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Nathan Goodyear

Targeting the IDO1 pathway in cancer: from bench to bedside | Journal of Hematology & O... - 0 views

jhoonline.biomedcentral.com/...s13045-018-0644-y

tryptophan disordered tryptophan metabolism IDO2 IDO IDO1 indoleamine dioxygenase cancer NAD

shared by Nathan Goodyear on 25 Nov 22 - No Cached
  • Kyn is generated via two major routes: in peripheral tissues, controlled by the rate-limiting enzymes indoleamine 2, 3-dioxygenase 1 (IDO1) and indoleamine 2, 3-dioxygenase 2 (IDO2), and the hepatic route, in which tryptophan 2, 3-dioxygenase (TDO) is the rate-limiting enzyme
Nathan Goodyear

Mechanisms dependent on tryptophan catabolism regulate immune responses in pr... - 0 views

www.ncbi.nlm.nih.gov/...PMC1809473

Sjogren sjögren syndrome autoimmune disease Tryptophan metabolism IDO disordered

shared by Nathan Goodyear on 30 Oct 13 - No Cached
  • Nathan Goodyear on 30 Oct 13
     
    Disordered Tryptophan metabolism is a useful biomarker for those with Sjogren's syndrome.  This study found an increased degradation of Tryptophan and increased IDO activity that correlated with increased severity of Sjogren's syndrome.
Nathan Goodyear

Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats ... - 0 views

www.sciencedirect.com/...S0024320520301740

GSH inflammation IDO indoleamine dioxygenase glutathione melatonin

shared by Nathan Goodyear on 18 Nov 22 - No Cached
  • Nathan Goodyear on 18 Nov 22
     
    Melatonin as a downregulator of IDO and GSH in neuroinflammation.
Nathan Goodyear

Targeting the IDO1 pathway in cancer: from bench to bedside - 0 views

TME inflammation cancer tumor microenvironment immunosuppression IDO indoleamine dioxygenase

shared by Nathan Goodyear on 18 Feb 21 - No Cached
  • Nathan Goodyear on 18 Feb 21
     
    Awesome read!
Nathan Goodyear

Indoleamine 2,3 dioxygenase and quinolinic acid im... [Neuropathol Appl Neurobiol. 2005... - 0 views

www.ncbi.nlm.nih.gov/...16008823

indoleamine 2 3 Alzheimer's disease inflammation

shared by Nathan Goodyear on 20 Apr 11 - No Cached
  • kynurenine pathway is up-regulated in Alzheimer's disease (AD) brain
  • increases in the excitotoxin quinolinic acid (QUIN
  • indoleamine 2,3 dioxygenase (IDO) is abundant in AD compared with controls
  • ...1 more annotation...
  • QUIN may be involved in the complex and multifactorial cascade leading to neuro-degeneration in AD
  • Nathan Goodyear on 20 Apr 11
     
    immune system, inflammation, and brain come together to develop Alzheimer's disease
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