Skip to main content

Home/ Dr. Goodyear/ Group items tagged Tryptophan

Rss Feed Group items tagged

Nathan Goodyear

Tryptophan availability and the susceptibility to stress in multiple sclerosis: a hypot... - 0 views

  •  
    low serum and CSF tryptophan found in patients with chronic MS.  This points to disordered tryptophan metabolism
Nathan Goodyear

Mechanisms dependent on tryptophan catabolism regulate immune responses in pr... - 0 views

  •  
    Disordered Tryptophan metabolism is a useful biomarker for those with Sjogren's syndrome.  This study found an increased degradation of Tryptophan and increased IDO activity that correlated with increased severity of Sjogren's syndrome.
Nathan Goodyear

Serum Tryptophan, Kynurenine, and Neopterin in Patients with Guillain-Barre-Syndrome (G... - 0 views

  •  
    disordered tryptophan metabolism in GB and MS.
Nathan Goodyear

Tryptophan-Kynurenine Metabolism as a Common Mediator of Genetic and Environmental Impa... - 0 views

  •  
    Disordered tryptophan metabolism in depression
Nathan Goodyear

Gonadal hormone levels and platelet tryptophan and serotonin concentrations in perimeno... - 0 views

  •  
    Interesting: study finds no association between tryptophan and serotonin levels and depression.  The study found no difference between 44 "depressed" perimenopausal women and 19 "without depression".  Serotonin therapy of depression??  However, poor sleep and hot flashes did.
Nathan Goodyear

Estrogen receptor-β regulates human tryptophan hydroxylase-2 through an estro... - 0 views

  •  
    Estradiol upregulates tryptophan hydroxylase and thus serotonin production.  The signaling was via ER beta and estrogen response elements.
Nathan Goodyear

Tryptophan kynurenine metabolism ... [Isr J Psychiatry Relat Sci. 2010] - PubMed - NCBI - 0 views

  •  
    Tryptophan and kynurenine metabolism involved in depression
Nathan Goodyear

Figure 1 : Endogenous kynurenines as targets for drug discovery and developme... - 0 views

  •  
    nice diagram of Tryptophan metabolism
Nathan Goodyear

Cortisol, serotonin and depression: all stressed out? - 0 views

  •  
    Some with depression are found to have elevated salivary cortisol and others are not.  Likewise, some with depression have low serotonin and others do not.  The point is that the biochemistry of depression is complex and cortisol, serotonin, 5-HTP, tryptophan all may play a role in an individuals "depression".   One thing not included is the out.  How are these individuals metabolizing their cortisol?  As the author stated, some are hyper secretors of cortisol; why not hyper metabolizers?  Weibe has shown many are.
Nathan Goodyear

2008 Clinical approach to irrit... [Minerva Gastroenterol Dietol. 2008] - PubMed - NCBI - 0 views

  •  
    soluble fiber, probiotics, and tryptophan shown to be beneficial in those with IBS.
Nathan Goodyear

Kynurenine Metabolites and Migraine: Experimental Studies and Therapeutic Perspectives - 0 views

  •  
    Disordered tryptophan metabolism and migraine headaches.
Nathan Goodyear

Entrez PubMed - 0 views

  •  
    Neither tryptophan or levodopa shown to improve depression in hospitalized patients
Nathan Goodyear

Interferon-alpha-induced changes in tryptoph... [Biol Psychiatry. 2003] - PubMed - NCBI - 0 views

  •  
    paroxetine, SSRI, shown to improve depressive symptoms without altering kynurenine levels.  Revealing underlying issue of depression in many individuals is disordered tryptophan metabolism due to inflammation
Nathan Goodyear

Understanding the Roles of the Kynurenine Pathway in Multiple Sclerosis Progression - 0 views

  •  
    disordered tryptophan metabolism and MS
Nathan Goodyear

Targeting the IDO1 pathway in cancer: from bench to bedside | Journal of Hematology & O... - 0 views

  • Kyn is generated via two major routes: in peripheral tissues, controlled by the rate-limiting enzymes indoleamine 2, 3-dioxygenase 1 (IDO1) and indoleamine 2, 3-dioxygenase 2 (IDO2), and the hepatic route, in which tryptophan 2, 3-dioxygenase (TDO) is the rate-limiting enzyme
Nathan Goodyear

Protein Restriction, Epigenetic Diet, Intermittent Fasting as New Approaches for Preven... - 0 views

  •  
    Calorie restriction and protein restriction inhibit IGF-1, insulin, AkT, PI3K, and mTOR. In addition, those with protein intake >20%, compared to 10%, was associated with a 4 fold increase in cancer death risk and a 75% increase in overall mortality. Protein restriction inhibits tumor growth, associated with a 30-70% reduction in IGF-1, reduced the accumulation of oxidized proteins. The restriction of tryptophan alone reduced inflammation.
1 - 20 of 31 Next ›
Showing 20 items per page