Skip to main content

Home/ Dr. Goodyear/ Group items tagged RA

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Risk of major cardiovascular events in patients with psoriatic arthritis, psoriasis and... - 0 views

ard.bmj.com/...annrheumdis-2014-205675

inflammation cardiovascular RA rheumatoid arthritis psoriasis disease CVD

shared by Nathan Goodyear on 20 Nov 14 - No Cached
  • Nathan Goodyear on 20 Nov 14
     
    Abstract: Inflammatory diesease (psoriasis and RA in this study) associated with increased cardiovascular events.
Nathan Goodyear

Effects of Angiotensin, Vasopressin and Aldosterone on Proliferation of MCF-7 Cells and... - 0 views

ar.iiarjournals.org/...1843.full

cancer breast cancer renin angiotensin system aldosterone

shared by Nathan Goodyear on 10 Sep 18 - No Cached
  • The renin-angiotensin system (RAS) has been associated with local tumor growth, inflammation, angiogenesis and facilitation of metastasis
  • Aldosterone and vasopressin did not alter cellular growth (Figure 1) and did not alter doxorubicin sensitivity
  • angiotensin increased the growth of MCF-7 cells
  • ...2 more annotations...
  • losartan
  • evidence that breast cancer chemotherapy can be influenced by anti-hypertensive treatment
  • Nathan Goodyear on 10 Sep 18
     
    upregulated RAS associated with stimulated breast cancer growth.  Anti-hypertensive therapy not only can it impact the cancer growth potential but also can augment chemotherapy.
Nathan Goodyear

Relationship between rheumatoid arthritis and Mycoplasma pneumoniae: a case-control stu... - 0 views

academic.oup.com/...keh630

RA rheumatoid arthritis arthritis mycoplasma

shared by Nathan Goodyear on 17 Jul 17 - No Cached
  • Nathan Goodyear on 17 Jul 17
     
    mycoplasma as a potential causative factor in RA.
Nathan Goodyear

Estradiol, Tamoxifen, and Flaxseed A... [J Clin Endocrinol Metab. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22930784

diet estradiol flaxseed breast cancer Ca inflammation cytokines IL-1alpha IL-1Beta IL-1Ra

shared by Nathan Goodyear on 17 Nov 12 - No Cached
  • Nathan Goodyear on 17 Nov 12
     
    Tamoxifen and more importantly, flaxseed increases endogenous IL-1Ra that is a known inhibitor of the pro-inflammatory cytokines IL-1alpha and IL-1beta. These pro-inflammatory cytokines are associated with breast cancer.  Conclusion: diet modification can effect inflammatory cytokines associated with breast cancer.  This should be explored as true preventative therapies for women. This study also found a positive association with estradiol and IL-1Beta in breast tissue and SC fat; inversely associated with IL-Ra in the breast.
Nathan Goodyear

Estrogen Regulates Tumor Growth Through a Nonclassical Pathway that Includes the Transc... - 0 views

stke.sciencemag.org/...ra22

prostate cancer ER-beta ER estrogen receptor receptors tumor suppression factor KLF5

shared by Nathan Goodyear on 06 Oct 12 - No Cached
  • Nathan Goodyear on 06 Oct 12
     
    ER-beta inhibits prostate tumor growth through the tumor suppression factor KLF5.
Nathan Goodyear

Regulatory effects of estriol on T cell migra... [J Neuroimmunol. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11958828

Estriol E3 inflammation NF-kappaB Th2 T-cells rheumatoid arthritis RA MS multiple

shared by Nathan Goodyear on 19 Mar 14 - No Cached
  • Nathan Goodyear on 19 Mar 14
     
    Pregnancy is a immunosuppressive state.  Estriol therapy mimics that through decrease in T cell migration and activation.  Estriol moved the Tcells to a Th2 dominance and also was found to inhibit NF-kappaB.  Estriol decreased TNF-alpa through IL-10 production.
Nathan Goodyear

Immune Modulation in Multiple Sclerosis Patients Treated with the Pregnancy Hormone Est... - 0 views

www.jimmunol.org/...6267.long

MS RA rheumatoid arthritis psoriasis multiple sclerosis Estriol autoimmune disease inflammation hormone hormones E3

shared by Nathan Goodyear on 19 Mar 14 - No Cached
  • A beneficial effect of pregnancy on clinical symptoms has been observed in MS and other Th1-mediated autoimmune diseases, including rheumatoid arthritis (RA), psoriasis, uveitis, and thyroiditis
  • In general, Th1 lymphocytes secrete proinflammatory cytokines (e.g., IL-2, IL-12, IFN-γ, and TNF-α) that promote cellular immunity, while Th2 lymphocytes produce anti-inflammatory cytokines (e.g., IL-4, IL-5, IL-6, and IL-10) that promote humoral immunity
  • Th2 cytokines are associated with the down-regulation of Th1 cytokines and may confer protection from Th1-mediated autoimmune diseases
  • ...1 more annotation...
  • During pregnancy, there is a shift from Th1 to Th2 that occurs both locally, at the fetal maternal interface, (23, 24, 25), and systemically
  • Nathan Goodyear on 19 Mar 14
     
    MS is in part a Th1 autoimmune disease.  Estriol therapy induces a shift to Th2 through increase in Th10.  Estriol also decreases TNF-alpha cytokine production.
Nathan Goodyear

Boswellia Serrata, A Potential Antiinflammatory Agent: An Overview - 0 views

www.ncbi.nlm.nih.gov/...PMC3309643

boswellia Frankincense inflammation NF-kappaB arthritis cancer osteoarthritis rheumatoid arthritis

shared by Nathan Goodyear on 07 Jun 16 - No Cached
  • Nathan Goodyear on 07 Jun 16
     
    review article of anti-inflammatory effects of Boswellia.  Boswellia inhibits 5-LOX and resultant leukotrienes.  3-actyl-11-keto-Beta-boswellic acid is the most potent inhibitor of 5-LOX.  As it relates to disease states and symptoms, Boswellia reduces pain in OA and RA.  Boswellia also shown to inhibit NF-kappa B: a potent nuclear transcription factor for inflammation.  In prostate cancer, Boswellia inhibits prostate tumor growth.
Nathan Goodyear

Effects of vitamin D on immune disorders with special regard to asthma, COPD and autoim... - 0 views

www.expert-reviews.com/...ers.12.57

vitamin d vitamin autoimmune diseases asthma COPD

shared by Nathan Goodyear on 12 Aug 13 - No Cached
  • Nathan Goodyear on 12 Aug 13
     
    Vitamin D is an important immunomodulator.  Vitamin D shown to have benefit in Th1 and Th2 mediated disease states. Asthma and COPD benefit and other Th1 mediated diseases, such as MS, type 1 Diabetes, RA...
Nathan Goodyear

Low free testosterone levels in rheumatoid arthritis. - 0 views

www.ncbi.nlm.nih.gov/...PMC1003446

low testosterone arthritis Rheumatoid

shared by Nathan Goodyear on 12 Apr 11 - No Cached
  • Nathan Goodyear on 12 Apr 11
     
    low Testosterone associated with increased RA in men in small study
Nathan Goodyear

Multiple Myeloma Tumor Cells are Selectively Killed by Pharmacologically-dosed Ascorbic... - 0 views

www.ebiomedicine.com/...fulltext

multiple myeloma vitamin C IV vitamin C smoldering myeloma cancer

shared by Nathan Goodyear on 25 Sep 17 - No Cached
  • Recent reports indicate that a certain ROS concentration is required for high-dose vitamin C to induce cytotoxicity in cancer cells.
  • The generation of ascorbyl- and H2O2 radicals by PAA increases ROS stress in cancer cells
  • In this study, we report that PAA is efficacious in killing MM cells in vitro and in vivo models, which generated levels of 20–40 mM ascorbate and 500 nM ascorbyl radicals after intraperitoneal administration of 4 g ascorbate per kilogram of body weight (Chen et al., 2008Chen et al., 2008), in xenograft MM mice
  • ...33 more annotations...
  • These data suggest that PAA may show a therapeutic advantage to blood cancers vs solid tumors because of the communication between tumor cells and blood plasma
  • These results strongly suggest that the mechanism of PAA killing of MM cells is indeed iron-dependent
  • These results suggest that PAA administration in SMM may be able to prevent progression to symtomatic MM
  • A recent study by Yun and colleagues demonstrated that vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH, but spares normal cells
  • RAS family genes show the most frequent mutations in MM. KRAS, NRAS and BRAF are mutated in 22%, 20% and 7% of MM samples
  • the disease stage rather than the mutation of RAS and/or BRAF is the major predictive factor for PAA sensitivity in MM treatment
  • Other molecular mechanisms including ATP depletion and ATM-AMPK signaling have been reported to explain PAA-induced cell death
  • our pilot study also suggested that PAA could overcome drug resistance to bortezomib in MM cells
  • Our findings complement reported studies and further address the mechanism of action using clinical samples in which we observed that PAA killed tumor cells with high iron content, suggesting that iron might be the initiator of PAA cytotoxicity
  • combination of PAA with standard therapeutic drugs, such as melphalan, may significantly reduce the dose of melphalan needed
  • Combined treatment of reduced dose melphalan with PAA achieved a significantly longer progression-free survival than the same dose of melphalan alone.
  • These data also suggest that the bone marrow suppression induced by high-dose melphalan can be ameliorated by the combination of PAA with lower dose of melphalan because of the lack of toxicity of PAA on normal cells with low iron content.
  • if creatinine clearance is <30 mL/min, high dose ascorbic acid should be not administrated.
  • In MM preclinical and clinical studies, ascorbate was used as an adjunct drug and showed controversial results (Harvey et al., 2009, Perrone et al., 2009, Held et al., 2013, Sharma et al., 2012, Nakano et al., 2011, Takahashi, 2010, Sharma et al., 2009, Qazilbash et al., 2008). However, none of these tests used pharmacological doses of ascorbate and intravenous administration
  • Multiple myeloma (MM) is a plasma cell neoplasm.
  • Cameron and Pauling reported that high doses of vitamin C increased survival of patients with cancer
  • pharmacologically dosed ascorbic acid (PAA) 50–100 g (Chen et al., 2008, Padayatty et al., 2004, Hoffer et al., 2008, Padayatty et al., 2006, Welsh et al., 2013), administered intravenously, has potent anti-cancer activity and its role as anti-cancer therapy is being studied at the University of Iowa and in other centers
  • In the presence of catalytic metal ions like iron, PAA administered intravenously exerts pro-oxidant effects leading to the formation of highly reactive oxygen species (ROS), resulting in cell death
  • the labile iron pool (LIP) is significantly elevated in MM cells
  • The survival of CD138+ cells in vitro was significantly decreased following PAA treatment in all 9 MM
  • In contrast, no significant change of cell viability was observed in CD138− BM cells from the same patients
  • The same effect of PAA was also observed in the SMM patients
  • no response to PAA was detected in CD138+ cells from the 2 MGUS patients
  • the combination of melphalan plus PAA showed greater tumor burden reduction than each drug alone, suggesting a synergistic activity between these two drugs
  • Both catalase and NAC protect cells from oxidative damage
  • cells pretreated with NAC and catalase became resistant to PAA even at high doses
  • adding deferoxamine (DFO), an iron chelator, to OCI-MY5 cells before PAA treatment was also sufficient to prevent PAA-induced cellular death
  • iron is essential for PAA to achieve its anti-cancer activity
  • PAA induced early necrosis (Fig. 3Fig. 3A, 60 min) followed by late apoptosis
  • results further indicated that PAA induced mitochondria-mediated apoptosis
  • PAA by reacting with LIP and generating ROS induces mitochondria-mediated apoptosis in which AIF1 cleavage is important for cell death.
  • ROS and H2O2 are well known factors mediating PAA-induced cancer cell death
  • PAA was sensitive to all 9 MMs and 2 SMMs
  • Nathan Goodyear on 25 Sep 17
     
    animal study finds high-dose, pharmacologic vitamin C found to kill multiple myeloma cells via pro-oxidant effect found in similar studies in dealing with different cancers.
Nathan Goodyear

PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling | O... - 0 views

ocg.cancer.gov/...ately-activates-mapk-and-met-0

PAK1 oncogene oncogenes cancer

shared by Nathan Goodyear on 21 Mar 18 - No Cached
  • Nathan Goodyear on 21 Mar 18
     
    PAK1 is an oncogene. Here that is linked to genesis of breast cancer through the RAS-RAF-MEK-ERK-MAPK pathway. Ivermectin, a common anti-parasitic, is know to block this oncogene activity.
Nathan Goodyear

Demystified . . . Human endogenous retroviruses - 0 views

www.ncbi.nlm.nih.gov/...PMC1187282

HERV retroviruses human endogenous retroviruses

shared by Nathan Goodyear on 14 May 18 - No Cached
  • HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits
  • However, several HERVs have been implicated in certain cancers and autoimmune diseases
  • HERVs constitute about 1% of the human genome
  • ...16 more annotations...
  • Human endogenous retroviruses (HERVs) represent footprints of previous retroviral infection and have been termed “fossil viruses”
  • HERVs possess a similar genomic organisation to present day exogenous retroviruses such as human immunodeficiency virus (HIV) and human T cell leukaemia virus (HTLV)
  • Retroviruses in effect are retrograde, because the flow of genetic information is reversed compared with the normal pathway of molecular biosynthesis—DNA → RNA → protein. Indeed, all retroviruses necessitate the conversion of viral RNA into a cDNA intermediary, which is catalysed by the enzyme reverse transcriptase
  • Overall, human endogenous retroviruses constitute about 1% of the human genome”
  • some HERVs have been implicated in certain autoimmune diseases and cancers
  • A unit of sugar, phosphate, and base is strictly termed a nucleotide
  • human genes are composed of exons, which are transcribed and translated into amino acids
  • introns, which are interspersed between exons and represent non-translated regions that contribute to the large size of some genes
  • convincing argument for the possible involvement of HERVs in malignancy
  • HERVs may be involved in carcinogenesis by virtue of the expression of HERV mRNA,26 functional proteins,27 or retroviral-like particles
  • They may also be associated with the generation of new promoters29 or the activation of proto-oncogenes
  • inhibition of an effective immune response,
  • encode immunosuppressive proteins
  • “It has been suggested that HERV-K may be important in the progression of testicular germ cell tumours through inhibition of an effective immune response”
  • HERV-K might be important in the pathogenesis of human breast cancer
  • activation of proto-oncogenes of the ras family is common in many tumour types, and some studies have suggested a potential role for HERVs in ras activation
  • Nathan Goodyear on 14 May 18
     
    good review of HERVs.
trungtamnamkhoa

Tìm hiểu cách kinh doanh căn hộ dịch vụ sinh lời cao - 4 views

npgroup.vn/-doanh-can-ho-dich-vu-sinh-loi

Thiếtkế thiếtkếxâydựng côngtythiếtkếxâydựng bulding npgroup NguyênPhátGroup

shared by trungtamnamkhoa on 25 Feb 20 - No Cached
  • trungtamnamkhoa on 25 Feb 20
     
    Các bước chuẩn bị trước khi kinh doanh căn hộ dịch vụ Xác định phân khúc khách hàng Để đảm bảo cho việc kinh doanh căn hộ dịch vụ của bạn có nhiều lời lãi nhất thì bạn nên xác định chính xác phân khúc khách hàng nhé. Theo kinh nghiệm của chúng tôi thì bạn có thể chia phân khúc khách hàng làm ra 2 loại: phân khúc bình dân và phân khúc cao cấp. Đối với phân khúc khách hàng bình dân là nói đến những người có thu nhập không cao như sinh viên, học sinh, nhân viên văn phòng. Đối với phân khúc khách hàng cao cấp là những người có thu nhập cao, người ngoại quốc. Do đó, nếu bạn xác định chính xác đối tượng khách hàng mà bạn hướng tới thì có thể có những kế hoạch chính xác cho loại hình dịch vụ của bạn. ác định mô hình đầu tư Để đảm bảo việc kinh doanh căn hộ này của bạn được thuận lợi và tiết kiệm nhất thì bạn có thể xây dựng nhà trên chính khu đất của mình. Tuy nhiên, một trong những khó khăn khi xây nhà trên chính mảnh đất của mình chính là vị trí không được thuận lợi như xa trường học, xa siêu thị,… Ngoài ra, bạn cũng có thể thuê đất của người khác để xây căn hộ. Do đó, bạn nên lựa chọn những mảnh đất gần trung tâm, gần trường học để đảm bảo thuận lợi cho việc kinh doanh căn hộ dịch vụ nhé. Bài viết này thuộc bản quyền của tác giả Công Ty Cổ Phần Tư Vấn Thiết Kế Xây Dựng Nguyên Phát (https://npgroup.vn )
daodung250996

Bệnh nổi mề đay là gì? Những thông tin cần biết về bệnh mề đay - 0 views

viemdatreem.com/benh-noi-me-day

Bệnh nổi mề đay

shared by daodung250996 on 08 Nov 19 - No Cached
  • daodung250996 on 08 Nov 19
     
    Giao mùa cũng là thời điểm nhiều người gặp phải bệnh ngứa nổi mề đay. Thông thường bệnh không gây ra nguy hiểm đến tính mạng nhưng gây khó chịu
Nathan Goodyear

Dihydroartemisinin is potential therapeutics for treating late-stage CRC by targeting t... - 0 views

www.nature.com/...s41419-021-04247-w

dihydroartemisinin c-myc cancer

shared by Nathan Goodyear on 21 Sep 22 - No Cached
  • Nathan Goodyear on 21 Sep 22
     
    Ras mutation connected to abnormal expression of Myc
‹ Previous 21 - 40 of 68 Next › Last »
Showing 20▼ items per page