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Contents contributed and discussions participated by Nathan Goodyear

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Nathan Goodyear

Testosterone Supplementation Therapy in the Treatment of Patients With Metabolic Syndro... - 0 views

postgradmed.org/...pgm.2014.11.2843

metabolic syndrome Testosterone low T low Testosterone men male hormone hormones

shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • Nathan Goodyear on 24 Nov 14
     
    Only abstract available.  Review of literature of Testosterone in men with Metabolic Syndrome.
Nathan Goodyear

Weekly Versus Monthly Testosterone Administration on Fast and Slow ... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25387260

Testosterone muscle sarcopenia low T low Testosterone low T men male hormones

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  • Nathan Goodyear on 24 Nov 14
     
    Weekly Testosterone injections increase type 1 slow muscle fibers more than type II fast twitch muscle fibers compared to monthly injections.  The study looked at older men with sarcopenia and low T.
Nathan Goodyear

Race differences in obesity and its relationship to the sex hormone milieu : Hormone Mo... - 0 views

www.degruyter.com/...34F8BE807519B51BD841611C00492B

androgens women men male female hormone hormones Testosterone bioavailable Testosterone obesity

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  • increased abdominal and visceral adipose tissue (VAT) – found in women and marked by low sex hormone binding globulin (SHBG) and high bioavailable testosterone (BT) – is related to the metabolic risk profile
  • In men, increased BT is related to decreased abdominal obesity and a decrease in the metabolic risk profile
  • Nathan Goodyear on 24 Nov 14
     
    Only abstract available here.  Race (black vs white) is associated with changes in obesity effects on adrogenicity, particularly in women.  One wonders if this is a result of other variables i.e.vitamin D.
Nathan Goodyear

Testosterone Treatment of Men With Mild Cognitive Impairment and Lo... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25392187

low T low Testosterone low T Testosterone cognition cognitive decline men male hormone hormones memory hypogonadism

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  • Nathan Goodyear on 24 Nov 14
     
    small study finds limited improvement in cognition in men with low T and mild Cognitive impairment.  Little application from this study.
Nathan Goodyear

Testosterone Supplementation Improves Carbohydrate and Lipid Metabolism in Some Older M... - 0 views

www.ncbi.nlm.nih.gov/...PMC4225803

Testosterone adipose obesity LDL triglycerides lipids metabolism insulin resistance insulin sensitivity men male hormone hormones

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  • Nathan Goodyear on 24 Nov 14
     
    In some men, Testosterone therapy (10 mg transdermal) is associated with adipose tissue.  In those with a decrease in adipose tissue, a decrease in LDL, decrease in Triglycerides, increase in insulin sensitivity, and lower HDL were found.
Nathan Goodyear

Age, Insulin Requirements, Waist Circumference, and Triglycerides P... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25394376

diabetes men male hormone hormones low T Testosterone low T low Testosterone hypogonadism age waist circumference insulin

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  • Nathan Goodyear on 24 Nov 14
     
    Study looked at low T in men with type 1 Diabetes.  Only abstract available here.  Study finds appx 10% prevalence with age, waist circumference and insulin requirements as predictive of low T in men with type 1 Diabetes.
Nathan Goodyear

Low incidence of new biochemical hypogonadism after intensity modul... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25407866

radiation prostate cancer Testosterone hypogonadism men male hormone hormones

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  • Nathan Goodyear on 24 Nov 14
     
    Radiation for prostate cancer associated with decline in serum Total Testosterone at 6 months, which resolved at 12 months.
Nathan Goodyear

http://press.endocrine.org/doi/pdf/10.1210/jc.2014-1725 - 0 views

press.endocrine.org/...jc.2014-1725

libido women female hormones relationships Testosterone DHEA

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  • Nathan Goodyear on 24 Nov 14
     
    New study finds "modest" association between Testosterone, DHEA, and FSH with libido, masturbation, and climax in women.  The author describes them as "subtle".  The association was not statistically significant.  The study found a great association with relationships than with Testosterone. This study points out the complexity that is libido in women.  It also casts doubt on the massive Testosterone push in women with little documented data.
Nathan Goodyear

Deiodinases - National Academy of HypothyroidismNational Academy of Hypothyroidism - 0 views

www.nahypothyroidism.org/deiodinases

Thyroid hormone hormones physiology T4 T3 rT3 reverse T3 metabolites deiodinase

shared by Nathan Goodyear on 23 Nov 14 - No Cached
  • Nathan Goodyear on 23 Nov 14
     
    Great review of thyroid metabolism.
Nathan Goodyear

Adult Obesity in the United States: The State of Obesity - 0 views

stateofobesity.org/adult-obesity

Obesity rates obese

shared by Nathan Goodyear on 21 Nov 14 - No Cached
  • Nathan Goodyear on 21 Nov 14
     
    startling obesity trends that don't show much sign of leveling off.
Nathan Goodyear

Obesity Rates Increased in These 6 States - 0 views

www.livescience.com/rates-increase-six-states.html

obesity rates obese

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  • Nathan Goodyear on 21 Nov 14
     
    New study finds previous obesity data woefully underestimating rates.  This study finds that obesity rates exceed 35% in Mississippi and West Virginia.
Nathan Goodyear

http://www.ketogenic-diet-resource.com/support-files/p00246.pdf - 0 views

www.ketogenic-diet-resource.com/...p00246.pdf

blood sugar log blood sugar log ketogenic diet

shared by Nathan Goodyear on 20 Nov 14 - No Cached
  • Nathan Goodyear on 20 Nov 14
     
    Blood Sugar Log Booklet
Nathan Goodyear

Risk of major cardiovascular events in patients with psoriatic arthritis, psoriasis and... - 0 views

ard.bmj.com/...annrheumdis-2014-205675

inflammation cardiovascular RA rheumatoid arthritis psoriasis disease CVD

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  • Nathan Goodyear on 20 Nov 14
     
    Abstract: Inflammatory diesease (psoriasis and RA in this study) associated with increased cardiovascular events.
Nathan Goodyear

British Journal of Cancer - Dichloroacetate inhibits aerobic glycolysis in multiple mye... - 0 views

www.nature.com/...bjc2013120a.html

DCA dichloroacetate cancer

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Nathan Goodyear on 19 Nov 14
     
    Dichloroacetate (DCA) inhibits aerobic glycolysis via inhibition of Pyruvate Dehydrogenase kinase (PDK), which allows for the phosphorylation of Pyruvate Dehydrogenase and the formation of acetylCo-A.  This then feeds the krebs cycle.  Increased mitochondrial activity increases ROS and resultant apoptosis of cancer cells.
Nathan Goodyear

Can dehydroepiandrostenedione (DHEA) target PRL-3 to prevent colon cancer metastasis? -... - 0 views

europepmc.org/...23462371

DHEA dehydroepiandrosterone colon hormone hormones cancer colon cancer colorectal cancer

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  • Nathan Goodyear on 19 Nov 14
     
    DHEA proposed to be used to prevent/inhibit colorectal metastasis via inhibition of PRL-3 prenylation.
Nathan Goodyear

Differential Effects of Dehydroepiandrosterone and Testosterone in Prostate and Colon C... - 0 views

press.endocrine.org/...en.2012-2249

testosterone prostate colon colon cancer cancer NGF nerve growth factor dhea dehydroepiandrosterone

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  • Several studies indicate that DHEA may enhance cancer-promoting activities in several prostate cancer cell lines acting as agonist or antagonist for the intracellular AR
  • the estrogenic metabolites of DHEA, 5a-androstane-3b, 17b-diol (3b-Adiol) and E2 bind to estrogen receptors but not to AR
  • no specific receptor has been identified for DHEA
  • ...16 more annotations...
  • Different members of neurotrophins are expressed during cancer progression, suggesting their involvement in cell proliferation, anoikis protection, and malignancy
  • Regulation of the apoptotic machinery in prostate and colon cancer cells by testosterone occurs rapidly and is initiated at the plasma membrane level through specific membrane-binding sites not involving the classical cytoplasmic AR
  • testosterone exerts potent regulatory effects on prostate and colon cancer cell apoptosis
  • Testosterone increased cell death in a dose-dependent manner
  • testosterone antagonizes the prosurvival effects of DHEA in neuronal cells, blocking its binding to NGF receptors
  • treatment of cells with DHEA exerted a strong antiapoptotic effect,
  • Androgens hold a central role in prostate and colon cancer biology
  • elevated levels of DHEA or its sulfate ester DHEA-sulfate in young adults are associated to low incidence of androgen-dependent tumors
  • DHEA may play a protective role in young prostate
  • The decline of DHEA with aging may contribute to prostate cancer progression associated with advanced age
  • DHEA is an effective antiapoptotic factor, reversing the serum deprivation-induced apoptosis in prostate cancer cells (DU145 and LNCaP cell lines) as well as in colon cancer cells
  • NGF appears to exert similar antiapoptotic actions in both prostate and color cancer cells
  • exposure of prostate DU145 and colon Caco2 cancer cells to testosterone totally blocked the protective effects of both DHEA and NGF. These findings suggest that testosterone acts as an antagonist of DHEA and NGF
  • These findings support the hypothesis that testosterone may inhibit cancer cell growth by antagonizing the proliferative, antiapoptotic effects of endogenous factors, such as DHEA or NGF, in the case of prostate and colon cancer cells
  • intratumor hormonal microenvironment may play a critical role in tumor progression.
  • The paracrine interactions of androgens with locally produced NGF may define tumor cell fate
  • Nathan Goodyear on 19 Nov 14
     
    Full article of previously posted abstract.  Cancers are unique.  Not all cancers are alike.  Whether they are tissue specific or not, cancers are unique.  This article describes the uniqueness of DHEA and Testosterone cancer, with particular attention to colon.
Nathan Goodyear

Associations between ERα, ERβ, and AR Genotypes and Colon and Rectal Cancer - 0 views

cebp.aacrjournals.org/...2936.full.pdf+html

colon cancer colorectal cancer ER ER alpha ER-alpha ER beta ER-beta HRT estrogen receptors

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  • Nathan Goodyear on 19 Nov 14
     
    Study finds ER-beta plays more significant role in the development of Colon cancer than ER-alpha in women.  HRT in women reduces colon cancer risk in comparison to breast, which is increased.  Shows the different tissue expression of ER-alpha and ER-beta, as well as the HRT itself.
Nathan Goodyear

Inhibition of 1,2-dimethylhydrazine-induced colon tumorigenesis in Balb/c mice by dehyd... - 0 views

carcin.oxfordjournals.org/...57.abstract

colon cancer tumor DHEA dehydroepiandrosterone hormone hormones

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  • Nathan Goodyear on 19 Nov 14
     
    Only abstract available here.  DHEA, in mouse model, finds reduced malignant lesions in colon.
Nathan Goodyear

Prevention of diabetes, hepatic injury, and colon cancer with dehyd... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12943737

DHEA dehydroepiandrosterone cancer colon colon cancer diabetes liver insulin hormone hormones

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  • Nathan Goodyear on 19 Nov 14
     
    This article focus' more on the liver and insulin effect of DHEA, but highlights the 2002 study of DHEA and decreased aberrant crypt foci in potential cancer prevention.
Nathan Goodyear

Chemoprevention of precursors to colon cancer by dehydroepiandroste... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12269389

colon colon cancer cancer DHEA dehydroepiandrosterone

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  • Nathan Goodyear on 19 Nov 14
     
    Animal study suggests DHEA is preventative in colon cancer.
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