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Nathan Goodyear

Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling - 0 views

www.ncbi.nlm.nih.gov/...PMC2647704

thyroid hormone T3 T4 rT3 deiodinase selenium hormones

shared by Nathan Goodyear on 10 Nov 14 - No Cached
  • Nathan Goodyear on 10 Nov 14
     
    Anything and everything one would want to know regarding thyroid hormone signaling.  Doctors, especially endocrinologists, need to read this.  T4 is not or is ever inside target cells.  The enzymes, deiodinase types 1, 2, and 3, are what control the thyroid hormone at the cellular levels.  Deiodinase-2 is what generates T3 in the cytosol of the cell.  In contrast, deiodinase-3 is what generates rT3 which is inactive.  High Fat diet increases deiodinase-3.
Nathan Goodyear

Type 1 5'-deiodinase activity is inhibited by oxidative stress and restored by alpha-li... - 0 views

www.ncbi.nlm.nih.gov/...26947333

thyroid T3 oxidative stress alpha lipoic acid deiodinase rT3 reverse T3 thyroid metabolites thyroid metabolism hormones

shared by Nathan Goodyear on 28 Sep 16 - No Cached
  • Nathan Goodyear on 28 Sep 16
     
    oxidative stress decreased type 1 deiodinase activity and thus T4 to T3 conversion, resulting in increased rT3 production.  Of interesting note, Alpha lipoic acid increased type I deiodinase activity and T4 to T3 conversion.
Nathan Goodyear

Type 3 Deiodinase: Role in Cancer Growth, Stemness, and Metabolism - 0 views

www.ncbi.nlm.nih.gov/...PMC4269192

rT3 reverse T3 HIF-1alpha CSC deiodinase D3 cancer stem cells cancer

shared by Nathan Goodyear on 30 Jan 21 - No Cached
  • Nathan Goodyear on 30 Jan 21
     
    Amazing article. Increased deiodinase 3 activity in cancer increases rT3 production. What drives the increase in deiodinase 3?
Nathan Goodyear

Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling: Endocri... - 0 views

press.endocrine.org/...er.2008-0019

thyroid deiodinase T3 T4 hormone hormones

shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • From a broad perspective, this paradigm can be seen as an example of how hormones are activated or inactivated in a controlled fashion in specific extraglandular tissues, in an analogous role to 5α-reductase and P450 aromatase in sex steroid metabolism and to 11β-hydroxysteroid dehydrogenase in glucocorticoid metabolism.
  • Nathan Goodyear on 24 Nov 14
     
    better source for previous post on thyroid metabolism and deiodinase.
Nathan Goodyear

Proinflammatory cytokines inhibit the expre... [Eur J Endocrinol. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11916626

inflammation cytokines cytokine IL-1beta IL-6 TNF-alpha thyroid hypothyroid hypothyroidism deiodinase

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    inflammatory cytokine IL-1beta reduced deiodinase transcription, thus reducing T4 to T3 conversion.  The inflammatory cytokines TNF-alpha and IL-6 did also but to a lesser degree.
Nathan Goodyear

Deiodinases - National Academy of HypothyroidismNational Academy of Hypothyroidism - 0 views

www.nahypothyroidism.org/deiodinases

Thyroid hormone hormones physiology T4 T3 rT3 reverse T3 metabolites deiodinase

shared by Nathan Goodyear on 23 Nov 14 - No Cached
  • Nathan Goodyear on 23 Nov 14
     
    Great review of thyroid metabolism.
Nathan Goodyear

IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while prom... - 0 views

europepmc.org/3083773

rT3 reverse T3 T3 thyroid deiodinase-3 inflammation IL-6 thyroid hormones T4

shared by Nathan Goodyear on 04 Feb 21 - No Cached
  • Nathan Goodyear on 04 Feb 21
     
    IL-6 decreases deiodinase type I and 2; but increases type 3. The result is an increase in rT3 and in cancer-growth.
Nathan Goodyear

ACTH-secreting pituitary microadenomas... [Clin Endocrinol (Oxf). 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22587880

saliva salivary hormone hormones cortisol microadenomas hypothyroidism hypothyroid ACTH

shared by Nathan Goodyear on 26 Sep 12 - No Cached
  • Nathan Goodyear on 26 Sep 12
     
    Individuals with ACTH secreting microadenomas have a higher incidence of hypothyroidism and should be evaluated. This only makes physiologic sense, knowing the impact on 5'deiodinase, and TSH production. Also of importance, is the methodology of cortisol evaluation.  They used salivary cortisol levels to follow.  This study was conducted at John Hopkins school of Medicine, Division of Endocrinology.  Some how others here in Louisiana have missed this (Namely LSBME and BCBS).
Nathan Goodyear

Combination L-T3 and L-T4... [Curr Opin Endocrinol Diabetes Obes. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23974776

hypothyroid hypothyroidism T4 T3 thyroid therapy

shared by Nathan Goodyear on 09 Sep 13 - No Cached
  • Nathan Goodyear on 09 Sep 13
     
    This article reviews the genetic polymorphisms that play role in low T4 to T3 conversion and thus combination T4/T3 therapy is indicated.  This study fails to recognize the environmental impacts on the deiodinase enzymes.
Nathan Goodyear

Deiodination in cancer growth: the role of type III deiodinase - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/23235188

cancer T4 T3 deiodinase rT3

shared by Nathan Goodyear on 31 Jan 21 - No Cached
  • Nathan Goodyear on 31 Jan 21
     
    Only abstract available here. Trying to track down the full article.
Nathan Goodyear

Peripheral autoregulation of thyroxine to triiodot... [Horm Metab Res Suppl. 1984] - Pu... - 0 views

www.ncbi.nlm.nih.gov/...6595193

Thyroid T4 T3 hormone hormones 5' deiodinase

shared by Nathan Goodyear on 19 Nov 10 - No Cached
  • Nathan Goodyear on 19 Nov 10
     
    Thyroid T4 to T3 conversion
Nathan Goodyear

SpringerLink - Cellular and Molecular Life Sciences, Volume 57, Numbers 13-14 - 0 views

www.springerlink.com/...t34vwu3k118cag2f

T4 T3 thyroid hypothyroid

shared by Nathan Goodyear on 20 Dec 10 - No Cached
  • deiodinases are envisaged as guardians to the gate of thyroid hormone action mediated by T3 receptors
  • Nathan Goodyear on 20 Dec 10
     
    Heavy read; but how/why is T4 to T3 conversion important
Nathan Goodyear

Proinflammatory cytokines inhibit the expression and function of human type I 5'-deiodi... - 0 views

www.eje-online.org/...559

hypothyroid hypothyroidism thyroid inflammation cytokines proinflammatory

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • Nathan Goodyear on 01 Feb 11
     
    inflammation inhibits thyroid function
Nathan Goodyear

Tissue-specific deiodinase regulation during food restriction and low replacement dose ... - 0 views

ajpendo.physiology.org/...E1157.abstract

T4 T3 weight loss obesity

shared by Nathan Goodyear on 05 Apr 11 - No Cached
  • Nathan Goodyear on 05 Apr 11
     
    chronic dieting will result in low T4 to T3 production; hindering weight loss
Nathan Goodyear

The Role of Thyroid Hormones in Hepatocyte Proliferation and Liver Cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC6730500

oxidative stress deiodinase T3 T4 thyroid hormones rT3 HIF-1alpha

shared by Nathan Goodyear on 30 Jan 21 - No Cached
  • Nathan Goodyear on 30 Jan 21
     
    Oxidative stress/inflammation via HIF-1alpha increase D3 which increases rT3 to increase proliferation in cancer; in contrast, there is a decrease in D1 and D2 to decrease T3 and T4. The question is the systemic versus the TME.
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