusions take no part in reporting the whole truth, just that which supports their hypothesis. The diagnosis of low T in this study was < 300 ng/dl

Again, Testosterone and here Estradiol are merely there for libido and sex.  What tunnel vision?!  What about hsCRP?  What about fibrinogen?  What about IL-1beta?  What about TNF-alpha?  These inflammatory cytokines have all been reported to elevate as a result of estrogen production in men.   And PSA?  No mention of it here.   This linear, tunnel vision thinking on hormones has got to stop! The study points out that all clients were using AIs and SERMs irregardless of whether they had elevated estrogens or not.  That is not a well designed study.  One group should have had AI's if elevated estrogens were present and another group should not--this would compare the effects of aromatase activity.  Second, this was simply a retrospective chart review.  Third, a 50% conversion of 34,000 + men is very high when you look at the literature.  Fourth, they point to gynecomastia as a means of negative?  The cardiovascular implications are more significant.  These studies just seem to focus on superficial things.  Fifth, did libido problems exist before?  What were the free levels?   This falls in the paucity of data (2 studies) that point to excessive lowering of estradiol effecting libido and sexual performance.

Review of the data points to poor quality of evidence dealing with DHEA in post-menopausal women with normal adrenal function.  Yet if DHEA is low, which is >95% produced by adrenals in women, then how can the adrenal function be "normal".   The meta-analysis found no improvement in libido and/or sexual function, and no improvement in lipids, glucose, weight... was noted.  Essentially not positive or negative effects were noted.  Abstract only available here, so dosage is a question.

data on androgen therapy in women is sparse at best.  The conclusion here is suspect: "evidence supports the short-term efficacy and safety of high physiological doses of T" for women with with hypoactive sexual desire, yet the same authors recommend against long-term therapy.  How do those 2 go together???  They don't.  Support with physiologic Testosterone when appropriate testing reveals low T and symptoms support the same.  This is a practice guideline that lacks evidence to strongly back it up because so little evidence exists.  Practice guidelines are for lazy physicians.

autoimmune disease sexual preference appears to have Gut origins.

Now this is an interesting study.  In utero exposure to letrozole (femara) which is an aromatase inhibitor, is associated with same sex preference.  Only abstract available, but this study points to environment, hormone effects in early development and future sexual preference.  No difference in serum hormone levels were seen.  

One of the strongest and consistent benefits of marriage is better physical health and its consequence longer life,Marriage Increases the Quality of Life, Sexual fulfillment.

study finds restoration of HPA in men with low T.  This was performed via clomid therapy at 25 to 50 mg daily for 4 months.  Increase in pulsatile LH, increase in serum Testosterone levels, and increase in sexual function was found.  Clomid restores HPA function that is suppressed from estrogen inhibition.  In this case, clomid is function as an estrogen antagonist.

New study finds Testosterone therapy provides less than statistical significant improvement in constitutional/sexual symptoms, in obese men with type II diabetes with symptoms classified as mild-moderate with modest reductions in Total Testosterone.  This study highlights that low Testosterone is a biomarker of poor health and multiple comorbidities and that simply adding in Testosterone therapy will not cure all male woes.  The authors did state that ED and low T are separate issues and I will differ with them on this--they are in fact link.  This association may vary between individuals, but to flatly state they are completely separate issues is devoid of the fact that testosterone has been shown to reduce inflammatory cytokines and improve PDE5 therapy.  

Cochrane review for Testosterone therapy for women points to lacking data.  The lengths of study reached a maximum of 2 years with the average at 6 months.  Improvement in sexual function was found in post-menopausal women, but safety and long-term data is lacking.

Only abstract available.  Meta-analysis of Testosterone therapy in post-menopausal women finds significant bias, some improvement in sexual function and cholesterol levels, yet safety and long-term data is significantly lacking.  Take this with studies on endogenous Testosterone in women, significant caution needs to be followed with Testosterone in women. Only abstract available here.

His answer would be probably after a little thinking: "Yes" or "No", he will know the answer clearly and completely. But if our offer image unknown man and we raised the same question on the mirror, it will be assumed her answer: "I'm still not sure, it comes to how I would feel after in-depth knowledge and deal with it, and maybe then you will know." Difference in libido between the sexes! Differences in approach in the expression of feelings is not a coincidence, it is a clear and distinct. Is it possible that women are more reluctant than men? Or maybe the point of view based on the components did not know the men? Studies suggest that women need more information to see her passion and expression of feelings toward the man standing front of them, including. http://www.weightloss24.tk/2015/02/is-sexual-arousal-vary-according-to.html