paroxetine, SSRI, shown to improve depressive symptoms without altering kynurenine levels. Revealing underlying issue of depression in many individuals is disordered tryptophan metabolism due to inflammation
A number of the
catabolites produced along this pathway show neurotoxic or neuroprotective activities, and their role in the generation of
central nervous system inflammation is well documented.
We show the presence of neuroinflammation in ALS and provide the first strong evidence for the involvement of the KP in ALS. These data point to an inflammation-driven excitotoxic-chelation defective mechanism in ALS, which may be amenable to inhibitors of the KP