Postmenopausal cognitive decline is a common complaint. Declining Estradiol and progesterone have been implicated, in part, to this cognitive decline. This study finds that progesterone increases expression of Transthyretin, a protein that processes amyloid Beta protein. This amyloid Beta protein is associated with damage found in Alzheimer's.
Folic acid inversely associated with brain atrophy. Also, homocysteine is associated directly with brain atrophy in the cortical, subcortical, and hippocampus regions.
Huperzine A, a natural acetylcholinesterase inhibitor, provides neuroprotection through increase mitochondrial function and decrease in accumulated amyloid Beta protein.
meta-analysis found no high level of evidence to support Huperzine A in the treatment of vascular dementia. The conclusion sounds scientifically sound, but when you look at the studies included: this is a meta-analysis of 1 of Huperzine A and vascular dementia. This one study was of 14 participants only and they found improvement in daily functioning.
There are a lot of animal studies that point out benefits of huperzine A and even the mechanisms of action, but human studies are lacking. That is a better conclusion.
This review summarizes new insights based on the interaction of mitoenergetic failure, glutamate excitotoxicity, and amyloid
toxicity in the exacerbation of AD.
Referring to AD as type 3 diabetes has its foundation in the fact that the CNS in AD is characterized by a paucity of insulin and resistance of the insulin receptors