Group items tagged

LR’s acid base balance is superior to that of NS’s

There were no significant differences between LR and NS groups in fibrinogen concentrations or platelet count

Total protein dropped

no significant differences in Hct (Table  1) or total protein between LR and NS groups

Bicarbonate HCO3- levels were decreased by hemorrhage but returned to pre-hemorrhage values by 3 h after LR resuscitation, whereas no return was observed with NS resuscitation

Na+ was increased after NS resuscitation

No changes in Na+ or K+ were observed

K+ did not change initially after NS resuscitation but was elevated at 6 h afterwards

Ca++ was similarly decreased

Cl- was elevated for 6 h after NS resuscitation, with no changes shown after LR resuscitation

PT was similarly prolonged by resuscitation with LR (from 11.2 ± 0.2 sec at baseline to 12.1 ± 0.2 sec at 6 h) and NS

Plasma aPTT was also similarly prolonged by resuscitation with LR (from 17.1 ± 0.5 sec baseline to 20.1 ± 1.2 sec at 6 h) or NS

NS resuscitation resulted in better oxygen delivery and oxygen delivery-to-oxygen demand ratio as an index of oxygen debt

NS had better tissue perfusion and oxygen metabolism than LR

LR resuscitation returned BE and bicarbonate to pre-hemorrhage levels within 3 h, but no return of BE or bicarbonate was observed for 6 hr with NS resuscitation

current blood bank guidelines state that LR should not be mixed with blood to prevent the risk of clot formation from calcium included in LR

LR resuscitation should not be given with blood through the same iv-line and crystalloids should be avoided in patients with blood transfusion

PT and aPTT were prolonged for 6 h after hemorrhage and resuscitation, suggesting a hypocoagulable states

potential thrombotic risk from LR resuscitation is unlikely.

we suspected that the blood pressure after NS resuscitation would be lower than that of LR due to its vasodilator effects

NS required a larger resuscitation volume and was associated with poor acid base status and elevated serum potassium in this model

NS required 50% more volume and was associated with a higher cardiac output and lower peripheral resistance, as compared to LR resuscitation

These differences are possibly due to the vasodilator effects from NS

an elevation of K+ was observed at 6 h post NS resuscitation, while no change of K+ was observed after LR resuscitation

The mechanism for the increase of K+ from NS is not fully known

NS is associated with vasodilator effects and the risks of metabolic acidosis and hyperkalemia