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Nathan Goodyear

RB&E | Abstract | Levothyroxine and lung cancer in females: the importance of oxidative... - 0 views

www.rbej.com/...abstract

levothyroxine T4 lung cancer hypothyroid oxidative stress

shared by Nathan Goodyear on 22 Dec 13 - No Cached
  • Nathan Goodyear on 22 Dec 13
     
    Interesting study finds T4 therapy, levothyroxine,  linked to increased lung cancer.  The link could be through oxidative stress.
Nathan Goodyear

Effect of Levothyroxine Replacement on Lipid Profile and Intima-Media Thickness in Subc... - 0 views

jcem.endojournals.org/...2099.long

levothyroxin subclinical hypothyroidism functional hypothyroidism hypothyroid lipids hypothyroidism cholesterol metabolism thyroid IMT

shared by Nathan Goodyear on 27 Jul 13 - No Cached
  • Nathan Goodyear on 27 Jul 13
     
    synthetic T4, as levothyroxine, in subclinical hypothyroidism is shown to improve cholesterol levels and intima-media thickness.
Nathan Goodyear

Levothyroxine Monotherapy Cannot Guarantee Euthyroidism in All Athyreotic Patients - 0 views

www.ncbi.nlm.nih.gov/...PMC3148220

Thyroid hypothyroidism levothyroxine

shared by Nathan Goodyear on 16 Aug 17 - No Cached
  • Nathan Goodyear on 16 Aug 17
     
    retrospective study finds that levothyroxine, T4 only therapy, is ineffective in adequately supporting peripheral T3 production in up to 20%, I would gather much higher based on my 11 years of practice.
Nathan Goodyear

Metabolic Effects of Liothyronine Therapy in Hypothyroidism: A Randomized, Double-Blind... - 0 views

jcem.endojournals.org/...3466.abstract

T3 T4 hypothyroid hypothyroidism functional armour thyroid cholesterol LDL weight-loss overweight obesity metabolic effects therapy

shared by Nathan Goodyear on 08 Dec 11 - No Cached
  • Nathan Goodyear on 08 Dec 11
     
    T3 shown increase weight loss, lower LDL, decrease apolipoprotein B, decrease T cholesterol versus T4.  This flies in the face of conventional medical dogma, that T 4 (synthroid, levothyroxine) is the only route of thyroid replacement.  In fact, this suppports the use of armour thyroid, a T4/T3 combination.
Nathan Goodyear

Levothyroxine therapy and serum free thyroxine and... [J Endocrinol Invest. 2002] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...11929079

hypothyroid hypothyroidism T4 synthroid levothyroxine T3

shared by Nathan Goodyear on 20 Dec 10 - No Cached
  • Nathan Goodyear on 20 Dec 10
     
    T4 therapy (synthroid) alone does not increase serum free T3 concentrations in many patients
Nathan Goodyear

Levothyroxine and lung cancer in females: the importance of oxidative stress - 0 views

www.rbej.com/...1477-7827-11-75.pdf

T4 synthroid lung cancer oxidative stress ROS reactive oxygenation species

shared by Nathan Goodyear on 13 Aug 13 - No Cached
  • Nathan Goodyear on 13 Aug 13
     
    Study links synthetic T4, synthroid, to increased risk of Lung cancer. The authors acknowledge that the limitations of this study are large. Yet, the association is evident. The proposed mechanism is likely the overdosing and the resultant ROS as a result.
Nathan Goodyear

Desiccated Thyroid Extract Compared With Levothyroxine in the Treatment of Hypothyroidi... - 0 views

press.endocrine.org/...jc.2012-4107

hypothyroid hypothyroidism thyroid T4 T3 hormones metabolism

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Our study has shown DTE therapy caused modest weight loss, and nearly half (48.6%) of the study patients expressed preference for DTE over l-T4
  • our study showed significantly higher TSH in the DTE-treated group, which suggests that the improvement observed in the DTE-treated group is not mediated through the changes in TSH levels
  • Nathan Goodyear on 24 Sep 14
     
    Study finds desiccated thyroid (armour thyroid) was associated with great weight loss, mood improvement than T4 alone.  Desiccated thyroid was preferred by patients in the study.  Conversion rate was 100 mcg T4 to 88 mg desiccated thyroid.
Nathan Goodyear

Metabolic Effects of Liothyronine Therapy in Hypothyroidism: A Randomized, Double-Blind... - 0 views

press.endocrine.org/...jc.2011-1329

T4 T3 hypothyroid hypothyroidism thyroid lipids weight loss metabolism cholesterol hormones

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • tissue euthyroidism is the net result of multiple steps including conversion of the prohormone T4 into its active metabolite T3, which is ultimately responsible for signaling at the end-organ target level
  • The circulating and intracellular pools of T3 of treated hypothyroid patients (i.e. devoid of endogenous TH production) depend entirely on the conversion of exogenous l-T4 into T3
  • TH is the major regulator of basal metabolic rate
  • ...8 more annotations...
  • The substitution of l-T3 for l-T4 caused a significant weight loss
  • The substitution of l-T3 for l-T4 caused a significant reduction in lipid parameters
  • Despite the increase in serum T3, the l-T3 treatment did not cause major changes in cardiovascular or musculoskeletal function, as indicated by the echocardiographic and maximal exercise tolerance tests and DXA studies.
  • The changes in serum lipid metabolism parameters are similar to the effects observed with drugs approved for the treatment of dyslipidemia
  • This differential response appears to be limited to the lipid metabolism and SHBG, whereas no differences in indices of insulin resistance were detected. This is remarkable because hyperthyroid states are associated with an increase in hepatic gluconeogenesis (37), and overt thyrotoxicosis is a known cause of secondary diabetes.
  • TH action is increased in the liver, and the SHBG increase supports this hypothesis
  • Similarly, no significant differences were observed in blood pressure, heart rate, or endothelial vascular function
  • In conclusion, the results of this pharmacology, proof-of-concept study indicate that replacement therapy of hypothyroidism with l-T3, compared with l-T4 causes weight loss and favorable changes in the lipid profile without appreciable side effects
  • Nathan Goodyear on 24 Sep 14
     
    Crossover study finds T3 versus T4 results in more weight loss, improved lipid management and increased SHBG without any adverse cardiovascular effects.   The T3 was dosed 3 x daily due to its short half life compared to T4.
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