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Nathan Goodyear

Changes in the number of astrocytes and micr... [Neurotoxicology. 1996] - PubMed - NCBI - 0 views

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    low methylmercury shown to accumulate in the brains of monkeys in the form of inorganic mercury.  Specifically, astrocytes and microglial cells accumulated the inorganic mercury.  Long-term low exposure can result in neuro-accumulation of inorganic mercury and neurotoxicity.
Nathan Goodyear

Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury... - 0 views

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    Animal study finds that methyl Hg is not useful in determining effects of ethyl mercury.  According to this study, the conclusion is that the ethyl Mercury from Thimerosal is converted to inorganic Hg as evident in the results.  So, in essence, the ethyl mercury, considered less toxic than methyl mercury, is converted to inorganic Mercury a more toxic compound.  The results of the study revealed a higher % of inorganic Hg in the brains of those exposed to thimerosal to those exposed to methylMercury.
Nathan Goodyear

ScienceDirect - Environmental Research : Inorganic arsenic exposure and type 2 diabetes... - 0 views

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    Arsenic exposure, inorganic, shown to be diabetogenic.
Nathan Goodyear

http://www.epa.gov/teach/chem_summ/mercury_inorg_summary.pdf - 0 views

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    EPA paper on inorganic Mercury.
Nathan Goodyear

Mercury Levels in Newborns and Infants After Receipt of Thimerosal-Containing Vaccines - 0 views

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    good letter to the editor on the accumulation of inorganic Hg in the brain from Thimerosal.
Nathan Goodyear

Chronic inorganic mercury induced peripheral neuropathy. - PubMed - NCBI - 0 views

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    Only abstract available: chronic inorganic Hg associated with demyelinating sensorimotor polyneuropathy.  The exposure in this case study was through herbal supplements.
Nathan Goodyear

Occupational mercury exposure and its consequences... [Int Arch Occup Environ Health. 1... - 0 views

  • Mercury is a known neurotoxin
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    inorganic effects of mercury on behaviour and cognitive function
Nathan Goodyear

Accumulation of methylmercury and inorganic mercury in the brain - Springer - 0 views

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    Mercury does bioaccumulate in the brain.  This is important as Hg is a significant neurotoxin.
Nathan Goodyear

Saliva--a diagnostic window to the body, both in h... [J Med Life. 2009 Apr-Jun] - PubM... - 0 views

  • Saliva includes a large number of inorganic and organic compounds, which act as a "mirror of the body's health."
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    saliva testing is broad in its diagnostic potential
Nathan Goodyear

Arsenic Exposure and Prevalence of Type 2 Diabetes in US Adults, August 20, 2008, Navas... - 0 views

  • After adjustment for biomarkers of seafood intake, total urine arsenic was associated with increased prevalence of type 2 diabetes. This finding supports the hypothesis that low levels of exposure to inorganic arsenic in drinking water, a widespread exposure worldwide, may play a role in diabetes prevalence
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    Arsenic and type 2 Diabetes link
Nathan Goodyear

1210_article_14 - 0 views

  • These modulatory effects - which most likely involve binding with functional thiol residues - are interwoven with neurotoxic actions of both mercurials.
  • THIM is metabolized in the body to ethyl mercury (EtHg) and subsequently to inorganic mercury forms, which accumulate in tissues of vital organs, including the brain (22). Information about neurochemical and neurotoxic effects of THIM is still limited, but the existing data indicate that in pharmacodynamics and toxicity THIM/EtHg does not differ significantly from methyl mercury (MeHg), which has been studied more extensively, although these compounds differ somewhat in pharmacokinetics (8).
  • Several studies documented that the neurotoxic effects of mercurials involve glutamate-mediated excitotoxicty, due to their ability to inhibit uptake of glutamate in astrocytes, resulting in an increase of the extracellular level of this excitatory amino acid
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    neurotoxic effects of thimerosal
Nathan Goodyear

Chemical toxins: a hypothesis to explain the globa... [J Altern Complement Med. 2002] -... - 0 views

  • Because the obesity epidemic occurred relatively quickly, it has been suggested that environmental causes instead of genetic factors maybe largely responsible
  • exponential production and usage of synthetic organic and inorganic chemicals. Many of these chemicals are better known for causing weight loss at high levels of exposure but much lower concentrations of these same chemicals have powerful weight-promoting actions.
  • his paper presents a hypothesis that the current level of human exposure to these chemicals may have damaged many of the body's natural weight-control mechanisms. Furthermore, it is posited here that these effects, together with a wide range of additional, possibly synergistic, factors may play a significant role in the worldwide obesity epidemic.
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    Toxins as chemical cause of obesity problem?
Nathan Goodyear

Occupational Lead Poisoning - February 15, 1998 - American Family Physician - 0 views

  • The freely diffusible plasma fraction is distributed extensively throughout tissues, reaching highest concentrations in bone, teeth, liver, lungs, kidneys, brain and spleen
  • Inorganic lead does not undergo any metabolic transformation or digestion in the intestines, or detoxification in the liver.5
  • With chronic exposure over a long period of time, most absorbed lead ends up in bone
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  • The total bodily content of lead is called the body burden; in a steady state, about 90 percent of the body burden is bound to bone.2
  • n general, lead is excreted quite slowly from the body (with the biologic half-life estimated at 10 years). Since excretion is slow, accumulation in the body occurs easily.2
  • hronic toxicity is an insidious illness with protean manifestations.3,6 Symptoms may include arthralgias, headache, weakness, depression, loss of libido, impotence and vague gastrointestinal difficulties.
  • Late effects may include chronic renal failure, hypertension, gout and chronic encephalopathy.6
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    occupational lead poisoning
Nathan Goodyear

Muscle Hypertrophy 2011 - 0 views

  • mechanical tension, muscle damage and metabolic stress are the three primary factors that promote hypertrophy from exercise
  • The mechanical tension is directly related to intensity of the exercise, which is the key to stimulating muscle growth
  • Muscle damage, that leads to muscle soreness, from exercise training initiates an inflammatory response, which activates satellite cells growth processes
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  • metabolic stress that is a result of the byproducts of anaerobic metabolism (i.e., hydrogen ions, lactate, inorganic phosphates) is now also believed to promote hormonal factors leading to muscle hypertrophy
  • The upper extremities tend to show more growth earlier then the lower body
  • Maximal growth occurs with loads between 80-95% of 1 repetition maximum
  • weightlifters and powerlifters show more favorable hypertrophy of type II (fast twitch) muscle fibers
  • body builders appear to have comparable hypertrophy in both the type I (slow twitch) and type II muscle fibers
  • Multi-joint exercises have been shown to produce larger increases of anabolic hormones than single-joint exercises
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    Review of the physiology of muscle building.  The authors review the evidence behind the types of muscle building exercises and the physiology responsible for muscle hypertrophy.  The authors point to Schoenfeld's description of mechanical tension, muscle damage, and metabolic stress to build muscle.
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