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Nathan Goodyear

Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased... - 0 views

www.ncbi.nlm.nih.gov/...PMC535701

sleep leptin ghrelin overweight weight loss obesity

shared by Nathan Goodyear on 14 Jul 11 - No Cached
  • Participants with short sleep had reduced leptin and elevated ghrelin
  • Nathan Goodyear on 14 Jul 11
     
    poor sleep reduces leptin and elevates ghrelin.  This will contribute to weight gain.
Nathan Goodyear

Long-Term Statin Use and Risk of Ductal and Lobular Breast Cancer among Women 55 to 74 ... - 0 views

cebp.aacrjournals.org/...1529.abstract

statins statin therapy breast cancer invasive lobular ductal carcinoma women

shared by Nathan Goodyear on 25 Mar 14 - No Cached
  • Nathan Goodyear on 25 Mar 14
     
    Why has this study not received major press?  Study finds that 10+ year users of statin therapies have an 83% increased risk of invasive ductal carcinoma of the breast, a 97% increase in invasive lobular carcinoma of the breast.  In women with elevated cholesterol, the data gets worse.  There is a 204% increased risk of invasive ductal carcinoma of the breast and a 243% increased risk of invasive lobular carcinoma of the breast in women with elevated lipids and on statins 10+ years.  No matter how  you try to slice this data, this is not good news for a large sub set of women.
Nathan Goodyear

Life events are positively associated with luteinizin... [Stress. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24881484

cortisol LH leutenizing hormone stress hormone hormones men male low T Testosterone

shared by Nathan Goodyear on 03 Jun 14 - No Cached
  • Nathan Goodyear on 03 Jun 14
     
    Elevated Cortisol, life events as this study refers to, is associated with low Testosterone.  The authors found a positive association of cortisol with LH.  The result is elevated cortisol, low Testosterone, increased LH.
Nathan Goodyear

Dose effects of caffeine ingestion... [J Sports Med Phys Fitness. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24867603

caffeine sports fitness resistance training cortisol Testosterone male hormone hormones insulin sensitivity

shared by Nathan Goodyear on 03 Jun 14 - No Cached
  • Nathan Goodyear on 03 Jun 14
     
    high caffeine intake found to be associated with increased Testosterone and cortisol pre and post resistance work out times.  An elevated Testosterone would be good at both points.  However, an elevated cortisol would be catabolic during the recovery phase.  The study also found a decrease in insulin sensitivity with high caffeine intake.  This was improved with moderate and low intake.
Nathan Goodyear

Male gonadal function in coeliac disease: 2. Sex hormones. - 0 views

www.ncbi.nlm.nih.gov/...PMC1420172

Testosterone men male hormone hormones celiac disease celiac gluten Estrogen free androgen index DHT

shared by Nathan Goodyear on 27 Jul 14 - No Cached
  • Nathan Goodyear on 27 Jul 14
     
    Interesting study of men with Celiac's disease.  Men with untreated Celiac's were found to have elevated TT and free Androgen index, but DHT was reduced with a slight increase in Estrogen.  LH was elevated.  This is consistent with inflammation increased aromatase activity.
Nathan Goodyear

Sex Hormone Levels in Patients with Sudden Cardiac Arrest - Heart Rhythm - 0 views

www.heartrhythmjournal.com/...abstract

hormone hormones Testosterone Estrogen men women heart health cardiac arrest myocardial infarction cardiovascular disease

shared by Nathan Goodyear on 07 Sep 14 - No Cached
  • Nathan Goodyear on 07 Sep 14
     
    Study looked at hormone levels via serum analysis at the time of sudden cardiac arrest in both men and women.  Low Testosterone and elevated Estrogen levels in  men were associated with increased odds (OR) versus women only had increased odds with elevated Estrogen.   ManBoob nation, my first book, discusses the mechanism behind this for men.  The finding in women really calls into question the Estrogen only model currently employed by physicians for post menopausal women.
Nathan Goodyear

Androgen Deprivation Therapy and the Re-em... [Oncol Hematol Rev. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24932461

androgen deprivation therapy ADT estrogen Testosterone men male hormone hormones Prostate cancer CVD cardiovascular disease

shared by Nathan Goodyear on 08 Jul 14 - No Cached
  • Nathan Goodyear on 08 Jul 14
     
    Sometimes I think medicine has lost its mind.  Or at least, it is not thinking things through.  To give IV estrogen to decrease Testosteorne in men with prostate cancer is devoid of the pathophysiology of prostate cancer and cardiovascular disease in men.  Elevated Estradiol in men increases CRP, IL-1beta, and TNF-alpha to name a few cytokines.  The proported purpose of the IV estrogen is to prevent the cardiovascular complications associated with ADT.  Yet, elevated aromatase activity and low T in men are both shown to be associated with increased CVD in men.
Nathan Goodyear

Serum Free Light Chain in Waldenstrom Macroglobulinemia. | Blood Journal - 0 views

www.bloodjournal.org/...2420

Waldenstrom lymphoma Cancer

shared by Nathan Goodyear on 30 Oct 18 - No Cached
  • Nathan Goodyear on 30 Oct 18
     
    Study found that elevated kappa and lambda light chains (sFLC's), as well as cytopenias, elevated Beta-2 macroglobulinemia correlated with poor response.
Nathan Goodyear

Comparisons of normal saline and lactated Ringer's resuscitation on hemodynamics, metab... - 0 views

www.ncbi.nlm.nih.gov/...PMC4029282

IV fluids lactated ringers normal saline LR NS

shared by Nathan Goodyear on 03 Jul 18 - No Cached
  • NS contains 154 mM Na+ and Cl-, with an average pH of 5.0 and osmolarity of 308 mOsm/L.
  • LR solution has an average pH of 6.5, is hypo-osmolar (272 mOsm/L), and has similar electrolytes (130 mM Na+, 109 mM Cl-, 28 mM lactate, etc.) to plasma
  • hyperchloremic acidosis
  • ...26 more annotations...
  • LR’s acid base balance is superior to that of NS’s
  • There were no significant differences between LR and NS groups in fibrinogen concentrations or platelet count
  • Total protein dropped
  • no significant differences in Hct (Table  1) or total protein between LR and NS groups
  • Bicarbonate HCO3- levels were decreased by hemorrhage but returned to pre-hemorrhage values by 3 h after LR resuscitation, whereas no return was observed with NS resuscitation
  • Na+ was increased after NS resuscitation
  • No changes in Na+ or K+ were observed
  • K+ did not change initially after NS resuscitation but was elevated at 6 h afterwards
  • Ca++ was similarly decreased
  • Cl- was elevated for 6 h after NS resuscitation, with no changes shown after LR resuscitation
  • PT was similarly prolonged by resuscitation with LR (from 11.2 ± 0.2 sec at baseline to 12.1 ± 0.2 sec at 6 h) and NS
  • Plasma aPTT was also similarly prolonged by resuscitation with LR (from 17.1 ± 0.5 sec baseline to 20.1 ± 1.2 sec at 6 h) or NS
  • NS resuscitation resulted in better oxygen delivery and oxygen delivery-to-oxygen demand ratio as an index of oxygen debt
  • NS had better tissue perfusion and oxygen metabolism than LR
  • LR resuscitation returned BE and bicarbonate to pre-hemorrhage levels within 3 h, but no return of BE or bicarbonate was observed for 6 hr with NS resuscitation
  • current blood bank guidelines state that LR should not be mixed with blood to prevent the risk of clot formation from calcium included in LR
  • LR resuscitation should not be given with blood through the same iv-line and crystalloids should be avoided in patients with blood transfusion
  • PT and aPTT were prolonged for 6 h after hemorrhage and resuscitation, suggesting a hypocoagulable states
  • potential thrombotic risk from LR resuscitation is unlikely.
  • we suspected that the blood pressure after NS resuscitation would be lower than that of LR due to its vasodilator effects
  • NS required a larger resuscitation volume and was associated with poor acid base status and elevated serum potassium in this model
  • NS required 50% more volume and was associated with a higher cardiac output and lower peripheral resistance, as compared to LR resuscitation
  • These differences are possibly due to the vasodilator effects from NS
  • an elevation of K+ was observed at 6 h post NS resuscitation, while no change of K+ was observed after LR resuscitation
  • The mechanism for the increase of K+ from NS is not fully known
  • NS is associated with vasodilator effects and the risks of metabolic acidosis and hyperkalemia
  • Nathan Goodyear on 03 Jul 18
     
    LR vs NS crystalloid.
Nathan Goodyear

Clinical experience with intravenous administration of ascorbic acid: achievable levels... - 0 views

www.ncbi.nlm.nih.gov/...PMC3751545

IV vitamin C dosing ascorbic acid inflammation disease cancer IV vitamin C intravenous vitamin C IV intravenous vitamin C vitamin C CRP therapy treatment alternative

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Patients with higher tumor markers are likely to have higher tumor burden, higher oxidative stress and, therefore, are more likely to have lower post IVC plasma levels.
  • Our data also showed that cancer patients with metastasis tend to have lower post-IVC vitamin C levels than those without metastasis
  • Lower peak plasma concentrations are obtained in cancer patients than in healthy subjects. Cancer patients who are deficient in vitamin C prior to therapy tend to achieve lower plasma levels post infusion.
  • ...25 more annotations...
  • Patients with higher inflammation or tumor burdens, as measured by CRP levels or tumor antigen levels, tend to show lower peak plasma ascorbate levels after IVC.
  • Patients with metastatic tumors tend to achieve lower post infusion plasma ascorbate levels than those with localized tumors.
  • Meta-analyses of clinical studies involving cancer and vitamins also conclude that antioxidant supplementation does not interfere with the efficacy of chemotherapeutic regiments
  • Most of the prostate cancer patients studied, 75±19% (95% confidence), showed reductions in PSA levels during the course of their IVC therapy
  • Laboratory studies suggest that, at high concentrations, ascorbate does not interfere with chemotherapy or irradiation and may enhance efficacy in some situations
  • Cameron and Pauling observed fourfold survival times in terminal cancer patients treated with intravenous ascorbate infusions followed by oral supplementation
  • The inflammatory microenvironment of cancer cells leads to increasing oxidative stress, which apparently depletes vitamin C, resulting in lower plasma ascorbate concentrations in blood samples post IVC infusion. Another explanation for this finding may be that cancers are themselves more metabolically active in their uptake of vitamin C, causing subjects to absorb more of the vitamin, and as a results show lower plasma ascorbate concentrations in blood post IVC infusion.
  • patients with severely elevated CRP levels attain plasma ascorbate concentrations after IVC infusions that are only 65% of those attained for subjects with normal CRP levels
  • The finding of decreased plasma ascorbate levels in cancer patients may relate to the molecular structure of ascorbic acid; in particular, the similarity of its oxidized form, dihydroascorbic acid, to glucose
  • Since tumor have increased requirement for glucose [67], transport of dehydroascorbate into the cancer cells via glucose transport molecules and ascorbate through sodium-dependent transporter may be elevated
  • Increased accumulation of ascorbic acid in the tumor site was supported by measurements of the level of ascorbic acid in tumors in animal experiments
  • patients with advanced malignancies may have lower level of ascorbic acid in tissue, creating a higher demand for the vitamin C
  • IVC therapy appears to reduce CRP levels in cancer patients.
  • CRP concentrations directly correlate with disease activity in many cases and can contribute to disease progression through a range of pro-inflammatory properties.
  • Being an exquisitely sensitive marker of systemic inflammation and tissue damage, CRP is very useful in screening for organic disease and monitoring treatment responses
  • ncreases in CRP concentrations have been associated with poorer prognosis of survival in cancer patients, particularly with advance disease independent of tumor stage
  • Regarding inflammation, 73±13% of subjects (95% confidence) showed a reduction in CRP levels during therapy. This was an even more dramatic 86±13% (95% confidence) in subjects who started therapy with CRP levels above 10 mg/L
  • patients treated by IVC with follow-up several year showed that suppression of inflammation in cancer patients by high-dose IVC is feasible and potentially beneficial
  • Inflammation is a marker of high cancer risk, and poor treatment outcome
  • The subjects with highly elevated CRP concentrations have a three-fold elevation “all-cause” mortality risk and a twenty-eight fold increase in cancer mortality risk
  • cancer patients may need higher doses to achieve a given plasma concentration.
  • patients with lower vitamin C levels may see more distribution of intravenously administered ascorbate into tissues and thus attain less in plasma.
  • When treating patients with IVC, the first treatment likely serves to replenish depleted tissue stores, if those subjects were vitamin C deficient at the beginning of the treatment. Then, in subsequent treatments, with increasing doses, higher plasma concentrations can be attained. On-going treatments serve to progressively reduce oxidative stress in cancer patients.
  • large doses given intravenously may result in maximum plasma concentrations of roughly 30 mM, a level that has been shown to be sufficient for preferential cytotoxicity against cancer cells
  • oral intake of vitamin C exceeded 200 mg administered once daily, it was difficult to increase plasma and tissue concentrations above roughly 200 μM.
  • Nathan Goodyear on 26 Aug 14
     
    Great review on the use of IV vitamin C in cancer and to reduce inflammation.  The article does a great job of discussing the mechanism of vitamin C therapy in cancer as well as the proposed reasons for low vitamin C in cancer patients.  The study also highlights the obstacles to rise in vitamin C levels post IV vitamin C in cancer patients.
anastasiadaunne

Thought Elevators - 0 views

www.thoughtelevatorsinfo.com

brain waves Thought Elevators Eric Taller theta meditation guided relaxation self improvement

shared by anastasiadaunne on 15 Mar 17 - No Cached
  • anastasiadaunne on 15 Mar 17
     
    Full review of Thought Elevators Program by Eric Taller
  • anastasiadaunne on 15 Mar 17
     
    Please read this information on a wonderful program I have found that helps me find peace and mental wellness in my life!
Nathan Goodyear

Ferritin Level Is Positively Associated with Chronic Kidney Disease in Korean Men, Base... - 0 views

www.ncbi.nlm.nih.gov/...PMC5129268

ferritin Iron kidney disease nutrition health

shared by Nathan Goodyear on 27 Sep 17 - No Cached
  • The overloading of body iron plays a role as an oxidative stressor
  • active radicals can affect lipids, proteins, and deoxyribonucleic acid (DNA), resulting in tissue injury and dysfunction
  • Excess iron causes oxidative stress and induces inflammation, leading to renal disease progression
  • ...4 more annotations...
  • Serum ferritin levels correlate with total body iron storage and systemic inflammation
  • The level of serum ferritin, an acute phase protein, is increased in an inflammatory environment
  • Previous studies have reported that elevated serum ferritin levels are associated with insulin resistance syndrome, hypertension, dyslipidemia, obesity, and metabolic syndrome as risk factors of CKD
  • elevated serum ferritin levels in hemodialysis patients predict higher mortality
  • Nathan Goodyear on 27 Sep 17
     
    great review and study: finds that elevated ferritin levels (> 200 ng/ml in men) was associated with increased chronic kidney disease in Korean study.
Nathan Goodyear

Age and BMI Adjusted Comparison of Reproductive Hormones in PCOS - 0 views

www.ncbi.nlm.nih.gov/...PMC3893977

PCOS polycystic ovarian syndrome LH FSH SHBG Testosterone progesterone hormones bmi

shared by Nathan Goodyear on 13 Sep 17 - No Cached
  • Nathan Goodyear on 13 Sep 17
     
    study of Saudi women with PCOS finds elevated LH/FSH ratio and elevated total Testosterone levels independent of age and weight; in addition, lower FSH, SHBG, and progesterone levels we found.
Nathan Goodyear

SERUM PROLACTIN IN MELANOMA PATIENTS WITH INTERFERON ALPHA2B TREATMENT - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/27328525

prolactin melanoma malignant melanoma

shared by Nathan Goodyear on 28 Sep 20 - No Cached
  • Nathan Goodyear on 28 Sep 20
     
    Elevated prolactin found statistically elevated in melanoma versus dysplastice nevi.
Nathan Goodyear

Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy ... - 0 views

www.ncbi.nlm.nih.gov/...PMC2359758

relora stress anxiety cortisol elevated cortisol magnolia officinalis phellodendron amurense

shared by Nathan Goodyear on 29 May 13 - No Cached
  • Nathan Goodyear on 29 May 13
     
    Just a pilot study, but relora shown to reduce anxiety attributable to elevated cortisol.
Nathan Goodyear

Altered Cortisol Metabolism in Polycystic Ovary Syndrome: Insulin Enhances 5α... - 0 views

jcem.endojournals.org/...5907.short

PCOS women lean 11-betaHSD1 5-alpha-reductase androgens testosterone insulin syndrome

shared by Nathan Goodyear on 25 Apr 12 - No Cached
  • Nathan Goodyear on 25 Apr 12
     
    lean women with PCOS found to have reduced 11 beta-HSD1 and increased 5 alpha reductase activity.  This, in part, is associated with the elevated cortisol and androgens in these women.
Nathan Goodyear

Chronic burnout, somatic arousal and elevate... [J Psychosom Res. 1999] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10454175

burnout stressed stress saliva salivary cortisol hormon hormones CVD cardiovascular disease

shared by Nathan Goodyear on 30 Apr 12 - No Cached
  • Nathan Goodyear on 30 Apr 12
     
    This study showed that "burnout" was associated with elevated salivary cortisol and this could explain part of the pathophysiology of CVD in these individuals.  This is a great article that shows that stress is a physiologic response and it kills
Nathan Goodyear

Relationship between endogenous testosterone and cardiovascular risk in early postmenop... - 0 views

www.metabolismjournal.com/...abstract

testosterone women high elevated CRP inflammation BMI obesity overweight post-menopausal CVD

shared by Nathan Goodyear on 10 May 12 - No Cached
  • Body mass index and waist circumference were significantly higher in the group with testosterone levels
  • Median CRP levels were greater in the group with higher testosterone level
  • ET-1 levels were also higher in women with greater testosterone levels
  • ...2 more annotations...
  • An association of testosterone with CRP (r = 0.416, P = .004) and ET-1 (r = 0.323, P = .031) was observed
  • Testosterone was also associated with waist circumference and blood pressure (P = .001)
  • Nathan Goodyear on 10 May 12
     
    testosterone associated with elevated CRP, increase BMI, and increased waist circumference in early, post-menopausal women.
Nathan Goodyear

Associations of Insulin Resistance and Adiponectin With Mortality in Women With Breast ... - 0 views

jco.ascopubs.org/...32.abstract

elevated insulin adiponectin breast cancer mortality obesity

shared by Nathan Goodyear on 17 Mar 12 - No Cached
  • Nathan Goodyear on 17 Mar 12
     
    Elevated insulin and low adiponectin levels associated with increased breast cancer mortality.  Both are found and play a role in the development of obesity.
Nathan Goodyear

Elevated C-Reactive Protein Levels in Overweight and Obese Adults - 0 views

jama.ama-assn.org/...2131.full.pdf

CRP overweight obese inflammation

shared by Nathan Goodyear on 15 Mar 12 - No Cached
  • Nathan Goodyear on 15 Mar 12
     
    Overweight and obese adults, irregardless of age, were associated with elevated CRP. This indicates inflammation and creates the link between adipose induced inflammation and a direct contribution to CVD and other associated disease of aging.
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