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Nathan Goodyear

Tryptophan kynurenine metabolism ... [Isr J Psychiatry Relat Sci. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20686200

tryptophan kynurenine metabolism depression serotonin

shared by Nathan Goodyear on 14 Sep 11 - No Cached
  • Nathan Goodyear on 14 Sep 11
     
    Tryptophan and kynurenine metabolism involved in depression
Nathan Goodyear

QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NON-INFLAMMATORY NEUROLOGICAL DISEASE - 0 views

brain.oxfordjournals.org/...1249.short

Kynurenine pathway quinolinic inflammtion

shared by Nathan Goodyear on 12 Apr 11 - No Cached
  • QUIN and kynurenic acid are mediators of neuronal dysfunction and nerve cell death in inflammatory diseases.
  • Nathan Goodyear on 12 Apr 11
     
    kynurenine pathway and neurological inflammation
Nathan Goodyear

Characterization of the Kynurenine Pathway in Human Neurons - 0 views

www.jneurosci.org/...12884.full

disordered tryptophan metabolism kynurenine pathway quinolinate picolinate neurodegenerative disorders excitotoxicity ALS Parkinson's disease Alzheimer's depression

shared by Nathan Goodyear on 27 Oct 11 - No Cached
  • Nathan Goodyear on 27 Oct 11
     
    review of the kynurenine pathway 
Nathan Goodyear

Mitochondria, metabolic disturbances, oxidative st... [J Neurol Sci. 2007] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...17462670

mitochondria Coq10 kynurenine neurodegenerative disease Parkinson's Alzheimer's Huntington's

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • Nathan Goodyear on 07 Feb 11
     
    Great article on CoQ10, mitochondrial function, the kynurenine system and neurodegenerative diseases
Nathan Goodyear

Interferon-alpha-induced changes in tryptoph... [Biol Psychiatry. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...14573318

paroxetine SSRI depression kynurenine pathway disorded tryptophan metabolism inflammation

shared by Nathan Goodyear on 14 Sep 11 - No Cached
  • Nathan Goodyear on 14 Sep 11
     
    paroxetine, SSRI, shown to improve depressive symptoms without altering kynurenine levels.  Revealing underlying issue of depression in many individuals is disordered tryptophan metabolism due to inflammation
Nathan Goodyear

Kynurenine Pathway Metabolites in Humans: Disease and Healthy States - 0 views

www.la-press.com/and-healthy-stat-article-a1204

kynurenine pathway neurodegenerative disorders excitotoxicity ALS Parkinson's disease Alzheimer's mood disorder depression anxiety quinolinate picolinate disordered tryptophan metabolism

shared by Nathan Goodyear on 27 Oct 11 - No Cached
  • Nathan Goodyear on 27 Oct 11
     
    review of studies looking at kyneurenine pathway and it's contribution to neurodegenerative disorders and mood disorders
Nathan Goodyear

Kynurenine Metabolites and Migraine: Experimental Studies and Therapeutic Perspectives - 0 views

www.ncbi.nlm.nih.gov/...PMC3131728

migraine headaches headache NMDA tryptophan Kynurenine pathway quinolinate glial cells astrocytes

shared by Nathan Goodyear on 26 Sep 13 - No Cached
  • Nathan Goodyear on 26 Sep 13
     
    Disordered tryptophan metabolism and migraine headaches.
Nathan Goodyear

Tryptophan-Kynurenine Metabolism as a Common Mediator of Genetic and Environmental Impacts in Major Depressive Disorder: The Serotonin Hypothesis Revisited 40 Years Later - 0 views

www.ncbi.nlm.nih.gov/...PMC3021918

disordered tryptophan metabolism depression kynurenine pathway Tryptophan

shared by Nathan Goodyear on 26 Sep 13 - No Cached
  • Nathan Goodyear on 26 Sep 13
     
    Disordered tryptophan metabolism in depression
Nathan Goodyear

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis - 0 views

brain.oxfordjournals.org/...1259.short

kynurenine inhibition inflammation neurotoxicity

shared by Nathan Goodyear on 12 Apr 11 - No Cached
  • A number of the catabolites produced along this pathway show neurotoxic or neuroprotective activities, and their role in the generation of central nervous system inflammation is well documented.
  • Nathan Goodyear on 12 Apr 11
     
    kyneurenine pathway leads to CNS inflammation and neurotoxicity
Nathan Goodyear

The kynurenine pathway and inflammation in amyotro... [Neurotox Res. 2010] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...19921535

kynurenine pathway inflammation neurodegenerative disease

shared by Nathan Goodyear on 12 Apr 11 - No Cached
  • We show the presence of neuroinflammation in ALS and provide the first strong evidence for the involvement of the KP in ALS. These data point to an inflammation-driven excitotoxic-chelation defective mechanism in ALS, which may be amenable to inhibitors of the KP
  • Nathan Goodyear on 12 Apr 11
     
    kynnurenine pathway, inflammation and neurodegenerative disease
Nathan Goodyear

Serum Tryptophan, Kynurenine, and Neopterin in Patients with Guillain-Barre-Syndrome (GBS) and Multiple Sclerosis (MS) - 0 views

www.researchgate.net/..._GBS_and_Multiple_Sclerosis_MS

disordered tryptophan metabolism tryptophan Guillain Barre Syndrome GBS MS multiple sclerosis

shared by Nathan Goodyear on 30 Oct 16 - No Cached
  • Nathan Goodyear on 30 Oct 16
     
    disordered tryptophan metabolism in GB and MS.
Nathan Goodyear

Figure 1 : Endogenous kynurenines as targets for drug discovery and development : Nature Reviews Drug Discovery - 0 views

www.nature.com/...nrd870_F1.html

Tryptophan metabolism

shared by Nathan Goodyear on 14 Dec 11 - No Cached
  • Nathan Goodyear on 14 Dec 11
     
    nice diagram of Tryptophan metabolism
Nathan Goodyear

Indoleamine 2,3 dioxygenase and quinolinic acid im... [Neuropathol Appl Neurobiol. 2005] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...16008823

indoleamine 2 3 Alzheimer's disease inflammation

shared by Nathan Goodyear on 20 Apr 11 - No Cached
  • kynurenine pathway is up-regulated in Alzheimer's disease (AD) brain
  • increases in the excitotoxin quinolinic acid (QUIN
  • indoleamine 2,3 dioxygenase (IDO) is abundant in AD compared with controls
  • ...1 more annotation...
  • QUIN may be involved in the complex and multifactorial cascade leading to neuro-degeneration in AD
  • Nathan Goodyear on 20 Apr 11
     
    immune system, inflammation, and brain come together to develop Alzheimer's disease
Nathan Goodyear

Understanding the Roles of the Kynurenine Pathway in Multiple Sclerosis Progression - 0 views

www.ncbi.nlm.nih.gov/...PMC3195238

kynurenate disordered tryptophan metabolism multiple Sclerosis multiple sclerosis MS

shared by Nathan Goodyear on 07 Jan 14 - No Cached
  • Nathan Goodyear on 07 Jan 14
     
    disordered tryptophan metabolism and MS
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