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Nathan Goodyear

The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence - 0 views

www.ncbi.nlm.nih.gov/...PMC3627294

TA-65 telomere Telomerase telomerase activator aging natural wellness health

shared by Nathan Goodyear on 16 May 16 - No Cached
  • studies have demonstrated that the shortest telomeres are causal of reduced cell viability
  • a stable and enforced expression of telomerase leads to an improved health-span, accompanied by an extension of lifespan
  • TA-65 influences the percentage of cellular short telomeres through the activation of telomerase
  • ...17 more annotations...
  • TA-65 administration during 4 months significantly improved the capacity to uptake glucose after a glucose pulse
  • liver protective action of TA-65
  • A disadvantage of mTERT potentiation could be associated to its capacity to favor proliferation of cancerous cells in murine models
  • TA-65 treated mice presented a similar incidence of malignant cancers at time of death, with a tendency to show decreased sarcomas and slightly increased lymphomas
  • We demonstrate here that TA-65 leads to a significant rescue of short telomeres through telomerase activation
  • TA-65 treatment increases proliferation and mobilization potential of mouse keratinocytes in vitro, a situation mimicking telomerase overexpression
  • TAT2, a similar molecule, have beneficial effects in the activation of CD8+ T lymphocytes from HIV-infected patients where they observe an increase of the proliferative potential and enhancement of cytokine/chemokine production
  • TA-65 resulted in a similar rescue of short telomeres in leukocytes post-treatment as observed with humans, most likely through an activation of telomerase
  • we observe that TA-65 lead to 10 fold increase of telomerase RNA levels in the liver of treated mice comparing to the non-treated same-age cohorts
  • TA-65 regulates telomerase at the transcription level, probably through the regulation of the MAPK pathway
  • TA-65 dependent telomerase activation results in a better organ fitness as demonstrated by the improved scores at the glucose tolerance test and insulin levels at fasting
  • TA-65 supplemented mice also present modest enhancement of the subcutaneous and epidermal thickness, as well as higher bone density, representative of an overall fitness status improvemen
  • TA-65 treated mice present higher levels of RBC and hemoglobin comparing to the control cohorts
  • improved health-span of TA-65 treated mice is not accompanied by increased cancer incidence, which may be related to the fact that TERT levels are very modestly increased in all tissues tested except for the liver
  • systemic telomerase overexpression from the germline leads to protection from aging associated pathologies
  • similar situation could be mimicked expressing telomerase late in life in a telomerase deficient background
  • we observed a higher proliferation rate and a partial protection from cell death in some tissues of TA65 treated mice
  • Nathan Goodyear on 16 May 16
     
    TA-65 shown to increase telomerase activity, and thus telomere length of short telomeres, in mouse study.  
Nathan Goodyear

Testosterone Treatment Enhances Regional Brain Perfusion in Hypogonadal Men: The Journal of Clinical Endocrinology & Metabolism: Vol 88, No 7 - 0 views

press.endocrine.org/...jc.2002-020632

low T low testosterone brain cognition ED Testosterone therapy male hormones

shared by Nathan Goodyear on 09 Jan 17 - No Cached
  • it is established that androgen modulates various neurotransmitters in the CNS. Testosterone decreases γ-aminobutyric acid concentration in the hypothalamus, which is blocked by flutamide, a testosterone receptor blocker (14, 15). Testosterone, probably by its conversion to estradiol, increases serotonin transporter mRNA expression in dorsal raphe nucleus (16), and it also increases the density of 5-hydroxytryptamine receptors and serotonin transporter sites in the forebrain (3, 16) of castrated male rats.
  • Nathan Goodyear on 09 Jan 17
     
    very interesting study of 7 men.  Increase brain perfusion found and symptom improvement as a result of Testosterone therapy in men ages 58-72.  Specific increase perfusion by SPECT scans were in the midbrain and Brodman areas 8 and 24 of the cerebral cortex.
Nathan Goodyear

Plasticity in mitochondrial cristae density allows metabolic capacity modulation in human skeletal muscle - Nielsen - 2016 - The Journal of Physiology - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...763493D2C50D44B6157B92C.f03t04

mitochondria exercise endurance exercise muscle

shared by Nathan Goodyear on 29 Nov 16 - No Cached
  • Nathan Goodyear on 29 Nov 16
     
    New study suggests endurance training can change mitochondria to improve energy production efficiency.
Nathan Goodyear

Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review -- Ravnskov et al. 6 (6) -- BMJ Open - 0 views

bmjopen.bmj.com/...e010401.full

LDL cholesterol mortality elderly

shared by Nathan Goodyear on 14 Jun 16 - No Cached
  • Nathan Goodyear on 14 Jun 16
     
    review study of 263 studies finds no association between LDL and mortality in elderly.  In fact, the review found an inverse association between LDL and mortality i.e. increasing LDL associated with lower mortality in elderly.
Nathan Goodyear

Adrenocortical dysregulation as a major player in insulin resistance and onset of obesity - 0 views

ajpendo.physiology.org/...E1465.long

cortisol insulin resistance metabolic syndrome obesity overweight

shared by Nathan Goodyear on 14 Mar 12 - No Cached
  • acute GC secretion during stress mobilizes peripheral amino acids from muscle as well as fatty acids and glycerol from peripheral fat stores to provide substrates for glucose synthesis by the liver
  • chronically elevated GC levels alter body fat distribution and increase visceral adiposity as well as metabolic abnormalities in a fashion reminiscent of metabolic syndrome
  • This local production may play an important role in the onset of obesity and insulin resistance.
  • ...9 more annotations...
  • In adipocytes, cortisol inhibits lipid mobilization in the presence of insulin, thus leading to triglyceride accumulation and retention.
  • Since the density of GC receptors is higher in intra-abdominal (visceral) fat than in other fat depots, the activity of cortisol leading to accumulation of fat is accentuated in visceral adipose tissue (24, 158), providing a mechanism by which excessive endogenous or exogenous GC lead to abdominal obesity and IR
  • obese patients generally have normal or subnormal plasma cortisol concentrations
  • This may be explained by an increased intratissular/cellular concentration of cortisol in adipose tissues
  • Intracellular GC may be produced from recycling of GC metabolites such as cortisone in adipose tissues
  • Local GC recycling metabolism is mediated by 11β-hydroxysteroid dehydrogenase enzymes (11β-HSD1 and 11β-HSD2
  • Cortisol also increases 11β-HSD1 expression in human adipocytes
  • In humans, elevated 11β-HSD1 expression in visceral adipose tissue is also associated with obesity
  • even if obese patients generally have normal or subnormal plasma cortisol concentrations (131, 158), triglyceride accumulation in visceral adipose tissue may be due, at least in part, to the local production of GC in insulin- and GC-responsive organs such as adipose tissue, liver, and skeletal muscle
  • Nathan Goodyear on 14 Mar 12
     
    another nice article on the dysregulation of cortisol and its role in insulin resistance, metabolic syndrome, and obesity.
Nathan Goodyear

JAMA Network | Archives of Internal Medicine | Plasma Total Homocysteine Level and Bone Mineral DensityThe Hordaland Homocysteine Study - 0 views

archinte.jamanetwork.com/article.aspx

homocysteine folate folic acid folic acid BMD women bone mineral osteoporosis density

shared by Nathan Goodyear on 23 Jul 12 - No Cached
  • Nathan Goodyear on 23 Jul 12
     
    elevated homocysteine and low folic acid levels associated with decreasing BMD in women.
Nathan Goodyear

Low Doses of Lipopolysaccharide and Minimally Oxidized Low-Density Lipoprotein Cooperatively Activate Macrophages via Nuclear Factor κB and Activator Protein-1 - 0 views

circres.ahajournals.org/...56.full

LPS oxidized LDL inflammation macrophages NF-KappaB AP-1 atherosclerosis CAD

shared by Nathan Goodyear on 26 Sep 12 - No Cached
  • Nathan Goodyear on 26 Sep 12
     
    LPS and minimal oxidized LDL have synergistic effects on inflammatory signaling.  Together the two promote inflammatory signaling from macrophages at much lower levels than either one alone.  They do this through macrophage NF-KappaB and AP-1 pathways.  And this resultant inflammation promotes atherosclerosis.  Where does all this start?  our diet and our gut.
Nathan Goodyear

The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996. - 0 views

www.ncbi.nlm.nih.gov/...PMC1240129

sperm count men male fertility

shared by Nathan Goodyear on 27 Jul 13 - No Cached
  • Nathan Goodyear on 27 Jul 13
     
    Re-analysis of Carlsen's work on sperm count finds consistent decline in sperm count.  Swan and authors found a 1.5% decline in US men from 1934-1996 and 3% annual decline in European/Australian men over same time frame.  This was a meta-analysis of 101 studies from 1934-1996.  Yes, there is geographical variation, but the overall trend is one of decline.
Nathan Goodyear

Inhibition of low-density lipoprotein oxidation by astaxanthin. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11521685

astaxanthin antioxidant antioxidants oxLDL LDL CVD cardiovascular disease

shared by Nathan Goodyear on 14 Jul 15 - No Cached
  • Nathan Goodyear on 14 Jul 15
     
    astaxanthin reduced oxLDL in in-vitro study.
Nathan Goodyear

Testosterone Increases Human Platelet Thromboxane A2 Receptor Density and Aggregation Responses - 0 views

circ.ahajournals.org/...2742.full

testosterone thrombaxane A2 TXA2 plateletes

shared by Nathan Goodyear on 06 Nov 13 - No Cached
  • Nathan Goodyear on 06 Nov 13
     
    Thrombaxane A2 increased by Testosterone in small study.  This is a human study.
wheelchairindia9

Cp Child Wheelchair - 0 views

www.wheelchairindia.com/...CP-Wheelchair

Wheelchair Offers New Vistas For Persons With Cerebral Palsy cerebellum and the cortex common causes of brain damage cause like chicken pox or measles neurological problems are properly managed

shared by wheelchairindia9 on 05 May 15 - No Cached
  • wheelchairindia9 on 05 May 15
     
    young children have a different set of needs than adults. Aesthetically, devices designed for kids are often sleek and colorful, and functionally, they are typically lightweight and adjustable. As any parent knows, young people don't stay the same size for long and since a wheelchair is a major purchase -- don't want a simple growth spurt to render it useless. Wheelchair category offers models that feature seat width and depth adjustability, elevating legrests, and other versatile features. As a weight-bearing activity is critical to proper physical and mental function-which is why children with cerebral palsy, who may sit for stretches in a wheelchair and typically are unable to stand on their own, can benefit greatly from pediatric standers as part of a comprehensive pediatric rehabilitation program. Pediatric standers are offered in passive, active and mobile formats: Passive standers stay in one place and feature a support surface, active standers allow reciprocal movement of the extremities while in a standing position, and mobile standers enable users to self-propel. Cerebral Palsy Wheelchair: Cerebral Palsy Wheelchair Description: The model designed for cerebral palsy child only. Ultra light weight aluminium alloy frame. Seat Width 38 cms (15"). Net Weight: 18.5 kgs. Epoxy powder coated frame. Detachable arm rest & foot rest provided. Elevated and swinging foot rest. Elevated foot rest provided to elevate leg angle. Height adjustable and detachable head rest. Hydraulic reclining high back for a comfortable posture. Hydraulic adjustable seat angle. Detachable back and seat pad. Extra cushion upholstery provided to under arm, head & calg Foldable. Lever and paddle brakes provided. Safety belt provided. Maintenance free rear solid wheels. Cloth look like water proof upholstery. Anti wheels for better safety and stability. Extra cushion upholstery provided to under arm, head & leg. Folding action. Lever and paddle brakes provide
Nathan Goodyear

Interferon-[alpha] reduces the density of monoaminergic axon... : NeuroReport - 0 views

journals.lww.com/..._reduces_the_density_of.7.aspx

depression inflammation IFN-gamma 5-HT serotnin noradrenergic neurotransmitter

shared by Nathan Goodyear on 14 Sep 11 - No Cached
  • Nathan Goodyear on 14 Sep 11
     
    inflammation, IFN-gamma, shown to lead to 5-HT and noradrenergic axon degeneration.  This reveals another inflammatory contribution to depression
Nathan Goodyear

Sex hormones and high density lipoproteins i... [Atherosclerosis. 1979] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...229880

Testosterone hormone hormones male men HDL cholesterol lipids

shared by Nathan Goodyear on 08 Jan 14 - No Cached
  • Nathan Goodyear on 08 Jan 14
     
    Higher serum testosterone levels associated with higher HDL
Nathan Goodyear

Plasma testosterone, high density lipoprotein c... [Am J Cardiol. 1981] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7304438

testosterone lipids cholesterol HDL triglycerides VLDL male hormone hormones men

shared by Nathan Goodyear on 08 Jan 14 - No Cached
  • Nathan Goodyear on 08 Jan 14
     
    Free and total Testosterone in men found to be positively associated with HDL, but negatively associated with triglycerides and VLDL in this study.
Nathan Goodyear

Therapeutic Testosterone Administration Preserves Excitatory Synaptic Transmission in the Hippocampus during Autoimmune Demyelinating Disease - 0 views

www.jneurosci.org/...12312.long

Testosterone polyneuropathy MS multiple Sclerosis Estriol hormones autoimmune disease

shared by Nathan Goodyear on 17 Mar 15 - No Cached
  • direct androgen receptor activation is not a mutually exclusive requirement of testosterone-mediated neuroprotection.
  • Testosterone treatment after EAE induction restores synaptic transmission and corresponding synaptic protein levels within the hippocampus during EAE
  • A growing body of evidence suggests that testosterone enhances hippocampal synaptogenesis
  • ...7 more annotations...
  • This study demonstrates that testosterone treatment either before or after EAE disease induction partially restores deficits in synaptic transmission, preserves presynaptic and postsynaptic integrity, and prevents hippocampal pathology.
  • treatment with a pregnancy estrogen, estriol, can prevent deficits in excitatory synaptic transmission in the hippocampus during EAE
  • testosterone is important to the maintenance of normal synaptic spine density in the hippocampus
  • estriol treatment was also capable of preserving levels of synaptic proteins that are known to orchestrate functional synaptic transmission within the hippocampus.
  • Estriol is a therapeutic candidate in MS because it has widespread effects on the immune system and the CNS
  • MS patients have significantly decreased relapse rates during the third trimester of pregnancy, when estriol levels are most elevated, and relapse rates rebound during the postpartum period coinciding with an abrupt decline in serum estriol levels
  • In nonpregnant MS patients, estriol treatment has been shown to significantly reduce gadolinium-enhancing lesion number and volumes measured by MRI
  • Nathan Goodyear on 17 Mar 15
     
    Testosterone restores/preserves nerve synapsis within the hippocampus in autoimmune demyelinating disease.  Testosterone appears to have neuroprotection.  The authors conclude that the majority of the protective effect was through aromatase activity.
Nathan Goodyear

Testosterone for the aging male; current evidence and recommended practice - 0 views

www.ncbi.nlm.nih.gov/...PMC2544367

leptin Testosterone low T low Testosterone male hormone hormones

shared by Nathan Goodyear on 27 Oct 14 - No Cached
  • Total serum testosterone consists of free testosterone (2%–3%), testosterone bound to sex hormone binding globulin (SHBG) (45%) and testosterone bound to other proteins (mainly albumin −50%)
  • Testosterone binds only loosely to albumin and so this testosterone as well as free testosterone is available to tissues and is termed bioavailable testosterone
  • Testosterone bound to SHBG is tightly bound and is biologically inactive
  • ...13 more annotations...
  • Bioavailable and free testosterone are known to correlate better than total testosterone with clinical sequelae of androgenization such as bone mineral density and muscle strength
  • peak levels seen in the morning following sleep, which can be maintained into the seventh decade
  • Samples should always be taken in the morning before 11 am
  • The reliable measurement of serum free testosterone requires equilibrium dialysis. This is not appropriate for clinical use as it is very time consuming and therefore expensive.
  • With increasing age, a greater number of men have total testosterone levels just below the normal range or in the low-normal range. In these patients total testosterone can be an unreliable indicator of hypogonadal status.
  • It is advised that at least two serum testosterone measurements, taken before 11 am on different mornings, are necessary to confirm the diagnosis.
  • Patients with serum total testosterone consistently below 8 nmol/l invariably demonstrate the clinical syndrome of hypogonadism and are likely to benefit from treatment. Patients with serum total testosterone in the range 8–12 nmol/l often have symptoms attributable to hypogonadism and it may be decided to offer either a clinical trial of testosterone treatment or to make further efforts to define serum bioavailable or free testosterone and then reconsider treatment. Patients with serum total testosterone persistently above 12 nmol/l do not have hypogonadism and symptoms are likely to be due to other disease states or ageing per se so testosterone treatment is not indicated.
  • Total testosterone levels fall at an average of 1.6% per year whilst free and bioavailable levels fall by 2%–3% per year.
  • With advancing age there is also a reduction in androgen receptor concentration in some target tissues and this may contribute to the clinical syndrome of LOH
  • Metabolic clearance declines with age
  • Gonadotrophin levels rise during aging (Feldman et al 2002) and testicular secretory responses to recombinant human chorionic gonadotrophin (hCG) are reduced
  • There are changes in the lutenising hormone (LH) production which consist of decreased LH pulse frequency and amplitude, (Veldhuis et al 1992; Pincus et al 1997) although pituitary production of LH in response to pharmacological stimulation with exogenous GnRH analogues is preserved
  • the decreases in testosterone levels with aging seem to reflect changes at all levels of the hypothalamic-pituitary-testicular axis
  • Nathan Goodyear on 27 Oct 14
     
    Leptin inhibits male Testosterone production at the level of the hypothalamus and at the testicle level.
Nathan Goodyear

Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...0009661593

total Testosterone bioavailable Testosterone hormone hormones

shared by Nathan Goodyear on 05 Apr 15 - No Cached
  • Nathan Goodyear on 05 Apr 15
     
    Total Testosterone in men decreased by 30% over the lifetime of men in this study compared to 64% decrease in bioavailable Testosterone in men.  Decreased BMD was associated with this loss.  Similar findings for Estrogen was also noted in men.
Nathan Goodyear

Effects of aromatase inhibition vs. testosterone in older men with low testosterone: randomized-controlled trial. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...26588809

low T low Testosterone Testosterone testosterone therapy aromatase inhibitors aromatase inhibition aromatase inhibitor aromatase men male hormones strength muscle mass muscle bone mineral density

shared by Nathan Goodyear on 07 Dec 15 - No Cached
  • Nathan Goodyear on 07 Dec 15
     
    No surprise that Testosterone therapy improves Testosterone levels in men with low T, but aromatase inhibition (AI) did as well.  In this study, only lean mass increased compared to Testosterone therapy and placebo.  Strength increased in both Testosterone and AI.
Nathan Goodyear

Oxidized Low-Density Lipoprotein - 0 views

www.ncbi.nlm.nih.gov/...PMC3315351

Ox LDL

shared by Nathan Goodyear on 28 Oct 17 - No Cached
  • Nathan Goodyear on 28 Oct 17
     
    Good review of Ox LDL
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