Contents contributed and discussions participated by Nathan Goodyear - Dr. Goodyear

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation - 0 views

www.sciencedirect.com/...S0098299711000501

oxidative Stress health disease

shared by Nathan Goodyear on 05 Dec 14 - No Cached

Nathan Goodyear on 05 Dec 14

Oxidative Stress

<div class="cArrow"> </div><div class="cContentInner">Oxidative Stress</div>

...

Cancel

Incidence of Prostate Cancer in Hypogonadal Men Receiving Testosterone Therapy: Observa... - 0 views

www.jurology.com/...abstract

low T low testosterone low t Testosterone prostate cancer men male hormone hormones therapy

shared by Nathan Goodyear on 03 Dec 14 - No Cached

Nathan Goodyear on 03 Dec 14

new study looked at 3 cohorts of Testosterone therapy in men. The active cohorts found not increased risk of Prostate cancer in men with testosterone therapy at 5 years.

<div class="cArrow"> </div><div class="cContentInner">new study looked at 3 cohorts of Testosterone therapy in men. The active cohorts found not increased risk of Prostate cancer in men with testosterone therapy at 5 years.</div>

...

Cancel

Effects of testosterone administration on cognitive function in hys... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25430996

Testosterone women female hormone hormones menopause brain cognition memory hysterectomy

shared by Nathan Goodyear on 02 Dec 14 - No Cached

Nathan Goodyear on 02 Dec 14

Testosterone therapy in women post-hysterectomy, with low total and low free Testosterone, provides no benefit in cognitive function.

<div class="cArrow"> </div><div class="cContentInner">Testosterone therapy in women post-hysterectomy, with low total and low free Testosterone, provides no benefit in cognitive function.</div>

...

Cancel

Testosterone and benign prostatic hyperplasia Jarvis TR, Chughtai B, Kaplan SA, - Asian... - 0 views

www.ajandrology.com/preprintarticle.asp

Testosterone BPH low T low Testosterone prostate cancer men male hormone hormones

shared by Nathan Goodyear on 01 Dec 14 - No Cached

The prevalence of hypogonadism (often defined as serum testosterone < 300 ng dl−1 ) ranges from 6% [10] to as high as 38%
...

Cancel
The process of BPH, however, continues as men age and despite the fact their serum testosterone decreases
...

Cancel
Liu et al. [12] demonstrated that in a group of older males (mean age 59.8 years) that there was not a significant correlation of serum testosterone levels (total, free or bioavailable) with either prostate volume or International Prostate Symptom Score (IPSS)
...

Cancel
...11 more annotations...
in eugonadal men, studies have demonstrated that the prostate can increase in volume by approximately 12%
...

Cancel
There seems to be little doubt that the treatment with testosterone of a young hypogonadal male leads to significant growth of the prostate
...

Cancel
Behre et al. [22] demonstrated increased prostate volume and prostate-specific antigen (PSA) levels in hypogonadal men
...

Cancel
Most studies, however, have shown no effect of exogenous androgens on PSA or prostate volume for older hypogonadal males
...

Cancel
They argue that the prostate is relatively insensitive to changes in androgen concentration at normal levels or in mild hypogonadism because the AR is saturated by androgens and therefore maximal androgen-AR binding is achieved. Conversely, the prostate is very sensitive to changes in androgen levels when testosterone is low
...

Cancel
saturation model
...

Cancel
visceral obesity (one of the most significant components of metabolic syndrome) is associated with prostate volume and influences prostate growth during TRT.
...

Cancel
This hypothesis of inflammation induced LUTS is also argued to be a mechanism for improvement of LUTS with PDE5I
...

Cancel
The concept, therefore, that treatment with TRT of hypogonadal males with metabolic syndrome might lead to improvement/stabilization of their LUTS, appears to be confirmed in recent work by Francomano et al.
...

Cancel
There was also an improvement in components of the patient's metabolic syndrome (such as BMI, waist circumference, hemoglobin A1c [HbA1c], insulin sensitivity, and lipid profile) as well as inflammatory markers and C-reactive protein.
...

Cancel
They concluded that TRT was safe in this group of men, and hypothesize that TRT mitigates the pro-inflammatory factors associated with metabolic syndrome.
...

Cancel

Nathan Goodyear on 01 Dec 14

Authors review the literature behind Testosterone and BPH. The authors highlight the 4 proposed theories behind BPH: Testosterone, Estrogen, inflammation, and metabolic. The conclusion is mixed: pointing out that no high level of evidence exists on either side of the debate of Testosterone and BPH.

<div class="cArrow"> </div><div class="cContentInner">Authors review the literature behind Testosterone and BPH. The authors highlight the 4 proposed theories behind BPH: Testosterone, Estrogen, inflammation, and metabolic. The conclusion is mixed: pointing out that no high level of evidence exists on either side of the debate of Testosterone and BPH.</div>

...

Cancel

Testosterone deficiency and cardiovascular mortality Morgentaler A, - Asian J Androl - 0 views

www.ajandrology.com/preprintarticle.asp

testosterone low t low Testosterone CVD cardiovascular mortality therapy

shared by Nathan Goodyear on 01 Dec 14 - No Cached

overall mortality and CV mortality were inversely associated with serum T concentrations.
...

Cancel
men with low serum T, defined as < 8.7 nmol l−1 (250 ng dl−1 ), demonstrated significantly greater all-cause mortality than men with higher serum T (hazard ratio [HR]: 2.24; 95% CI: 1.41-3.57), as well as greater CV mortality
...

Cancel
lower T levels were significantly associated with the presence of any CV disease
...

Cancel
...19 more annotations...
more than 30 years of studies suggesting that low levels of T represent an increased risk for CV and overall mortality,
...

Cancel
lower serum T concentrations also are associated with CV disease, including incident coronary artery disease [17],[18],[19] and atherosclerosis,
...

Cancel
the actual rate of adverse events was only half as great in the T group (123 events in 1223 men at risk = 10.1%) as in the untreated group (1587 events in 7486 men = 21.2%)
...

Cancel
The study by Vigen et al. [7] has already undergone two published corrections,
...

Cancel
29 medical societies have called for retraction of the article, asserting "gross data mismanagement and contamination," that rendered the study "no longer credible
...

Cancel
Mortality in T-treated men was reduced by approximately half in treated men compared with untreated men, at 10.3% versus 20.7%, respectively
...

Cancel
The mortality rate for men who received TTh was 3.4 deaths per 100 person-years, and 5.7 deaths per 100 person-years in untreated men
...

Cancel
HR of 0.61 (95%CI: 0.42-0.88; P = 0.008), indicating a significant reduction in mortality with TTh
...

Cancel
men in the highest prognostic MI risk quartile, treatment with TTh was associated with reduced risk
...

Cancel
tripling in T prescriptions in the US over the last decade
...

Cancel
a majority of observational studies have found that low endogenous serum T levels are associated with increased mortality.
...

Cancel
Men who received TTh were able to exercise significantly longer without ischemia compared with men who received placebo
...

Cancel
In men with congestive heart failure, those who received T demonstrated greater walking distance and other functional endpoints compared with those who received placebo
...

Cancel
TTh has been shown uniformly and repeatedly to improve several known CV risk factors, including reduced fat mass, body fat percent, and waist circumference, and increased lean mass
...

Cancel
improved glycemic control
...

Cancel
reductions in insulin resistance.
...

Cancel
the evidence strongly points to improved CV status with normal serum T or treatment with TTh in men with TD
...

Cancel
analysis of health insurance claims data that reported a 36% increased rate of nonfatal MI in the 90d following receipt of a T prescription compared with the 12 prior months.
...

Cancel
Comparison with men who received a prescription for a phosphodiesterase type 5 inhibitor (PDE5i) revealed no increased rate of MI following the prescription
...

Cancel

Nathan Goodyear on 01 Dec 14

Great review by Morgentaler of Testosterone and CVD. He highlights the significant flaws in the JAMA and the NEJM articles of Testosterone therapy risks. Morgentaler highlights the significant evidence that points to low T and increased risk of CVD. On contention I have, is Morgantaler seems to flip aside the massive uptick of Testosterone use in the US as compared to other countries. The evidence definitely points to Testosterone therapy as being safe in those with low T, but there is definitely a problem of significant Testosterone doping that is taking place as well.

<div class="cArrow"> </div><div class="cContentInner">Great review by Morgentaler of Testosterone and CVD. He highlights the significant flaws in the JAMA and the NEJM articles of Testosterone therapy risks. Morgentaler highlights the significant evidence that points to low T and increased risk of CVD. On contention I have, is Morgantaler seems to flip aside the massive uptick of Testosterone use in the US as compared to other countries. The evidence definitely points to Testosterone therapy as being safe in those with low T, but there is definitely a problem of significant Testosterone doping that is taking place as well.</div>

...

Cancel

Inflammation and Native American medicine: the role of botanicals - 0 views

ajcn.nutrition.org/...339.long

inflammation native Americans medicine botanicals herbs medicinal natural

shared by Nathan Goodyear on 30 Nov 14 - No Cached

Nathan Goodyear on 30 Nov 14

review of medicinal botanicals used by native Americans.

<div class="cArrow"> </div><div class="cContentInner">review of medicinal botanicals used by native Americans.</div>

...

Cancel

Resistance exercise training improves heart rate variability and mu... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25384514

exercise resistance training HRV heart rate variability muscle coronary artery disease CAD

shared by Nathan Goodyear on 25 Nov 14 - No Cached

Nathan Goodyear on 25 Nov 14

High repetition, low weight is associated with improved Heart rate variability, muscle strength and endurance in non-healthy-CAD patients.

<div class="cArrow"> </div><div class="cContentInner">High repetition, low weight is associated with improved Heart rate variability, muscle strength and endurance in non-healthy-CAD patients.</div>

...

Cancel

Recovery from endurance exercise. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...1406207

endurance exercise recovery carbohydrates glycogen

shared by Nathan Goodyear on 25 Nov 14 - No Cached

Nathan Goodyear on 25 Nov 14

Carbohydrates required to restore muscle/liver glycogen stores. This older article, abstract available, points to 8-10 grams of carbohydrates/kg body weight. Though repletion of glycogen stores can occur, recovery of muscle performance may require longer time. Studies have point to 4-6 days.

<div class="cArrow"> </div><div class="cContentInner">Carbohydrates required to restore muscle/liver glycogen stores. This older article, abstract available, points to 8-10 grams of carbohydrates/kg body weight. Though repletion of glycogen stores can occur, recovery of muscle performance may require longer time. Studies have point to 4-6 days.</div>

...

Cancel