Contents contributed and discussions participated by Nathan Goodyear - Dr. Goodyear

Androgen receptor expression is inversely correlated with pathologic tumor stage in bla... - 0 views

www.goldjournal.net/...abstract

androgen receptor androgen receptors bladder cancer bladder cancer men male hormone hormones AR

shared by Nathan Goodyear on 04 Jan 15 - No Cached

Nathan Goodyear on 04 Jan 15

Study finds that loss of Androgen receptors associated with advanced stage bladder cancer in men.

<div class="cArrow"> </div><div class="cContentInner">Study finds that loss of Androgen receptors associated with advanced stage bladder cancer in men.</div>

...

Cancel

Promoting effects and mechanisms of action of androgen in bladder c... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9129932

bladder cancer bladder cancer Testosterone men male hormone hormones

shared by Nathan Goodyear on 04 Jan 15 - No Cached

Nathan Goodyear on 04 Jan 15

Another animal study finds Testosterone plays a role in bladder cancer development. The study used anti androgen and 5 alpha reductase inhibitor therapy to see if these add on therapies provided anything to ADR whether via castration or pituitary suppression--the answer was no. The authors concluded that Testosterone played more of a role with AR versus the more active 5alpha-DHT metabolite.

<div class="cArrow"> </div><div class="cContentInner">Another animal study finds Testosterone plays a role in bladder cancer development. The study used anti androgen and 5 alpha reductase inhibitor therapy to see if these add on therapies provided anything to ADR whether via castration or pituitary suppression--the answer was no. The authors concluded that Testosterone played more of a role with AR versus the more active 5alpha-DHT metabolite.</div>

...

Cancel

http://cdn.intechopen.com/pdfs-wm/27785.pdf - 0 views

cdn.intechopen.com/...27785.pdf

low T low testosterone low T Testosterone men male hormone hormones LUTS BPH prostate lower urinary tract symptoms

shared by Nathan Goodyear on 04 Jan 15 - No Cached

Nathan Goodyear on 04 Jan 15

Nice review of the literature of low T and LUTS in men.

<div class="cArrow"> </div><div class="cContentInner">Nice review of the literature of low T and LUTS in men.</div>

...

Cancel

Promotion of Bladder Cancer Development and Progression by Androgen Receptor Signals - 0 views

jnci.oxfordjournals.org/...558.full

bladder cancer bladder cancer androgen receptor androgen receptors AR receptor men male hormones hormone

shared by Nathan Goodyear on 04 Jan 15 - No Cached

Nathan Goodyear on 04 Jan 15

Animal study finds that Androgen Receptors play role in bladder cancer development and progression in men.

<div class="cArrow"> </div><div class="cContentInner">Animal study finds that Androgen Receptors play role in bladder cancer development and progression in men.</div>

...

Cancel

http://ehp.niehs.nih.gov/wp-content/uploads/118/12/ehp.1002720.pdf - 0 views

ehp.niehs.nih.gov/...ehp.1002720.pdf

liver enzymes NAFLD liver disease cirrhosis hepatitis PCBs polychlorinated biphenyls Lead Pb Mercury Hg

shared by Nathan Goodyear on 22 Dec 14 - No Cached

Nathan Goodyear on 22 Dec 14

PCBs, Lead, and Mercury associated with liver disease in American adults. These possible causes need to be considered with non-explainable hepatitis.

<div class="cArrow"> </div><div class="cContentInner">PCBs, Lead, and Mercury associated with liver disease in American adults. These possible causes need to be considered with non-explainable hepatitis.</div>

...

Cancel

European Journal of Clinical Nutrition - Effect of maternal n-3 long-chain polyunsatura... - 0 views

www.nature.com/...ejcn2014158a.html

nutrition n-3 omega 3 omega-3 fish oil pregnancy childhood obesity

shared by Nathan Goodyear on 22 Dec 14 - No Cached

It is estimated that approximately 30% of children and adolescents in the United States and about 15–30% of those in Europe can be classified as overweight or obese
...

Cancel
An increasing body of evidence now suggests that the nutritional environment encountered in utero and the early postnatal life may elicit permanent alterations in adipose tissue structure or function and, thereby, programme the individual’s propensity to later obesity
...

Cancel
The composition of fatty acids in the Western diets has shifted toward an increasing dominance of n-6 relative to n-3 LCPUFAs over the past decades.9,10 This shift is also reflected in the fatty acid composition of breast milk
...

Cancel
...8 more annotations...
Evidence from animal studies suggests that the n-6 LCPUFA arachidonic acid promotes adipose tissue deposition, whereas the n-3 LCPUFAs eicosapentaenoic acid and docosahexaenoic acid seem to exert an opposite effect
...

Cancel
Overall, no effect of supplementation was found on BMI in preschool (<5 years) and school-aged (6–12 years) children
...

Cancel
increased adiposity, once established in childhood, tends to track into adulthood
...

Cancel
Many studies have shown that even children <2 years with a high BMI are at increased risk of developing obesity later in life
...

Cancel
The acquisition of fat cells early in life appears to be an irreversible process
...

Cancel
Evidence from cell culture and animal studies suggests that early exposure to n-3 LCPUFAs has the potential to limit adipose tissue deposition mainly by attenuating the production of the arachidonic acid metabolite prostacyclin, which has been shown to enhance adipogenesis
...

Cancel
In conclusion, there is currently no evidence to support that maternal n-3 LCPUFA supplementation during pregnancy and/or lactation exerts a favourable programming effect on adiposity status in childhood
...

Cancel
our systematic review highlights that most of the trials reviewed were prone to methodological limitations
...

Cancel

Nathan Goodyear on 22 Dec 14

Literature review finds limited data (9 studies, only 6 RCTs) of omega-3 during pregnancy. No data was found that supported reduced obesity in children by mothers taking n-3 during pregnancy. No harm was found either. Data was sparse. Take home: not enough data, no harm to pregnancy, children, thus if indications are present for mother, then recommend n-3. At this point not studies have pointed to reduced obesity in children.

<div class="cArrow"> </div><div class="cContentInner">Literature review finds limited data (9 studies, only 6 RCTs) of omega-3 during pregnancy. No data was found that supported reduced obesity in children by mothers taking n-3 during pregnancy. No harm was found either. Data was sparse. Take home: not enough data, no harm to pregnancy, children, thus if indications are present for mother, then recommend n-3. At this point not studies have pointed to reduced obesity in children.</div>

...

Cancel

Incidence of Prostate Cancer in Hypogonadal Men Receiving Testosterone Therapy: Observa... - 0 views

www.jurology.com/...fulltext

low t low Testosterone hypogonadism low T Testosterone men male hormone hormones prostate cancer therapy treatment

shared by Nathan Goodyear on 17 Dec 14 - No Cached

Nathan Goodyear on 17 Dec 14

Study of 3 cohorts with a median of 5 years of Testosterone therapy in men with low T, finds no increase risk in prostate cancer.

<div class="cArrow"> </div><div class="cContentInner">Study of 3 cohorts with a median of 5 years of Testosterone therapy in men with low T, finds no increase risk in prostate cancer.</div>

...

Cancel

Program Planner | Presentation - 0 views

www.abstractsonline.com/pp8

CAD cardiovascular disease women hormone hormones Estradiol progesterone BHRT bio-identical hormones female

shared by Nathan Goodyear on 16 Dec 14 - No Cached

Nathan Goodyear on 16 Dec 14

Just an abstract from the Presentation at the 2014 Scientific Session. The abstract points to a 40% reduction in CAD with the onset of BHRT (Estradiol and progesterone topical) within 6 years of menopause compared to women 10 years post-menopause. This points to timing as a critical component of BHRT in women and CAD.

<div class="cArrow"> </div><div class="cContentInner">Just an abstract from the Presentation at the 2014 Scientific Session. The abstract points to a 40% reduction in CAD with the onset of BHRT (Estradiol and progesterone topical) within 6 years of menopause compared to women 10 years post-menopause. This points to timing as a critical component of BHRT in women and CAD.</div>

...

Cancel