In this animal study, estradiol is added to Testosterone to increase prostate carcinogenesis. Previous rat studies have shown that adding estradiol to Testosterone, which occurs naturally, increases prostate cancer risk.
Bulbine natalensis Baker stem extract found to increase LH and Testosterone in wistar rats in 7 days at doses of 25 to 50 mg/kg; this effect was not found at 100 mg/kg. The result was an increase in testes size, rate of mating, libido, and fertility.
high fructose diet for just 9 weeks, > 60% liquid fructose, in rat model found to increase visceral adiposity, triglycerides, and lead to leptin resistance.
Testosterone can block the effect of estradiol on prostatitis, however treatment with an anti-estrogen or an aromatase inhibitor to block estrogen action does not improve prostatitis in the rat
Estradiol and imbalanced Testosterone:Estradiol ratio contributes to prostatitis. In this study, with rats, aromatase inhibitors did not improve prostatitis.
progesterone shown to provide substantial reduction in volume of infarct in rat stroke model. This is very promising, and with with other studies revealing the same benefit in the human brain, progesterone should become a part of initial treatment in those with acute brain injuries and should be evaluated for those with aging diseases of the brain.
Calorie restriction increases adiponectin secretion from adipocytes. Another plus of calorie restriction. Remember, adiponectin and insulin are inversely associated. Granted, this is in a rat model, but still supporting the overall health benefits of calorie restriction.
Rat study finds balance of DHT and estradiol play important role. The production of DHT removes Testosterone from the pool to make estradiol through aromatase activity.
Testosterone modulates dopaminergic pathways in the the brain. This was a rat model. This points to some of the euphoria experienced by men on Testosterone likely occurs through dopamine.
Rat study, but it finds that n-3, capsaicin, and curcumin can not only decrease the inflammation associatied with arthritis, but it can delay it all together.