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jasminegibbons

Knowing When to Let Go: Toxic Relationship with Your Office Chair - 0 views

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    Yes, your relationship with your office chair can be toxic but it doesn't mean you have no choice but to go with it. Unlike personal relationships, you don't need to walk away from it completely (because that's impossible especially if your work involves sitting in front of a computer). You simply need to know how to fight its bad effects and instead try to reverse them.
Nathan Goodyear

Association between Lead and Cadmium and Reproductive Hormones in Peripubertal U.S. Girls - 0 views

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    Study finds higher Pb levels in young girls is associated with delayed puberty onset.  This occurs through an inverse relationship with inhibin B and follicular development.  This relationship was also found with Cadmium.  Both of these heavy metals are toxic to the ovaries.
Nathan Goodyear

Testosterone suppression in opioid users: A systematic review and m... - PubMed - NCBI - 0 views

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    Opioid use, despite type (including methadone), is associated with lower Testosterone in men.  This is not new information, but this meta-analysis reconfirms this relationship, particularly that methadone has the same effect.  This relationship was not found in women.  These physicians that regularly prescribe opiates  to men are doing them an incredible disservice.  A lower T in men is a significant negative health biomarker.
Nathan Goodyear

Low testosterone is associated with poor health status in men with ... - PubMed - NCBI - 0 views

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    Lower Testosterone levels are found in men with more advanced HIV.  This relationship is bidirectional.  This decreased biomarker is likely more a biomarker of poor health than one of a direct relationship.  As in the fT3 is lower in hypogonadal men versus eugonadal men.  This points to the significant problems in the way Testosterone is thought of and used in therapy for men today.  For many men, low T is the effect and not the cause.
Nathan Goodyear

Relationship between Low Free Testosterone Levels and Loss of Muscle Mass : Scientific ... - 0 views

  • Our data confirm that a low FT level is a significant predictor of a risk for loss of appendicular muscle
  • Total lean mass is associated with bioavailable T in postmenopausal women
  • Further studies are needed to determine the role of androgens in preserving muscle mass in women
  • ...11 more annotations...
  • Approximately 1% to 2% of T in the blood exists as FT
  • appendicular muscle loss was significantly associated with low levels of FT
  • These results suggest that a threshold level of FT exists for muscle loss, rather than a dose-response relationship
  • In the previous cross-sectional and longitudinal studies of French and American men, no dose-response relationships were reported between T and muscle mass
  • A minimal serum level of FT may be needed to preserve muscle mass in men, regardless of race/ethnicity.
  • Our result is in line with previous studies that reported a relationship between low FT and low muscle mass in men
  • T stimulates protein synthesis and inhibits protein degradation in muscle cells
  • T also increases satellite cell replication and activation in older men
  • In this study, no significant association between TT levels and muscle loss were observed
  • Although a progressive decrease in TT levels with ageing is observed in middle-aged and elderly American men16, 17, the TT levels do not change during ageing in Japanese men
  • FT levels may be a good marker for the loss of muscle mas
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    study of Japanese men finds that low free Testosterone was a predictor of decrease in muscle mass.
Nathan Goodyear

NF-κB and cancer: how intimate is this relationship - 0 views

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    NF-KappaB plays a critical role in the development of cancer. NF-kappaB is a transcription factor that promotes inflammation.  This reveals the important relationship between inflammation and cancer.
Nathan Goodyear

Sex steroids and cardiovascular disease Yeap BB - Asian J Androl - 0 views

  • Levels of SHBG are higher in older men, therefore levels of free T decline more steeply than total T as men's age increases.
  • calculations based on mass action equations may not reflect precisely free T measured using a reference method
  • free T declines more steeply with age than total T in both cross-sectional [35] and longitudinal studies, [36] as does free E2 in comparison to total E2
  • ...22 more annotations...
  • T may slow development of or progression of atherosclerosis by modulating effects on insulin resistance, inflammation, endothelial function, preclinical atherosclerosis or the vasculature.
  • these cross-sectional and longitudinal studies support a relationship between low circulating T with CIMT and higher E2 with its progression
  • lower levels of T are biomarkers for aortic vascular disease
  • circulating free T was negatively associated with the presence of AAA
  • luteinizing hormone (LH) was positively associated.
  • low levels of total or bioavailable T were associated with aortic atherosclerosis manifested as calcified deposits detected by radiography
  • Men with total or free T in the lowest quartile had increased adjusted ORs for PAD defined as ABI <0.90, as did men with free E2 in the highest quartile of values
  • The apparent association of SHBG with intermittent claudication reflects the correlation of total T with SHBG, while the contribution of E2 to risk of PAD remains unclear
  • men with total T in the lowest quartile of values (<11.7 nmol l−1 ) experienced an increased incidence of stroke or transient ischemic attack
  • lower total T with increased incidence of CVD events
  • cohort studies in mostly older men have supported the association of lower androgen levels with higher mortality
  • lower total or free T levels were associated with mortality in older men, but with discordant results for cause-specific mortality and for associations of E2
  • several large studies identifying lower endogenous levels of total or free T as independent predictors of all-cause or CVD-related deaths in middle-aged and older men
  • T exhibits anti-inflammatory effects, enhances flow-mediated brachial artery reactivity, and reduces arterial stiffness
  • Short-term T therapy had a beneficial effect on exercise-induced myocardial ischemia in middle-aged men with coronary artery disease or chronic stable angina, [95],[96],[97] and reduced angina frequency in older men with diabetes and coronary artery disease
  • T therapy resulted in an increase in treadmill test duration and time to ST segment depression
  • there are interventional studies supporting a protective effect of exogenous T against myocardial ischemia in men with coronary artery disease
  • employ conservative doses
    • Nathan Goodyear
       
      This dosing is 100 fold higher then peak production of a  young man at 20-22.
  • Observational studies indicate that lower levels of endogenous T in older men are associated with the presence of carotid atherosclerosis, aortic and peripheral vascular disease, and incidence of CVD events and mortality
  • Interventional studies have shown beneficial effects of exogenous T on vascular function and on exercise-induced myocardial ischemia in men with coronary artery disease
    • Nathan Goodyear
       
      the therapies employed in these studies were massively overdosed.
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    Nice review of all the sex hormones and their relationship to CVD in men.  
Nathan Goodyear

Relationship between salivary progesterone, 17-hyd... [Fertil Steril. 2001] - PubMed re... - 0 views

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    Relationship between salivary progesterone, 17-hydroxyprogesterone, and cortisol levels throughout the normal menstrual cycle of healthy postmenarcheal girls.
tapforfreedom

- StumbleUpon - 0 views

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    Kalleen provides one-to-one sessions where she will teach you how to effectively get through stress, relationship issues, personal losses, struggles with trauma and/or physical difficulties
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    Kalleen provides one-to-one sessions where she will teach you how to effectively get through stress, relationship issues, personal losses, struggles with trauma and/or physical difficulties
Nathan Goodyear

http://press.endocrine.org/doi/pdf/10.1210/jc.2014-1725 - 0 views

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    New study finds "modest" association between Testosterone, DHEA, and FSH with libido, masturbation, and climax in women.  The author describes them as "subtle".  The association was not statistically significant.  The study found a great association with relationships than with Testosterone. This study points out the complexity that is libido in women.  It also casts doubt on the massive Testosterone push in women with little documented data.
therapy1on1

Does Relations Counseling Really Work? - Therapy 1 on 1 - Medium - 0 views

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    Taking a step forward towards a healthy relationship and eliminating the toxic dynamics. Statistics say that married couple counselling, pre-marital counselling, breakup counselling has helped people a lot in regaining trust and take a step forward towards a healthy and happy life and when you take a conscious effort things do change.
Nathan Goodyear

Obesity in men: the hypogonadal-estrogen rece... [Med Hypotheses. 2008] - PubMed - NCBI - 0 views

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    This article discusses there relationship of ER-beta and glucose homeostasis.  In this study, low testosterone was associated with increased ER-beta expression.  This resulted in down regulation of GLUT4 and the result is insulin resistance.
Nathan Goodyear

Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study - 0 views

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    Good article. Discusses the association between low Testosterone and cardiovascular risk in men. The conclude that no direct cause effect relationship has been provided, but a clear association is seen. Numerous studies have shown this association.
Rachel Renner

Saving A Relationship By Easing Snoring Issues - 1 views

I almost lost my long term partner because of my snoring problem. He used to have a bad sleep and stayed awake at night because of the irritating noise I produced. There was nothing I can do about ...

started by Rachel Renner on 20 Nov 12 no follow-up yet
Nathan Goodyear

Heart-brain medicine: Update 2008 - 0 views

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    It does appear that medicine is moving in the direction of a non-linear approach to disease.  This brief review discusses the early analysis of the relationship of psychiatric conditions, inflammation, and cardiovascular disease.
Nathan Goodyear

Waist-to-height ratio as a predictor of serum testosterone in ageing men with symptoms ... - 0 views

  • WHt ratio was calculated by dividing waist (cm) by height (cm)
  • nverse relationships of BMI and WC with TT and cFT have been previously documented in unselected cohorts of adult men
  • over the age of 54 years
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  • adjusting WC for height (WHt ratio) improves the prediction of TT and cFT compared with either BMI or WC alone
  • there were inverse correlations between cFT, TT and either BMI or WC
  • for each unit increase in BMI, there was a 2% fall in TT and cFT
  • for each 10 cm increment in WC, TT and cFT levels declined by 7%.
  • The magnitude of this relationship between increasing BMI and decreasing TT is similar to that described in the Massachusetts Male Ageing Study
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    waist to height ratio reliable predictor of low T in men.
Nathan Goodyear

Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution - 0 views

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    great review article on the relationship between gut dysbiosis and type I diabetes--particularly the bacteroidetes and Veillonella species; in contrast, Prevotella and Akkermansia special protects and maintains a healthy gut epithelium.
Nathan Goodyear

Influence of increasing body mass index on semen and reproductive hormonal parameters i... - 0 views

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    retrospective cohort finds mild but significant relationships b/t BMI and total Testosterone, Testosterone:Estradiol and Estradiol alone.  BMI was inversely correlated with Testosterone and the T:E2 ratio; but directly correlated with E2 alone. There was also a negative correlation with sperm concentration, motility and morphology.
Nathan Goodyear

Effects of hormones on skin wrinkles and rigidity vary by race/ethnicity: fou... - 0 views

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    new study concludes that hormone therapy does not improve skin aging.  Though I would like to see hormone levels evaluated to assure physiologic hormone levels were obtained to conclude this lack of relationship.
Nathan Goodyear

ERβ inhibits proliferation and invasion of breast cancer cells - 0 views

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    good review of the relationship of ERbeta and ERalpha in breast cancer.  A short review of other cancers also included.
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