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Fructose upregulates fructokinase activity and this increase liver triglyceride production increasing non-alcoholic fatty liver disease also known as NAFLD.

non-alcoholic fatty liver disease the result of Metabolic syndrome.  New epidemic associated with obesity. Scary statistics about the children of America.

Testosterone replacement in older men with low T not shown to improve liver fat content.  This has obvious implications to non-alcoholic hepatic steatosis.

with an estimated 25% of Americans with non-alcoholic fatty liver disease (NAFLD), elevated liver enzymes are becoming a more common finding.  Nice review article on what the tests mean and what disease are underlying.

non-alcoholic fatty liver disease is the new epidemic.  But the scary point is NAFLD is found in many of our children.  As goes obesity, so goes NAFLD

obesity and non-alcoholic fatty liver disease are one in the same.

high Fructose dietary intake results in Copper deficiency.  Result is increase in non-alcoholic fatty liver.

metabolic endotoxemia plays role in NAFLD.  Gut bacterial balance plays a role in NAFLD.

good review of the effects of Mediterranean diet and NAFLD.

Mediterranean diet reduced insulin resistance and liver steatosis in those with NAFLD.

In those with NAFLD, mediterranean diet associated with reduced insulin resistance and reduced severity of liver disease; it did not resolve NAFLD

Mediterranean diet decreases fatty liver deposits in NAFLD at 6 months.

The fastest growing liver disease today is NAFLD, which is a direct result of the rising obesity epidemic.  This is a good review of the current understanding on the pathophysiology of NAFLD.

Despite evidence that non-smoking, normal BMI, regular exercise, high fruit/vegetable intake and low/moderate alcohol intake, less than 1% of men change lifestyle.  Translation:  many don't want health even when presented with evidence of its benefits and the means to achieve it.   This study found a decrease in cognitive decline in individuals undergoing these lifestyle changes.

PCBs, Pb, and Hg associated with elevated liver enzymes, and non-alcohol fatty liver disease.  

gut microbiome plays a role in metabolic syndrome, IR and it should come as no surprise--NAFLD

great read on how HCFS has significantly contributed to the obesity epidemic and the new epidemic of NAFLD

Low Testosterone increased nonalcoholic fatty liver disease in men. The prevalence of NAFLD reached 85% with Total Testosterone was < 300 ng/dl.  Free Testosterone required a greater drop to increase the NAFLD, but it to still was found to be associated.

Oral NAC useful for elevated liver enzymes in NAFLD

Lower Testosterone associated with increased prevalence of NAFLD in men.   Higher Testosterone levels did not reduce or reverse progression of NAFLD in men. This points to Testosterone as just one piece of the metabolic puzzle in metabolic syndrome, NAFLD... in men.