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Contents contributed and discussions participated by Nathan Goodyear

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Nathan Goodyear

Deiodinases - National Academy of HypothyroidismNational Academy of Hypothyroidism - 0 views

www.nahypothyroidism.org/deiodinases

Thyroid hormone hormones physiology T4 T3 rT3 reverse T3 metabolites deiodinase

shared by Nathan Goodyear on 23 Nov 14 - No Cached
  • Nathan Goodyear on 23 Nov 14
     
    Great review of thyroid metabolism.
Nathan Goodyear

Adult Obesity in the United States: The State of Obesity - 0 views

stateofobesity.org/adult-obesity

Obesity rates obese

shared by Nathan Goodyear on 21 Nov 14 - No Cached
  • Nathan Goodyear on 21 Nov 14
     
    startling obesity trends that don't show much sign of leveling off.
Nathan Goodyear

Obesity Rates Increased in These 6 States - 0 views

www.livescience.com/rates-increase-six-states.html

obesity rates obese

shared by Nathan Goodyear on 21 Nov 14 - No Cached
  • Nathan Goodyear on 21 Nov 14
     
    New study finds previous obesity data woefully underestimating rates.  This study finds that obesity rates exceed 35% in Mississippi and West Virginia.
Nathan Goodyear

http://www.ketogenic-diet-resource.com/support-files/p00246.pdf - 0 views

www.ketogenic-diet-resource.com/...p00246.pdf

blood sugar log blood sugar log ketogenic diet

shared by Nathan Goodyear on 20 Nov 14 - No Cached
  • Nathan Goodyear on 20 Nov 14
     
    Blood Sugar Log Booklet
Nathan Goodyear

Risk of major cardiovascular events in patients with psoriatic arthritis, psoriasis and... - 0 views

ard.bmj.com/...annrheumdis-2014-205675

inflammation cardiovascular RA rheumatoid arthritis psoriasis disease CVD

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  • Nathan Goodyear on 20 Nov 14
     
    Abstract: Inflammatory diesease (psoriasis and RA in this study) associated with increased cardiovascular events.
Nathan Goodyear

British Journal of Cancer - Dichloroacetate inhibits aerobic glycolysis in multiple mye... - 0 views

www.nature.com/...bjc2013120a.html

DCA dichloroacetate cancer

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  • Nathan Goodyear on 19 Nov 14
     
    Dichloroacetate (DCA) inhibits aerobic glycolysis via inhibition of Pyruvate Dehydrogenase kinase (PDK), which allows for the phosphorylation of Pyruvate Dehydrogenase and the formation of acetylCo-A.  This then feeds the krebs cycle.  Increased mitochondrial activity increases ROS and resultant apoptosis of cancer cells.
Nathan Goodyear

Can dehydroepiandrostenedione (DHEA) target PRL-3 to prevent colon cancer metastasis? -... - 0 views

europepmc.org/...23462371

DHEA dehydroepiandrosterone colon hormone hormones cancer colon cancer colorectal cancer

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  • Nathan Goodyear on 19 Nov 14
     
    DHEA proposed to be used to prevent/inhibit colorectal metastasis via inhibition of PRL-3 prenylation.
Nathan Goodyear

Differential Effects of Dehydroepiandrosterone and Testosterone in Prostate and Colon C... - 0 views

press.endocrine.org/...en.2012-2249

testosterone prostate colon colon cancer cancer NGF nerve growth factor dhea dehydroepiandrosterone

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Several studies indicate that DHEA may enhance cancer-promoting activities in several prostate cancer cell lines acting as agonist or antagonist for the intracellular AR
  • the estrogenic metabolites of DHEA, 5a-androstane-3b, 17b-diol (3b-Adiol) and E2 bind to estrogen receptors but not to AR
  • no specific receptor has been identified for DHEA
  • ...16 more annotations...
  • Different members of neurotrophins are expressed during cancer progression, suggesting their involvement in cell proliferation, anoikis protection, and malignancy
  • Regulation of the apoptotic machinery in prostate and colon cancer cells by testosterone occurs rapidly and is initiated at the plasma membrane level through specific membrane-binding sites not involving the classical cytoplasmic AR
  • testosterone exerts potent regulatory effects on prostate and colon cancer cell apoptosis
  • Testosterone increased cell death in a dose-dependent manner
  • testosterone antagonizes the prosurvival effects of DHEA in neuronal cells, blocking its binding to NGF receptors
  • treatment of cells with DHEA exerted a strong antiapoptotic effect,
  • Androgens hold a central role in prostate and colon cancer biology
  • elevated levels of DHEA or its sulfate ester DHEA-sulfate in young adults are associated to low incidence of androgen-dependent tumors
  • DHEA may play a protective role in young prostate
  • The decline of DHEA with aging may contribute to prostate cancer progression associated with advanced age
  • DHEA is an effective antiapoptotic factor, reversing the serum deprivation-induced apoptosis in prostate cancer cells (DU145 and LNCaP cell lines) as well as in colon cancer cells
  • NGF appears to exert similar antiapoptotic actions in both prostate and color cancer cells
  • exposure of prostate DU145 and colon Caco2 cancer cells to testosterone totally blocked the protective effects of both DHEA and NGF. These findings suggest that testosterone acts as an antagonist of DHEA and NGF
  • These findings support the hypothesis that testosterone may inhibit cancer cell growth by antagonizing the proliferative, antiapoptotic effects of endogenous factors, such as DHEA or NGF, in the case of prostate and colon cancer cells
  • intratumor hormonal microenvironment may play a critical role in tumor progression.
  • The paracrine interactions of androgens with locally produced NGF may define tumor cell fate
  • Nathan Goodyear on 19 Nov 14
     
    Full article of previously posted abstract.  Cancers are unique.  Not all cancers are alike.  Whether they are tissue specific or not, cancers are unique.  This article describes the uniqueness of DHEA and Testosterone cancer, with particular attention to colon.
Nathan Goodyear

Associations between ERα, ERβ, and AR Genotypes and Colon and Rectal Cancer - 0 views

cebp.aacrjournals.org/...2936.full.pdf+html

colon cancer colorectal cancer ER ER alpha ER-alpha ER beta ER-beta HRT estrogen receptors

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Nathan Goodyear on 19 Nov 14
     
    Study finds ER-beta plays more significant role in the development of Colon cancer than ER-alpha in women.  HRT in women reduces colon cancer risk in comparison to breast, which is increased.  Shows the different tissue expression of ER-alpha and ER-beta, as well as the HRT itself.
Nathan Goodyear

Inhibition of 1,2-dimethylhydrazine-induced colon tumorigenesis in Balb/c mice by dehyd... - 0 views

carcin.oxfordjournals.org/...57.abstract

colon cancer tumor DHEA dehydroepiandrosterone hormone hormones

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Nathan Goodyear on 19 Nov 14
     
    Only abstract available here.  DHEA, in mouse model, finds reduced malignant lesions in colon.
Nathan Goodyear

Prevention of diabetes, hepatic injury, and colon cancer with dehyd... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12943737

DHEA dehydroepiandrosterone cancer colon colon cancer diabetes liver insulin hormone hormones

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  • Nathan Goodyear on 19 Nov 14
     
    This article focus' more on the liver and insulin effect of DHEA, but highlights the 2002 study of DHEA and decreased aberrant crypt foci in potential cancer prevention.
Nathan Goodyear

Chemoprevention of precursors to colon cancer by dehydroepiandroste... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12269389

colon colon cancer cancer DHEA dehydroepiandrosterone

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Nathan Goodyear on 19 Nov 14
     
    Animal study suggests DHEA is preventative in colon cancer.
Nathan Goodyear

Differential Effects of Dehydroepiandrosterone and Testosterone in Prostate and Colon C... - 0 views

www.researchgate.net/..._Growth_Factor_(NGF)_Receptors

NGF nerve growth factor Testosterone DHEA cancer apoptosis colon cancer

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  • Nathan Goodyear on 19 Nov 14
     
    Study finds Testosterone induces apoptosis via deactivation of NGF.  Testosterone counters the proliferation of DHEA, via NGF activation.  Without evaluation of aromatase activity, this study is incomplete.
Nathan Goodyear

Associations between Testosterone Levels and Incident Prostate, Lung, and Colorectal Ca... - 0 views

cebp.aacrjournals.org/...1319.full

Testosterone cancer men male hormone hormones

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  • Nathan Goodyear on 19 Nov 14
     
    Study finds that increased free Testosterone is associated with increased incidence of prostate cancer.  Higher Total Testosterone was associated with lung cancer and androgens were not associated with colorectal cancer incidence.  That being said, the evaluation of androgens only is a significant limiting factor of this study.  
Nathan Goodyear

Quality of life, self-esteem, fatigue, and sexual function in young men after cancer - ... - 0 views

onlinelibrary.wiley.com/...abstract

low T low Testosterone cancer quality of life fatigue men male hormone hormones

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  • Nathan Goodyear on 19 Nov 14
     
    Low Testosterone is common among male cancer survivors after therapy.  Many studies point to low T at the time of diagnosis as a prognostic biomarker.  The low T impairs QOL in this men.
Nathan Goodyear

[Serum testosterone: a possible marker for colorectal cancer]. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8295527

Testosterone colon cancer colorectal cancer low Testosterone low T CEA men male hormone hormones

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  • Nathan Goodyear on 19 Nov 14
     
    Colorectal cancer associated with decreased Testosterone levels in men.  This paper looked at total serum Testosterone.  The authors proposed that CEA plus Testosterone could be used in follow up.
Nathan Goodyear

Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to incr... - 0 views

stke.sciencemag.org/...ra106.abstract

nitric oxide NO inflammation SIRT1 sirloins disease aging

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  • Nathan Goodyear on 19 Nov 14
     
    Nitic Oxide (NO) via inflammation deactivates SIRT1 is a common finding in inflammatory diseases of aging, proposes authors of this paper.
Nathan Goodyear

Audiology and Neurotology 2010, Vol. 15, No. 1 - Elevated Antithyroid Peroxid... - 0 views

www.karger.com/...218357

inflammation autoimmune Meniere's disease

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  • Nathan Goodyear on 18 Nov 14
     
    Authors of this study postulate that "immune dysregulation" on the orders of autoimmune is likely involved in Meniere's disease.
Nathan Goodyear

JAMA Network | JAMA Otolaryngology-Head & Neck Surgery | Prevalence of Thyroi... - 0 views

archotol.jamanetwork.com/article.aspx

meniere's disease hypothyroid hypothyroidism thyroid dysfunction inflammation autoimmune

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  • Nathan Goodyear on 18 Nov 14
     
    study finds active Meniere's disease is associated with hypothyroidism.
Nathan Goodyear

PLOS ONE: High Prevalence of Systemic Autoimmune Diseases in Patients with Me... - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0026759

meniere's disease autoimmune inflammation

shared by Nathan Goodyear on 18 Nov 14 - No Cached
  • Nathan Goodyear on 18 Nov 14
     
    Those with Meniere's disease found to have increased autoimmune disease.
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