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Matti Narkia

NEJM -- Mercury, Fish Oils, and the Risk of Myocardial Infarction - 0 views

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    Mercury, fish oils, and the risk of myocardial infarction. Guallar E, Sanz-Gallardo MI, van't Veer P, Bode P, Aro A, Gómez-Aracena J, Kark JD, Riemersma RA, Martín-Moreno JM, Kok FJ; Heavy Metals and Myocardial Infarction Study Group. N Engl J Med. 2002 Nov 28;347(22):1747-54. PMID: 12456850 Conclusions The toenail mercury level was directly associated with the risk of myocardial infarction, and the adipose-tissue DHA level was inversely associated with the risk. High mercury content may diminish the cardioprotective effect of fish intake.
Matti Narkia

25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men: A Prospective Study, June... - 0 views

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    25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Giovannucci E, Liu Y, Hollis BW, Rimm EB. Arch Intern Med. 2008 Jun 9;168(11):1174-80. PMID: 18541825 Conclusion Low levels of 25(OH)D are associated with higher risk of myocardial infarction in a graded manner, even after controlling for factors known to be associated with coronary artery disease.
Matti Narkia

NEJM -- Fish Consumption and the 30-Year Risk of Fatal Myocardial Infarction - 0 views

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    Fish consumption and the 30-year risk of fatal myocardial infarction. Daviglus ML, Stamler J, Orencia AJ, Dyer AR, Liu K, Greenland P, Walsh MK, Morris D, Shekelle RB. N Engl J Med. 1997 Apr 10;336(15):1046-53. PMID: 9091800 Conclusions These data show an inverse association between fish consumption and death from coronary heart disease, especially nonsudden death from myocardial infarction.
Matti Narkia

The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol, and HDL chol... - 0 views

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    The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls. Parish S, Peto R, Palmer A, Clarke R, Lewington S, Offer A, Whitlock G, Clark S, Youngman L, Sleight P, Collins R; International Studies of Infarct Survival Collaborators. Eur Heart J. 2009 Sep;30(17):2137-46. Epub 2009 Jun 11. PMID: 19520708 doi:10.1093/eurheartj/ehp221 Conclusion: Apolipoprotein ratios are more informative about risk than lipid fractions are. This suggests that, among lipoprotein particles of a particular type (LDL or HDL), some smaller and larger subtypes differ in their effects on risk. Direct measurements of even more specific subtypes of lipoprotein particles may be even more informative about risk.
Matti Narkia

Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial in... - 0 views

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    Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Singh RB, Neki NS, Kartikey K, Pella D, Kumar A, Niaz MA, Thakur AS. Mol Cell Biochem. 2003 Apr;246(1-2):75-82. PMID: 12841346
Matti Narkia

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocar... - 0 views

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    Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico.\nLancet. 1999 Aug 7;354(9177):447-55. Erratum in: Lancet 2001 Feb 24;357(9256):642. Lancet. 2007 Jan 13;369(9556):106.\nPMID: 10465168
Matti Narkia

Mediterranean Diet, Traditional Risk Factors, and the Rate of Cardiovascular Complicati... - 0 views

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    Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. de Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Mamelle N. Circulation. 1999 Feb 16;99(6):779-85. PMID: 9989963
Matti Narkia

Glycemic index, glycemic load, and the risk of acute myocardial infarction in Finnish m... - 0 views

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    Glycemic index, glycemic load, and the risk of acute myocardial infarction in Finnish men: The Kuopio Ischaemic Heart Disease Risk Factor Study. Mursu J, Virtanen JK, Rissanen TH, Tuomainen TP, Nykänen I, Laukkanen JA, Kortelainen R, Voutilainen S. Nutr Metab Cardiovasc Dis. 2009 Oct 14. [Epub ahead of print] PMID: 19836217 doi:10.1016/j.numecd.2009.08.001 Conclusions Our results suggest that both high dietary GI and GL are associated with increased risk of AMI among overweight and GL possibly among less physically active men.
Matti Narkia

Fish consumption and risk of subclinical brain abnormalities on MRI in older adults - 0 views

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    Fish consumption and risk of subclinical brain abnormalities on MRI in older adults. Virtanen JK, Siscovick DS, Longstreth WT Jr, Kuller LH, Mozaffarian D. Neurology. 2008 Aug 5;71(6):439-46. PMID: 18678827 doi: 10.1212/01.wnl.0000324414.12665.b0 Conclusions: Among older adults, modest consumption of tuna/other fish, but not fried fish, was associated with lower prevalence of subclinical infarcts and white matter abnormalities on MRI examinations. Our results add to prior evidence that suggest that dietary intake of fish with higher eicosapentaenoic acid and docosahexaenoic acid content, and not fried fish intake, may have clinically important health benefits
Matti Narkia

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocar... - 0 views

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    Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. [No authors listed] Lancet. 1999 Aug 7;354(9177):447-55. Erratum in: Lancet 2001 Feb 24;357(9256):642. Lancet. 2007 Jan 13;369(9556):106. PMID: 10465168 Interpretation Dietary supplementation with n-3 PUFA led to a clinically important and satistically significant benefit. Vitamin E had no benefit. Its effects on fatal cardiovascular events require further exploration
Matti Narkia

Calcium:Magnesium Ratio in Local Groundwater and Incidence of Acute Myocardial Infarcti... - 0 views

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    Calcium:magnesium ratio in local groundwater and incidence of acute myocardial infarction among males in rural Finland. Kousa A, Havulinna AS, Moltchanova E, Taskinen O, Nikkarinen M, Eriksson J, Karvonen M. Environ Health Perspect. 2006 May;114(5):730-4. doi:10.1289/ehp.8438 PMID: 16675428 Results of this study with specific Bayesian statistical analysis support earlier findings of a protective role of Mg and low Ca:Mg ratio against coronary heart disease but do not support the earlier hypothesis of a protective role of Ca
Matti Narkia

{alpha}-Linolenic Acid and Risk of Nonfatal Acute Myocardial Infarction -- Campos et al... - 0 views

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    Alpha-linolenic acid and risk of nonfatal acute myocardial infarction. Campos H, Baylin A, Willett WC. Circulation. 2008 Jul 22;118(4):339-45. Epub 2008 Jul 7. Erratum in: Circulation. 2008 Sep 16;118(12):e492. PMID: 18606916 doi: 10.1161/CIRCULATIONAHA.107.762419 Conclusions - Consumption of vegetable oils rich in {alpha}-linolenic acid could confer important cardiovascular protection. The apparent protective effect of {alpha}-linolenic acid is most evident among subjects with low intakes.
Matti Narkia

NephroPal: Omega 3 Fatty Acid and Adiponectin Levels - 0 views

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    "Friday, December 18, 2009 Omega 3 Fatty Acid and Adiponectin Levels Today my wife was watching the Oprah show. A commercial came on and I looked up. It was a Christmas special on liposuction in the local area. Considering that the fat tissue (adipose tissue) is now viewed as an endocrine organ and not just a collection of fat cells, I have always thought that sucking out the fat cells maybe a bad idea. Yet, I have never seen proof of this. But, the science of the adipose tissue as an endocrine organ is relatively new. It seems that in the medical literature adiponectin is receiving the most attention from all of the other adipose hormones - or also referred to as adipokines. This is for good reason. As stated before, adiponectin has the following effects: * reduces liver glucose production * increases glucose uptake in the muscles and adipose tissues * causes oxidation of fats which leads to less lipid production * has anti-inflammatory properties * protects the heart against ischemia and reduces myocardial infarct size * acts as an anti-clotting factor * increases nitric oxide production in the vasculature leading to a greater dilation of the vessels"
Matti Narkia

The Diet-Heart Hypothesis: Subdividing Lipoproteins - Whole Health Source - 0 views

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    The Diet-Heart Hypothesis: Subdividing Lipoproteins Two posts ago, we made the rounds of the commonly measured blood lipids (total cholesterol, LDL, HDL, triglycerides) and how they associate with cardiac risk. It's important to keep in mind that many things associate with cardiac risk, not just blood lipids. For example, men with low serum vitamin D are at a 2.4-fold greater risk of heart attack than men with higher D levels. That alone is roughly equivalent to the predictive power of the blood lipids you get measured at the doctor's office. Coronary calcium scans (a measure of blood vessel calcification) also associate with cardiac risk better than the most commonly measured blood lipids. Lipoproteins Can be Subdivided into Several Subcategories In the continual search for better measures of cardiac risk, researchers in the 1980s decided to break down lipoprotein particles into sub-categories. One of these researchers is Dr. Ronald M. Krauss. Krauss published extensively on the association between lipoprotein size and cardiac risk, eventually concluding (source): The plasma lipoprotein profile accompanying a preponderance of small, dense LDL particles (specifically LDL-III) is associated with up to a threefold increase in the susceptibility of developing [coronary artery disease]. This has been demonstrated in case-control studies of myocardial infarction and angiographically documented coronary disease. Krauss found that small, dense LDL (sdLDL) doesn't travel alone: it typically comes along with low HDL and high triglycerides*. He called this combination of factors "lipoprotein pattern B"; its opposite is "lipoprotein pattern A": large, buoyant LDL, high HDL and low triglycerides. Incidentally, low HDL and high triglycerides are hallmarks of the metabolic syndrome, the quintessential modern metabolic disorder. Krauss and his colleagues went on to hypothesize that sdLDL promotes atherosclerosis because of its ability to penetrate the artery wall more easily
Matti Narkia

Japan EPA Lipid Intervention Study (JELIS) - Дискуссионный Клуб Русского Меди... - 0 views

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    "18 645 patients with a total cholesterol of 6·5 mmol/L or greater were recruited from local physicians throughout Japan between 1996 and 1999. Patients were randomly assigned to receive either 1800 mg of EPA daily with statin (EPA group; n=9326) or statin only (controls; n=9319) with a 5-year follow-up. The primary endpoint was any major coronary event, including sudden cardiac death, fatal and non-fatal myocardial infarction, and other non-fatal events including unstable angina pectoris, angioplasty, stenting, or coronary artery bypass grafting. Analysis was by intention-to-treat. Findings At mean follow-up of 4·6 years, we detected the primary endpoint in 262 (2·8%) patients in the EPA group and 324 (3·5%) in controls-a 19% relative reduction in major coronary events (p=0·011). Post-treatment LDL cholesterol concentrations decreased 25%, from 4·7 mmol/L in both groups. Serum LDL cholesterol was not a significant factor in a reduction of risk for major coronary events. Unstable angina and non-fatal coronary events were also significantly reduced in the EPA group. Sudden cardiac death and coronary death did not differ between groups. In patients with a history of coronary artery disease who were given EPA treatment, major coronary events were reduced by 19% (secondary prevention subgroup: 158 [8·7%] in the EPA group vs 197 [10·7%] in the control group; p=0·048). In patients with no history of coronary artery disease, EPA treatment reduced major coronary events by 18%, but this finding was not significant (104 [1·4%] in the EPA group vs 127 [1·7%] in the control group; p=0·132)."
Matti Narkia

The JELIS Trial - The Heart Scan Blog: - 0 views

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    "The Japan eicosapentaenoic acid (EPA) Lipid Intervention Study (JELIS) is a clinical trial that all Track Your Plaquers should know about. This enormous trial followed a simple design: Japanese men, between 40-75 years, and Japanese postmenopausal women aged
Matti Narkia

Egg consumption in relation to cardiovascular disease and mortality: the Phys... - 0 views

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    Egg consumption in relation to cardiovascular disease and mortality: the Physicians' Health Study. Djoussé L, Gaziano JM. Am J Clin Nutr. 2008 Apr;87(4):964-9. PMID: 18400720 Results: In an average follow-up of 20 y, 1550 new myocardial infarctions (MIs), 1342 incident strokes, and 5169 deaths occurred. Egg consumption was not associated with incident MI or stroke in a multivariate Cox regression. In contrast, adjusted hazard ratios (95% CI) for mortality were 1.0 (reference), 0.94 (0.87, 1.02), 1.03 (0.95, 1.11), 1.05 (0.93, 1.19), and 1.23 (1.11, 1.36) for the consumption of < 0.0001). This association was stronger among diabetic subjects, in whom the risk of death in a comparison of the highest with the lowest category of egg consumption was twofold (hazard ratio: 2.01; 95% CI: 1.26, 3.20; P for interaction = 0.09). Conclusions: Infrequent egg consumption does not seem to influence the risk of CVD in male physicians. In addition, egg consumption was positively related to mortality, more strongly so in diabetic subjects, in the study population.
Matti Narkia

Inflammation and cardiovascular disease mechanisms -- Libby 83 (2): 456S -- American Jo... - 0 views

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    Libby P. Inflammation and cardiovascular disease mechanisms. Am J Clin Nutr. 2006 Feb;83(2):456S-460S. Review. PMID: 16470012 [PubMed - indexed for MEDLINE]
Matti Narkia

Fish Oil-Derived Fatty Acids, Docosahexaenoic Acid and Docosapentaenoic Acid, and the R... - 0 views

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    Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: the Kuopio ischaemic heart disease risk factor study. Rissanen T, Voutilainen S, Nyyssönen K, Lakka TA, Salonen JT. Circulation. 2000 Nov 28;102(22):2677-9. PMID: 11094031 Methods and Results-We studied this association in the Kuopio Ischaemic Heart Disease Risk Factor Study, a prospective population study in Eastern Finland. Subjects were randomly selected and included 1871 men aged 42 to 60 years who had no clinical coronary heart disease at baseline examination. A total of 194 men had a fatal or nonfatal acute coronary event during follow-up. In a Cox proportional hazards' model adjusting for other risk factors, men in the highest fifth of the proportion of serum DHA+DPA in all fatty acids had a 44% reduced risk (P=0.014) of acute coronary events compared with men in the lowest fifth. Men in the highest fifth of DHA+DPA who had a low hair content of mercury (2.0 µg/g). There was no association between proportion of eicosapentaenoic acid and the risk of acute coronary events. Conclusions-Our data provide further confirmation for the concept that fish oil-derived fatty acids reduce the risk of acute coronary events. However, a high mercury content in fish could attenuate this protective effect.
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