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Nathan Goodyear

Clinical Utility of Common Serum Rheumatologic Tests - American Family Physician - 0 views

www.aafp.org/...p1073.html

rheumatoid arthritis RA SLE lupus RF ANA autoimmune disease

shared by Nathan Goodyear on 25 Oct 16 - Cached
  • Nathan Goodyear on 25 Oct 16
     
    older, but good review on autoimmune testing.
Nathan Goodyear

Increased frequency of delayed type hypersensitivity to metals in patients with connect... - 0 views

www.ncbi.nlm.nih.gov/...25636536

mercury gold nickel lupus autoimmune disease autoimmune disease RA rheumatoid arthritis arthritis Sjogren's

shared by Nathan Goodyear on 26 Sep 16 - No Cached
  • Nathan Goodyear on 26 Sep 16
     
    increased delayed type hypersensitivity reactions in individuals with certain autoimmune diseases.
thanhngan100795

Cach chua tri benh viem xoang ham pho bien hien nay - 1 views

xoangzoha.com/em-xoang-ham-pho-bien-hien-nay

chua-tri-viem-xoang

shared by thanhngan100795 on 12 Apr 17 - No Cached
  • thanhngan100795 on 12 Apr 17
     
    Đã chữa trị thành công những bệnh nhân ở Hoa Kì và đem phương thuốc sáng giá này về Việt Nam giúp Việt Nam không còn đau đầu loay hoay trong việc tìm ra phương thuốc và Cách chữa bệnh viêm xoang hàm.
Nathan Goodyear

Endogenous Estrogen Regulation of Inflammatory Arthritis and Cytokine Express... - 0 views

onlinelibrary.wiley.com/...A9BD5D2255232A4DBCA476F.d01t03

RA rheumatoid arthritis inflammation ER-alpha estrogen receptor alpha

shared by Nathan Goodyear on 26 Apr 12 - No Cached
  • Nathan Goodyear on 26 Apr 12
     
    this study looked at estrogen in rheumatoid arthritis in mice. They found an anti-inflammatory effect of estrogen in men through ER-alpha. This is in contrast to other studies. Maybe the immunomodulatory effects of estrogen is, in part, through which receptors are activated.
Nathan Goodyear

Interleukin-6 and rheumatic diseases - 0 views

www.ncbi.nlm.nih.gov/...PMC2946778

IL-6 sIL-6Ralpha autoimmune disease Rheumatoid arthritis RA

shared by Nathan Goodyear on 28 Apr 12 - No Cached
  • Nathan Goodyear on 28 Apr 12
     
    IL-6 and sIL-6Ralpha (soluble receptor) associated with autoimmune disease.
Nathan Goodyear

Intraarticular progesterone: effects of a local ... [J Rheumatol. 1988] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...3397966

progesterone inflammation anti-inflammatory RA rheumatoid arthritis

shared by Nathan Goodyear on 29 May 12 - No Cached
  • Nathan Goodyear on 29 May 12
     
    progesterone injections shown to be effective as a local treatment in rheumatoid arthritis.
Nathan Goodyear

S-Adenosylmethionine Inhibits the Growth of Cancer Cells by Reversing the Hypomethylati... - 0 views

www.ncbi.nlm.nih.gov/...PMC2999854

SAMe methylation oncogenes colon cancer cancer

shared by Nathan Goodyear on 27 Jun 12 - No Cached
  • Nathan Goodyear on 27 Jun 12
     
    SAMe shown to resolve the hypomethylation status of oncogenes. This allows increased genetic expression.  By improving methylation with SAMe, we can reduce oncogenic expression and thus be a useful cancer therapy adjunct.
Nathan Goodyear

Cambridge Journals Online - Abstract - Effect of vitamin D supplementation during pregn... - 0 views

journals.cambridge.org/...displayAbstract

vitamin D3 pregnanacy

shared by Nathan Goodyear on 14 Sep 12 - No Cached
  • Nathan Goodyear on 14 Sep 12
     
    Vitamin D3 during pregnancy shown to have only positive effects on pregnancy.  Granted this is a small study with only 3 doses of small amounts of vitamin D3.  But still positive.
Nathan Goodyear

Cambridge Journals Online - British Journal of Nutrition - Abstract - Post-exercise whe... - 0 views

journals.cambridge.org/...displayAbstract

Whey protein exercise recovery amino acids muscle nutrition

shared by Nathan Goodyear on 17 Sep 13 - No Cached
  • Nathan Goodyear on 17 Sep 13
     
    Whey protein hydrolysate shown to be superior to amino acids in recovery phase of exercise.  
Nathan Goodyear

Cambridge Journals Online - Proceedings of the Nutrition Society - Fulltext -... - 0 views

journals.cambridge.org/...displayFulltext

11-betaHSD1 metabolism obesity energy cortisol nutrition

shared by Nathan Goodyear on 08 Oct 13 - No Cached
  • Nathan Goodyear on 08 Oct 13
     
    Peripheral 11Beta-HSD1 plays critical role in fat metabolism and energy utilization.  Good discussion on the role that extra-adrenal 11Beta-HSD1 plays in metabolism
Nathan Goodyear

PLOS ONE: Low Mercury Concentration Produces Vasoconstriction, Decreases Nitric Oxide B... - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0049005

Hg mercury NO RAS renin angiotensin system ROS hypertension oxidative stress vasoconstriction

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Animal model found that low Hg decreased NO availability.  The result is vasoconstriction induced by ROS and hypertension. The hypertension is the result of an activation of the renin angiotensin system.  The importance here is that low Hg levels induced this change.
Nathan Goodyear

Cambridge Journals Online - Abstract - Effects of whey protein isolate on body composit... - 0 views

journals.cambridge.org/...displayAbstract

Whey protein elevated cholesterol insulin resistance diabetes

shared by Nathan Goodyear on 20 Jan 11 - No Cached
  • The present study demonstrated that supplementation with whey proteins improves fasting lipids and insulin levels in overweight and obese individuals.
  • Nathan Goodyear on 20 Jan 11
     
    Whey protein improves fasting lipids and insulin levels
Nathan Goodyear

Cambridge Journals Online - Abstract - Resveratrol improves insulin sensitivity, reduce... - 0 views

journals.cambridge.org/...displayAbstract

resveratrol insulin resistance sensitivity oxidative stress

shared by Nathan Goodyear on 24 May 11 - No Cached
  • resveratrol improves insulin sensitivity in humans,
  • Nathan Goodyear on 24 May 11
     
    Resveratrol improves insulin sensitivity
Nathan Goodyear

Cambridge Journals Online - Abstract - Health effects of green tea catechins in overwei... - 0 views

journals.cambridge.org/...displayAbstract

EGCG green tea catechins overweight weight gain obese

shared by Nathan Goodyear on 08 Jun 11 - No Cached
  • Nathan Goodyear on 08 Jun 11
     
    Green tea shown to reduce weight and protect against weight gain
Nathan Goodyear

Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to incr... - 0 views

stke.sciencemag.org/...ra106.abstract

nitric oxide NO inflammation SIRT1 sirloins disease aging

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Nathan Goodyear on 19 Nov 14
     
    Nitic Oxide (NO) via inflammation deactivates SIRT1 is a common finding in inflammatory diseases of aging, proposes authors of this paper.
Nathan Goodyear

Inborn-like errors of metabolism are determinants of breast cancer risk, clinical respo... - 0 views

www.ncbi.nlm.nih.gov/...PMC6114970

cancer metabolism breast cancer glutamine glutamate aspartate oncogenes

shared by Nathan Goodyear on 24 Sep 18 - No Cached
  • We now recognize that human cancers evolve in an environment of metabolic stress. Rapidly proliferating tumor cells deprived of adequate oxygen, nutrients, hormones and growth factors up-regulate pathways that address these deficiencies to overcome hypoxia (HIF), vascular insufficiency (VEGF), growth factor deprivation (EGFR, HER2) and the loss of hormonal support (ER, PR, AR) all to enhance survival and proliferation
  • RAS, PI3K, TP53 and MYC
  • The results suggest that breast cancer could be preceded by systemic subclinical disturbances in glucose-insulin homeostasis characterized by mild, likely asymptomatic, IEM-like biochemical changes
  • ...16 more annotations...
  • The process would include variable periods of hyperinsulinemia with the consequent systemic MYC activation of glycolysis, glutaminolysis, structural lipidogenesis and further exacerbation of hypoglycemia, the result of MYC's known role as an inhibitor of liver gluconeogenesis
  • The metabolic changes we describe in breast cancer arise in concert with IEM-like changes in oxidative phosphorylation as detected by increased values of the ratio lactate/pyruvate (Supplementary Table 2A, 2B) characteristic of Ox/Phos deficiency [25]. In our study, 76% (70/92) of the European breast cancer patients had lactate/pyruvate ratios values higher than the normal value of 25.8
  • four-fold higher frequency of cancer (including breast) in patients with energy metabolism disorders
  • growing recognition that cancer cells differ from their normal counterparts in their use of nutrients, synthesis of biomolecules and generation of energy
  • glutamine concentrations in the cancer patients were reduced to nearly 1/8 of the levels observed in the normal population
  • blood concentrations of aspartate (p = 1.7e-67, FDR = 8.3e-67) (Figure ​(Figure1E)1E) and glutamate (p = 6.4e-96, FDR = 6.2e-95) (Figure ​(Figure1F)1F) were nearly 10 fold higher than the normal ranges of 0–5 μM/L and 40 μM/L, respectively
  • glutamine consumption associated with parallel increases in glutamate and aspartate (Figure ​(Figure1A1A red arrows) is considered a hallmark of MYC-driven “glutaminolysis”
  • Gln/Glu ratio inversely correlates with i- late stage metabolic syndrome and with ii- increased chance of death
  • changes in glutamine consumption, reflected by the Gln/Glu ratio could provide a metabolic link between breast cancer initiation and diabetes, reflective of a systemic metabolic reprogramming from glucose to glutamine as the preferred source of precursors for biosynthetic reactions and cellular energy
  • lower Gln/Glu ratios inversely correlated with insulin resistance and the risk of diabetes
  • the metabolic dependencies of cancer characterized by excessive glycolysis, glutaminolysis and malignant lipidogenesis, previously considered a consequence of local tumor DNA aberration [23] could, instead, represent a systemic biochemical aberration that predates and very likely promotes tumorigenesis
  • these metabolic disturbances would be expected to remain extant after therapeutic interventions
  • accumulation of very long chain acylcarnitines such as C14:1-OH (p = 0.0, FDR = 0.0), C16 (p = 0.0, FDR = 0.0), C18 (p = 0.0, FDR = 0.0) and C18:1 (p = 1.73e-322, FDR = 1.16-321) and lipids containing VLCFA (lysoPC a C28:0) (p = 1.14-e95, FDR = 1.65e-95) in the blood of breast and colon cancer patients
  • Among the most powerful metabolic equations for MYC-activation is that which links the widely used MYC-driven desaturation marker ratio of SFA/MUFA to the MYC glutaminolysis-associated ratio of (Asp/Gln)
  • liver dysfunction shares many features with both IEM and cancer suggesting a role for hepatic dysfunction in carcinogenesis
  • cancer “conscripts” the human genome to meet its needs under conditions of systemic metabolic stress
  • Nathan Goodyear on 24 Sep 18
     
    Breast cancer is a metabolic disease.  Now, where have I heard that cancer is a metabolic disease?
Nathan Goodyear

Mitochondria and Cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC4779192

cancer mitochondria

shared by Nathan Goodyear on 05 Oct 18 - No Cached
  • aerobic glycolysis
  • aerobic glycolysis
  • the “Warburg effect” is the basis for tumor imaging by FDG-PET
  • ...1 more annotation...
  • In most cancers, oncogenic driver mutations such as activation of K-ras, c-Myc and phosphatidylinositol-3 (PI3) kinase or loss of phosphatase and tensin homolog (Pten) and p53, not mutations that inactivate mitochondrial respiration complexes, promote glycolysis
  • Nathan Goodyear on 05 Oct 18
     
    great read on mitochondria and cancer.
Nathan Goodyear

Broad targeting of angiogenesis for cancer prevention and therapy - 0 views

www.ncbi.nlm.nih.gov/...PMC4737670

cancer curcumin VEGF EGCG green tea melatonin quercetin Resveratrol silymarin flavonoids HIF-1alpha

shared by Nathan Goodyear on 01 Jun 18 - No Cached
  • vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), interleukin-8 (IL-8), placental growth factor (PlGF), transforming growth factor-beta (TGFbeta), platelet derived growth factor (PDGF), angiopoietins (Angs) and others (reviewed in [4])
  • The switch may also involve down-regulation of endogenous inhibitors of angiogenesis such as endostatin, angiostatin or thrombospondin (reviewed in [5]) and has thus been regarded as the result of tipping the net balance between positive and negative regulators
  • There is a complex interrelationship between tumor hypoxia and tumor angiogenesis
  • ...17 more annotations...
  • chronic hypoxia
  • acute hypoxia
  • Environmental stress as a result of low oxygen and proper nutrient deprivation, such as glucose deprivation, are capable of inducing VEGF mRNA stabilization resulting in increased levels of the secreted ligand and angiogenic growth
  • HIFalpha subunits accumulate in the cytoplasm where they bind HIFbeta to form a heterodimer that subsequently translocates to the nucleus to activate transcription of target genes, including genes important for various processes such as metabolism (glucose transporter (GLUT)-1, hexokinase (HK)-1), cell growth (cyclin (CCN)-D1 [23]) and also angiogenesis, such as erythropoietin, VEGF and PDGF [24] (summarized in Fig. 1)
  • When oxygen levels are low (hypoxia; red arrow) PHDs cannot hydroxylate HIFalphas thereby allowing them to escape pVHL-mediated degradation. HIFalpha subunits accumulate and bind to their heterodimeric partner, HIFbeta, translocate into the nucleus and activate a cascade of hypoxic signaling first by the transcription of various target genes including microRNAs that are important for tumor promoting pathways
  • c-Src is also capable of activating HIFs by indirectly inhibiting PHD activity via the NADPH oxidase/Rac pathway.
  • mTOR can also promote stabilization and HIF transcriptional activity
  • hypoxia inducible factors (HIFs), heterodimeric transcription factors composed from alpha and beta subunits, which can be rapidly stabilized to fluidly adapt to and overcome the effects of a hypoxic environment
  • Curcumin inhibits the expression of epidermal growth factor receptor (EGFR), VEGFR-1, VEGFR-2 and VEGFR-3, and the kinase activity of Src and FAK, which are responsible for the induction of angiogenic genes as well as endothelial cell polarity and migration
  • Curcumin also reduces the MMP-2 and MMP-9 expression, along with the suppression of growth and invasion potential of tumor cells in culture and xenograft experiments
  • The expression of angiogenic biomarkers COX-2 and serum levels of VEGF were significantly reduced in the curcumin-treated group
  • Resveratrol inhibits capillary endothelial cell growth and new blood vessel growth in animals
  • interrupting cell proliferation, inducing apoptosis
  • [155] and impeding angiogenesis by suppressing VEGF expression through down-regulation of HIF-1alpha
  • resveratrol was reported to inhibit cell proliferation of human ovarian cancer cells and human osteosarcoma cells by attenuating HIF-1alpha
  • prevents cytokine-induced vascular leakage and tumor metastasis
  • The underlying molecular mechanisms include: blocking VEGF- and FGF-receptor-mediated MAPK activation, inhibiting Akt- and MAPK-driven HIF-1alpha basal expression and its induction by IGF-1, stimulating the proteasomal degradation of HIF-1alpha, inhibiting phosphatidyl inositol (PI)-3K/Akt and Ras/mitogen/extracellular signal-regulated kinase (MEK)/ERK pathways, and activation of forkhead box (FOX)O transcription factors
  • Nathan Goodyear on 01 Jun 18
     
    natural compounds to attach cancer explained.
Nathan Goodyear

Vitamin D and inflammation: Dermato-Endocrinology: Vol 6, No 1 - 0 views

www.tandfonline.com/...19381980.2014.983401

vitamin d inflammation disease lupus RA MS inflammatory disease

shared by Nathan Goodyear on 29 Jun 17 - No Cached
  • Nathan Goodyear on 29 Jun 17
     
    vitamin D reduces inflammation in inflammatory diseases.
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