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Nathan Goodyear

Marathons damage the hearts of less fit runners for up to three months - - Heart and St... - 0 views

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    Summary of 2010 report on marathons and the heart.  Less fit runners can do significant damage to the heart i.e. fibrosis compared to fit runners.  V02 max is a good way to assess aerobic endurance and differentiate between the two.  Dr Larose showed via MRI that it can take 3 months for the heart to recover.
Nathan Goodyear

Effect of Arnica D30 in marathon runners. Pooled ... [Homeopathy. 2003] - PubMed - NCBI - 0 views

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    Arnica found to lower muscle soreness after marathons, but not found to lower cell damage markers.
Nathan Goodyear

http://shammer-irsc.weebly.com/uploads/1/9/8/6/19866071/ibuprofen_use_endotoxemia_inxam... - 0 views

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    ibuprofen provided no reduction in muscle damage/soreness in 29 ultra marathoners.  However, LPS, CRP, IL-6, IL-10, IL-8, IL-1ra, GSF, MCP-1, and MIP-1beta were increased in the ibuprofen group.  TNF-alpha was unaffected.
Nathan Goodyear

Exertional Dysnatremia in Collapsed Marathon Runners - 0 views

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    Nice review of the treatment of hyper/hyponatremia with marathon runners.
Nathan Goodyear

Running: the risk of coronary events † - 0 views

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    This study shows that "healthy marathon" runners may not be as healthy as once thought.  Basically, current strategies to assess coronary artery calcification is inadequate.  Point: damage is being done that is not being detected.
Nathan Goodyear

Study of hematological and biochemical parameters in runners comple... - PubMed - NCBI - 0 views

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    No cases of hyponatremia noted in marathon runners.   Of note, over hydration was prevented through limited stations enroute.  NSAIDS negatively altered renal function
Nathan Goodyear

PLOS Medicine: Leisure Time Physical Activity of Moderate to Vigorous Intensity and Mor... - 0 views

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    no surprise that sedentary lifestyle associated with decreased lifespan. Exercise is beneficial in normal weight and obese individuals.  Also of note, one does not need to train for a marathon to see the health benefits.  Exercise is more about intensity than it is about duration/frequency.
Nathan Goodyear

Weight changes, sodium levels, and performance in the South African... - PubMed - NCBI - 0 views

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    Body weight post race was inversely associated with serum sodium i.e.  less weight loss was associated with lower serum sodium.  Body weight loss was unrelated to marathon time.
Nathan Goodyear

Dysnatremia predicts a delayed recovery in collapsed ultramarathon ... - PubMed - NCBI - 0 views

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    The majority of ultra marathon runners deal with hypernatremia versus hyponatremia.  The majority were normonatremic.  Intravenous fluids can more rapidly resolve hypernatremia versus oral liquids and serves as useful means to reduce hypernatremia when oral liquids proves intolerable.
Nathan Goodyear

Exercise-induced right ventricular dysfunction and structural remodelling in endurance ... - 0 views

  • In a cohort of well-trained athletes, we demonstrated that intense endurance exercise causes an acute reduction in RV function that increases with race duration and correlates with increases in biomarkers of myocardial injury
  • no relationship between LV function and biomarker levels
  • focal gadolinium enhancement and increased RV remodelling were more prevalent in those athletes with a longer history of competitive sport, suggesting that repetitive ultra-endurance exercise may lead to more extensive RV change and possible myocardial fibrosis
  • ...22 more annotations...
  • he cardiac impact of both acute and cumulative exercise is greatest on the RV.
  • Greater reductions in RV function occurred in those athletes competing for a longer duration, suggesting that the heart has a finite capacity to maintain the increased work demands of exercise
  • cardiac injury is greatest in the least trained
  • Previous investigators have documented reductions in RV function in less trained subjects over the marathon distance
  • We enrolled elite and subelite athletes and found a significant association between fitness (VO2max) and the reduction in post-race RVEF
  • Even after many years of detraining, cardiac dilation may not completely regress in elite athletes
  • The focus on well-trained athletes may be of particular relevance, given that they perform exercise of highest intensity and duration most frequently, and, thus, may be at a greater risk of cumulative injury.
  • The lack of correlation between increases in troponin and changes in LV function seen in this study has been previously interpreted as evidence that post-exercise elevations in cardiac biomarkers are benign.
  • a significant correlation between changes in RVEF and post-race biomarker levels and this relationship was even stronger in the athletes who completed the race of longest duration, the ultra-triathlon
  • The correlations with RVEF, but not LVEF, provide further evidence of the differential effects of intense exercise on RV and LV function
  • BNP release during intense exercise is associated with greater relative increases in RV systolic pressures, but not LV pressures
  • BNP may provide a measure of both acute RV load and the resultant fatigue which occurs when this load is sustained
  • It has been demonstrated that ventricular load increases with exercise intensity and is greater for the RV than the LV,29 thus potentially explaining why the RV is more susceptible to fatigue after prolonged exercise.
  • This study demonstrates, for the first time, an association between endurance exercise of increasing duration and structural, functional, and biochemical markers of cardiac dysfunction in highly trained athletes
  • Functional abnormalities were confined to the RV and were largely reversible 1 week following the event
  • there remained a significant minority of athletes in whom there was evidence of myocardial fibrosis in the interventricular septum
  • RV abnormalities may be acquired through cumulative bouts of intense exercise and provides direction for prospective investigations aimed at elucidating whether extreme exercise may promote arrhythmias in some athletes.
  • the acute injury and chronic remodelling of the myocardium both disproportionately affect the RV and it remains possible that the two are linked.
  • focal DGE was confined to the interventricular septum and commonly at the site of RV attachment
  • emerging evidence that intense endurance exercise may be associated with an excess in arrhythmic disorders, the mechanisms for which remain unexplained
  • RVEF (and not LVEF) was reduced in athletes with complex ventricular arrhythmias when compared with healthy athletes and non-athletes without arrhythmias
  • it is premature to conclude that these changes may represent a proarrhythmic substrate
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    Study finds endurance racing results in reduce Right ventricle ejection fraction even in elite athletes.  This post-race RVEF reduction is associated with VO2max.
Nathan Goodyear

http://www.msma.org/docs/communications/momed/Excessive_Endurance_Exercise_and_Heart_Di... - 0 views

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    great review of data on cardiac damage associated with extreme endurance training.  These EEEs, that they are called, are rare in those < 40 and usually involved genetic defects.  This article points to aggressive preventive testing in those > 50.
Nathan Goodyear

Hypertonic (3%) sodium chloride for emergent treatment of exercise-... - PubMed - NCBI - 0 views

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    event over hydration with under renal excretion can lead to hyponatremia.  SIADH and resultant increased ECW is involved.  Weight is an adequate means to evaluate--no weight loss and/or weight gain may suggest fluid overload and potential hyponatremia.
Nathan Goodyear

Serum biochemistry and morbidity among runners presenting for medic... - PubMed - NCBI - 0 views

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    Study looked at 9 athletes that were treated with IV fluids and found no significant morbidity with exercise associated hyponatremia.
Nathan Goodyear

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1332190/pdf/brjsmed00019-0063.pdf - 0 views

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    study finds IV hydration with glucose and larger volume did not recover as well as those with 100 ml  of IV fluids.  This conclusion is incomplete as the time differences between the 2 groups was significant--group 2 (2.5 L fluid group) finished much faster and studies have shown that these endurance athletes are more prone to dehydration, more significant weight loss, adverse effects from the event.  This likely explains the difference between the 2 groups.
Nathan Goodyear

https://www.cayugamed.org/docs/Nutrition_Update_for_the_Ultraendurance_Athlete%208.pdf - 0 views

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    Nutrition for ultra endurance.  To be read.
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