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Matti Narkia

Serum 25-hydroxyvitamin D and the risk of ovarian cancer - ScienceDirect - European Jou... - 0 views

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    Serum 25-hydroxyvitamin D and the risk of ovarian cancer.
    Toriola AT, Surcel HM, Agborsangaya C, Grankvist K, Tuohimaa P, Toniolo P, Lukanova A, Pukkala E, Lehtinen M.
    Eur J Cancer. 2009 Aug 25. [Epub ahead of print]
    PMID: 19713101
    doi:10.1016/j.ejca.2009.08.002

    Conclusion
    Overall, we did not observe a significant association between serum 25-OHD concentrations and the risk of ovarian cancer. However, we found evidence suggestive of an increased risk among women with low to insufficient serum 25-OHD concentrations.
Matti Narkia

Lack of Association between Serum Levels of 25-Hydroxyvitamin D and the Subsequent Risk... - 0 views

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    Lack of association between serum levels of 25-hydroxyvitamin D and the subsequent risk of prostate cancer in Finnish men.
    Faupel-Badger JM, Diaw L, Albanes D, Virtamo J, Woodson K, Tangrea JA.
    Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2784-6.
    PMID: 18086789
    doi: 10.1158/1055-9965.EPI-07-0672
Matti Narkia

Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized tr... - 0 views

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    Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis.
    Salonen JT, Nyyssönen K, Salonen R, Lakka HM, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Lakka TA, Rissanen T, Leskinen L, Tuomainen TP, Valkonen VP, Ristonmaa U, Poulsen HE.
    J Intern Med. 2000 Nov;248(5):377-86.
    PMID: 11123502
    DOI: 10.1046/j.1365-2796.2000.00752.x

    Conclusions. Our study shows that a combined supplementation with reasonable doses of both vitamin E and slow-release vitamin C can retard the progression of common carotid atherosclerosis in men. This may imply benefits with regard to other atherosclerosis-based events.
Matti Narkia

Six-Year Effect of Combined Vitamin C and E Supplementation on Atherosclerotic Progress... - 0 views

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    Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study.
    Salonen RM, Nyyssönen K, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Rissanen TH, Tuomainen TP, Valkonen VP, Ristonmaa U, Lakka HM, Vanharanta M, Salonen JT, Poulsen HE; Antioxidant Supplementation in Atherosclerosis Prevention Study.
    Circulation. 2003 Feb 25;107(7):947-53.
    PMID: 12600905
    doi: 10.1161/01.CIR.0000050626.25057.51

    Conclusions- These data replicate our 3-year findings confirming that the supplementation with combination of vitamin E and slow-release vitamin C slows down atherosclerotic progression in hypercholesterolemic persons.
Matti Narkia

Mercury, Fish Oils, and Risk of Acute Coronary Events and Cardiovascular Disease, Coron... - 0 views

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    Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland.
    Virtanen JK, Voutilainen S, Rissanen TH, Mursu J, Tuomainen TP, Korhonen MJ, Valkonen VP, Seppänen K, Laukkanen JA, Salonen JT.
    Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):228-33. Epub 2004 Nov 11.
    PMID: 15539625
    doi: 10.1161/01.ATV.0000150040.20950.61

    Conclusions- High content of mercury in hair may be a risk factor for acute coronary events and CVD, CHD, and all-cause mortality in middle-aged eastern Finnish men. Mercury may also attenuate the protective effects of fish on cardiovascular health.

    Mercury may increase the risk of cardiovascular diseases. In this study, high mercury content in hair increased the risk of cardiovascular morbidity and mortality in middle-aged Finnish men and attenuated the beneficial effects of fish oils on cardiovascular health. Regular consumption of fish with high mercury content should be avoided.
Matti Narkia

High dietary methionine intake increases the risk of acute coronary events in middle-ag... - 0 views

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    High dietary methionine intake increases the risk of acute coronary events in middle-aged men.
    Virtanen JK, Voutilainen S, Rissanen TH, Happonen P, Mursu J, Laukkanen JA, Poulsen H, Lakka TA, Salonen JT.
    Nutr Metab Cardiovasc Dis. 2006 Mar;16(2):113-20. Epub 2005 Nov 2.
    PMID: 16487911
    doi:10.1016/j.numecd.2005.05.005

    Conclusions
    The main finding of this study is that long-term, moderately high dietary methionine intake may increase the risk of acute coronary events in middle-aged Finnish men free of prior CHD. More prospective research is needed to confirm the role of dietary methionine in the development of CVD, and whether its effects are independent of homocysteine.
Matti Narkia

Glycemic index, glycemic load, and the risk of acute myocardial infarction in Finnish m... - 0 views

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    Glycemic index, glycemic load, and the risk of acute myocardial infarction in Finnish men: The Kuopio Ischaemic Heart Disease Risk Factor Study.
    Mursu J, Virtanen JK, Rissanen TH, Tuomainen TP, Nykänen I, Laukkanen JA, Kortelainen R, Voutilainen S.
    Nutr Metab Cardiovasc Dis. 2009 Oct 14. [Epub ahead of print]
    PMID: 19836217
    doi:10.1016/j.numecd.2009.08.001

    Conclusions
    Our results suggest that both high dietary GI and GL are associated with increased risk of AMI among overweight and GL possibly among less physically active men.
Matti Narkia

Serum Long-Chain n-3 Polyunsaturated Fatty Acids and Risk of Hospital Diagnosis of Atri... - 0 views

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    Serum Long-Chain n-3 Polyunsaturated Fatty Acids and Risk of Hospital Diagnosis of Atrial Fibrillation in Men.
    Virtanen JK, Mursu J, Voutilainen S, Tuomainen TP.
    Circulation. 2009 Dec 8;120(23):2315-21. Epub 2009 Nov 23.
    PMID: 19933935
    doi: 10.1161/CIRCULATIONAHA.109.852657

    Conclusions- An increased concentration of long-chain n-3 PUFAs in serum, a marker of fish or fish oil consumption, may protect against AF. Serum docosahexaenoic acid concentration had the greatest impact
Matti Narkia

Vitamin D supplementation during the first year of life and risk of schizophrenia: a Fi... - 0 views

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    Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study.
    McGrath J, Saari K, Hakko H, Jokelainen J, Jones P, Järvelin MR, Chant D, Isohanni M.
    Schizophr Res. 2004 Apr 1;67(2-3):237-45.
    PMID: 14984883

    Conclusion: Vitamin D supplementation during the first year of life is associated with a reduced risk of schizophrenia in males. Preventing hypovitaminosis D during early life may reduce the incidence of schizophrenia.
Matti Narkia

Association between serum 25(OH)D concentrations and bone stress fractures in Finnish y... - 0 views

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    Association between serum 25(OH)D concentrations and bone stress fractures in Finnish young men.
    Ruohola JP, Laaksi I, Ylikomi T, Haataja R, Mattila VM, Sahi T, Tuohimaa P, Pihlajamäki H.
    J Bone Miner Res. 2006 Sep;21(9):1483-8.
    doi: 10.1359/jbmr.060607

    Conclusions: A lower level of serum 25(OH)D concentration may be a generally predisposing element for bone stress fractures. Considering the obvious need of additional vitamin D in prevention of stress fractures, the effects of vitamin D fortification of foods and supplementation will be subjects of interest for future research
    PMID: 16939407
Matti Narkia

Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone... - 0 views

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    Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls.
    Cheng S, Tylavsky F, Kröger H, Kärkkäinen M, Lyytikäinen A, Koistinen A, Mahonen A, Alen M, Halleen J, Väänänen K, Lamberg-Allardt C.
    Am J Clin Nutr. 2003 Sep;78(3):485-92. Erratum in: Am J Clin Nutr. 2006 Jan;83(1):174.
    PMID: 12936933

    CONCLUSIONS: Vitamin D-deficient girls have low cortical BMD and high iPTH concentrations, which are consistent with secondary hyperparathyroidism. A low vitamin D concentration accompanied by high bone resorption (TRAP 5b) may limit the accretion of bone mass in young girls.
Matti Narkia

Vitamin D status affects serum parathyroid hormone concentrations during winter in fema... - 0 views

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    Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density.
    Outila TA, Kärkkäinen MU, Lamberg-Allardt CJ.
    Am J Clin Nutr. 2001 Aug;74(2):206-10.
    PMID: 11470722

    Conclusion: A large percentage of adolescent females have low vitamin D status during the winter in Finland, which seems to have negative effects on bone health.
Matti Narkia

A high prevalence of hypovitaminosis D in Finnish medical in- and outpatients. - J Inte... - 0 views

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    A high prevalence of hypovitaminosis D in Finnish medical in- and outpatients.
    Kauppinen-Mäkelin R, Tähtelä R, Löyttyniemi E, Kärkkäinen J, Välimäki MJ.
    J Intern Med. 2001 Jun;249(6):559-63.
    PMID: 11422663
    DOI: 10.1046/j.1365-2796.2001.00847.x

    CONCLUSION: Hypovitaminosis D is very common amongst Finnish in- and outpatients in both sexes, causing secondary hyperparathyroidism in females. More extensive studies are warranted to elucidate the vitamin D status of the Finnish population.
Matti Narkia

Vitamin D deficiency and bone health in healthy adults in Finland: could this be a conc... - 0 views

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    Vitamin D deficiency and bone health in healthy adults in Finland: could this be a concern in other parts of Europe?
    Lamberg-Allardt CJ, Outila TA, Kärkkainen MU, Rita HJ, Valsta LM.
    J Bone Miner Res. 2001 Nov;16(11):2066-73.
    PMID: 11697803

    Low vitamin D status was prevalent in these young adults in northern Europe in winter, although the vitamin D intake met the recommendation. This probably is not a local problem for northern Europe, because the natural sources of vitamin D are scarce and fortification is not very common in Europe, and with the exception of the southern part of Europe, sunshine is not very abundant in this part of the world. Thus, the results of this study indicate that more attention should be focused on vitamin D status and the sources of vitamin D in these countries.
Matti Narkia

Half of the patients with an acute hip fracture suffer from hypovitaminosis D: a prospe... - 0 views

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    Half of the patients with an acute hip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland.
    Nurmi I, Kaukonen JP, Lüthje P, Naboulsi H, Tanninen S, Kataja M, Kallio ML, Leppilampi M.
    Osteoporos Int. 2005 Dec;16(12):2018-24. Epub 2005 Aug 24.
    PMID: 16133642

    Half of the patients with a hip fracture suffered from hypovitaminosis D. The situation was worst in institutional and residential care, although there are personnel for taking care of vitamin D supplementation. In the late summer, one-third and in late winter two-thirds of the patients suffered from hypovitaminosis D. The geographical location of Finland indicates extensive efforts to increase the use of vitamin D supplements among elderly.
Matti Narkia

Vitamin D fortification as public health policy: significant improvement in vitamin D s... - 0 views

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    Vitamin D fortification as public health policy: significant improvement in vitamin D status in young Finnish men.
    Laaksi IT, Ruohola JP, Ylikomi TJ, Auvinen A, Haataja RI, Pihlajamäki HK, Tuohimaa PJ.
    Eur J Clin Nutr. 2006 Aug;60(8):1035-8. Epub 2006 Feb 15.
    PMID: 16482069
Matti Narkia

Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual a... - 0 views

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    Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial.
    Cheng S, Lyytikäinen A, Kröger H, Lamberg-Allardt C, Alén M, Koistinen A, Wang QJ, Suuriniemi M, Suominen H, Mahonen A, Nicholson PH, Ivaska KK, Korpela R, Ohlsson C, Väänänen KH, Tylavsky F.
    Am J Clin Nutr. 2005 Nov;82(5):1115-26; quiz 1147-8.
    PMID: 16280447
Matti Narkia

Vitamin D intake is low and hypovitaminosis D comm...[Eur J Clin Nutr. 1999] - PubMed R... - 0 views

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    Vitamin D intake is low and hypovitaminosis D common in healthy 9- to 15-year-old Finnish girls.
    Lehtonen-Veromaa M, Möttönen T, Irjala K, Kärkkäinen M, Lamberg-Allardt C, Hakola P, Viikari J.
    Eur J Clin Nutr. 1999 Sep;53(9):746-51.
    PMID: 10509773

    CONCLUSION: Hypovitaminosis D is fairly common in growing Finnish girls in the wintertime, and three months of vitamin D supplementation with 10 microg/d was insufficient in preventing hypovitaminosis D. The daily dietary vitamin D intake was insufficient (< 5 microg/d) in the majority of participants, while the calcium intake was usually sufficient.
Matti Narkia

A seasonal variation of calcitropic hormones, bone turnover and bone mineral density in... - 0 views

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    A seasonal variation of calcitropic hormones, bone turnover and bone mineral density in early and mid-puberty girls - a cross-sectional study.
    Viljakainen HT, Palssa A, Kärkkäinen M, Jakobsen J, Cashman KD, Mølgaard C, Lamberg-Allardt C.
    Br J Nutr. 2006 Jul;96(1):124-30.
    PMID: 16870000

    Seasonal variation in S-25-OHD and bone remodelling markers accompanied by negative correlation between S-25-OHD and S-iPTH was seen in this cross-sectional study of adolescent girls. In addition, the seasonal rhythm contributed 7.0-7.6 % difference in the BMD of lumbar vertebrae and left femur in early puberty girls. This variation should be avoided since it could hamper peak bone mass attainment.
Matti Narkia

A positive dose-response effect of vitamin D supplementation on site-specific bone mine... - 0 views

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    A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: a double-blinded randomized placebo-controlled 1-year intervention.
    Viljakainen HT, Natri AM, Kärkkäinen M, Huttunen MM, Palssa A, Jakobsen J, Cashman KD, Mølgaard C, Lamberg-Allardt C.
    J Bone Miner Res. 2006 Jun;21(6):836-44.
    PMID: 16753014
    doi: 10.1359/jbmr.060302

    We conclude that the current vitamin D recommendation for adolescent girls, at least in the northern latitudes, is too low to ensure sufficient vitamin D status during winter. Intake of vitamin D at rates of 10-15 μg/day aids to maintain stable S-25(OH)D concentrations during winter. Vitamin D induced BMC augmentation by decreasing bone resorption, but not affecting bone formation, which was reflected by the biochemical markers of bone turnover. Optimizing bone mineral gain in adolescence is crucial to the prevention of osteoporosis later in life. Increasing vitamin D intake to 10-15 μg/day aids in attaining this goal.
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