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Nathan Goodyear

Importance of TNF-alpha and leptin in obesity and ... [Exerc Immunol Rev. 1998] - PubMe... - 0 views

www.ncbi.nlm.nih.gov/...9644096

obesity leptin inflammation exercise

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • weight loss reduces adipose TNF-alpha expression and serum leptin levels and is associated with improved insulin sensitivity and lipid metabolism
  • Nathan Goodyear on 08 Mar 11
     
    weight loss reduces adipose inflammation signaling, TNF-alpha expression, and serum leptin levels and is associated with improved insulin sensitivity and lipid metabolism.
Nathan Goodyear

» Blog Archive » 'Bad' Cholesterol Not As Bad As People Think, Shows Texas A&... - 0 views

tamunews.tamu.edu/...ple-think-shows-texas-am-study

cholesterol HDL LDL

shared by Nathan Goodyear on 10 May 11 - No Cached
  • he bottom line is that LDL – the bad cholesterol – serves as a reminder that something is wrong and we need to find out what it is
  • “It gives us warning signs. Is smoking the problem, is it diet, is it lack of exercise that a person’s cholesterol is too high? It plays a very useful role, does the job it was intended to do, and we need to back off by always calling it ‘bad’ cholesterol because it is not totally bad.”
  • Nathan Goodyear on 10 May 11
     
    LDL cholesterol is not all bad; it is a warning signal.  We just need to be listening.
Nathan Goodyear

L-Arginine Potentiates Fat Loss ( May 2011) Townsend Letter for Doctors & Patients - 0 views

www.townsendletter.com/...exercise0511.html

L-Arginine fat loss weight obesity obese overweight

shared by Nathan Goodyear on 09 Jul 11 - No Cached
  • Nathan Goodyear on 09 Jul 11
     
    L-Arginine helps preserve muscle mass and increase fat loss.  This has enormous implications in maintaining weight loss long-term
Nathan Goodyear

Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet... - 0 views

ajpendo.physiology.org/...E906.full

L-Arginine weight loss diet overweight obesity insulin-resistant diabetic patients

shared by Nathan Goodyear on 09 Jul 11 - No Cached
  • L-arginine supplementation further decreased FM (P < 0.05) and waist circumference (P < 0.0001), preserving FFM (P < 0.03), and improved mean daily glucose profiles (P < 0.0001) and fructosamine (P < 0.03). Moreover, change in area under the curve of cGMP (second messenger of nitric oxide; P < 0.001), superoxide dismutase (index of antioxidant capacity; P < 0.01), and adiponectin levels (P < 0.02) increased, whereas basal endothelin-1 levels (P < 0.01) and leptin-to-adiponectin ratio (P < 0.05) decreased in the L-arginine group.
  • Nathan Goodyear on 09 Jul 11
     
    L-Arginine helps to preserve muscle, while increase fat loss.  This will help to prevent fat rebound in weight loss programs.  Additionally, insulin resistance improved.
Nathan Goodyear

Testosterone deficiency and cardiovascular mortality Morgentaler A, - Asian J Androl - 0 views

www.ajandrology.com/preprintarticle.asp

testosterone low t low Testosterone CVD cardiovascular mortality therapy

shared by Nathan Goodyear on 01 Dec 14 - No Cached
  • overall mortality and CV mortality were inversely associated with serum T concentrations.
  • men with low serum T, defined as < 8.7 nmol l−1 (250 ng dl−1 ), demonstrated significantly greater all-cause mortality than men with higher serum T (hazard ratio [HR]: 2.24; 95% CI: 1.41-3.57), as well as greater CV mortality
  • lower T levels were significantly associated with the presence of any CV disease
  • ...19 more annotations...
  • more than 30 years of studies suggesting that low levels of T represent an increased risk for CV and overall mortality,
  • lower serum T concentrations also are associated with CV disease, including incident coronary artery disease [17],[18],[19] and atherosclerosis,
  • the actual rate of adverse events was only half as great in the T group (123 events in 1223 men at risk = 10.1%) as in the untreated group (1587 events in 7486 men = 21.2%)
  • The study by Vigen et al. [7] has already undergone two published corrections,
  • 29 medical societies have called for retraction of the article, asserting "gross data mismanagement and contamination," that rendered the study "no longer credible
  • Mortality in T-treated men was reduced by approximately half in treated men compared with untreated men, at 10.3% versus 20.7%, respectively
  • The mortality rate for men who received TTh was 3.4 deaths per 100 person-years, and 5.7 deaths per 100 person-years in untreated men
  • HR of 0.61 (95%CI: 0.42-0.88; P = 0.008), indicating a significant reduction in mortality with TTh
  • men in the highest prognostic MI risk quartile, treatment with TTh was associated with reduced risk
  • tripling in T prescriptions in the US over the last decade
  • a majority of observational studies have found that low endogenous serum T levels are associated with increased mortality.
  • Men who received TTh were able to exercise significantly longer without ischemia compared with men who received placebo
  • In men with congestive heart failure, those who received T demonstrated greater walking distance and other functional endpoints compared with those who received placebo
  • TTh has been shown uniformly and repeatedly to improve several known CV risk factors, including reduced fat mass, body fat percent, and waist circumference, and increased lean mass
  • improved glycemic control
  • reductions in insulin resistance.
  • the evidence strongly points to improved CV status with normal serum T or treatment with TTh in men with TD
  • analysis of health insurance claims data that reported a 36% increased rate of nonfatal MI in the 90d following receipt of a T prescription compared with the 12 prior months.
  • Comparison with men who received a prescription for a phosphodiesterase type 5 inhibitor (PDE5i) revealed no increased rate of MI following the prescription
  • Nathan Goodyear on 01 Dec 14
     
    Great review by Morgentaler of Testosterone and CVD.  He highlights the significant flaws in the JAMA and the NEJM articles of Testosterone therapy risks.  Morgentaler highlights the significant evidence that points to low T and increased risk of CVD. On contention I have, is Morgantaler seems to flip aside the massive uptick of Testosterone use in the US as compared to other countries.  The evidence definitely points to Testosterone therapy as being safe in those with low T, but there is definitely a problem of significant Testosterone doping that is taking place as well.
Nathan Goodyear

Greater survival after breast cancer in physically active women wit... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17557947

breast cancer nutrition cancer diet exercise

shared by Nathan Goodyear on 06 Jan 15 - No Cached
  • Nathan Goodyear on 06 Jan 15
     
    Study finds that 5+ daily servings of fruits/vegetables and 30 mins walking 6 days/week is associated with improved survival in women with breast cancer.
Nathan Goodyear

Marathons damage the hearts of less fit runners for up to three months - - Heart and St... - 0 views

www.heartandstroke.nb.ca/...content2.aspx

endurance training running runners marathon marathons heart health CVD exercise

shared by Nathan Goodyear on 09 Jan 15 - No Cached
  • Nathan Goodyear on 09 Jan 15
     
    Summary of 2010 report on marathons and the heart.  Less fit runners can do significant damage to the heart i.e. fibrosis compared to fit runners.  V02 max is a good way to assess aerobic endurance and differentiate between the two.  Dr Larose showed via MRI that it can take 3 months for the heart to recover.
Nathan Goodyear

http://shammer-irsc.weebly.com/uploads/1/9/8/6/19866071/ibuprofen_use_endotoxemia_inxam... - 0 views

shammer-irsc.weebly.com/...ation_and_plasma_cytokines.pdf

ibuprofen marathons exercise ultra-marathons elite athletes endurance training runners running inflammation CRP cytokines

shared by Nathan Goodyear on 09 Jan 15 - No Cached
  • Nathan Goodyear on 09 Jan 15
     
    ibuprofen provided no reduction in muscle damage/soreness in 29 ultra marathoners.  However, LPS, CRP, IL-6, IL-10, IL-8, IL-1ra, GSF, MCP-1, and MIP-1beta were increased in the ibuprofen group.  TNF-alpha was unaffected.
Nathan Goodyear

The endurance athletes heart: acute stress and chronic adaptation -- George et al. 46 (... - 0 views

bjsm.bmj.com/...i29.full

heart health endurance athletes endurance exercise athletes athletic heart

shared by Nathan Goodyear on 10 Jan 15 - No Cached
  • Nathan Goodyear on 10 Jan 15
     
    acute and chronic heart changes to endurance training/events.
Nathan Goodyear

The effects of an acute dose of Rhodiola... [J Strength Cond Res. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23443221

rhodiola rhodiola rosea endurance exercise

shared by Nathan Goodyear on 23 Aug 14 - No Cached
  • Nathan Goodyear on 23 Aug 14
     
    rhodiola improves endurance performance.
Nathan Goodyear

Using testosterone and cortisol as bioma... [J Strength Cond Res. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25144130

Total Testosterone cortisol testosterone:cortisol hormone hormones performance exercise stress

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Study followed Total Testosterone:Cortisol ratios to monitor catabolic/anabolic states in basketball players.  The authors followed serum levels and monitored them 24-36 hours post game.  Those playing > 25 min/game had the lowest TT:C and highest cortisol indicating a catabolic state and making recovery critical.
Nathan Goodyear

Idiopathic hypogonadotropic hypogonadism in a ... [Fertil Steril. 1997] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9093212

clomid HPA hypothalmus pituitary low T Testosterone male men hormone hormones endurance exercise athlete

shared by Nathan Goodyear on 24 Jul 14 - No Cached
  • Nathan Goodyear on 24 Jul 14
     
    Case study finds clomid restores HPA function and normalizes Testosterone production in HPA suppressed endurance athlete.
Nathan Goodyear

Leisure-Time Running Reduces All-Cause and Cardiovascular Mortality Risk - 0 views

www.sciencedirect.com/...S0735109714027466

runners running cardiovascular risk mortality exercise cardio heart health

shared by Nathan Goodyear on 29 Jul 14 - No Cached
  • Nathan Goodyear on 29 Jul 14
     
    Runners have a 30% lower all-cause mortality and a 45% cardiovascular mortality compared to non-runners in study.  What is interesting, is that only 5-10 minutes a day at very slow speeds is all that is required to receive these benefits.  As other studies have now shown, more is not necessarily better.
Nathan Goodyear

Hormonal response to L-arginine supplementation in physically active individuals - 0 views

www.ncbi.nlm.nih.gov/...PMC3967014

Arginine HGH growth hormone IGF-1 insulin exercise

shared by Nathan Goodyear on 30 Jun 14 - No Cached
  • Nathan Goodyear on 30 Jun 14
     
    Small study finds that Arginine supplementation has no effect on HGH, IGF-1, and insulin secretion in runners.
Nathan Goodyear

Age-related hormonal adaptations, muscle circumference and strength development with 8w... - 0 views

www.biomedsearch.com/...23337018.html

resistance training resistance training exercise strength muscle Testosterone GH growth hormone ACTH cortisol hormone hormones men male

shared by Nathan Goodyear on 03 Sep 14 - No Cached
  • Nathan Goodyear on 03 Sep 14
     
    Moderate resistance training program over 8 weeks associated with increased Testosterone production in young and middle age lean men.  Growth hormone was also increased in both groups.  ACTH and cortisol decreased in this lean men.  
Nathan Goodyear

Effect of saline infusion on body temperature and endurance during ... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2745343

IV intravenous fluid nutrition athlete athletes exercise

shared by Nathan Goodyear on 13 Jan 15 - No Cached
  • Nathan Goodyear on 13 Jan 15
     
    to be read
Nathan Goodyear

Physical activity and all-cause mortality across levels of overall and abdominal adipos... - 0 views

ajcn.nutrition.org/...ajcn.114.100065

exercise health wellness lifestyle walking EPIC

shared by Nathan Goodyear on 20 Jan 15 - No Cached
  • Nathan Goodyear on 20 Jan 15
     
    New study finds that inactive lifestyle leads to more early deaths than obesity.  Of course, the 2 are interrelated.  The study found a 16-30% reduction in early death due to 20 minutes of walking daily.  This came from analysis of the EPIC study
Nathan Goodyear

International Journal of Impotence Research - Obesity, low testosterone levels and erec... - 0 views

www.nature.com/...ijir200842a.html

low T low Testosterone men male hormone hormones ED erectile dysfunction Testosterone diabetes metabolic syndrome obesity

shared by Nathan Goodyear on 27 Jan 15 - No Cached
  • Studies have shown that ED may be an early biomarker of general endothelial dysfunction, atherosclerosis and CVD
  • testosterone treatment of hypogonadal young and older men improves sexual function, increases lean mass and decreases fat mass
  • In men with low serum testosterone (for example, <8 or 230 nmol l−1) with obesity, metabolic syndrome and diabetes mellitus, treatment with testosterone is warranted
  • ...12 more annotations...
  • In obese middle-aged men, testosterone treatment reduced visceral adipocity, insulin resistance, serum cholesterol and glucose levels
  • testosterone replacement has a favorable impact on body mass, insulin secretion and sensitivity, lipid profile and blood pressure in hypogonadal men with the metabolic syndrome as well as type 2 diabetes mellitus
  • Testosterone significantly inhibits lipoprotein lipase activity, which reduces triglycerides uptake into adipocytes in the abdominal adipose tissue
  • testosterone treatment decreased endogenous inflammatory cytokines (tumor necrosis factor-α and IL-1β) and lipids (total cholesterol) and increased IL-10 in hypogonadal men
  • Testosterone treatment reduced leptin and adiponectin levels in hypogonadal type 2 diabetic men after 3 months of testosterone replacement
  • available data clearly show a relationship between obesity, low testosterone levels and ED
  • Obesity adversely affects endothelial function and lowers serum testosterone levels through the development of insulin resistance and metabolic syndrome
  • Metabolic disturbances as well as production of cytokines and adipokines by inflamed fat cells may be causal factors in the development of ED
  • The onset of ED and the associated risk of CVD may be delayed through lifestyle modifications that affect obesity, such as diet and exercise
  • Very low testosterone levels contribute to the development of ED in obesity, metabolic syndrome and type 2 diabetes mellitus
  • Obesity is associated with low total testosterone levels that can be explained at least partially by lower sex hormone-binding globulin (SHBG) in obese men
  • epidemiological studies have shown a negative correlation between BMI and total testosterone and to a lesser extent with free and bioavailable (biologically active) testosterone levels
  • Nathan Goodyear on 27 Jan 15
     
    Obesity is associated with low Testosterone and ED in men.
Nathan Goodyear

Dysnatremia predicts a delayed recovery in collapsed ultramarathon ... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17620783

hyponatremia hypernatremia ultramarathon runners endurance athletes endurance exercise IV fluids athletes

shared by Nathan Goodyear on 27 Jan 15 - No Cached
  • Nathan Goodyear on 27 Jan 15
     
    The majority of ultra marathon runners deal with hypernatremia versus hyponatremia.  The majority were normonatremic.  Intravenous fluids can more rapidly resolve hypernatremia versus oral liquids and serves as useful means to reduce hypernatremia when oral liquids proves intolerable.
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