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Nathan Goodyear

Frontiers | Can Reverse T3 Assay Be Employed to Guide T4 vs. T4/T3 Therapy in Hypothyro... - 0 views

www.frontiersin.org/...full

cancer thyroid hormones reverse T3 thyroid metabolism rT3

shared by Nathan Goodyear on 30 Jan 21 - No Cached
  • Nathan Goodyear on 30 Jan 21
     
    This study claims no viable benefit for the follow of rT3 in patients on T4/T3 treatment; yet, rT3 increases cancer cell proliferation by up to 80%?!?! Inflammation increases rT3!?!? Context, context, context.
Nathan Goodyear

Sex Hormone-Binding Globulin in the Diagnosis of Peripheral Tissue Resistance to Thyroi... - 0 views

jcem.endojournals.org/...740.abstract

hypothyroid thyroid thyroid disease T3 T4 SHBG hormone resistance hormones

shared by Nathan Goodyear on 10 Dec 12 - No Cached
  • Nathan Goodyear on 10 Dec 12
     
    T3, and T4 for that matter, increases SHBG.  This would be a novel method to determine thyroid hormone receptor insensitivity or resistance.
Nathan Goodyear

Reduced Activation and Increased Inactivation of Thyroid Hormone in Tissues of Critical... - 0 views

jcem.endojournals.org/...3202.full

TSH hypothyroid hypothyroidism T3 rT3 T4 thyroid hormone inflammation

shared by Nathan Goodyear on 07 Feb 12 - No Cached
  • Nathan Goodyear on 07 Feb 12
     
    critical illness is associated with low TSH, reduced T3, and increased rT3 production.  Inflammation is critically involved in this process.  This study from JCEM shows how unreliable TSH and T4 are.
Nathan Goodyear

Low-T3 Syndrome - 0 views

circ.ahajournals.org/...708.full

low T3 syndrome T4 TSH CVD cardiac hypothyroid hypothyroidism thyroid

shared by Nathan Goodyear on 07 Feb 12 - No Cached
  • Nathan Goodyear on 07 Feb 12
     
    low T3, not T4 or TSH, found to be associated with a strong predictor of death in cardiac patients.  This also has implications in predicting outcome in cardiac patients.
Nathan Goodyear

Decreased Basal and Stimulated Thyrotropin Secretion in Healthy Elderly Men - 0 views

jcem.endojournals.org/...177.abstract

TSH TRH aging men elderly thyroid hormone T3 T4 pituitary

shared by Nathan Goodyear on 07 Feb 12 - No Cached
  • Nathan Goodyear on 07 Feb 12
     
    This study shows that older men are associated with low TSH, reduced response to TRH, lowered T3, and normal T4 levels.  The main find in this study was the decrease in pituitary responsiveness to TRH and the reduced TSH as we age.  TSH is unreliable as a test.
Nathan Goodyear

thyroid disease and the heart - 0 views

www.ncbi.nlm.nih.gov/...v084p00455.pdf

thyroid disease heart T3 T4 thyroxine try-idodothyronine

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    nice review of how thyroid disease effects cardiac function. Notice the author of this paper describes "thy- roxine (T4) which is a prohormone and tri-iodothyronine (T3) which acts as the final mediator".
Nathan Goodyear

RB&E | Abstract | Levothyroxine and lung cancer in females: the importance of oxidative... - 0 views

www.rbej.com/...abstract

levothyroxine T4 lung cancer hypothyroid oxidative stress

shared by Nathan Goodyear on 22 Dec 13 - No Cached
  • Nathan Goodyear on 22 Dec 13
     
    Interesting study finds T4 therapy, levothyroxine,  linked to increased lung cancer.  The link could be through oxidative stress.
Nathan Goodyear

Levothyroxine and lung cancer in females: the importance of oxidative stress - 0 views

www.rbej.com/...1477-7827-11-75.pdf

T4 synthroid lung cancer oxidative stress ROS reactive oxygenation species

shared by Nathan Goodyear on 13 Aug 13 - No Cached
  • Nathan Goodyear on 13 Aug 13
     
    Study links synthetic T4, synthroid, to increased risk of Lung cancer. The authors acknowledge that the limitations of this study are large. Yet, the association is evident. The proposed mechanism is likely the overdosing and the resultant ROS as a result.
Nathan Goodyear

Induction of oral tolerance in human autoimmune thyr... [Thyroid. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9545109

T4 T3 autoimmune autoimmune disease immune system thyroid disease

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    combined T4/T3 in desiccated thyroid found to reduce cellular immunity in those with autoimmune thyroid disease.
Nathan Goodyear

http://press.endocrine.org/doi/pdf/10.1210/jc.2013-1813 - 0 views

press.endocrine.org/...jc.2013-1813

thyroid hormone hormones T4 T3 cognition

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Higher T4 and T3 results in improved cognitive function.  Higher with the normal reference range that is.  Thyroid levels cannot be taken purely in reference to "normal".
Nathan Goodyear

Peripheral autoregulation of thyroxine to triiodot... [Horm Metab Res Suppl. 1984] - Pu... - 0 views

www.ncbi.nlm.nih.gov/...6595193

Thyroid T4 T3 hormone hormones 5' deiodinase

shared by Nathan Goodyear on 19 Nov 10 - No Cached
  • Nathan Goodyear on 19 Nov 10
     
    Thyroid T4 to T3 conversion
Nathan Goodyear

Levothyroxine therapy and serum free thyroxine and... [J Endocrinol Invest. 2002] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...11929079

hypothyroid hypothyroidism T4 synthroid levothyroxine T3

shared by Nathan Goodyear on 20 Dec 10 - No Cached
  • Nathan Goodyear on 20 Dec 10
     
    T4 therapy (synthroid) alone does not increase serum free T3 concentrations in many patients
Nathan Goodyear

SpringerLink - Cellular and Molecular Life Sciences, Volume 57, Numbers 13-14 - 0 views

www.springerlink.com/...t34vwu3k118cag2f

T4 T3 thyroid hypothyroid

shared by Nathan Goodyear on 20 Dec 10 - No Cached
  • deiodinases are envisaged as guardians to the gate of thyroid hormone action mediated by T3 receptors
  • Nathan Goodyear on 20 Dec 10
     
    Heavy read; but how/why is T4 to T3 conversion important
Nathan Goodyear

Thyroid hormone action in mitochondria -- Wrutniak-Cabello et al. 26 (1): 67 -- Journal... - 0 views

jme.endocrinology-journals.org/...67

T3 T4 mitochondria energy fatigue

shared by Nathan Goodyear on 20 Dec 10 - No Cached
  • Triiodothyronine (T3) is considered a major regulator of mitochondrial activity
  • Nathan Goodyear on 20 Dec 10
     
    T3 is major regulator of mitochondrial activity; not T4
Nathan Goodyear

[Serum thyroid hormone levels correlate with cardi... [J Cardiol. 1993] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...8176632

hypothyroid hypothyroidism T3 T4 rT3 cardiovascular disease CHF tachycardia

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • Patients with ventricular tachycardia demonstrated significantly lower serum values of FT3 and FT3/FT4, and significantly higher values of rT3. Serum thyroid hormone levels can provide a quantitative index for evaluating the severity of chronic heart failure and predicting ventricular tachycardia.
  • Nathan Goodyear on 01 Feb 11
     
    Full thyroid evaluation, not TSH or just T4, is predictive in severity of CHF and heart tachycardia
Nathan Goodyear

Effect of metoclopramide--a dopaminergic blocker a... [Acta Endocrinol (Copenh). 1985] ... - 0 views

www.ncbi.nlm.nih.gov/...4002999

cortisol T4 T3 rT3

shared by Nathan Goodyear on 14 Mar 11 - No Cached
  • High levels of cortisol may be responsible for the altered TT4 peripheral metabolism to TT3 and rT3 in these patients.
  • Nathan Goodyear on 14 Mar 11
     
    elevated cortisol blocks T4 to T3 conversion and increases rT3 production
Nathan Goodyear

Extrathyroidal Conversion of Thyroxine to 3,3',5'-Triiodothyronine (Reverse-T3)and to 3... - 0 views

jcem.endojournals.org/...733

reverse T3 free T4 hypothyroid hypothyroidism extrathyroidal conversion

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Nathan Goodyear on 08 Mar 11
     
    reverse T3 comes from peripheral conversion from free T4
Nathan Goodyear

Impaired Peripheral Conversion of Thyroxine to Trhodothyronine - Annual Review of Medic... - 0 views

www.annualreviews.org/...annurev.me.28.020177.000421

hypothyroid hypothyroidism thyroxine t4 reverse t3

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Nathan Goodyear on 08 Mar 11
     
    peripheral conversion of t4 to reverse t3
Nathan Goodyear

Tissue-specific deiodinase regulation during food restriction and low replacement dose ... - 0 views

ajpendo.physiology.org/...E1157.abstract

T4 T3 weight loss obesity

shared by Nathan Goodyear on 05 Apr 11 - No Cached
  • Nathan Goodyear on 05 Apr 11
     
    chronic dieting will result in low T4 to T3 production; hindering weight loss
Nathan Goodyear

Endocrine actions of pesticides m... [Environ Sci Pollut Res Int. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25138556

pesticides organophosphates xenoestrogens hormone hormones free T4 TSH sexual development

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    low dose pesticide (organophosphates) exposure associated with delayed sexual development in boys and girls.  In addition, there was an inverse correlation with free T4 and a positive correlation with TSH.  
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