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Nathan Goodyear

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1337411/pdf/cmaj00058-0090.pdf - 0 views

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    Estrogen is neuroprotective in postmenopausal women.
Nathan Goodyear

Progesterone enhances transthyretin expressio... [J Mol Neurosci. 2011] - PubMed - NCBI - 0 views

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    Postmenopausal cognitive decline is a common complaint.  Declining Estradiol and progesterone have been implicated, in part, to this cognitive decline.  This study finds that progesterone increases expression of Transthyretin, a protein that processes amyloid Beta protein.  This amyloid Beta protein is associated with damage found in Alzheimer's. 
Nathan Goodyear

Endogenous estrogen levels and Alzheimer's disease... [Neurology. 2000] - PubMed - NCBI - 0 views

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    Women with the lower estradiol levels have an associated increased risk of Alzheimer's disease.  Inverse relationship found in women.
Nathan Goodyear

Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms o... - 0 views

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    Small case study of 3 finds significant improvement in Alzheimer's with Turmeric.
Nathan Goodyear

1α,25-dihydroxyvitamin D_{3} Interacts with Curcuminoids to Stimulate Amyloid... - 0 views

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    curcumin and vitamin D synergistic in beta-amyloid removal in Alzheimer's disease. 
Nathan Goodyear

Serum Folate, Homocysteine, Brain Atrophy, and Auto-CM System: The Treviso Dementia (TR... - 0 views

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    Folic acid inversely associated with brain atrophy.  Also, homocysteine is associated directly with brain atrophy in the cortical, subcortical, and hippocampus regions.
Nathan Goodyear

Decreased Accumulation of Subcellular Amyloid-β with Improved Mitochondrial F... - 0 views

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    Huperzine A, a natural acetylcholinesterase inhibitor, provides neuroprotection through increase mitochondrial function and decrease in accumulated amyloid Beta protein.
Nathan Goodyear

Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treat... - 0 views

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    Huperzine reduces CNS iron.  This is in addition to the other neuroprotective effects of Huperzine A
Nathan Goodyear

http://www.update-software.com/BCP/WileyPDF/EN/CD007365.pdf - 0 views

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    meta-analysis found no high level of evidence to support Huperzine A in the treatment of vascular dementia.  The conclusion sounds scientifically sound, but when you look at the studies included: this is a meta-analysis of 1 of Huperzine A and vascular dementia.  This one study was of 14 participants only and they found improvement in daily functioning.   There are a lot of animal studies that point out benefits of huperzine A and even the mechanisms of action,  but human studies are lacking.  That is a better conclusion.  
Nathan Goodyear

Treating senile dementia with traditional Chinese medicine - 0 views

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    Great review of the literature supporting herbal therapies in the treatment of dementia.
Nathan Goodyear

Huperzine A in the Treatment of Alzheimer's Disease and Vascular Dementia: A Meta-Analysis - 0 views

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    Good review of the data on Huperzine A and Alzheimer's dementia.
Nathan Goodyear

http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.po... - 0 views

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    Another meta-analysis, this time of 20 studies, finds benefit of huperzine A in the treatment of Alzheimer's disease.
Nathan Goodyear

Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carniti... - 0 views

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    Meta-analysis of 21 studies on acetyl Carnitine finds improvement with mild cognitive impairment and/or prevention of cognitive deterioration.
Nathan Goodyear

Mitochondrial pathobiology in Parkinson's disease ... [J Alzheimers Dis. 2010] - PubMed... - 0 views

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    mitochondria and contribution to neurodegenerative diseases, Parkinson's disease and ALS
Nathan Goodyear

Mitoenergetic failure in Alzheimer disease - 0 views

  • This review summarizes new insights based on the interaction of mitoenergetic failure, glutamate excitotoxicity, and amyloid toxicity in the exacerbation of AD.
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    discussion on mitochondria, neuro-excitotoxicity, and Alzheimer's Disease
Nathan Goodyear

Therapeutic rescue of neurodegeneration in experim... [J Alzheimers Dis. 2006] - PubMed... - 0 views

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    poor insulin/glucose control contributes to Alzheimer's risk
Nathan Goodyear

New Prevalence Study Suggests Dramatically Rising Numbers of People with Alzheimer's Di... - 0 views

  • Scientists project that some 13.2 million older Americans will have Alzheimer's disease (AD) by 2050
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    neurodegenerative disease on the rise, unless we become very proactive
Nathan Goodyear

1alpha,25-dihydroxyvitamin D3 interacts with curcu... [J Alzheimers Dis. 2009] - PubMed... - 0 views

  • 1,25D3 strongly stimulated Abeta phagocytosis and clearance while protecting against apoptosis
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    Vitamin D3 and Alzheimer's disease
Nathan Goodyear

The Relationship between Alzheimer's Disease and Diabetes: Type 3 Diabetes? - ACAM Inte... - 0 views

  • AD has its foundation in neuroendocrinology
  • Referring to AD as type 3 diabetes has its foundation in the fact that the CNS in AD is characterized by a paucity of insulin and resistance of the insulin receptors
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    Insulin/Glucose dysregulation and Alzheimer's disease
Nathan Goodyear

Current alcohol consumption and its relationship to incident dementia: results from a 3... - 0 views

  • ight-to-moderate alcohol consumption is inversely related to incident dementia
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    light to moderate alcohol intake helps to reduce dementia risk
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