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Nathan Goodyear

When and how to evaluate mildly elevated liver enzymes in apparently healthy patients - 0 views

ccjm.org/195.full

elevated liver enzymes non-alcoholic fatty disease (NAFLD)

shared by Nathan Goodyear on 05 Mar 12 - No Cached
  • Nathan Goodyear on 05 Mar 12
     
    with an estimated 25% of Americans with non-alcoholic fatty liver disease (NAFLD), elevated liver enzymes are becoming a more common finding.  Nice review article on what the tests mean and what disease are underlying.
Nathan Goodyear

The antioxidant effects of vitamin C on liver enzymes: aspartate aminotransferase, alan... - 0 views

www.pagepressjournals.org/...1170

vitamin C liver enzymes antioxidant

shared by Nathan Goodyear on 18 Sep 13 - No Cached
  • Nathan Goodyear on 18 Sep 13
     
    Vitamin C, in oral route, prevents elevations in liver enzymes after liver insult from Paraquat.
Nathan Goodyear

Antioxidants as Therapeutic Agents for Liver Disease - 0 views

www.ncbi.nlm.nih.gov/...PMC3228367

IV vitamin C IV intravenous C antioxidant therapy antioxidants hepatitis liver

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    This study concludes that evidence is small and inadequate despite consistent reductions of elevated liver enzymes.  The review of the data here includes both IV and oral therapy.  These modalities are not comparable.  IV vitamin C has been shown to reduce elevated liver enzymes where oral does not.
Nathan Goodyear

Transaminase Levels and Vigorous Exercise - 0 views

www.ncbi.nlm.nih.gov/...PMC3104191

exercise liver enzymes

shared by Nathan Goodyear on 14 Mar 18 - No Cached
  • We accept 1–2 times the upper limit of normal to be attributable to exercise
  • Some physicians, whether they are gastroenterol-ogists or internists, forget that exercise can cause this abnormality
  • it is good for patients with liver disease to exercise, particularly those with fatty liver disease
  • ...4 more annotations...
  • we see a trend toward improved ALT and AST levels in patients performing moderate exercise, regardless of the etiology of their liver disease
  • We therefore discourage very heavy exercise in these patients, but a moderate amount does not cause a problem
  • once enzymes are abnormal, they remain abnormal for up to 1 week. Were subjects to exercise vigorously again during that week, transaminase levels could increase further
  • there is a ratio that in healthy individuals is considered normal. AST levels normally measure at approximately 0.8 of ALT levels. A dysregularity of this ratio can also signal hepatic illness but usually inflammation of any kind affects both measures
  • Nathan Goodyear on 14 Mar 18
     
    Vigorous exercise yields abnormal liver enzymes.  How one defines vigorous exericse is going to vary from person to person.
Nathan Goodyear

A case of amoxicillin-induced hepatocellular liver injury with bile-duct damage - 0 views

www.ncbi.nlm.nih.gov/...PMC3304646

amoxil amoxicillin liver antiobioitic liver enzymes

shared by Nathan Goodyear on 16 Apr 15 - No Cached
  • Nathan Goodyear on 16 Apr 15
     
    amoxil induced liver injury manifest with elevated liver enzymes.
Nathan Goodyear

Long term administration of a licorice extract in the treatment of - 0 views

www.greenmedinfo.com/...patitis-c-effective-preventi-0

licorice licorice root extract liver enzymes liver cirrhosis liver Hepatitis C HCV hepatitis

shared by Nathan Goodyear on 10 Sep 14 - No Cached
  • Nathan Goodyear on 10 Sep 14
     
    Licorice root extract shown to significantly reduce liver enzymes in those with chronic hepatitis C and to prevent progression to liver cirrhosis.  
Nathan Goodyear

Unintended effects of statins from observational studies in the general population: sys... - 0 views

www.ncbi.nlm.nih.gov/...PMC3998050

statin therapy statins myopathy cholesterol side effects diabetes liver liver enzymes

shared by Nathan Goodyear on 19 Mar 15 - No Cached
  • A markedly increased risk of myopathy was observed
  • One cohort study (Women’s Health Initiative) of higher quality and larger sample size found stronger evidence of an increased risk of self-reported T2DM (OR=1.47; 95% CI 1.32 to 1.64) for the groups of women who reported statin use at baseline and three years later
  • Hippisley-Cox et al. found an increased risk of liver enzyme changes
  • ...5 more annotations...
  • weak evidence of an increased risk of type 2 diabetes mellitus (T2DM) was observed
  • Smeeth et al. found an increased risk of incident liver disease in the first year after the index date
  • The cumulative incidence of T2DM after three years of statin treatment was 6.25%, corresponding to an excess risk of 2.25%
  • We found no increased risk of peripheral neuropathy, depression, common eye diseases, renal disorders or arthritis associated with taking statins. Studies of higher quality did not show previously reported protective effects of statins on fractures, venous thrombo-embolism or pneumonia
  • There was evidence of an increase in myopathy, raised liver enzymes and diabetes.
  • Nathan Goodyear on 19 Mar 15
     
    Statin use associated with increased myopathy, liver dysfunction, and type II Diabetes.  The authors conclude that the absolute risk is very low, yet OR was 1.47 for type II Diabetes (translated 47% increased odds of developing Diabetes as a result of statins) and OR of 2.63 in risk of myopathy (translated 163% increased odds of developing myopathy as a result of statins).  Seems the authors "low risk" statement is just applies to those without symptoms/side effects.  Physicians need to do a better job of understanding risks and customizing therapies.
Nathan Goodyear

N-Acetylcysteine Improves Liver Function in Patients with Non-Alcoholic Fatty Liver Dis... - 0 views

www.ncbi.nlm.nih.gov/...PMC3270338

NAC N-acetylcysteine NAFLD non-alcoholic fatty liver fatty liver liver enzymes

shared by Nathan Goodyear on 17 Jul 18 - No Cached
  • Nathan Goodyear on 17 Jul 18
     
    Oral NAC useful for elevated liver enzymes in NAFLD
Nathan Goodyear

Cases Journal | Full text | Sudden elevation of liver enzymes in a 64-year-old patient:... - 0 views

www.casesjournal.com/...205

antibiotics amoxicillin clarithromycin liver enzymes liver hepatitis

shared by Nathan Goodyear on 16 Apr 15 - No Cached
  • Nathan Goodyear on 16 Apr 15
     
    case study of elevated liver enzymes induced by antibiotics.
Nathan Goodyear

Effects of vitamin C on liver enzymes an... [Gen Physiol Biophys. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15900086

liver enzymes vitamin C hepatocellular injury

shared by Nathan Goodyear on 15 Oct 11 - No Cached
  • Nathan Goodyear on 15 Oct 11
     
    Vitamin C protects the liver against injury and lowers enzymes
Nathan Goodyear

AmeliorativeEffect ofVitaminC on Serum Liver Enzymes in Lead-Induced Toxicity in Wistar... - 0 views

www.dropbox.com/...IV%20vitamin%20C

IV vitamin C IV intravenous vitamin C hepatitis liver disease Pb toxicity

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    Study in Wistar Rats finds that IV vitamin C reduces the liver damage (manifested through elevated liver enzymes) associated with lead toxicity.
Nathan Goodyear

[Glutathione in the treatment of ch... [Recenti Prog Med. 1995 Jul-Aug] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7569285

IV glutathione detoxification fatty liver disease NAFLD

shared by Nathan Goodyear on 10 Nov 11 - No Cached
  • Nathan Goodyear on 10 Nov 11
     
    high dose IV glutathione shown to reduce liver enzymes and thus liver cell damage in those with chronic fatty liver disease
Nathan Goodyear

Role of Polymorphic Human Cytochrome P450 Enzymes in Estrone Oxidation - 0 views

cebp.aacrjournals.org/...551.long

estrogen metabolism estrogen metabolites cytochrome P450 estrogen estrone hormones detoxification metabolites

shared by Nathan Goodyear on 11 Sep 15 - No Cached
  • CYP1A1 and CYP1B1 are not expressed in any significant quantity in the liver. Therefore, they would not be expected to contribute to the overall systemic metabolism of estrone. However, both enzymes have been identified in breast tissue
  • CYP1A1 displayed relatively high activity for all three hydroxylations, suggesting that it may play an important role in extrahepatic tissues where it is expressed
  • CYP1A1 was more active with regard to 2-hydroxylation and 4-hydroxylation, it also displayed one of the greatest 16α-hydroxylating activities of the CYP enzymes tested.
  • ...4 more annotations...
  • CYP1B1 displayed a high affinity for estrone and preferentially catalyzed 4-hydroxylation over 2-hydroxylation
  • CYP1B1 did not seem to contribute to 16α-hydroxylation.
  • CYP1B1 was shown to preferentially catalyze 4-hydroxylation, whereas CYP1A1 was shown to preferentially catalyze 2-hydroxylation
  • Among the CYP enzymes expressed in the liver, CYP1A2 was the most active with regard to 2-hydroxylation
  • Nathan Goodyear on 11 Sep 15
     
    good discussion of estrogen metabolism and the P450 enzymes.
Nathan Goodyear

World J Gastroenterol - 0 views

www.wjgnet.com/...5317.htm

hepatitis IV vitamin C IV intravenous vitamin C glutathione B-complex HCV

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    IV antioxidant mixture of vitamin C, glutathione, glycyrrhiza, and B-complex reduces liver enzymes.  Arm taking only oral shows no decline in liver enzymes.
Nathan Goodyear

When and how to evaluate mildly elevated liver enzymes in apparently healthy patients - 0 views

www.ccjm.org/...195.full

AST ALT liver enzymes

shared by Nathan Goodyear on 10 Jun 14 - No Cached
  • Nathan Goodyear on 10 Jun 14
     
    Nice review of elevated liver enzymes.
Nathan Goodyear

Prevalence and Predictors of Abnormal Liver Enzymes in Young Women with Anorexia Nervosa - 0 views

www.ncbi.nlm.nih.gov/...PMC2561189

anorexia liver enzymes malnutrition women nutrition

shared by Nathan Goodyear on 20 Jul 15 - No Cached
  • Nathan Goodyear on 20 Jul 15
     
    liver enzymes inversely associated with body fat in women with anorexia.
Nathan Goodyear

Effects of vitamin C and E on liver enzymes ... [Vet Hum Toxicol. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15303390

liver enzymes vitamin C hepatocellular damage injury toxin

shared by Nathan Goodyear on 15 Oct 11 - No Cached
  • Nathan Goodyear on 15 Oct 11
     
    vitamin c prevented increase in liver enzymes from aflatoxin
Nathan Goodyear

http://worldsciencepublisher.org/journals/index.php/JOS/article/viewFile/1186/899 - 0 views

worldsciencepublisher.org/...899

lead Pb IV vitamin C intravenous liver enzymes

shared by Nathan Goodyear on 31 Mar 14 - No Cached
  • Nathan Goodyear on 31 Mar 14
     
    IV vitamin C shown to decrease elevated liver enzymes in rat model of lead induced liver toxicity.
Nathan Goodyear

Polychlorinated Biphenyls, Lead, and Mercury Are Associated with Liver Disease in Ameri... - 0 views

www.ncbi.nlm.nih.gov/...PMC3002193

NAFLD liver enzymes disease non-alcoholic fatty liver PCBs Lead Mercury Hg Pb

shared by Nathan Goodyear on 31 Mar 14 - No Cached
  • Nathan Goodyear on 31 Mar 14
     
    full article that revealed PCBs, Lead, and Mercury associated with elevated liver enzymes and NAFLD.
Nathan Goodyear

Polychlorinated biphenyls, lead, and... [Environ Health Perspect. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21126940

PCBs polychlorinated biphenyls Pb Hg Mercury Lead liver enzymes damage NAFLD fatty

shared by Nathan Goodyear on 31 Mar 14 - No Cached
  • Nathan Goodyear on 31 Mar 14
     
    PCBs, Pb, and Hg associated with elevated liver enzymes, and non-alcohol fatty liver disease.  
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