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Nathan Goodyear

Estradiol, but not testosterone, heightens cortisol-mediated negative feedback on pulsa... - 0 views

ajpregu.physiology.org/...R627

Testosterone Estradiol hormone hormones cortisol ACTH stress

shared by Nathan Goodyear on 04 Apr 15 - No Cached
  • Nathan Goodyear on 04 Apr 15
     
    INteresting.  Estradiol enhances cortisol negative feedback on ACTH production in both men and women.
Nathan Goodyear

ACTH-secreting pituitary microadenomas... [Clin Endocrinol (Oxf). 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22587880

saliva salivary hormone hormones cortisol microadenomas hypothyroidism hypothyroid ACTH

shared by Nathan Goodyear on 26 Sep 12 - No Cached
  • Nathan Goodyear on 26 Sep 12
     
    Individuals with ACTH secreting microadenomas have a higher incidence of hypothyroidism and should be evaluated. This only makes physiologic sense, knowing the impact on 5'deiodinase, and TSH production. Also of importance, is the methodology of cortisol evaluation.  They used salivary cortisol levels to follow.  This study was conducted at John Hopkins school of Medicine, Division of Endocrinology.  Some how others here in Louisiana have missed this (Namely LSBME and BCBS).
Nathan Goodyear

Cortisol inhibition of vasopressin and ACTH res... [Am J Physiol. 1990] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2154137

cortisol ACTH vasopressin hormone hormones

shared by Nathan Goodyear on 06 Aug 13 - No Cached
  • Nathan Goodyear on 06 Aug 13
     
    negative feedback of cortisol on pituitary ACTH and vasopressin release.  Animal study, but shows the central feedback of cortisol on the pituitary.
Nathan Goodyear

Age-related hormonal adaptations, muscle circumference and strength development with 8w... - 0 views

www.biomedsearch.com/...23337018.html

resistance training resistance training exercise strength muscle Testosterone GH growth hormone ACTH cortisol hormone hormones men male

shared by Nathan Goodyear on 03 Sep 14 - No Cached
  • Nathan Goodyear on 03 Sep 14
     
    Moderate resistance training program over 8 weeks associated with increased Testosterone production in young and middle age lean men.  Growth hormone was also increased in both groups.  ACTH and cortisol decreased in this lean men.  
Nathan Goodyear

Exercise and circulating cortisol levels... [J Endocrinol Invest. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18787373

Cortisol exercise hormone hormones ACTH high intensity training low intensity testing

shared by Nathan Goodyear on 03 Aug 14 - No Cached
  • Nathan Goodyear on 03 Aug 14
     
    Study finds moderate and high intensity exercise associated with an elevated ACTH and serum Cortisol.
Nathan Goodyear

HPA Axis Reactivity and Lymphocyte Glucocorticoid Sensitivity in Fibromyalgia Syndrome ... - 0 views

www.psychosomaticmedicine.org/...65.abstract

fibromyalgia saliva salivary cortisol urinary metabolites stress HPA

shared by Nathan Goodyear on 24 Apr 12 - No Cached
  • Nathan Goodyear on 24 Apr 12
     
    Individuals with Fibromyalgia shown to have lowered salivary cortisol levels.  This study suggested that this could be due to reduced adrenal reactivity to ACTH.  Another thought, is there increased metabolism of cortisol in these clients.  This would be found in the urinary metabolites.
Nathan Goodyear

Low early morning plasma cortisol in posttraumatic stress disorder is associated with c... - 0 views

www.sciencedirect.com/...S0306453009002509

PTSD low cortisol stress disorder depression

shared by Nathan Goodyear on 03 Feb 12 - No Cached
  • Nathan Goodyear on 03 Feb 12
     
    Low cortisol found in those with PTSD.  This study suggest the high ACTH/cortisol ratio is not due to enhanced peripheral sensitization to glucocorticoids.
Nathan Goodyear

HPA axis changes during the initial phase of psychosocial stressor exposure in male mice - 0 views

joe.endocrinology-journals.org/...193.abstract

HPA stress cortisol pituitary metabolism hormone hormones

shared by Nathan Goodyear on 24 Jul 13 - No Cached
  • Nathan Goodyear on 24 Jul 13
     
    Stress response in a animal model is blunted at the level of pituitary through a decrease in ACTH release and through increase in peripheral metabolism
Nathan Goodyear

Association of Hypertension and Hypokalemia with Cushing's Syndrome Caused by Ectopic A... - 0 views

onlinelibrary.wiley.com/...85BD06C2AC6C2355181DC95.d02t04

hypokalemia low potassium cortisol

shared by Nathan Goodyear on 24 Apr 12 - No Cached
  • cortisol may act as a mineralocorticoid when in excess, perhaps by saturating the 11β-hydroxysteroid-dehydrogenase (11β-HSD2 enzyme) that inactivates cortisol at the renal tubule
  • high cortisol levels may be the principal cause of hypokalemic alkalosis
  • Nathan Goodyear on 24 Apr 12
     
    high cortisol, whether exogenous or endogenous, can have a mineral corticoid effect and resultant low potassium.
Nathan Goodyear

The Androgen 5α-Dihydrotestosterone and Its Metabolite 5α-Androstan-3β, 17β-D... - 0 views

www.jneurosci.org/...1448.full

DHT 3 beta androstanediol androgens Hypothalamus HPA hormones stress

shared by Nathan Goodyear on 15 Jul 15 - No Cached
  • Sex steroid hormones are primarily responsible for sex difference in adult HPA function; androgens inhibit whereas estrogens enhance HPA axis activation after a stressor
  • the PVN contains relatively high levels of AR (Bingaman et al., 1994; Zhou et al., 1994) and ERβ (Alves et al., 1998; Hrabovszky et al., 1998; Somponpun and Sladek, 2003) but is essentially devoid of ERα
  • the nonaromatizable androgen DHT and the nonselective ER ligand E2 influence HPA reactivity by acting on neurons within or surrounding the PVN
  • ...9 more annotations...
  • inhibitory action of DHT is detectable at both the level of hormone secretion as well as PVN c-fos mRNA expression
  • the inhibition can be mimicked by the DHT metabolite 3β-diol and by the subtype selective ERβ agonist DPN
  • E2 acts to enhance HPA reactivity
  • the ability of the ER antagonist tamoxifen, but not the AR antagonist flutamide, to block the inhibitory actions of DHT, speaks to the intracellular mechanism by which this inhibitory signal might be transduced.
    • Nathan Goodyear
      Nathan Goodyear on 15 Jul 15
       
      that is because the interaction with the DHT metabolite is not with the AR, but with the ER-beta.
  • the DHT metabolite 3β-diol and the ERβ-subtype-selective agonist DPN suppressed ACTH, corticosterone, and c-fos mRNA responses to restraint stress in a manner similar to DHT
  • metabolism of DHT to 3β-diol and subsequent binding to ERβ can be inhibitory to HPA reactivity, and this is one possible mechanism for the action of DHT.
  • Our data also suggest that E2 enhances the reactivity of the HPA axis to stress by acting on or near neurons of the PVN
  • the actions of E2 appear to be through an ERα-dependent mechanism
  • these studies suggest that ERβ, within the male hypothalamus, acts to inhibit the HPA axis and that the inhibitory effects of DHT may be, at least in part, via its intracellular conversion to 3β-diol and subsequent binding to ERβ
  • Nathan Goodyear on 15 Jul 15
     
    DHT metabolites: particularly 3beta-androstanediol inhibit HPA axis through ER-beta.
Nathan Goodyear

Salivary cortisol as a biomarker in stress researc... [Psychoneuroendocrinology. 2009] ... - 0 views

www.ncbi.nlm.nih.gov/...19095358

saliva salivary cortisol hormone testing HPA

shared by Nathan Goodyear on 13 Jul 11 - No Cached
  • psychobiological mechanisms, which trigger the hypothalamus-pituitary-adrenal axis (HPAA) can only indirectly be assessed by salivary cortisol measures. The different instances that control HPAA reactivity (hippocampus, hypothalamus, pituitary, adrenals) and their respective modulators, receptors, or binding proteins, may all affect salivary cortisol measures.
  • linear relationship with measures of plasma ACTH and cortisol in blood or urine does not necessarily exist
  • Nathan Goodyear on 13 Jul 11
     
    saliva cortisol testing is a better assessment tool for HPA axis function, compared to serum cortisol
Nathan Goodyear

Which Patients Do Not Require a GH Stimulation Test for the Diagnosis of Adult GH Defic... - 0 views

press.endocrine.org/...jcem.87.2.8216

HGH GH human growth hormone growth hormone IGF-1

shared by Nathan Goodyear on 04 Nov 14 - No Cached
  • Four studies have reported that the probability of GHD (peak GH criteria ranging from < 2.3 to < 5 μg/liter) in patients with three to four PHDs ranges from 91% to 100%
  • 95% accuracy by the presence of either three or more PHDs or a serum IGF-I concentration less than 84 μg/lite
  • adult GHD could be predicted with 95% accuracy by the presence of either three or four PHDs or a serum IGF-I concentration less than 84 μg/liter
  • ...5 more annotations...
  • Hypopituitary adults with GHD have been reported to have normal serum IGF-I levels in 37–70% of patients in various studies (5, 9, 18, 21, 22). This is owing in part to the fact that multiple factors regulate serum IGF-I concentrations including nutritional status; hepatic and renal function; and circulating concentrations of thyroid hormone, androgens, and estrogens
  • changes in concentrations of IGF-binding proteins (IGFBPs) influence the total concentration of IGF-I in plasma
  • Among patients with an IGF-I sd score above −1 in the present study, 46% had a peak GH less than 2.5 μg/liter and 67% had a peak GH less than 5 μg/liter.
  • In summary, adult GHD can be predicted with 95% accuracy by the presence of either three or four PHDs or a serum IGF-I concentration less than 84 μg/liter
  • We propose that adult patients with three or four PHDs (three or four of the following deficiencies: TSH, ACTH, gonadotropins [LH and/or FSH], and AVP [central diabetes insipidus]) do not require a GH stimulation test to make the diagnosis of adult GHD
  • Nathan Goodyear on 04 Nov 14
     
    Insulin Tolerance Test is the gold standard for HGH diagnosis, but this an unpopular test do to long list of side effects.  This study finds a 95% accuracy for IGF-1 less than 84 with 3 or more coexisting pituitary hormone deficiencies.
Nathan Goodyear

Corticosteroids: way upstream - 0 views

www.ncbi.nlm.nih.gov/...PMC2841592

HPA axis cortisol stress ACTH corticosteroids

shared by Nathan Goodyear on 03 Sep 17 - No Cached
  • Nathan Goodyear on 03 Sep 17
     
    Great read on the hypothalmo-pituitary-adrenal axis.  
Nathan Goodyear

Secondary Adrenal Insufficiency: An Overlooked Cause of Hyponatremia - 0 views

www.ncbi.nlm.nih.gov/...PMC4330026

adrenal insufficiency hyponatraemia sodium ADH cortisol CRH ACTH

shared by Nathan Goodyear on 25 Sep 17 - No Cached
  • Nathan Goodyear on 25 Sep 17
     
    Good case review of secondary adrenal insufficiency.  A common cause of low sodium and needs to be considered in elderly patients.  Also, low cortisol is associated with increased ADH.  In the case of adrenal insufficiency, the negative feed back of cortisol to the HPA is lost and recreation of CRH, which is an ADH secretagogue, will increase ADH secretion.
Nathan Goodyear

Low-Dose Chemotherapy with Insulin (Insulin Potentiation Therapy) in Combination with H... - 0 views

www.ncbi.nlm.nih.gov/...PMC3357525

prostate cancer IPTLD low-dose chemotherapy cancer chemotherapy insulin potentiation therapy LDMC low-dose metronomic chemotherapy IPT

shared by Nathan Goodyear on 25 Jan 18 - No Cached
  • The method of insulin potentiation therapy was empirically invented in 1930 from Mexican doctor D. Perez Garsia
  • increases the permeability of cell membrane
  • influences the metabolic processes in human body with the increase of the regenerating processes
  • ...9 more annotations...
  • facilitates the transport of intra and extra cellular liquids which helps the organism to eliminate the toxic products
  • The increased number of insulin receptors on the tumor cell, in comparison to the normal one, allows the before mentioned 2 factors to act predominantly
  • Increased permeability after the insulin effect on the cellular membrane results in increased intracellular quantity of antitumor agents
  • have other endocrine effects: directly stimulates suprarenal gland to produce epinephrine and glucocorticoid hormones and stimulates ACTH secretion. These endocrine effects also have a positive influence on the regenerating processes
  • Insulin influences the intracellular metabolism of the tumor cell, which leads to increase of the number of cells in phase S, where they are with highly sensitive to specific chemotherapeutics.
  • After the first 6 IPT applications overall (groups A and B) response to treatment on PSA criteria shows partial effect and stabilization in 12 of 16 (75%) patients
  • After the 10th IPTLD application or 3 months after starting treatment, complete response, partial response, and stabilization were observed in 4 of 9 (66.6%), while in 3 of 9 (33.3%) was registered complete effect
  • the advanced stage of disease in patients treated
  • Quality of life after the second IPTLD application is significantly improved
  • Nathan Goodyear on 25 Jan 18
     
    IPT found to be effextive in treated castrate-resistant prostate cancer.
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