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spineneuro

Deep Brain Stimulation By Dr. Paresh Doshi Best Neurosurgeon in Jaslok - 0 views

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    Deep brain stimulation neurosurgeon Jaslok Hospital is credited with the largest number of stereotactic procedures performed by a single individual in the country, boasting a success rate exceeding 95%. Dr. Paresh Doshi is also distinguished for operating on the world's oldest patient (82 years old) with Parkinson's disease.
spineneuro

Hope Knows No Bounds: A Nigerian Patient's Encounter with Dr. Paresh Doshi - 0 views

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    The best deep brain stimulation neurosurgeon explained the entire DBS procedure to Mr. Adeoluwa and his family, ensuring they clearly understood what to expect. Dr. Paresh Doshi's surgical skills are second to none. The DBS procedure requires extreme precision and expertise, as the electrodes must be accurately placed within the brain's target areas. The surgery succeeded under the Best deep brain stimulation neurosurgeon's steady hands.
Nathan Goodyear

Gut microbe levels are linked to type 2 diabetes and obesity -- ScienceDaily - 0 views

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    Individuals with obesity and type II Diabetes been found to have significantly different gut bacteria populations compared to healthy individuals.  This is not new information.  The firmicutes:bacteroidetes ratio has been long known to be elevated in obese individuals vs those that are lean.  The question here is cause and effect.  Is the change in the bacterial population leading to obesity and type II diabetes?  Or is diabetes and obesity leading to changes in the bacterial population?  A heavy-laden carb diet is know to lead to a change to a more unhealthy gut bacterial population--maybe it is just a product of diet?  Maybe it is effected by vaginal delivery vs cesarean delivery?  Maybe breast feeding plays a role.  Maybe, all the above is required. The point is that the cause of obesity and type II diabetes may have its origins deep, deep in the...well you know. http://ow.ly/yqDML 
Party Pills

Clubbell Flow Evolution™ - Dare To Evolve - 0 views

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    Warning: To CHOOSE to step into the Hurricane is no small gesture. It comes from deep within, fortified by Courage and Determination. It speaks to truth at your ...
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    Warning: To CHOOSE to step into the Hurricane is no small gesture. It comes from deep within, fortified by Courage and Determination. It speaks to truth at your ...
spineneuro

Spine And Neuro Surgery Hospital India: Dr. Paresh Doshi Adding More to Life Through Ex... - 0 views

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    As a neurosurgeon, Dr. Paresh Doshi has performed many lifesaving surgeries to remove brain tumors and blood clots. Recently he has performed a unique deep brain stimulation (DBS) surgical treatment using a complicated auto-sensing device (percept computer) for controlling the signs and symptoms of Parkinson's disease of a forty two-years-old patient, a scientist from Ahmedabad. For Appointment Email: dr.pareshdoshi@neurospinehospital.com Phone No.: +91-9325887033
Nathan Goodyear

Testosterone: a vascular hormone in health and disease - 0 views

  • Testosterone has beneficial effects on several cardiovascular risk factors, which include cholesterol, endothelial dysfunction and inflammation
  • In clinical studies, acute and chronic testosterone administration increases coronary artery diameter and flow, improves cardiac ischaemia and symptoms in men with chronic stable angina and reduces peripheral vascular resistance in chronic heart failure.
  • testosterone is an L-calcium channel blocker and induces potassium channel activation in vascular smooth muscle cells
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  • Animal studies have consistently demonstrated that testosterone is atheroprotective, whereas testosterone deficiency promotes the early stages of atherogenesis
  • there is no compelling evidence that testosterone replacement to levels within the normal healthy range contributes adversely to the pathogenesis of CVD (Carson & Rosano 2011) or prostate cancer (Morgentaler & Schulman 2009)
  • bidirectional effect between decreased testosterone concentrations and disease pathology exists as concomitant cardiovascular risk factors (including inflammation, obesity and insulin resistance) are known to reduce testosterone levels and that testosterone confers beneficial effects on these cardiovascular risk factors
  • Achieving a normal physiological testosterone concentration through the administration of testosterone replacement therapy (TRT) has been shown to improve risk factors for atherosclerosis including reducing central adiposity and insulin resistance and improving lipid profiles (in particular, lowering cholesterol), clotting and inflammatory profiles and vascular function
  • It is well known that impaired erectile function and CVD are closely related in that ED can be the first clinical manifestation of atherosclerosis often preceding a cardiovascular event by 3–5 years
  • no decrease in the response (i.e. no tachyphylaxis) of testosterone and that patient benefit persists in the long term.
  • free testosterone levels within the physiological range, has been shown to result in a marked increase in both flow- and nitroglycerin-mediated brachial artery vasodilation in men with CAD
  • Clinical studies, however, have revealed either small reductions of 2–3 mm in diastolic pressure or no significant effects when testosterone is replaced within normal physiological limits in humans
  • Endothelium-independent mechanisms of testosterone are considered to occur primarily via the inhibition of voltage-operated Ca2+ channels (VOCCs) and/or activation of K+ channels (KCs) on smooth muscle cells (SMCs)
  • Testosterone shares the same molecular binding site as nifedipine
  • Testosterone increases the expression of endothelial nitric oxide synthase (eNOS) and enhances nitric oxide (NO) production
  • Testosterone also inhibited the Ca2+ influx response to PGF2α
  • one of the major actions of testosterone is on NO and its signalling pathways
  • In addition to direct effects on NOS expression, testosterone may also affect phosphodiesterase type 5 (PDE5 (PDE5A)) gene expression, an enzyme controlling the degradation of cGMP, which acts as a vasodilatory second messenger
  • the significance of the action of testosterone on VSMC apoptosis and proliferation in atherosclerosis is difficult to delineate and may be dependent upon the stage of plaque development
  • Several human studies have shown that carotid IMT (CIMT) and aortic calcification negatively correlate with serum testosterone
  • t long-term testosterone treatment reduced CIMT in men with low testosterone levels and angina
  • neither intracellular nor membrane-associated ARs are required for the rapid vasodilator effect
  • acute responses appear to be AR independent, long-term AR-mediated effects on the vasculature have also been described, primarily in the context of vascular tone regulation via the modulation of gene transcription
  • Testosterone and DHT increased the expression of eNOS in HUVECs
  • oestrogens have been shown to activate eNOS and stimulate NO production in an ERα-dependent manner
  • Several studies, however, have demonstrated that the vasodilatory actions of testosterone are not reduced by aromatase inhibition
  • non-aromatisable DHT elicited similar vasodilation to testosterone treatment in arterial smooth muscle
  • increased endothelial NOS (eNOS) expression and phosphorylation were observed in testosterone- and DHT-treated human umbilical vein endothelial cells
  • Androgen deprivation leads to a reduction in neuronal NOS expression associated with a decrease of intracavernosal pressure in penile arteries during erection, an effect that is promptly reversed by androgen replacement therapy
  • Observational evidence suggests that several pro-inflammatory cytokines (including interleukin 1β (IL1β), IL6, tumour necrosis factor α (TNFα), and highly sensitive CRP) and serum testosterone levels are inversely associated in patients with CAD, T2DM and/or hypogonadism
  • patients with the highest IL1β concentrations had lower endogenous testosterone levels
  • TRT has been reported to significantly reduce TNFα and elevate the circulating anti-inflammatory IL10 in hypogonadal men with CVD
  • testosterone treatment to normalise levels in hypogonadal men with the MetS resulted in a significant reduction in the circulating CRP, IL1β and TNFα, with a trend towards lower IL6 compared with placebo
  • parenteral testosterone undecanoate, CRP decreased significantly in hypogonadal elderly men
  • Higher levels of serum adiponectin have been shown to lower cardiovascular risk
  • Research suggests that the expression of VCAM-1, as induced by pro-inflammatory cytokines such as TNFα or interferon γ (IFNγ (IFNG)) in endothelial cells, can be attenuated by treatment with testosterone
  • Testosterone also inhibits the production of pro-inflammatory cytokines such as IL6, IL1β and TNFα in a range of cell types including human endothelial cells
  • decreased inflammatory response to TNFα and lipopolysaccharide (LPS) in human endothelial cells when treated with DHT
  • The key to unravelling the link between testosterone and its role in atherosclerosis may lay in the understanding of testosterone signalling and the cross-talk between receptors and intracellular events that result in pro- and/or anti-inflammatory actions in athero-sensitive cells.
  • testosterone functions through the AR to modulate adhesion molecule expression
  • pre-treatment with DHT reduced the cytokine-stimulated inflammatory response
  • DHT inhibited NFκB activation
  • DHT could inhibit an LPS-induced upregulation of MCP1
  • Both NFκB and AR act at the transcriptional level and have been experimentally found to be antagonistic to each other
  • As the AR and NFκB are mutual antagonists, their interaction and influence on functions can be bidirectional, with inflammatory agents that activate NFκB interfering with normal androgen signalling as well as the AR interrupting NFκB inflammatory transcription
  • prolonged exposure of vascular cells to the inflammatory activation of NFκB associated with atherosclerosis may reduce or alter any potentially protective effects of testosterone
  • DHT and IFNγ also modulate each other's signalling through interaction at the transcriptional level, suggesting that androgens down-regulate IFN-induced genes
  • (Simoncini et al. 2000a,b). Norata et al. (2010) suggest that part of the testosterone-mediated atheroprotective effects could depend on ER activation mediated by the testosterone/DHT 3β-derivative, 3β-Adiol
  • TNFα-induced induction of ICAM-1, VCAM-1 and E-selectin as well as MCP1 and IL6 was significantly reduced by a pre-incubation with 3β-Adiol in HUVECs
  • 3β-Adiol also reduced LPS-induced gene expression of IL6, TNFα, cyclooxygenase 2 (COX2 (PTGS2)), CD40, CX3CR1, plasminogen activator inhibitor-1, MMP9, resistin, pentraxin-3 and MCP1 in the monocytic cell line U937 (Norata et al. 2010)
  • This study suggests that testosterone metabolites, other than those generated through aromatisation, could exert anti-inflammatory effects that are mediated by ER activation.
  • The authors suggest that DHT differentially effects COX2 levels under physiological and pathophysiological conditions in human coronary artery smooth muscle cells and via AR-dependent and -independent mechanisms influenced by the physiological state of the cell
  • There are, however, a number of systematic meta-analyses of clinical trials of TRT that have not demonstrated an increased risk of adverse cardiovascular events or mortality
  • The TOM trial, which was designed to investigate the effect of TRT on frailty in elderly men, was terminated prematurely as a result of an increased incidence of cardiovascular-related events after 6 months in the treatment arm
  • trials of TRT in men with either chronic stable angina or chronic cardiac failure have also found no increase in either cardiovascular events or mortality in studies up to 12 months
  • Evidence may therefore suggest that low testosterone levels and testosterone levels above the normal range have an adverse effect on CVD, whereas testosterone levels titrated to within the mid- to upper-normal range have at least a neutral effect or, taking into account the knowledge of the beneficial effects of testosterone on a series of cardiovascular risk factors, there may possibly be a cardioprotective action
  • The effect of testosterone on human vascular function is a complex issue and may be dependent upon the underlying androgen and/or disease status.
  • the majority of studies suggest that testosterone may display both acute and chronic vasodilatory effects upon various vascular beds at both physiological and supraphysiological concentrations and via endothelium-dependent and -independent mechanisms
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    Good deep look into the testosterone and CVD link.
Nathan Goodyear

Nutritional protective mechanisms against gut inflammation - 0 views

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    Nice review of inflammation originating from the gut.  This article nicely points out the pathway involving PPAR gamma and its anti-inflammatory effects in gut inflammatory conditions such as IBD. This article also specifically discusses natural compounds that activate PPAR gamma and thus reduce inflammation.  Good deep biochemical discussion of how natural therapies reduce inflammation.  
Nathan Goodyear

Androgen Receptor (AR) Coregulators: An Overview - 0 views

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    Deep, but highly necessary discussion of androgen receptors.
Nathan Goodyear

Mechanisms of Estrogen Action - 0 views

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    good discussion of estrogen receptors and their role of estrogen signaling transmission.This article goes deep into coregulators, corepressors, cofactors, agonists, antagonists...
wheelchairindia9

Karma 8020 Wheelchair - 0 views

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    Heavy duty wheelchair can either be manually-operated or motorized, each with its own pros and cons. A manual heavy-duty wheelchair gives full control of motion to the user, but the added weight from the reinforcements makes pushing or propelling the wheelchair much harder than normal. A motorized heavy duty wheelchair offers a solution to this dilemma, but is often more expensive and harder to maintain than a manual wheelchair. Some designs offer a combination of both, with a small motor assisting those pushing the wheelchair. The proper choice between types of Heavy Duty wheelchair depends largely on the user's expected level of activity. Heavy duty wheelchairs typically have larger seats than conventional wheelchairs. The frames of these wheelchairs can be made from several different reinforced metals, although a titanium wheelchair is often the most popular choice. The wheels themselves are made of thicker rubber than normal, preventing any possible failure due to the greater amount of weight supported. Most makes of heavy duty wheelchairs fold like regular wheelchairs, making storage relatively easy despite the wheelchair increased size. Heavy Duty Wheelchair specialy design for disabled and handicapped persons. They are two types of Heavy Duty Wheelchair for handicapped and disability product like- Karma 8020 X Heavy Duty Wheelchair Karma 8520 Heavy Duty Wheelchair Karma 8020 X Heavy Duty Wheelchair: It comes with detachable swing away footrests. The wheel chair has flip-back armrests. It comes with centre of gravity adjustment. The wheel chair has wide profile casters. Seat Size 20'' inch & 22'' inch Total Weight 17 K.G. Designed for maximum strength & weight capacity for people over 250 lbs. These end to be heavier and wider. This heavy duty bariatric wheelchair has seat dimensions of 24 inches wide by 18 inches deep to accommodate a weight capacity of up to 400 lbs. This wheelchair is dual axle, which means that the floor to seat heigh
Nathan Goodyear

Glutamate and the glutamate receptor system: a tar... [Int J Geriatr Psychiatry. 2003] ... - 0 views

  • Under certain conditions, glutamate has a toxic action resulting from an activation of specific glutamate receptors, which leads to acute or chronic death of nerve cells.
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    deep, heavy read on glutamate excitotoxicity and neuronal death leading to neurodegenerative disease
Nathan Goodyear

Endocrine Disruption: Historical Perspectives and Its Impact on the Future of Toxicolog... - 0 views

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    deep read on the environment and endocrine disruptors
wheelchairindia9

Wrist and Forearm Splints Causes and Recovery Period | Health | Article Point - 0 views

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    Wrist and forearm splints may be suggested for people with weak wrists or for those that have been previously injured, for tendonitis wrist support and even as a preventative for those who awaken in the morning with pain or numbness after sleeping on their hands at night. The best orthopedic wrist braces for carpal tunnel syndrome, occupational stabilization and relief from the pain of wrist strains and sprains. This Right hand wrist and forearm splint from tynor is meant to be used among patients suffering from any injury or sprain in these regions. The splint is meant to provide controlled compression in various orthopaedic conditions. The splint immobilizes the area that helps in a speedier recovery. It has anatomical thumb opening that allows free movement of the thumb. It provides a lot of comfort and is easily breathable. Forearm splint is the term used to describe the forearm pain similarly the pain of lower leg over the shin is known as shin splints. Forearm splint describes the painful disease of elbow or wrist joint. Continuous pain in forearm is often caused by tendonitis, joint injury or hairline fracture of forearm bones (proximal radius or ulna near elbow joint). Overstretching of the elbow joint often causes forearm injury. Symptoms consist of a dull pain in the forearm. Pain is minor initially but increases as activity continues. Often pin-pointed to the dorsal or back of the hand side of the forearm, mid-way between the wrist and elbow. The patient may experience weakness in the wrist extensor muscles and tenderness deep in the forearm. Pain may be reproduced by attempting to bend the wrist backwards against resistance. They provided wrist splints are used in different medical institutions and hospitals for management of hand fractures. Our offered wrist splints are manufactured by skilled professionals using optimum quality basic material and advanced technology as per the set norms of market. As well, these wrist splints can be availed in v
fnfdoc

Exactly How Bad Are Trans Fats | Your Health Our Priority - 0 views

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    Are you worried you are getting heavier day by day? Well, it might be because of those fries you are addicted to. Deep fried foods are rich in trans fats which are directly related to obesity and heart failure. Trans fats build up the blood vessels, hindering the smooth flow of blood through them.
Nathan Goodyear

Colocalization of progesterone receptors A and B by dual immunofluourescent histochemis... - 0 views

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    PR-A and PR-B and regulation of the human menstural cycle.
wheelchairindia9

Tynor Wrist and Forearm Splint Right-Left - 0 views

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    Tynor Wrist and Forearm Splint Right-Left Wrist and Forearm Splint is designed to immobilize and provide firm and comfortable support to hand and wrist in various orthopedic conditions. It maintains the wrist in the functional position. Aesthetically appealing. Customizable splint. Perfect immobilization. Controlled compression. Anatomical thumb opening. Tynor Wrist and Forearm Splint Right-Left Features Made out of PUF fused Matty fabric Breathable Excellent aesthetics Improved comfort Enhanced life. Removable, Aluminum Splints Customized fitting Required degree of dorsi-flexion can be achieved Very good grip and immobilization Design features Long length of the brace, ensures enhanced immobilization Brace abuts the Palmer crease , allows free finger movement. Elegant tabs , allow easy application and removal Elegant tabs, also enhance the aesthetics of the product. Black Color, enhances the aethetics Hook loop closures Easy to apply and remove Ensures optimal compression , Built in opening for thumb abduction Better pain relief and healing. Thumb remains relaxed, no fatigue Improves comfort Tynor Wrist and Forearm Splint Right-Left Measurements Measure the Circumference at a distance 6" from the wrist along the arm
Nathan Goodyear

Hyperhomocysteinemia, deep vein thrombosi... [J Formos Med Assoc. 2007] - PubMed - NCBI - 0 views

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    Vitamin B12 deficiency will decrease methionine synthase activity, which will result in elevated homocysteine and the risk of DVT increases as a result.  In this article, the cause of the vitamin B12 depletion was metformin.  Diabetics and those with insulin resistance are already at an increased risk of blood clots.
Nathan Goodyear

Deep Morphea after Vaccination in Two Young Children - Torrelo - 2006 - Pediatric Derma... - 0 views

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    Vaccines linked to morphea in 2 case studies.  The mechanism is through autoimmune activation.
Nathan Goodyear

METHYLISOTHIAZOLINONE || Skin Deep® Cosmetics Database | Environmental Workin... - 0 views

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    good data review on methylisothiazolinone. Also known as MI for short.
Nathan Goodyear

Wasting syndrome with deep bradycardia as ... [BMC Endocr Disord. 2014] - PubMed - NCBI - 0 views

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    long standing low T linked to bradycardia and heart failure in case series.  Exact relationship of cause/effect unknown, though low T has been shown to be associated with wide spectrum of increased risk of CVD.
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