Short-term testosterone therapy failed to increase CV risk in women | Endocrinology - 0 views
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Nathan Goodyear on 23 May 1424 week study of 71 women post-hysterectomy finds no increase in cardiovascular biomarkers. Several problems with this study. First, there was a large drop out--24%. Second and most important, the women were pretreated with estrogen prior to Testosterone therapies were initiated. Other studies have proposed that this protects cardiovascular risk in women on Testosterone. Previous studies show increasing endogenous Testosterone is associated with increasing cardiovascular disease in women. This study would be much better if no estradiol was prescribed. That would give an unbiased view of Testosterone in post-hysterectomy women. Not much can be taken from this study. If you doctor doesn't know this, find another doctor. Inherent bias in this study as ties to the manufacturer of the Testosterone was disclosed. This study point to the inherent flaws in so much of the medical literature today. Most would read the headlines and read no further, but the "further" dispels the headline as flawed.